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Spleen in Medical News

Using Contrast Enhanced Sonography Improves Diagnosis of Liver and Spleen Injuries

Contrast-enhanced sonography shows liver and spleen injuries better than non-contrast enhanced sonography, according to a study conducted // at the University of California, Davis School of Medicine department of radiology in Sacramento, CA. This study included 22 liver, spleen or renal injur...

Decision Resources' Updated Rheumatoid Arthritis Report Now Includes Forecast for Rigel Pharmaceuticals' Fostamatinib Disodium

...ouncement regarding additional Phase II clinical data for fostamatinib disodium. The report finds that, owing to its impressive efficacy, the spleen tyrosine kinase (Syk) inhibitor fostamatinib disodium will likely precede TNF-alpha inhibitors such as Amgen/Wyeth/Takeda's Enbrel and Abbott/Eisai's ...

CryoLife Receives CE Mark Approval for BioFoam(R) Hemostatic Technology

...Foam at up to six centers in the United Kingdom, Germany, France and Italy to support its initial marketing efforts. Based on the number of liver and spleen procedures performed annually in the European Community, CryoLife estimates the annual European market opportunity for BioFoam to be approximately $30...

Spleen May Help Heart Recover From Disease

...ion doesn't rank down there with the appendix, the spleen isn't exactly known as a vital organ. In fact, ple... fine without it. But new research suggests the spleen plays a bigger role in the immune system than previously thought. In mice, scientists found, the spleen serves as a home for a type of white blood cell th...

Leukemia cells evade immune system by mimicking normal cells, Stanford studies show

...e as much CD47 as their normal counterparts, CD47 levels were also temporarily elevated in healthy bone marrow stem cells migrating to organs like the spleen or the liver in response to infection or inflammation, or to bone marrow sites to replenish missing stem cells. A closer look determined why. "Thes...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

... system in place to deal with viral infections, or just to complete their normal life cycle. Cells lining the gut, for example, or immune cells in the spleen and thymus are meant to live only a couple of days. "You lose three-quarters of a million cells per second in your body due to apoptosis," noted Guy S...
Spleen in Medical Technology

Novare Announces Completion of First Pediatric Single Port Spleen Removal Using RealHand(R) HD Instruments

8-year-old patient receives 'hidden scar' procedure; Pediatrics becomes 4th surgical specialty to benefit from single port surgery with RealHand HD instruments CUPERTINO, Calif., July 28 /PRNewswire/ -- Novare Surgical Systems announced the successful completion of...

Shire Reports Positive Results From First of Three Phase III Trials of velaglucerase alfa for Type 1 Gaucher Disease and Provides Important Updates on Interactions With FDA

...ant improvements compared with baselines were also observed in platelet and spleen sizes, and nominally significant improvements were observed in liver size a..., statistically significant improvements in hemoglobin, platelet count, and spleen volume were also demonstrated. The magnitude of changes in the 45U/kg dose ...

VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE

...ic pathway relates to monocyte deployment from the spleen to inflammatory sites, including myocardial infarc...d that monocytes were held in concentration in the spleen and released to injured tissue sites in the body t...firm "unambiguously the fate of monocytes from the spleen to the heart." "We see the integration of ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... patients with leukemia cutis had complete or partial clearance of skin lesions. One patient had a 36% reduction in lymph node size, a 28% decrease in spleen size and a significant increase (44%) in hemoglobin. Mild grade 1 or 2 infusion toxicity was observed and there were three dose-limiting toxicities re...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

...auses: low production of platelets in the bone marrow, increased breakdown of platelets in the bloodstream, or increased breakdown of platelets in the spleen or liver, which can be induced by certain anemias, cancers, infections, or medications. Symptoms can include bruising, nose bleeds, bleeding in the mo...

Gene Therapy Corrects Sickle Cell Disease in Laboratory Study

...apart. The resulting clogged blood vessels can lead to cognitive dysfunction by causing small strokes in the brain and cause damage to kidneys, liver, spleen and lungs. The only permanent cure for the disease is a bone marrow transplant to give recipients blood-forming cells that will form normal beta-globi...
Spleen in Medical Products

Ferritin IRMA Test

Description:...taining iron oxide and phosphate [1]. Ferritin is synthesized in the liver, spleen and numerous other body tissues, with major concentrations found in the liv...arrow, and intestinal mucosa [1,2]. Ferritin may comprise as much as 20% of spleen dry weight. In addition to serving as a major iron storage pool, ferritin m...
Company:Diagnostic Systems Laboratories, Inc.
Spleen in Medical Dictionary

Spleen

The spleen is an organ that is a part of the lymph system. ... To check for an enlarged spleen , he or she will percuss (tap) along the left ... The spleen is an oblong organ (some would say it is tongue-shaped) seated just ... The spleen contains lots of long winding narrow blo...

Visceromegaly

...ion. Visceromegaly is enlargement of the internal organs in the abdomen, such as ... Review provided by VeriMed Healthcare Network. ... Enlarged spleen - Visceromegaly pictures and images. ... Because of its wide variety of functions, ... Read article on Visceromegaly . Review Date : 5/6/2003 ... ...

