Navigation Links
Cytokinetics Reports Additional Clinical Trials Data for Ispinesib

II clinical trial designed to evaluate the safety and efficacy of ispinesib in the treatment of patients with chemotherapy-na? recurrent or metastatic malignant melanoma was recently completed. In Stage 1 of this two-stage clinical trial, 17 patients received ispinesib as monotherapy at 18 mg/m2 as a 1-hour intravenous infusion every 21 days. The trial s primary endpoint was objective response as determined using the RECIST criteria. This trial was designed to require at least 1 confirmed partial response in 15 patients in Stage 1 in order to proceed to Stage 2. The best overall response was stable disease seen in 6 of 17 patients treated. In this clinical trial, ispinesib did not satisfy the criteria for advancement to the second stage and therefore recruitment to Stage 2 was not opened. The toxicity profile was consistent with other previously reported Phase II clinical trials of ispinesib. A manuscript is being prepared.

A Phase II clinical trial designed to evaluate the safety and efficacy of ispinesib for the treatment of hormone refractory prostate cancer who had failed taxane-based chemotherapy was recently completed. In Stage 1 of this two-stage clinical trial, 21 patients received ispinesib as monotherapy at 18 mg/m2 as a 1-hour intravenous infusion every 21 days. The trial s primary endpoint was objective response as determined using the RECIST criteria and a prostate-specific antigen (PSA) response of a greater than 50% decline confirmed 3 weeks later. This trial was designed to require a minimum of 1 PSA response in the first 20 evaluable patients in Stage 1 in order to proceed to Stage 2. No patient met the criteria for a PSA response and the median time to PSA or clinical progression was 9 weeks. In this clinical trial, ispinesib did not satisfy the criteria for advancement to the next stage in the clinical trial. The toxicity profile was consistent with other previously reported Phase II clinical trials of ispinesib. A manuscrip
'"/>




Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting
2. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
3. Cobalis Reports Phase III Trial Results for PreHistin in Seasonal Allergic Rhinitis
4. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
5. Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis
6. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
7. Cytochroma Reports Positive Phase I Clinical Data for CTA018 Injection
8. Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension
9. Columbia Laboratories Reports Positive Results from Multi-dose Pharmacokinetic Study of Vaginally-administered Lidocaine
10. CytRx Reports Promising Data from Its Open-Label Extension Clinical Trial of Arimoclomol in ALS
11. Affymax Reports Phase 2 Clinical Dose Ranging Results of Once-Per-Month Hematide for the Treatment of Anemia
Post Your Comments:
(Date:1/23/2015)... 2015  A new analysis of Centers for Medicare and ... shows that 81 percent of seniors chose lower-cost preferred ... at certain pharmacies. The findings were released by ... now the foundation of Medicare Part D," said Pharmaceutical ...
(Date:1/23/2015)... a third of reproductive-aged women enrolled in Medicaid, and more ... prescription for an opioid pain medication each year during 2008-2012, ... Weekly Report (MMWR). Opioids are typically prescribed ... They are also found in some prescription cough medications. The ...
(Date:1/23/2015)... 2015  Pete Rose, baseball,s all-time hits leader, is the new ... Myoflex, Ducere Pharma has announced. "Pete,s a Hall ... have him on board with Myoflex," said Ducere Pharma Chief ... player who is known across all generations. The passion and ...
Breaking Medicine Technology:New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Pete Rose bets on Myoflex to relieve aches and pains 2
(Date:1/22/2015)... York, New York (PRWEB) January 22, 2015 ... http://www.vaginalmeshlawsuit2015.com/ ) in the U.S. District Court, Southern District of ... C.R. Bard, Inc. in that proceeding’s first bellwether trial. In ... request for a new trial after finding that C.R. Bard ...
(Date:1/22/2015)... has released a new blog post explaining the main features ... , Auto insurance quotes help many drivers find the best ... call an agent or visit an agency for price information. ... http://autocarinsurancebest.com/ . , Every business who relies heavily on ...
(Date:1/22/2015)... 22, 2015 A study recently ... flagship journal Medicine & Science in Sports & ... may help reduce gastrointestinal (GI) problems associated with ... Participants in the double-blind, placebo-controlled study took 10 ...
(Date:1/22/2015)... Boulder, Colorado (PRWEB) January 22, 2015 Four years ... is Queen – which coincided with the marriage of Avasa & ... album, THE ROAD, which is scheduled for release through White Swan ... heartfelt message that there is a sacred path available to all ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store for wedding dresses ... latest collection of wedding dresses , and launches a site-wide ... wedding dress on your big day; the wedding gown is ... wants to find the most suitable wedding dress. Now, we ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... , FORT WORTH, Texas , ... its customers during the holidays, RadioShack has collected more than ... organization that fights for the 28 million people around the ... Day 2010, which promotes cancer prevention, detection and treatment across ...
... leading cause of cancer-related deaths in the United States. Despite ... disease, rates of screening for colorectal cancer are consistently lower ... cervical. Although the screening rates in the target population of ... 1997 to nearly 55 percent in 2008 the rates ...
... 30-hour shifts need to be cut to 16 to avoid ... November 2000, Helen Haskell took her 15-year-old son to a ... days later, he was dead. The cause: failure to rescue, ... recognize and act upon declines in patients." , He was ...
... , , TORRANCE, Calif. , Feb. ... insurance brokerage and consulting firm in California , has ... management and wellness programs.  Nurtur and Healthyroads are the latest ... important dimension to the company,s extensive employee benefits practice. , ...
... , Feb 4 Smart Balance, Inc. (Nasdaq: SMBL ... February 25, 2010 , at 9:30 a.m. ET to ... 8:30 a.m. ET the same day.  The webcast will be in ... by dialing 1-800-895-0198 from the United States or 1-785-424-1053 from ...
... ... (UVC), a not-for-profit organization that seeks to accelerate the transformation of Upstate New ... to establish a large number of small, innovation-oriented companies. , ... Syracuse, NY (PRWEB) February ...
Cached Medicine News:Health News:RadioShack Customers Donate $1.3 Million to LIVESTRONG 2Health News:Panel calls for reducing colorectal cancer deaths by striking down barriers to screening 2Health News:Campaign Calls for Limits on Doctors' Hours 2Health News:Campaign Calls for Limits on Doctors' Hours 3Health News:Keenan Selects Nurtur and Healthyroads for Integrated Disease Management and Personal Wellness Programs 2Health News:Keenan Selects Nurtur and Healthyroads for Integrated Disease Management and Personal Wellness Programs 3Health News:Keenan Selects Nurtur and Healthyroads for Integrated Disease Management and Personal Wellness Programs 4Health News:Smart Balance to Host Webcast/Conference Call on 2009 Fourth-Quarter Results 2Health News:Silicon Valley Entrepreneur Launches Startup to Accelerate Tech Entrepreneurship in Upstate New York 2Health News:Silicon Valley Entrepreneur Launches Startup to Accelerate Tech Entrepreneurship in Upstate New York 3Health News:Silicon Valley Entrepreneur Launches Startup to Accelerate Tech Entrepreneurship in Upstate New York 4Health News:Silicon Valley Entrepreneur Launches Startup to Accelerate Tech Entrepreneurship in Upstate New York 5
... to move their imaging system from office to ... IMAGEnet Portable System features a rugged aluminum case ... portable PC solution can be coupled with any ... to your multi-site imaging needs. The patient database ...
... Based on the latest digital chip technology, ... System from Topcon features 3,072 x 2,048 ... for each color channel! The system provides ... features real-time image acquisition, which facilitates instant ...
... Ophthalmic Viewer, with its dual magnification ... more precise, convenient, and efficient than ... segment or endothelial cell count photos ... all your ophthalmic needs, without the ...
Inquire...
Medicine Products: