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Apoptosis in Medical News

Critical link in cell death pathway revealed

... found that XIAP (X-chromosome-linked inhibitor of apoptosis protein) is the critical factor that determines ... is FAS, but curiously it does not always activate apoptosis the same way, Professor Strasser said. "One of ... to kill the cells; amplification of the apoptosis signalling pathway is required." Professor ...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

... just that, by lighting up cells as they die. apoptosis is a carefully orchestrated sequence of ... is possible to noninvasively image the degree of apoptosis occurring in living animals' tumors, and thereby ... diagnostic method is safe for use in humans. apoptosis occurs all the time in healthy bodies. Cells have ...

Amgen Highlights Data to Be Presented at ASCO

... (Monday, June 1, 2009, 5:15pm-5:30pm) apoptosis As part of Amgen's mechanistic approach to targeted cancer therapies, the Company's apoptosis program is focused on the development of highly ... cell death. In cancer, the dysregulation of apoptosis is critical in the development and survival of ...

Cathepsin B increases apoptosis in fulminant hepatic failure

... implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis is involved in the pathogenesis of fulminant ... cathepsin B expression initiates hepatocyte apoptosis in fulminant hepatic failure. Cathepsin B, a ...

An adjuvant chemotherapeutic agent in gastric cancer therapy

... injection. Morphological changes were observed. apoptosis was determined by transmission electron microscope. apoptosis was also quantified by two methods: the detection ... cancer cell MKN45 were effective in inducing apoptosis in mesothelial cells in a time-dependent manner. ...

Prostaglandin receptor key to atherosclerosis development

... Linton said. The link between macrophage apoptosis and lesion development remains unclear, he said. ... have been some reports that increased macrophage apoptosis in early lesions reduces the lesion area, Linton said. Other studies have suggested that macrophage apoptosis creates a pro-inflammatory environment that ...

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Apoptosis in Medical Technology

Senesco Announces H1N1 Influenza Survival Test Results in Mice

... underscore Factor 5A's ability to mitigate apoptosis caused by inflammation, in this case from the ... is applicable in human medicine. Accelerating apoptosis may have applications to development of cancer treatments. Delaying apoptosis may have applications to certain diseases ...

Ascenta Therapeutics Announces Multiple Presentations on AT-101 at 2009 ASCO Annual Meeting

... Small molecule pan-bcl-2 inhibitor AT-101 induces apoptosis in NSCLC by upregulating noxa and enhances ... Mcl-1 inhibition) that has been shown to induce apoptosis directly by operating as a BH3 mimetic and ... lowers the threshold for cancer cells to undergo apoptosis in various tumor types. In Phase I and Phase II ...

Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer

... to date suggest that stimulating cancer cell apoptosis through Bcl-2 pathways with AT-101 may in fact ... the expression of proteins that inhibit apoptosis (programmed cell death). The most recognized ... that has been shown to directly induce apoptosis by operating as a BH3 mimetic and indirectly as ...

Human Genome Sciences Reports Substantial Progress Toward Commercialization and Announces 2009 Goals at JPMorgan Healthcare Conference

... any product in development that targets the TRAIL apoptosis pathway, and three randomized chemotherapy ... (inhibitor of apoptosis) proteins, thus allowing apoptosis to proceed and causing the cancer cells to die. ... cancer cells, they can help cancer cells resist apoptosis and resume growth and proliferation. ...

Human Genome Sciences Initiates First Clinical Trial of Lead IAP Inhibitor HGS1029 in Advanced Solid Tumors

... activity of IAP proteins, thus allowing apoptosis to proceed and causing the cancer cells to die. ... around its leading expertise in the apoptosis pathway. HGS has initiated new chemotherapy ... any product in development that targets the TRAIL apoptosis pathway. About Human Genome Sciences The ...

Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR

... inhibition of the target CRM1 with induction of apoptosis selectively in cancer cells compared to normal ... normal cells by regulating cell growth and apoptosis (cell death). Accumulation of these CRM1 cargo ... leads to the inhibition of cell growth and apoptosis selectively in cancer cells. Kosan's ...

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Apoptosis in Medical Products

VersaFluor Cuvette Fluorometer

Features:... filters Is the only instrument needed to detect and quantitate DNA from PCR amplification, restriction digests, and plasmid preps, to quantitate apoptosis activity, and to assay the reporter enzymes beta-glucuronidase (GUS) and beta-galactosidase Quantitates DNA at concentrations as low as 10 ng/ml ...
Company:Bio-Rad Laboratories

Epi-K

Features:... layer. Presence of an applanation front plate prevents cutting into the stroma. Implication of potential better wound healing: less apoptosis (more stable result). possibly less pain. Expected more rapid visual recovery. ...
Company:Moria S.A.
Apoptosis in Medical Definition

Thymocyte

... inability to bind MHC. Negative selection is the active induction of apoptosis in thymocytes with a high affinity for self peptides or MHC. This ... a T cell receptor incapable of binding MHC class I or class II undergo apoptosis . Some thymocytes are able to rescue failed positive selection by receptor ...

Central tolerance

... After exposure to self antigens, T cells and B cells become immunologically tolerant (non-reactive) in a number of ways : Negative selection ( apoptosis ) Anergy (non-responsiveness) Receptor editing (changing the specificity of the autoreactive cell) [4] Division to a regulatory lineage ...

Pathology

... able to adapt and survive. In necrosis, the componants of degenerating cells leak out, potentially contributing to inflammation and further damage. apoptosis , in contrast, is a regulated, orderly degeneration of the cell which occurs in the settings of both injury and normal physiological processes. [8] ...
Apoptosis in Biological News

Study by NTU professors provides important insight into apoptosis or programmed cell death

... shuts down. Too little or too much apoptosis plays a role in a great many diseases. When ... - for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and ... While it is established that cells undergo apoptosis when they are damaged by mechanical injury, ...

Genes that control cell death fingered in age-related hearing loss

... to research published online in the journal apoptosis a journal devoted to the topic of cell suicide, ... activity differed between the two groups. apoptosis itself is certainly nothing new. Such programmed ... cells that are damaged or no longer needed. When apoptosis happens, a cell's structure breaks up, and the ...

Refusal of suicide order: Why tumor cells become resistant

... cells simply degrade a protein that triggers apoptosis in the case of DNA damage. Blocking this protein degradation might set apoptosis back in operation and, thus, increase the ... suicide! Among the proteins that trigger apoptosis after severe DNA damage is the HIPK2 molecule. ...

Programmed death boosts business

... to undergo spontaneous self destruction. apoptosis is a very useful process. Under normal ... to separate for form tiny hands, for instance. apoptosis also allows the body to eradicate errant cells ... and Fernndez-Gonzlez suggest that business adopt apoptosis as a standard procedure within the organisation. ...

Early exposure to common weed killer impairs amphibian development

... hemorrhaging, intestinal coiling, edema and apoptosis (normal cell death that is "programmed" by the ... exposed tadpoles for increased incidence of apoptosis by measuring levels of active caspase-3 in the ... and midbrain. Caspase-3 is a protein needed for apoptosis to occur. They conducted measurements after 6, ...

JCI table of contents: Aug. 9, 2007

... the heart (cardiomyocytes) by a process known as apoptosis and decreased cardiomyocyte expression of the ... cardiomyocytes. However, although cardiomyocyte apoptosis was decreased, it was not completely eliminated. ... revealed that Bcl-2 inhibited only one pathway of apoptosis activated by the sustained inflammatory response ...

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Apoptosis in Biological Technology

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

... Therapeutics Preclinical Mechanism apoptosis in CLL Cells Occurs Via Distinct Mechanism ... study evaluating the effect of TRU-016 on direct apoptosis in CLL cells. (Logo: ... Modular ImmunoPharmaceutical (SMIP) on direct apoptosis in chronic lymphocytic leukemia cells via ...

First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418

... I (GGTase I) that induces apoptosis by downregulating several pivotal oncogenic and ... inhibitor of GGTase I that appears to induce apoptosis by downregulating several pivotal oncogenic and ... suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the ...

Telik Reports Preclinical Results at AACR Annual Meeting

... Aurora kinase activity induces growth arrest and apoptosis in cells and leads to tumor-growth inhibition in ... compounds induced growth arrest, polyploidy and apoptosis in human cancer cell lines, such as HCT116 ... in human solid tumor cell lines. The resulting apoptosis or senescence of these cells may depend on their ...

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

... the activity of at least three "inhibitors of apoptosis proteins" or IAPs (including XIAP, c-IAP1, and c-IAP2) to create conditions in which apoptosis can proceed. As such, AT-406 is considered a ... degradation of cIAP-1/2 proteins and promotes apoptosis through activation of caspase-8 and the ...

FDA Accepts Investigational New Drug (IND) Application for Tigris Pharmaceutical's GGTI-2418

... I (GGTase I) that induces apoptosis by downregulating several pivotal oncogenic and ... inhibitor of GGTase I that appears to induce apoptosis by downregulating several pivotal oncogenic and ... suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the ...

Tigris Pharmaceuticals Files IND Application for GGTI-2418

... I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and ... I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and ... suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the ...

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Apoptosis in Biological Products

CaspSCREEN from CHEMICON

Description:... of ICE-family proteases/caspases initiates apoptosis in mammalian cells. The CaspSCREEN Flow Cytometric apoptosis Detection Kit provides a simple and convenient ... than other fluorometric caspase substrates, apoptosis can easily be measured in intact cells by flow ...
Company:CHEMICON

Apoptosis Pathway SpliceArrays from ExonHit Therapeutics Inc.

Description:... the regulation of signaling pathways involved in apoptosis and cell death. Splice variants have been ... inhibition of defined apoptotic pathways. With apoptosis and Cell Death SpliceArrays you can perform a ... are expressed in the samples under study. The apoptosis and Cell Death SpliceArray monitors 5806 known ...
Company:ExonHit Therapeutics Inc.

