Navigation Links
Baraclude (entecavir) Therapy Resulted in Undetectable Levels of,Hepatitis B Virus in Cohort of Patients Who Re-Started Treatment

nts who discontinued study therapy in ETV-027, and subsequently restarted treatment in rollover study ETV-901, with a greater than 60 day gap between end of treatment in study ETV-027 and start of treatment in study ETV-901.

    -- ETV-027 compared 0.5 mg of BARACLUDE vs. 100 mg of lamivudine in
nucleoside-naive chronic HBeAg-negative chronic hepatitis B patients.
-- Rollover study ETV-901 was established as an open-label, follow-up
protocol for patients in phase II and III studies of BARACLUDE.
-- Due to ongoing blinding of study ETV-027, most patients retreated in
ETV-901 initially received a combination of 1 mg of BARACLUDE plus 100
mg of lamivudine, and were subsequently switched to 1 mg of BARACLUDE
monotherapy.

The analysis cohort was defined regardless of treatment response at the end of dosing in study ETV-027, and independent of virologic or ALT measurements at the start of dosing in study ETV-901. During off-treatment follow-up, the majority of patients had recurrent levels of hepatitis B virus in the blood (viremia) and increases in ALT.

    Data Results
At the end of dosing for study ETV-027:
-- 94 percent (n=93/99) of the re-treatment cohort had undetectable viral
load
-- 78 percent (n=77/99) had ALT normalization
At entry into ETV-901:
-- Four percent (n=4/99) of patients had undetectable viral load
-- Eight percent (n=8/97) of patients had ALT normalization
Following re-treatment in study ETV-901:
-- 93 percent (n=82/88) of patients had undetectable viral load (HBV DNA
<300 copies/mL) by week 48 of re-treatment with BARACLUDE
-- 83 percent (n=79/95) of patients had ALT normalization (ALT less than
or equal to 1 times the upper limit of normal) by week 48 of re-
treatment BARACLUDE
Adverse events in study ETV-027/901 re-treatment cohort:
-- 67 percent (n=66/99) of patients experienced an adverse event. The most
common adverse events occurring in greater than ten percent of patients
were abdominal pain, fa
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load Reduction Compared to Adefovir at 48 Weeks in Study of Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients
2. Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.
3. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
4. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
5. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
6. Response Genetics Announces Publication of a Phase III Clinical Trial Demonstrating That Low Levels of ERCC-1 Help to Predict Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer
7. New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV
8. Lexicon Develops Antibodies That Lower Triglycerides and Cholesterol as Potential New Therapy for Heart Disease
9. Studies of Drug Resistance May Lead to Individual Therapy for Rare Cancers
10. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
11. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
Post Your Comments:
(Date:9/12/2014)... LAUSANNE , Switzerland , September ... Genetics, leader européen de la médecine basée sur les ... son premier contrat avec le National Health Service au ... Cela fait suite à une forte hausse de la ... cliniques émanant des laboratoires et hôpitaux en Allemagne, en ...
(Date:9/12/2014)...  WellStar Paulding Hospital is the first hospital in ... in the U.S. to offer a new, innovative procedure ... System, Paulding Hospital is on the cutting edge of ... Inspire Therapy offers relief for moderate to ... to use traditional treatments, like Continuous Positive Airway Pressure ...
(Date:9/12/2014)... , Sept. 12, 2014 ... of the "Global Medical Technologies Market 2014-2018" ... Medical technology is a collective term for software ... to ensure good health. The Global Medical Technologies ... and respiratory technology, In vitro diagnostics technology, dental ...
Breaking Medicine Technology:Sophia Genetics annonce son premier contrat avec le National Health Service britannique et un grand laboratoire turc, élargissant ainsi sa clientèle européenne 2WellStar Pioneers New Sleep Apnea Treatment 2Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 2Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 3
... Transgenomic, Inc. (OTC/BB: TBIO) today announced the ... Results and Business Update Conference CallWhen: , Thursday, August ... How: , Live over the Internet -- Simply log ... Investor Relations, 402-452-5400To access the call via telephone, call ...
... 11, 2011 /PRNewswire-Asia/ -- ShangPharma Corporation (NYSE: ... pharmaceutical and biotechnology research and development outsourcing company, today ... two multi-staged projects in its biologics division, which portends ... The initial milestones were achieved for two oncology ...
Cached Medicine Technology:Transgenomic to Hold Second Quarter Financial Results Conference Call Today 2ShangPharma's Biologics Division Announces Accelerated Achievement of Milestones for Two Multi-Stage Projects 2
