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Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure,Reduction During Important Early Morning Period When Most Adverse,Cardiovascular Events Occur

night2. The same periodicity was observed in the onset of stroke. Striking evidence suggests that the morning surge in blood pressure is crucial in determining the rupture of critically weakened arterial walls and subjects with a large surge in morning blood pressure have a significantly elevated risk of intracerebral hemorrhage3 and stroke4.

Current hypertension therapy therefore aims at a full 24-hour blood pressure control. Commonly used angiotensin II receptor blockers (ARBs) were reported to achieve an ambulatory blood pressure reduction from baseline in the early morning hours of (SBP / DPB) - 8.7 / - 5.8 mm Hg (valsartan) and - 11.0 / - 7.6 mmHg (telmisartan), respectively5.

About hypertension
Hypertension, also termed high blood pressure, is a medical condition where the blood pressure is chronically elevated. Although asymptomatic in nature and in itself rarely an acute problem, persistent hypertension is one of the most important preventable causes of premature death worldwide and contributes to around half of all cardiovascular disease6. It is one of the major risk factors for stroke, myocardial infarction, heart failure, and arterial aneurysm, and is a leading cause of chronic renal failure. Genetic predisposition and lifestyle habits such as inadequate physical activity, high fat diet, and high salt intake promote high blood pressure. Up to 30% of adults in
most countries suffer from hypertension6. Despite effective and relatively inexpensive treatment available, a health survey in the UK revealed that only 9% of hypertensive individuals have their blood pressure controlled successfully7. This poor overall treatment success is mainly attributed to the asymptomatic nature of hypertension and the necessity for long-term treatment with medications that require at least once daily self-administration.

About CYT006-AngQb
CYT006-AngQb is a therapeutic vaccine in development for treatment of hypertensio
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