A new take on growth factor signaling in tamoxifen resistance

Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study, published in the open access journal BMC Medical Genomics , suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen because of increased GF signaling...

Scientists Unravel Mystery of Tamoxifen Resistance

Some breast tumors produce a protein that defeats the drug WEDNESDAY, Nov. 12 (HealthDay News) -- As many as 35 percent of women who take tamoxifen to prevent the return of breast cancer do not respond to the drug -- and now scientists think they know why. A battle between proteins ...

Research Reveals Why Tamoxifen Doesn't Always Work

Receptors on the surface of breast cancer cells may be the key, scientists say THURSDAY, Oct. 30 (HealthDay News) -- Scientists have uncovered new clues to how breast cancer cells become resistant to the widely-used prevention and treatment drug tamoxifen. The findings, from a team ...

Chemotherapy and tamoxifen reduce risk of second breast cancer

Among breast cancer patients, both chemotherapy and tamoxifen independently reduced the risk of developing a second cancer in the other breast, according to a study published online December 25 in the Journal of the National Cancer Institute . The risk reduction persisted for at least 10 and 5 ye...

Data Show ARIMIDEX(R) (Anastrozole) Continues To Be Superior to Tamoxifen in Helping Reduce the Risk of Recurrence in Patients With Early Breast Cancer

Effectiveness Of ARIMIDEX Still Evident More Than Three Years After Treatment SAN ANTONIO, Texas, Dec. 14 /PRNewswire-FirstCall/ -- Data released today show a continued benefit of ARIMIDEX when compared to tamoxifen in treating postmenopausal women with hormone ...

Arimidex Beats Tamoxifen in Keeping Breast Cancer at Bay

After more than 8 years of follow-up, older women taking the newer drug fared better, study finds FRIDAY, Dec. 14 (HealthDay News) -- The aromatase inhibitor drug Arimidex continues to outpace the old standard tamoxifen when it comes to preventing recurrences of hormone-receptor-positi...

Technique May Let More Women Use Tamoxifen

30% of breast cancers currently don't respond to this type of estrogen-linked drug MONDAY, Feb. 23 (HealthDay News) -- Researchers have found a way to "switch on" estrogen sensitivity in breast tumor cells, thereby making them vulnerable to the breast cancer drug tamoxifen. If succe...

Future hope for patients with breast cancers resistant to tamoxifen

Researchers have found a new family of therapeutic agents that interferes with the ability of estrogen to stimulate the growth of breast cancer cells. The results of the new study will be presented by Nicole Patterson at The Endocrine Society's 90th Annual Meeting in San Francisco. The cell-ba...

Acupuncture relieves hot flushes in breast cancer patients taking tamoxifen

Berlin, Germany: Acupuncture provides effective relief from hot flushes in women who are being treated with the anti-oestrogen tamoxifen following surgery for breast cancer, according to new research presented today (Friday) at the 6th European Breast Cancer Conference (EBCC-6) in Berlin. Mrs J...

Study Identifies Mechanism Which May Help Tamoxifen Work Better

The “crosstalk” between estrogen and a special protein responsible for cell development (Notch) helps breast cancer cells// proliferate and spread, a new study shows. “Breast cancer cells respond to loss of estrogen, which is caused by commonly used hormonal therapy, by increasing the Notch s...

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Tamoxifen in Medical Technology

New Study: Antidepressants Commonly Prescribed with Tamoxifen Put Women at Much Higher Risk for Recurrent Breast Cancer

- Several SSRIs more than double risk of cancer recurrence in tamoxifen treated patients - Nearly 30 percent of tamoxifen users take drugs that reduce its effectiveness against breast cancer ORLANDO, Fla., May 30 /PRNewswire-FirstCall/ -- An important new study finds that certain popula...

Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery

- Femara showed reduced risk of death by 13% (P=0.08), despite inclusion of patients crossing over from tamoxifen to Femara therapy - In a separate censored analysis excluding patients after they crossed over to Femara, reduction in risk of death was 19% - Long-term follow-up fro...

VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy

- Post-unblinding analysis of MA-17 trial data provides evidence for potential benefit of starting Femara up to seven years after finishing tamoxifen - Femara only member of aromatase inhibitor class with data demonstrating this potential benefit, as publishe...

First single breast cancer study to show significant survival benefit for women switching from tamoxifen to Arimidex

Anastrozole (ArimidexTM) improves overall survival in postmenopausal women with early breast cancer receiving treatment with tamoxifen – Survival benefit demonstrated for an AI over tamoxifen in a single trial – LUTON, England, Friday 15 June 2007: Analysis of the entire population...

Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal Women with Early Breast Cancer Receiving Treatment with Tamoxifen

Survival Benefit Demonstrated for an AI Over Tamoxifen in a Single Trial LUTON, UK, Friday 15 June 2007: Analysis of the entire population of a single trial has demonstrated that survival in early breast cancer can be significantly improved by switching from tamoxifen to anastrozole (Arimidex)...

Popular Breast Cancer Drug Used with Certain Antidepressants Puts New Jersey Women at Risk

...omen in New Jersey who take the breast cancer drug tamoxifen in conjunction with certain popular antidepressant...dicine released a study revealing that women using tamoxifen to prevent a recurrence of breast cancer who also ...ific analysis, Medco found that among nearly 2,000 tamoxifen patients in the state during 2008, 12 percent were...

Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival

...of estrogen and progesterone receptors and for the over-expression of HER2. Commonly used breast cancer therapies target these receptors; for example, tamoxifen for estrogen receptor and trastuzumab (Herceptin(r)) for HER2. However, 15-20% of all breast cancers lack over-expression of all three proteins, thus ...

Researchers at the Karmanos Cancer Institute in Detroit Discover Feasibility of Chemotherapy Alternative

... FDA-approved oral chemotherapy treatment, gaining approval for human use in 1998. Since then, other oral cancer agents have been developed, including tamoxifen for breast cancer patients and Methotrexate, which is used to treat breast, skin, head, neck and lung cancers. "There are not many low-dose appli...

New Research Shows Antidepressants May Thwart Breast Cancer Treatment

... Popular antidepressants taken with tamoxifen can increase the risk of breast cancer recurrence ...swire-USNewswire/ -- A new study found that taking tamoxifen with certain antidepressants more than doubled the...depressants inhibit an enzyme, CYP2D6, which helps tamoxifen work effectively. (Logo: http://www.newsco...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...rience better cognitive function than those taking tamoxifen - Phase II data show potential of Glivec(R)...verall cognitive function than the patients in the tamoxifen group (difference in mean composite scores =0.23, ...stmenopausal women receiving adjuvant letrozole or tamoxifen in the Breast International Group (BIG) 1-98 trial...

Tamoxifen in Medical Definition

Personalized medicine

...n have an increased lifetime risk of 85% for developing a breast cancer or up to 40% increased risk of getting ovarian cancer. Now medications such as tamoxifen are being shown to reduce incidence of disease. The exciting news is that cancer predisposition genes and families are being identified by genetic t...

Tamoxifen in Medical Dictionary

Estrogen

...an's ovaries produce most estrogen hormones, although the adrenal glands ... So the question comes, how to control the estrogen ?" Drugs like tamoxifen interfere with estrogen action, but Dr. Ghosh, and his ... Breast Cancer Advice. Keep up to date with the latest information and treatment of ...

Tamoxifen in Biological News

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

SAN ANTONIO - Findings from a new study have prompted Mayo Clinic researchers to recommend CYP2D6 gene testing for postmenopausal women about to begin tamoxifen therapy. This data confirms that women with an inherited deficiency in the CYP2D6 gene, which is important for the metabolism of tamoxife...

'New' estrogen receptor found to be key player in tamoxifen resistance

Washington, D.C. Researchers at Georgetown University Medical Center have discovered a novel way in which breast cancer cells become resistant to tamoxifen, the world's largest-selling breast cancer prevention and treatment drug. They say the findings could provide a way to identify tamoxifen us...

Restoring tamoxifen sensitivity in resistant breast cancer cells

The widely used breast cancer drug tamoxifen (Nolvadex®), which can become less effective over time, might retain its full strength indefinitely if used along with a second drug, according to new research in mice conducted by investigators from the National Cancer Institute (NCI), part of the Natio...