(Date:9/14/2014)... Top10BestSEOHosting.com always offers truly reliable information for ... carefully, the site has announced that Arvixe ( ... WordPress Hosting suppliers in the current market. , ... hosting provider, and the company’s reputation for reliability ... known for its flexible hosting packages, decent uptime ...
(Date:9/14/2014)... September 14, 2014 Final Cut Pro ... the production of the Flip Flop Theme template for ... Flop is a simple-to-use and simplistic template that allows ... ease in Final Cut Pro X," said Christina Austin, ... and On-Screen controls, the user has controls of the ...
(Date:9/13/2014)... Recently, an experienced supplier of wedding ... its new collection of eggplant evening dresses . ... discounted rates, up to 58% off. According to the ... September 23. , The company’s new items are ... vintage, plus size, modest, sexy outfits and so on. ...
(Date:9/13/2014)... Ticket Down is a dependable ... beloved pop-rock group that originally formed in 1994 in Los ... of the group had been anticipating a new album since ... excited yet about the release of their new album, they ... a massive worldwide tour beginning in the United States in ...
(Date:9/13/2014)... (PRWEB) September 13, 2014 MillionaireSinglesDating.com ... by Successful Match, the leading niche dating services ... site PositiveSingles.com, the leading sugar daddy site ... site , InterracialMatch.com. The site has recently reached ... millionaire singles and admirers. The members include CEOs, ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com: The Best Linux Web Hosting Suppliers Now Unveiled 2Health News:Pixel Film Studios Releases Flip Flop Theme for Final Cut Pro X Users 2Health News:Cheap Eggplant Evening Dresses Now Announced By Experienced Company iFitDress.com 2Health News:Maroon 5 Tickets Now on Sale in Philadelphia, Washington DC, Nashville, San Jose, Chicago, Dallas, Los Angeles, Tacoma, Saint Paul, Vancouver, San Diego & New York 2Health News:Maroon 5 Tickets Now on Sale in Philadelphia, Washington DC, Nashville, San Jose, Chicago, Dallas, Los Angeles, Tacoma, Saint Paul, Vancouver, San Diego & New York 3Health News:MillionaireSinglesDating.com Reaches 2 Million Users Milestone 2
... Adults with type 2 diabetes who eat unhealthy, ... this can be offset by taking antioxidant vitamins with ... There is already growing evidence linking diabetes to cognitive ... are especially vulnerable to acute meal-induced memory deficits after ...
... Form 10-Q,s for First Three Quarters of Fiscal 2008 ... for Fiscal 2008 Ended March 31, 2008 Points to ... ... ST. LOUIS, June 25 KV Pharmaceutical Company,(NYSE: KVa/KVb), a ...
... in Oral Biology Award will be presented to Dr. ... Pediatric Dentistry, University of Alabama at Birmingham School of ... for Dental Research (IADR) at its 86th General Session ... Dr. Childers, research has contributed to the understanding of ...
... Canada As part of the Opening Ceremonies of ... Metro Toronto Convention Centre, the International Association for Dental ... follow: , IADR Honorary Membership ... may select an Honorary Member who has made significant ...
... N.C., June 25 New research that explores,the tactics ... management is now available in the Best Practice Database, ... Best,Practices, LLC., To review sample key findings and ... with links to each study at this address:, http://www3.best-in-class.com/dr319.htm ...
... there,s a new infant formula that blocks transmission of ... status during pregnancy will affect her baby,s future dental ... prevents early-childhood tooth decay? ,These are but a few ... be presented when the International,Association for Dental Research (IADR) ...
Cached Medicine News:Health News:Seniors with type 2 diabetes may experience memory declines immediately after eating unhealthy meal 2Health News:Seniors with type 2 diabetes may experience memory declines immediately after eating unhealthy meal 3Health News:KV Pharmaceutical Company Completes Fiscal 2008 Filings With Securities and Exchange Commission 2Health News:KV Pharmaceutical Company Completes Fiscal 2008 Filings With Securities and Exchange Commission 3Health News:KV Pharmaceutical Company Completes Fiscal 2008 Filings With Securities and Exchange Commission 4Health News:International Association for Dental Research presents awards and fellowships 2Health News:International Association for Dental Research presents awards and fellowships 3Health News:International Association for Dental Research presents awards and fellowships 4Health News:International Association for Dental Research presents awards and fellowships 5Health News:Best Practice Database Adds Research on New Product Commercialization 2Health News:International Dental Research Association meets in Toronto 2Health News:International Dental Research Association meets in Toronto 3Health News:International Dental Research Association meets in Toronto 4
PDA-version of the leading portable drug reference....
PDA formatted guide containing outlines and detailed information on the diagnosis and treatment of HIV infection and AIDS....
PDA application contains 15,000+ ICD-9-CM Diagnosis codes....
Information on diagnosis and management of 500 common or important medical and surgical disorders....
Medicine Products: