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Actin in Medical News

St. Jude Scientists Discover a New Mechanism Controlling Neuronal Migration

... imaging to establish that Myosin II and actin made up the machinery of neuronal migration. ... used fluorescent dyes to label Myosin II and actin proteins, as well as key cell structures. The ... micromovies that revealed how the Myosin II and actin proteins and cell structures behaved during ...

Australian team reveals world-first discovery in a 'floppy baby' syndrome

... condition by replacing missing skeletal muscle actin a protein integral in allowing muscles to contract with similar actin found in the heart. "Earlier in our search to ... children who, despite having no skeletal muscle actin in their skeletal muscle due to their genetic ...

From mother to daughters: A central mystery in cell division solved

... is assembled from two protein filament types, actin and myosin, that are also used in muscle. ... contraction, the myosin filaments move along the actin filaments and constrict the ring. Constriction ... the contractile ring is built from long, straight actin filaments, which serve as tracks on which myosin ...

Penn researchers discover 'modus operandi' of heart muscle protein

... actin. Whats more, Lmod directs the assembly of actin to form the pumping unit of the heart. The ... [Tmod] that was already known to bind actin filaments in muscle cells. We found that one part ... that made us suspect that it could assemble the actin filaments of the heart muscle. This is exactly ...

How red blood cells nuke their nuclei

... red blood cell nears maturity, a ring of actin filaments contracts and pinches off a segment of ... 2 and mDia2 are involved in building the ring of actin filaments. We were very interested in that Rac ... proteins are known for their role in creating actin fibers in many body cells, and a necessary ...

Insights into cell movement likely to aid immune study, cancer research

... of proteins associated with the formation of actin networks, which are essential to cell movement. ... yeast, the proteins Cooper's lab studied regulate actin networks' contributions to a process called ... surface by forming pits on their cell membrane. actin networks provide the push that forms these pits ...

Scripps research scientists find new genetic mutation that halts the development of lupus

... gives more impetus to study these genes for autoimmunity. Because the actin cytoskeleton is essential for many crucial cellular functions and involves ... in specific cell types, these new findings highlight the importance of actin regulation in lupus pathogenesis. They also suggest that alteration of an ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

... is studying cell motility in the context of the developing nervous system. He aims to understand how external cues are coupled to changes in the actin cytoskeleton. As cell motility is essential for normal development as well as for cancer metastasis, new insights into the basic biology of motility ...

Researchers gain new insight on wonder of cell division

... where a cell divides into two identical daughter cells. The researchers have opened a new window on the assembly and activity of a ring of actin and myosin filaments that contract to pinch a cell at just the right time. They focused on key proteins whose roles drive signaling mechanisms that ...

Jacobs-Wagner named Howard Hughes Investigator

... of proteins at particular locations and times within the life cycle of cells. Scientists in the last few years, for instance, have discovered that actin and tubulin, two proteins crucial in determining the shape of eukaryotic cells are also at work in bacteria. Jacobs-Wagner found that some bacteria ...

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Actin in Medical Technology

Myriad Genetics Presents Azixa's Mode of Action at AACR

... rely on microtubules to maintain the cytoskeletal structure of their new vasculature, whereas mature vascular endothelium of healthy tissue uses actin filaments to provide the needed structure. Therefore, tumor vasculature is selectively targeted, leaving healthy normal tissue unaffected. Azixa is ...

Dr. Gabriel Sosne to Present New TB4 Data at 2007 ARVO Meeting

... is its ability to regulate the cell-building protein, actin, a vital component of cell structure and movement. Of the thousands of proteins in cells, actin represents up to 10% of the total protein and, thus, plays a major role in the physiology of the cell. RegeneRx has identified several ...
Actin in Medical Dictionary

Behavior

... ... ... ii. Motile behavior s of dividing mammalian cells- Using a dominant-negative chimeric tropomyosin, we have studied roles of actin filaments in cytokinesis, mitotic spindle orientation, and blebbing of dividing cells. Studies of behavior therapy for OCD have found it to be ...

Skeleton

... pneumonophora; pneumootoka; pneumophora; pneumo skeleton ; ... Rho GTPases play a central role in diverse biological processes such as actin cyto skeleton organ ization, microtubule dynamics, gene transcription, oncogenic transformation, adhesion and epithelial wound repair. ...
Actin in Biological News

Building memories with actin

... Memories aren't made of actin filaments. But their assembly is crucial for ... ( www.jcb.org ), Rex et al. reveal that LTP's actin reorganization occurs in two stages that are ... that depends on reorganization of the supporting actin cytoskeleton. However, researchers didn't know ...

Fate in fly sensory organ precursor cells could explain human immune disorder

... to a structure rich in actin. This specialized actin structure contains many membrane protrusions that ... "Normally, Delta is presented at the top of the actin structure," said Bellen. It is then encapsulated ... for the trafficking of Delta to the top of the actin structure," said Bellen. Notch signaling is ...

Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds

... this family are known to be key regulators of the actin cytoskeleton and affect many aspects of neuronal development," Van Aelst notes. The actin cytoskeleton is the gossamer, filament-like ... dendritic spines, where it locally regulates the actin cytoskeleton -- as it turns out, in proximity to ...

Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells

... Ph.D., has been investigating a process known as actin remodeling at the leading edge - the most forward ... tumor cells. "The events that reorganize the actin cytoskeleton at the leading edge are complex a ... be turned off if cancer cells are to migrate." actin filaments help make up the cytoskeleton of cells. ...

When intestinal bacteria go surfing

... a part of the cellular supportive skeleton - the actin skeleton - is rearranged in such a manner that ... the bacteria bring the host cells to convert the actin skeleton? Researchers at the Helmholtz Centre for ... cell. EspFU then triggers the signal for local actin conversion. "It has been unclear thus far how ...

A budding role for a cellular dynamo

... to the human body. Part of the cytoskeleton, actin assembles into networks of filaments that give ... researchers raise the curtain on how this actin maintains just the right filament length to keep ... Goode, set out to discover how the length of actin fibers is controlled. By answering this question, ...

Rong Li Lab probes mechanism of asymmetry in meiotic cell division

... protein that can promote the formation of actin filaments around the chromosomes. actin filaments undergo dynamic elongation and ... After the chromosomes reach the periphery, the actin filaments orient the cell division plane so that ...

Scientists identify a molecule that coordinates the movement of cells

... give cells their shape. "Inside the cell, actin cables converge at focal adhesions at the cell's ... that ACF7 guides microtubules along a roadway of actin cables and leads them toward the focal adhesions ... focal adhesions. Hence by coupling microtubule, actin and focal adhesion dynamics within the cell, ACF7 ...

Newly defined signaling pathway could mean better biofuel sources

... that determine the cell's shape and size?" actin filaments comprise the cytoskeleton, which is the ... growth and determine the cell shape and size. actin is an abundant protein in organisms that have ... of SPIKE1's functions is to control production of actin filament, which defines localized cell regions ...

Biophysical Society announces winners of 2008 Student Travel Awards

... Residues in Thymosin 4 are Critical for actin Binding. Khajak Berberian, Cornell ... in Cell Membranes Is Modulated by Cortical actin Activity. Travis J. Gould, University of ... Brannon McCullough, Yale University, The actin Severing Protein, Cofilin, Modulates the ...

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Actin in Biological Technology

Researchers decode viral process that prepares cells for HIV infection

... protein is then used to cut through the cortical actin cytoskeleton (the circular layer that lies just ... cofilin, which cuts and modifies the cortical actin cytoskeleton and permits the virus to cross it." ... with, or viral alteration of, the cortical actin cytoskeleton. "Now we have a basic ...

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

... cardiac contraction. Cardiac contractility is driven by the cardiac sarcomere, a highly ordered cytoskeletal structure composed of cardiac myosin, actin and a set of regulatory proteins, and is the fundamental unit of muscle contraction in the heart. The sarcomere represents one of the most ...

Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager

... Bovine cardiac muscle actin (Sigma-Aldrich) A3653 ... from 5 ng to 0.6 pg. Bovine cardiac muscle actin was loaded in a two-fold dilution series from 150 ... of human apotransferrin and bovine cardiac muscle actin was loaded onto Novex 12% Tris-glycine gels in ...

Detection and quantitation of low-abundant proteins with ECL Plex fluorescent Western blotting

... A model system, with two-fold serial dilutions of human apotransferrin and actin (not shown), was used to optimize system performance (Fig 2). Protein ... showed proportional increase when compared and quantitatively related to actin (Fig 4).

...

Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN siRNA and TransMessenger Transfection Reagent*

... DNA was. Cells were targeted with siRNA 58 days after plating. Double immunofluorescence labeling of MAP2 and the unrelated protein actin was performed 48 to 68 hours after transfection. The expression of MAP2 was specifically reduced in 7080% of cells, whereas the expression ...

L2

... Detection methods for transfection: The expression of EGFP driven by the insect actin promotor can be detected clearly after 24-48 hours by FACS analysis or under a fluorescence microscope. ...
Actin in Biological Products

Actin from Molecular Probes (Invitrogen)

Description:... actin from rabbit muscle Cell Biology Cytoskeletal Probes actin and actin ...
Company:Molecular Probes (Invitrogen)

Mouse Anti-muscle actin Monoclonal Antibody, Unconjugated, Clone HUC1-1 from Santa Cruz Biotechnology, Inc.

Description:... muscle actin ...
Company:Santa Cruz Biotechnology, Inc.
Actin in Biological Definition

Actin

... actin is a globular protein that polymerize helicaly forming actin filaments (or microfilaments ), which like the ... network inside an eukariotic cell . actin filaments provide mechanical support for the ...