Pak1 expression increases tamoxifen resistance in breast cancer patients

A protein that activates estrogen receptors in breast cancer may play a role in resistance to therapeutic effects of anti-estrogen tamoxifen treatment, according to a study in the May 17 Journal of the National Cancer Institute. Pak 1 is a member of a family of proteins involved in many cell ...

Statin therapy ineffective in breast cancer prevention

...imilarly, no effect of atorvastatin was observed in an estrogen receptor-negative model in mice. By contrast, when these mice were given 0.4 mg of tamoxifen or 80 mg of bexarotene there was a significant reduction in the multiplicity of mammary tumors. Combining these regimens with atorvastatin did not aug...

Master gene plays key role in blood sugar levels

...or SRC-1. His work with another called SRC-3 has led to better understanding of cancer and inflammation and led to the understanding of drugs such as tamoxifen in the treatment of breast cancer. "This again shows that these coactivators are important master genes for physiology," said O'Malley. "In the cas...

CTRC-AACR San Antonio Breast Cancer Symposium

...hts: Practice-changing data on the role of zolendric acid in late-stage breast cancer How changes in breast density can predict outcome with tamoxifen Why rest is as important as physical activity in breast cancer prevention Recurrence rates among patients with small HER2-positive tumors Evalua...

Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics

...d for the future with products in oncology and infectious disease. Its genetic tests include CYP450 for drug metabolism studies and HER-2 for use with tamoxifen therapy. Other companies covered in the GEN article include Myriad Genetics, Genomic Health, Genoptix, Luminex, Abbott Labs, Aureon, Autogenomics, ...

Breast cancer cells recycle to escape death by hormonal therapy

...r cells have receptors for the hormone estrogen, which acts as a nutrient and stimulates their growth. Patients typically get an antiestrogen such as tamoxifen for five years to try to starve them to death, says Dr. Patricia V. Schoenlein, cancer researcher in the Medical College of Georgia Schools of Medicin...

Caution on stem cell therapy

... cells in the intestinal lining. Labeling stem cells containing the Bmi1 gene involved tamoxifen, a drug used to treat and prevent breast cancer. tamoxifen was used to activate an enzyme in cells that contain the Bmi1 gene so that the cells appeared blue when viewed under a microscope. "We decided to ...

Tamoxifen in Biological Technology

Genomic Health Announces Third Quarter 2008 Financial Results and Business Progress

... Japanese women demonstrating that the Oncotype DX Recurrence Score(R) result may predict response to neoadjuvant endocrine therapy including tamoxifen and anastrozole at the ASCO Breast Cancer Symposium in September. Conference Call Details To access the live conference call today, November 5...

Breast Cancer Patients Take DNA Test to Determine Best Treatment

...rly one third of breast cancer patients prescribed tamoxifen currently fail treatment. According to the Nationa...ng their medications. Recent research shows that tamoxifen has to be activated into endoxifen by the liver en...t ten percent of breast cancer patients prescribed tamoxifen are missing CYP2D6 because of their DNA, and will ...

Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics

...d for the future with products in oncology and infectious disease. Its genetic tests include CYP450 for drug metabolism studies and HER-2 for use with tamoxifen therapy. Other companies covered in the GEN article include Myriad Genetics, Genomic Health, Genoptix, Luminex, Abbott Labs, Aureon, Autogenomics, ...

Multigene Test Predicts Who Could Avoid Chemotherapy Despite Positive Lymph Nodes in Early Breast Cancer

... survival (OS) compared with patients treated with tamoxifen alone. This RS assay was performed on the breast c...ic for 10-year DFS and OS in patients treated with tamoxifen alone. They then compared DFS in patients treated with tamoxifen versus patients treated with CAF-T across RSs. The...

Tamoxifen in Biological Definition

Cancer

...ily selenium or vitamin E or both experience a reduced incidence of prostate cancer in comparison to men taking placebo pills. Daily use of tamoxifen , a selective estrogen receptor modulator, for up to 5 years, has been demonstrated to reduce the risk of developing breast cancer in high-risk wo...