Splenomegaly

...ree being cytopenia(s), normal or... Enlarged spleen — Comprehensive overview covers symptoms, causes,.... ... Splenomegaly is an enlargement of the spleen beyond its normal size. ... Armitage J. Approach ...Overview, Splenomegaly is an enlargement of the spleen beyond its normal size. ... Approach to the patie...

Rectal cancer

...... Features information about colon cancer , also known as colorectal cancer . ... Rectal cancer , X-ray. Sigmoid colon cancer , X-ray. spleen metastasis - CT scan ... The rectum is the part of the large intestine right before the anus. ... cancer screening tests include digital...

Platelet count

...h is often already high because ... Platelet (thrombocyte) count . Platelets (thrombocytes) are the smallest type of blood cell. ... A large spleen can lower the platelet count . What Affects the Test ... Platelet count . Alternative Names: Thrombocyte count . Normal Values: ... A pla...

Osteomyelitis

...as vertebral osteomyelitis . ... The infection that causes osteomyelitis can also start in another part of the ... People who have had their spleen removed are also at higher risk for osteomyelitis . ... Detailed information on osteomyelitis , including symptoms, diagnosis, and treatment ...
Spleen in Biological News

Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf

NEW YORK (MAY 27, 2008) -- Researchers from Weill Cornell Medical College may have discovered the precise role of a gene in one of the world's most common blood disorders, beta-thalassemia, commonly known as Cooley's anemia. Along with sickle-cell anemia, Cooley's anemia is the most commonly inher...

Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice

Researchers at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins have invented a cost-effective and highly efficient way of analyzing what many have termed "junk" DNA and identified regions critical for controlling gene function. And they have found that these control regions from...

Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants

...llion yearly. "A key challenge to successful malaria intervention is our limited understanding of how the malarial parasite evades detection by the spleen our immune system's control centre," said Dr. Preiser. "With this grant, we will use new imaging tools to visualise and measure how many parasites a...

Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic

...s identified 1-AMA in a screen for compounds that bind to a cavity in horse spleen apoferritin, HSAF, that Eckenhoff and co-workers have shown to bind clinica...on constant, Kd 0.1 mM, for binding to the general anesthetic site in horse spleen apoferritin, meaning the compound is behaving as traditional general anesth...

Fireflies and jellyfish help illuminate quest for cause of infertility

...cing prolactin throughout the body. This included the pituitary gland, the thymus an organ in the chest which helps protect against autoimmunity the spleen and inflammatory cells in the abdominal cavity. ...

Lancet study supports new, highly effective treatment for blood disorder

...d weight gain. Other common treatments include IV anti-D and IV gammaglobulin, and also rituximab. More drastic measures, like surgical removal of the spleen (splenectomy) are sometimes taken in order to prevent the body from destroying platelet cells within the organ. However, this may put a patient at ris...
Spleen in Biological Technology

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...e against tuberculosis and have the potential to treat swine and other H1N1 influenzas. The TB investigators presented data that showed that blood and spleen cells from immunized mice produced gamma interferon in response to the vaccine, while the cells from mice in the various control groups did not. Othe...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

...y demonstrates the safety and early signs of efficacy of TRU-016 as shown by a reduction in tumor lymphocyte blood counts, reduction in lymph node and spleen size, and/or an improvement in hematopoiesis, or the production of red blood cells and platelets. Eight of the 10 patients had high-risk genomic ...

Safer nanoparticles spotlight tumors, deliver drugs

...d more of a drug. Yet they self-destruct, and the remnants can be filtered away by the kidneys. Close examination of vulnerable organs like liver, spleen and kidney, which help to remove toxins, revealed no lasting changes in mice treated with the new nanoparticles. ...

Portola Data on Its Novel Syk Inhibitors and Novel Universal Factor Xa Inhibitor Antidote to be Presented at 2008 American Society of Hematology (ASH) Meeting

... in cardiovascular disease, inflammatory disease and cancer, today announced that data related to the Company's series of novel compounds that inhibit spleen tyrosine kinase (Syk) and its novel universal Factor Xa inhibitor antidote will be presented at the annual meeting of the American Society of Hematolo...

Oncolytics Biotech Inc. Collaborators to Present Reovirus Research at ASGT Meeting

... pre-loaded with reovirus localize to lymph nodes, spleen and liver and deliver the virus to sites of metast...n, killing the tumour cells in the lymph nodes and spleen by reovirus generated potent anti-tumour immunity, preventing repopulation of the lymph nodes and spleen by further waves of cells spreading from the prima...

