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Activation in Medical News

Gene Mutation Could Be Key to Rare Blood Vessel Disease

... in individuals who have, in their blood, excess activation of the so-called complement system." The ... different complement proteins that cause excess activation of the system and cause loss of protection to the ... 1970s, the role of alternative pathway complement activation has been recognized as being important in ...

Critical link in cell death pathway revealed

... caspase-8 is recruited and activated, leading to activation of other enzymes (effector caspases) and rapid ... death-promoting protein called BID. Without this activation of BID the cells don't die. But the experiments ... as in several chronic liver diseases activation of FAS is thought to contribute to cell ...

Immune Response May Speed AIDS Progression in Women

... General Hospital. "Focusing on immune activation separately from viral replication might give us ... men, the study authors noted. "While stronger activation of the immune system might be beneficial in the ... viral replication and stronger chronic immune activation can lead to the faster progression to AIDS that ...

Soccer Injuries Differ by Gender

... of players have different alignment and muscle activation that might correlate to the injury patterns," ... compared with females, male players have more activation in the hip flexors of their kicking leg and in ... ACL injury, and it is interesting that its activation was markedly diminished in women," said Brophy, ...

Motion analysis helps soccer players get their kicks

... of players have different alignment and muscle activation that might correlate to the injury patterns." ... in both of these areas. Male players have more activation in the hip flexors of their kicking leg and in ... against ACL injury and it is interesting that its activation was markedly diminished in women," said Dr. ...

A new take on growth factor signaling in tamoxifen resistance

... ER+ breast cancer subtype. We propose that activation of GF signaling contributes to this highly ... determine that there is increased growth factor activation from the gene expression profiles of nearly 100 ... able to use gene expression data to identify that activation of GF signaling pathways as a possible ...

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Activation in Medical Technology

Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II

... C3 inhibitor, which shuts down the complement activation cascade that could otherwise lead to local ... the Complement System and POT-4 Complement activation is an inflammatory process involving dozens of ... through the membrane attack complex (MAC). activation of the complement system is an important part of ...

Stress-Related Disorders Affect Brain's Processing of Memory

... processed by the hippocampus, showed abnormal activation in the patients with stress-related disorders ... with stress-related disorders showed greater activation in the hippocampus, suggesting that insufficient activation of the prefrontal cortex could be the basis for ...

Potentia Pharmaceuticals Announces Positive Safety Data and Study Expansion in Phase I Trial for Lead Drug Candidate POT-4

... inhibitor, which shuts down the complement activation cascade that could otherwise lead to ... the Complement System and POT-4 Complement activation is an inflammatory process involving dozens ... through the membrane attack complex (MAC). activation of the complement system is an important part of ...

Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged

... by exerting stabilization effects, not by activation of the gene. This new finding throws a scientific cloud over the use of Sirtuin1 gene activation tests as a measure of resveratrol activity. ... has since abandoned the Sirtuin1 gene activation test as a measure of dietary supplement activity. ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... and homeostasis. For example, bile acid activation of FXR results in a decrease in serum triglyceride levels. -- The activation of TGR5 by bile acids increases energy ... These effects have been attributed primarily to activation of FXR. Additionally, mice that lack FXR have ...

DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin

... crossover study compared the effects on platelet activation and bleeding time of DG041 alone and in ... to substantially inhibit EP3 mediated platelet activation that is not being addressed by current therapy. ... inhibit platelet aggregation as well as platelet activation mediated specifically through ...

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Activation in Medical Products

BD Vacutainer® Push Button Blood Collection Set

Description:... you against needlestick injury. Its in-vein activation reduces risk of healthcare worker exposure to a contaminated needle, provides easy activation without patient discomfort, and is ideal for use in high-risk environments. The one-handed safety activation of the push button allows ...
Company:BD Diagnostic Systems

STA STACLOT PROTEIN C

Description:... Activity by STA© Analyzers. Lyophilized human plasma free of Protein C; highly purified extract of Agkistrodon c. contortrix venom for specific activation of protein C, freeze-dried with an activator selected specially for protein C ....
Company:Diagnostica Stago, Inc.

STA STACHROM PROTEIN C

Description:... Colorimetric Assay of Protein C Activity by STA© Analyzers. Highly purified extract of Agkistrodon c. contortrix venom for specific activation of protein C, with an activator selected specially for protein C ....
Company:Diagnostica Stago, Inc.

Metrologic MS9520 Voyager

Description:... The Metrologic MS9520 Voyager is a high performance single line laser bar code scanner with automatic activation and sophisticated data transmission via Metrologic proprietary CodeGate ....
Company:InfoLogix, Inc.

AeroScout T2 Tag: Advanced Wi-Fi Asset Tracking Tag

Description:... revenues. The AeroScout T2 Tag can be programmed via a wireless interface. The Tag Manager software allows for easy and efficient tag configuration, activation or deactivation and ....
Company:AeroScout

BD Vacutainer Eclipse Blood Collection Needle

Description:... Eclipse Blood Collection Needle has its safety feature built in, eliminating the need to attach a secondary safety accessory. Immediate, one-handed activation of the shield helps protect from accidental needlestick injuries and frees the user's other hand to maintain patient ....
Company:BD Diagnostic Systems

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Activation in Medical Definition

Episodic memory

... Gender differences in episodic memory performance According to Brain activation during episodic memory retrieval: sex differences , women tend to ... memory tasks. Age differences in episodic memory performance activation of specific brain areas (mostly the hippocampus ) seems to be different ...

Depolarization-induced suppression of inhibition

... its job is to inhibit the activity of primary neurons, such as the CA1 pyramidal neurons of the hippocampus or the Purkinje cells of the cerebellum. activation of GABA receptors on these cells, whether they are ionotropic or metabotropic , typically results in the influx of chloride ions into that target ...

Neuropsychiatry

... and Ortuno (2002) Schizophrenia Narcissistic/Poor maternal parenting/escapism/ unresolved feelings of homosexuality NMDA receptor activation in the human prefrontal cortex Ross et al (2006) Visual hallucination - retinogeniculocalcarine tract, ascending brainstem modulatory ...

Muscle atrophy

... normal balance between protein synthesis and protein degradation. During atrophy, there is a down-regulation of protein synthesis pathways, and an activation of protein breakdown pathways. The particular protein degradation pathway which seems to be responsible for much of the muscle loss seen in a muscle ...
Activation in Medical Dictionary

Allergic reactions

... reactions occurs via a variety of mechanisms, including decreasing the density of mast cells along mucosa l surfaces, decreasing chemotaxis and activation of eosinophil s , ... It can be caused by viral or bacterial infections or by allergic reactions to irritants such as tobacco smoke. The ...

Angioedema

... referred to as Quinke's disease .) Persons with it are born lacking an inhibitor protein (called C1 esterase inhibitor) that normally prevents activation of a cascade of ... Angioedema Definition: Angioedema is a swelling similar to urticaria ( hives ), but the swelling is beneath the ...

Angioplasty

... photo angioplasty Investigational procedure utilizes a photosensitizer (see Antrin) to localize areas of atherosclerosis in vessels and light activation to selectively destroy the plaque without dam aging the endothelium. Balloon angioplasty A surgical procedure in which a balloon catheter is ...

Atherosclerosis

... . photo angioplasty Investigational procedure utilizes a photosensitizer (see Antrin) to localize areas of atherosclerosis in vessels and light activation to selectively destroy the plaque without dam aging the endothelium. The exact cause is unknown, but risk factors include atherosclerosis and ...

Chlamydia

... therapy. J Clin Oncol 23 (22): 5067-73, 2005. [PUBMED Abstract] ... Trichomonas vagina lis, Chlamydia trachoma tis, etc.) leads to further activation of immune response s. Poor use of condoms can have devastating consequences on people's sexual health . Recent new figures showed the UK has ...

Immune

... movable. Co- infection with sexually transmitted infections (i.e., Trichomonas vagina lis, Chlamydia trachoma tis, etc.) leads to further activation of immune response s. They have to-there's no other way for their immune system s to build up immunity to the virus es and other germs ...

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Activation in Biological News

Got zinc? New zinc research suggests novel therapeutic targets

... supports healthy immune function, but increases activation of the cells (T cells) responsible for destroying ... taken from the zinc-supplemented group had higher activation than those from the placebo group. Specifically, cell activation stimulated the zinc transporter in T cells called ...

Distinguishing single cells with nothing but light

... implications for current understandings of cell activation and development. "In the cell sensing ... a pretty hot area to figure out how to analyze activation responses on a cell-by-cell basis," says Berger. ... Berger and Smith are actively investigating activation processes more explicitly. Preliminary IRAM ...

Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimer's disease

... paeleii, as a model system. Llins found that activation of CK2 blocks neurotransmission at the synapse ... possibility of designing a drug to inhibit CK2 activation in Alzheimer's patients. However, a prior study by Brady found that activation of another enzyme, GSK3, in Alzheimer's also ...

Tips from the American Journal of Pathology

... misfolded proteins; however, prolonged activation of the unfolded protein response, such as in ... report suggests that "unfolded protein response activation occurs at an early stage of neurofibrillary degeneration and that the prolonged activation of the [unfolded protein response] is involved in ...

A paradigm shift in immune response regulation

... "it means, that current knowledge on NF-κB activation and the role of linear ubiquitin chains needs to ... pathway", reports Soichi Wakatsuki. Increased activation of the NF-κB pathway is known to be linked ... is a mutation in the NEMO gene, which blocks the activation of the NF-κB pathway in epidermal and ...

Cellular discovery may lead to targeted treatment for rare form of anemia

... that the UC team hypothesizes leads to abnormal activation of p53, causing premature death of red blood ... cells. Previous research has attributed p53 activation to the passive diffusion of ribosomal protein L11 ... The UC research, however, suggests that p53 activation is not due to nucleolar breakdown, but is ...

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Activation in Biological Technology

Scientists demonstrate effect of confining dielectrics on semiconductor nanowire conductivity

... have demonstrated, for the first time, that the activation energy of impurities in semiconductor nanowires ... effect influences conductivity by changing the activation energy of dopants. Understanding the phenomenon ... the strength of the surface mirror. The dopant activation energies were obtained from the temperature ...

Samtheo Announces License Agreement with Moffitt Cancer Center for Exclusive Rights to Novel Akt Inhibitor

... to a small molecule that selectively inhibits the activation of all three isoforms of Akt. Persistent activation of the Akt pathway has been found to play an ... liver, ovarian and colorectal cancers. Increased activation is also linked with drug and radiation ...

Potentia Pharmaceuticals Appoints Johanna M. Seddon, M.D. and Janet Stoltz Sunness, M.D. to Scientific Advisory Board

... the Complement System and POT-4 Complement activation is an inflammatory process involving dozens ... through the membrane attack complex (MAC). activation of the complement system is an important part of ... function, inappropriate or excessive complement activation can have destructive consequences if left ...

Potentia Pharmaceuticals' Drug Candidate for Age-Related Macular Degeneration Shows Positive Safety Profile in Phase I Clinical Trial

... the Complement System and POT-4 Complement activation is an inflammatory process involving dozens ... through the membrane attack complex (MAC). activation of the complement system is an important part of ... function, inappropriate or excessive complement activation can have destructive consequences if left ...

Potentia Pharmaceuticals to Present ASaP Phase I Clinical Trial Data for POT-4 at the American Academy of Ophthalmology Annual Meeting

... the Complement System and POT-4 Complement activation is an inflammatory process involving dozens ... through the membrane attack complex (MAC). activation of the complement system is an important part of ... function, inappropriate or excessive complement activation can have destructive consequences if left ...

Affitech and Omeros Enter Into Antibody Discovery and Development Agreement

... serine protease-2, mediates activation of the complement system via the lectin pathway ... protein target, is involved in the activation of the complement system. The complement system ... for the function of, a principal complement activation pathway, known as the lectin pathway. ...

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Activation in Biological Products

GeneChoice TEMPase II DNA Polymerase from GeneChoice, Inc.

Description:... useful for performing automated hot start amplification due to its thermal activation at a temperature well above optimal annealing. The enzyme remains inactive ... the reaction reaches optimal annealing temperatures after a 15 minute activation step at 95C, the enzyme stays activated in the reaction. Since the ...
Company:GeneChoice, Inc.