MitoPT Detection of Mitochondrial Permeability from B-Bridge International

Description:... kit is used in conjunction with your existing apoptosis protocols. Grow your cells in culture and induce apoptosis according to your existing procedure (also ... as a negative control). Once you have induced apoptosis in your cells, add the 1X MitoPT solution to each ...
Company:B-Bridge International

Vybrant Apoptosis Assay Kit #4 from Molecular Probes (Invitrogen)

Description:... The Vybrant apoptosis Assay Kit #4 detects apoptosis on the basis of changes that occur in the permeability of cell membranes. ...
Company:Molecular Probes (Invitrogen)

Propidium Iodide Staining Solution Solution from BD Biosciences Pharmingen

Description:... with Annexin V-FITC to distinguish cells that are in the earlier stages of apoptosis (Annexin V positive, PI negative) from those that are in later stages of apoptosis or already dead (Annexin V-FITC positive, PI positive). PI is detected in ...
Company:BD Biosciences Pharmingen

ApoBrdU Red DNA Fragmentation Kit from MBL International

Description:... transfected cells Internucleosomal DNA fragmentation is a hallmark of apoptosis in mammalian cells. MBLs Apo-BrdU In Situ DNA Fragmentation Assay Kit ... anti-BrdU monoclonal antibody. The assay is suitable for studying apoptosis in GFP- or Azami Green-transfected ....
Company:MBL International

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Apoptosis in Biological Definition

Apoptosis

... In biology , apoptosis (from the Greek words apo = from and ptosis ... cell death that results from acute tissue injury, apoptosis is carried out in an ordered process that ... the cells in between the fingers to initiate apoptosis so that the fingers can separate. As will be ...

T cell

... high enough, survive. Other cells go into apoptosis and their remains are engulfed by macrophages. ... do not recognize them. Other T cells die by apoptosis (a small fraction actually survives but normally ... is called negative selection . T cells go into apoptosis if they cannot express their TCR receptors, if ...

Cancer

... with poor prognosis , since those tumor cells are less likely to go into apoptosis (programmed cell death) when damaged by therapy. There are more mutations ... , lymphoma or leukemia , have distinct properties: evading apoptosis unlimited growth potential (immortalitization) self-sufficiency of ...

Immune system

... strongly to an existing molecule in the body, it is destroyed by forced apoptosis , leaving behind T cells that can be safely released into the body. (This ... cell autoimmune disorders CD4 receptor /CD8 receptor / perforin / apoptosis /clonal selection immunosuppression immunosuppressive drug ...

Antigen

... I histocompatibility molecules . If cytotoxic CD8 + T cells recognize them, they begin to secrete different toxins that cause the lysis or apoptosis of the infected cell. In order to keep the cytotoxic cells from killing cells just for presenting normal proteins, they run through a test cycle ...

Cytotoxic T cell

... and eventually lyse . T C also release granzyme , a serine protease , that can enter target cells via the perforin-formed pore and induce apoptosis (cell death). Most T C cells have present on the cell surface the protein CD8 , which is attracted to portions of the Class I MHC molecule. This ...

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Apoptosis in Biological Dictionary

Programmed cell death

... cell death : S. Sper ... ... on apoptosis (also known as programmed cell death ) — a key process in cancer development ... apoptosis ( programmed cell death ) may occur through 2 ... cell death (apoptosis) quickly and cheaply. apoptosis articles relating to ' programmed cell death ...

Caspase

... -3 and -7" ... Caspase -2 induces apoptosis by releasing proapoptotic proteins from ... ... ... FLICA Caspase Detection Kits ... FLICA apoptosis CASPASE DETECTION KITS FOR ... If there is an ... covalent ... Pan Caspase Detection Kits ... apoptosis CASPASE DETECTION KITS FOR IN VITRO (FLICA) AND ...

Apoptosis

... apoptosis is the process of programmed cell death (PCD) ... Outlines the mechanisms of cell suicide. apoptosis n. Disintegration of cells into membrane-bound ... are then eliminated by phagocytosis or by ... apoptosis is a process by which cells in ... This ...

Mitochondrial membrane

... Mitochondrial Membrane Permeability Transition Detection Kits for apoptosis MitoPT ... MITOCHONDRIAL MEMBRANE POTENTIAL CYTOCHROME C RELEASE apoptosis DETECTION KITS ... Human protein-coding gene TOMM40. Represented by ...

Thyroid gland

... The Iodine Source is your source for detoxified iodine. ... 9) Iodine and the Thyroid Gland . 10) Iodine Functions in the Body. 11) Iodine and apoptosis ... What is your thyroid gland ? ... The thyroid gland is located in the middle of the lower neck, below the larynx ... "masses" in their ...

Schwann cells

... their ... tigate the changes in the Schwann cells found in Golgi tendon ... apoptotic death of these Schwann cells and that this apoptosis ... The Schwann cells are also present, and they closely cover every branch of the neuron. ... This work suggests that signal comes from the ...

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