Proteolix's Carfilzomib Receives Orphan Drug Designation for Treatment of Multiple Myeloma

... cells multiply out of control, producing large amounts of a protein called monoclonal immunoglobulin M. WM can result in enlargement of the liver and spleen due to anemia and large amounts of immunoglobulin M can lead to hyperviscosity syndrome, in which the blood becomes abnormally thick. Symptoms of this...
Spleen in Biological Products

Rat Tissue Array: Brain, heart, kidney, liver, lung, muscle, spleen and stomach, each tissue from 10 female and 10 male, respectively from BioChain

Description: Rat adult normal paraffin tissue array is designed for rapidly screening genes or proteins of interest in extensive panels of different types of tissues. Rat brain, heart, kidney, liver, lung, muscle, spleen and stomach tissues are arrayed on positively charged glass slide. Each tissue is from 10...
Company:BioChain

Pokeweed Mitogen Spleen Cell Conditioned Medium, 25 mL from StemCell Technologies, Inc.

Description: Source of colony stimulating factors for assays of mouse hematopoietic progenitors from bone marrow, spleen, blood and fetal liver. Suitable for the growth of mouse BFU-E, CFU-M, CFU-G and CFU-GEMM when added to methylcellulose at a final concentration of 2-5%, with addition of erythropoietin. Wi...
Company:StemCell Technologies, Inc.

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Human Spleen from OriGene Technologies

Description: The Rapid-Screen cDNA Library Panels were designed for full-length gene cloning and require just three sets of PCRs to identify the desired cDNA clone. The first PCR analysis is performed in a 96-well "Master Plate," where each well contains plasmid DNA from 5,000 clones. Having identified the posi...
Company:OriGene Technologies

Mouse Hematopoietic Stem Cell Expansion Cytokine Panel from R&D Systems

Description:...rare cells that reside in adult bone marrow where hematopoiesis is continuously taking place. They can also be found in cord blood, fetal liver, adult spleen and peripheral blood. Many HSC studies rely on ex vivo expansion of HSC in culture. The combined use of multiple cytokines, Flt-3 ligand, SCF and Tpo,...
Company:R&D Systems

Dynabeads Mouse Pan B (B220) from Dynal Biotech

Description:...Mouse pan B (B220), 4.5 m, coated with anti-B220 monoclonal antibody. For the efficient positive isolation or depletion of mouse B cells directly from spleen or lymph node cell suspensions. B220 antigen is expressed on mouse B cells and lytically active subsets of lymphokine activated killer cells from all ...
Company:Dynal Biotech

Rabbit Anti-Asb-2 Polyclonal Antibody, Unconjugated from IMGENEX

Description:...taining protein) This polyclonal antibody was raised against synthetic peptides containing amino acids 75-93 and 348-368 of human Asb-2 protein. Human spleen lysate (Imgenex Catalog No. 40149) can be used as a positive control. It should cross react with mouse and rat Asb-2, based on amino acid sequences us...
Company:IMGENEX
Spleen in Biological Definition

Anatomy

... Labia Larynx Liver Lung Nose Ovary Pharynx Pancreas Penis Placenta Rectum Skin Small intestine spleen Stomach Tongue Uterus Bones in the human skeleton : Collar bone (clavicle) Thigh bone (femur) Humerus Mandible ...

Blood

...e hormones are produced by the endocrine glands and the watery fraction maintained by the gut and the kidney . Blood cells are degraded by the spleen and the Kuppfer cells in the liver. The liver also clears proteins and amino acids (the kidney secretes many small proteins into the urine ). ...

Immune system

...l. It may be broken down into the adaptive immune system (only found in vertebrates [1] ), composed of four lymphoid organs ( thymus , lymph nodes , spleen and submucosal lymphoid nodules) and the group motile cells that are involved in the body's defense against foreign bodies. The term may also be used...

Immunology

...erous early physicians characterised organs that would later prove to be part of the immune system. The key organs of the immune system are thymus , spleen , bone marrow , lymph vessels , lymph nodes and secondary lymphatic tissues such as tonsils and adenoids ) and skin . The major organs, the th...

Kidney

...ans the kidneys are two organs located in the posterior part of the abdomen . There is one on each side of the spine just below the liver and spleen . Superior to each kidney is an adrenal gland (also called the suprarenal gland ). The kidneys are retroperitoneal, which means they lie behind...

Malaria

...from attack by the body's immune system because it stays inside liver and blood cells. However, circulating infected blood cells are killed in the spleen . To avoid this fate, the parasite produces certain surface proteins which infected blood cells express on their cell surface, causing the blood cel...
Spleen in Biological Dictionary

Spleen

The spleen is an organ found in all vertebrate animals with important roles in regard to red blood cells and the immune system In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells, holds a reserve in case of hemorrhagic... The spleen , an ...

Serosa

...sitive, serosa negative/positive cancers) with a well-known ... into the spleen or tumor invasion through serosa to the spleen was detected. ... Outside the abdominopelvic cavity the serosa is rep...

Monoclonal antibodies

... importantly, we can utilize monoclonal antibodies directly as therapy. ... To produce monoclonal antibodies , one removes B-cells from the spleen of an ... The process of producing monoclonal antibodies described above was invented by ... ... Methods of Producing Monoclonal Antibodies...

Dendritic cell

...ls —the preeminent component of the immune system that initiates and regulates the body's response ... Two dendritic cells (arrows) from the spleen of a mouse. ... Dendritic cells have a set of transmembrane receptors that recognize ... Dendritic cell subsets ... These dendritic cel...
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