AmpliTaq Gold DNA Polymerase from Applied Biosystems

Description:... annealing temperatures, the chemical moiety is cleaved during a heat activation step, releasing active AmpliTaq® DNA enzyme. The yield of specific ... enzyme in a "time-release" manner. With or without a limited up-front heat activation step, active enzyme is released slowly during thermal cycling to match ...
Company:Applied Biosystems

Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen

Description:... is one of three identified MAP kinase pathways in mammals. JNK pathway activation occurs in response to environmental stress, is associated with the nuclear ... of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathway. This observation led to the original hypothesis that ...
Company:Invitrogen

Mouse Anti-Factor V Heavy Chain Monoclonal Antibody, Unconjugated from GeneTex

Description:... Mouse monoclonal to Factor V Heavy Chain Immunogen: Purified human Factor V. Specificity: This antibody reacts with the activation C peptide (mw ~150,000) in the heavy chain of thrombin-cleaved human Factor V. KD = 1.15 x 10 -10 ....
Company:GeneTex

Molecular Immunology from Promega

Description:... B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other immunological control ....
Company:Promega

Rabbit Protein Phosphatase 1 (PP1) from Upstate

Description:... MnCl2, 1mM MgCl2, 1mM EGTA, 10 Properites: For selective in vitro dephosphorylation of proteins Purification: DEAE chromatography, divalent cation activation plus trypsin digestion, and gel filtration chromatography Quality Assurance: routinely evaluated by dephosphorylation of proteins Company:Upstate

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Activation in Biological Definition

Activation energy

... The activation energy in chemistry is the energy needed by a system to initiate a particular process. activation energy is often used to denote the minimum energy ... electron clouds repel. This requires energy - activation energy - and comes from the heat of the system, ...

Allostery

... enhance activity are referred to as allosteric activation , while the opposite is called allosteric ... 1.2 Sequential model 2 Allosteric activation 3 Allosteric inhibition 4 Related ... affinity in adjacent subunits Allosteric activation ...

Allostery

... enhance activity are referred to as allosteric activation , while the opposite is called allosteric ... 1.2 Sequential model 2 Allosteric activation 3 Allosteric inhibition 4 Related ... affinity in adjacent subunits Allosteric activation ...

Apoptosis

... in maintaining genomic integrity, and massive activation of PARP-1 can deplete the cell of ... and intrinsic pathways have in common the activation of central effectors of apoptosis , a group of ... from mitochondria (see below), and the amplified activation of caspase-8. Downstream from TNF-R1 and ...

Immune system

... destruction of the pathogen by formation and activation of the membrane attack complex , and ... After they leave the thymus, T cells require activation to proliferate and differentiate into "killer" T cells (CTLs). activation is provided by antigen presenting cells (APCs). A ...

Oncogene

... 1 Protooncogene 1.1 activation 2 Oncogene 2.1 Growth factors ... usually through its protein product. Upon activation , it (or its product) becomes a tumor inducing agent, an oncogene. activation The protooncogene can become an oncogene by a ...

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Activation in Biological Dictionary

Caspase

... proapoptotic proteins from ... Caspase activation can be mediated by intrinsic factors such as ... ... External signals can also effect a caspase activation cascade. ... Using 100μl of Caspase -Glo® ... ... "Role of FLASH in caspase -8-mediated activation of NF-kappaB: dominant-negative ... "The ...

Activation energy

... In chemistry, activation energy is a term introduced in 1889 by the ... to occur. Arrhenius' research was ... activation in (bio-)chemical sciences generally refers to ... In terms of the transition-state theory, the activation energy is the difference in energy content ...

Sigma Factor

... multiple species. ... of new sigma factors allows the coordinated activation of discrete sets of genes ... The primary sigma factor from ... control in vivo is mediated indirectly by altering sigma factor ... activation of alternative sigma factor -dependent transcription by ppGpp ... ...

Effector cell

... due to ... The resultant effector cells expressed the appropriate activation ... The effector cells are triggered when their antigen specific ... in which the tissue-homing effector memory T cells , ... B cell activation and effector functions are described in Humoral Immunity. ... The T ...

Cell-mediated immunity

... that does not involve antibodies or complement but rather involves the activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic ... immunity : application in HIV infection ... is closely correlated with activation of cell - mediated immunity . ... Introduction: Cell - Mediated ...

B cell

... into the B cell by receptor-mediated endocytosis. ... B - cell activation in the network of follicular dendritic cells ... V-gene repertoire ... structure on the antigen's surface. ... Antigen Dependent B Cell activation ... Information about B cell in the free online English dictionary ...

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(Date:8/31/2014)... data from the last 19 years reveals that fresh water ... of Antarctica to rise by 2cm more than the global ... detected the rapid rise in sea-level by studying satellite scans ... kilometres. , The melting of the Antarctic ice ... an excess of around 350 gigatonnes of freshwater to the ...
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