Cytoskeleton

... 1 The eukaryotic cytoskeleton 1.1 actin Filaments 1.2 Intermediate Filaments 1.3 ... three kinds of cytoskeletal filaments. actin Filaments Main article: microfilaments . ... nm. in diameter, this filament is composed of two actin chains oriented in an helicoidal shape. They are ...

Actin

... actin is a globular protein that polymerize helicaly forming actin filaments (or microfilaments ), which like the ... network inside an eukariotic cell . actin filaments provide mechanical support for the ...

Muscle

... are myofibrils ; myofibrils contain sarcomeres , which are composed of actin and myosin . Individual muscle cells are lined with endomysium . Muscle ... types of muscle have significant differences, but all use the movement of actin against myosin to produce contraction and relaxation. In skeletal ...

Myosin

... is a motor protein filament found in muscle tissue . Together with actin filaments, myosin provides the mechanism for muscle contraction , ... of three different filament systems, the thin filaments assembled by actin proteins, the thick filament system consisting of myosin as well as ...

Protein

... and much of the structure of animals is also protein: microtubules, actin , intermediate filaments, collagen and keratin are components of skin, ... and dynein. Muscles are composed largely of the proteins myosin and actin . Working with proteins Proteins can be picky about the environment ...

Pseudopod

... extends a membrane process, named lamellipodium . Polymerization of actin takes place and form filaments at the leading edge, which subsequently will blend into one another to form networks. We suppose that actin polymerization is at the origine of the force propelling the cell ....

Acrosome

... the ovum . Acrosome reaction When the sperm comes in contact with ZP3 in the zona pellucida, this reaction takes place, during which actin polymerizes to form the acrosomal process ; also, the acrosomal vesicle fuses with the plasma membrane of the egg cell, and digestive enzymes are ...

Acrosome

... the ovum . Acrosome reaction When the sperm comes in contact with ZP3 in the zona pellucida, this reaction takes place, during which actin polymerizes to form the acrosomal process ; also, the acrosomal vesicle fuses with the plasma membrane of the egg cell, and digestive enzymes are ...

Biomechanics

... biology have much to offer in the way of explaining the active and passive properties of living tissues. For example, the binding of myosin to actin is based on the biochemical reaction, where C a 2 + and ATP move the troponin and tropomyosin to allow for the crossbridges to bind ...

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Actin in Biological Dictionary

Myosin

... myosin molecule is composed of two ... actin n. A protein found in muscle that together ... involved in cytoplasmic streaming, which ... But actin and myosin working together allow muscle ... dictionary with ... Myosin and the protein actin form the contractile units (sarcomeres) of ...

Microfilament

... Microfilament " ... Microfilament actin cytoskeleton of mouse embryo fibroblasts , ... isothiocyanate - phalloidin Microfilaments (or actin filaments microfilament n. Any of the ... throughout the cytoplasm of cells, composed of actin and functioning primarily in maintaining the ...

Cytoskeleton

... framework of a cell, composed largely of actin filaments and ... actin cytoskeleton of mouse embryo fibroblasts, ... ... The Cytoskeleton . Index to this page. actin Filaments. Intermediate Filaments. Microtubules .....

Actin

... actin is a globular, roughly 42-kDa highly conserved ... differing by no ... Alpha-skeletal actin induces a subset of muscle genes independently of muscle ... Thymosin beta 4 binds actin in an extended conformation and contacts both ...

Sarcomere

... Sarcomere - Definition of Sarcomere at Dictionary.com a free online dictionary ... Sarcomeres are divided into bands of filaments made of actin or myosin. ... II. Events within the sarcoplasm and sarcomere . A. Release of calcium from the SR. ... The resulting shortening of the ...

Rhizoid

... cells of vascular plants. ... Root hairs are a specialized form of rhizoid . ... The rhizoid pole is marked by a cortical patch of dynamic actin that repositions ... Preferential accumulation at the presumptive rhizoid was first detectable at 4 h ... Cell-sheet and rhizoid remains ...

Muscle contraction

... Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten or remain the same. Though the term ' contraction ...

Muscle

... muscle in the free online English dictionary and encyclopedia. muscle system, ... Muscle cells contain filaments made of the proteins actin ... Much of muscle contraction ... Muscle is the contractile tissue of the body and is derived from the mesodermal ... like slow muscle , ...

Microtubules

... structures that are distributed throughout the cytoplasm of eukaryotic cells, providing The internal framework of a cell, composed largely of actin filaments and microtubules . ... Microtubules are slender cylindrical structures that exhibit a cytoplasmic ... Microtubules act as a ...

Endocytosis

... up to 80%, buy or rent. New and used books like Exocytosis and Endocytosis Methods in Molecular Biology 2nd edition ... ENDOCYTOSIS AND THE actin CYTOSKELETON. ENDOSOMES AS MOTILE SIGNALING PLATFORMS IN MAMMALS ... Endocytosis is the internalization of plasma membrane proteins ... ...

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