Navigation Links
Sorbent Therapeutics Initiates Phase 2b Clinical Trial of CLP-1001 for Treatment of Signs and Symptoms of Fluid Overload in Patients with Heart Failure
Date:4/11/2013

SUNNYVALE, Calif., April 11, 2013 /PRNewswire/ -- Sorbent Therapeutics, Inc., a biopharmaceutical company developing therapies for cardiovascular and renal diseases, today announced that patient dosing has commenced in its Phase 2b clinical trial of CLP-1001.  This trial, known as STEPWISE (a randomized, double-blind, multi-center STudy comparing cross-linkEd Polyelectrolyte (CLP) WIth placebo in HF SubjEcts), is designed to evaluate the safety and efficacy of CLP-1001 in addressing signs and symptoms of fluid overload in patients with congestive heart failure (HF).  CLP-1001 is a novel, non-absorbed oral polymer that acts by binding to and removing excess sodium and fluid in the GI tract independently of the kidneys.

"The objective of the STEPWISE trial is to further understand the magnitude of the effect of CLP-1001 on key measures and clinical endpoints of heart failure-induced congestion compared to current standard of care," said Howard C. Dittrich , M.D., F.A.C.C., Chief Medical Officer of Sorbent.  "Fluid overload in heart failure patients contributes importantly to hospitalizations -- including re-hospitalizations -- slows in-patient recovery, and results in poor quality of life and physical limitations.  Based on the positive clinical benefits observed in our Phase 2a clinical trial, we look forward to advancing CLP-1001 through late-stage registration studies."   

STEPWISE is a double-blind, randomized, placebo-controlled, multicenter, study designed to evaluate CLP-1001 in patients with heart failure.  Approximately 250 patients on stable, optimized, guideline heart failure therapy that have signs and symptoms of current fluid overload after a recent HF-related hospitalization will be randomized to receive 15 grams of CLP-1001 or placebo.  The primary objective of this trial is to assess the change from baseline to eight weeks across sever
'/>"/>

SOURCE Sorbent Therapeutics
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Sorbent Therapeutics CLP1001 Improves Heart Failure Symptoms In Phase 2 Clinical Study
2. Sorbent Therapeutics Presents CLP1001 Phase 2a Study Results at the 16th Annual Meeting of the Heart Failure Society of America
3. Sorbent Therapeutics Appoints Jason Levin Chief Business Officer
4. CytoSorbents Receives Approximately $400,000 in Non-Dilutive Capital from the Sale of Net Operating Loss Carryovers
5. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
6. Faruqi & Faruqi, LLP Encourages Investors Who Suffered Substantial Losses Investing in Chelsea Therapeutics International, Ltd. to Contact the Firm
7. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
8. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
9. Zacks Industry Outlook Highlights: Eli Lilly, Forest Labs, ViroPharma, Novartis and United Therapeutics
10. Oxford BioTherapeutics Appoints Senior Industry Leader to Head its New Clinical Development Operations in Basel, Switzerland
11. Nektar Therapeutics Reports Financial Results for the First Quarter of 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... This report analyzes the worldwide markets for Breast Pumps in ... and Powered Breast Pumps. The report provides separate comprehensive analytics ... Japan , Europe , ... forecasts are provided for the period 2014 through 2020. Also, ... data and analytics are derived from primary and secondary research. ...
(Date:4/20/2015)... 2015 Research published today in the ... (PNAS) demonstrates that technology invented by researchers at ... Institute can improve the clinical management of ... (OCT) angiography could largely replace current dye-based angiography ... OHSU researchers found that OCT angiography has considerable ...
(Date:4/20/2015)... , April 20, 2015 Actavis plc ... Charles M. Mayr , Chief Communications Officer, will ... health reasons.  In conjunction with Mayr,s retirement, ... the role of Chief Communications Officer, effective immediately. ... as Senior Vice President, Chief Communications Officer, Public ...
Breaking Medicine Technology:World Breast Pumps Industry 2World Breast Pumps Industry 3World Breast Pumps Industry 4World Breast Pumps Industry 5World Breast Pumps Industry 6World Breast Pumps Industry 7World Breast Pumps Industry 8World Breast Pumps Industry 9World Breast Pumps Industry 10World Breast Pumps Industry 11World Breast Pumps Industry 12World Breast Pumps Industry 13World Breast Pumps Industry 14Study shows new technology may improve management of leading causes of blindness 2Study shows new technology may improve management of leading causes of blindness 3Study shows new technology may improve management of leading causes of blindness 4Study shows new technology may improve management of leading causes of blindness 5Actavis Announces Retirement of Charles M. Mayr 2Actavis Announces Retirement of Charles M. Mayr 3
(Date:4/21/2015)... (PRWEB) April 21, 2015 Carinsurancesavings.biz has released ... car under proper surveillance and explaining the impact on a ... their vehicles safe and supervised may be eligible for advantageous ... plans in a simple and efficient way. This will also ... a convenient and simple way. , Finding low cost coverage ...
(Date:4/21/2015)... LifeWings Partners LLC today announced a toolkit to ... safety programs by getting more support from their physicians. ... ways to get more physician support and engagement in ... Act, the new model of health care reimbursement is ... volume of services. Health care leaders feel an increased ...
(Date:4/21/2015)... When a bandage sticks to an injury site ... solve this problem two inventors from Festus, Mo., designed ... helps a cut, burn, abrasion or wound heal more ... The bandage is easy to use, versatile and producible ... to the St. Louis office of InventHelp. It is ...
(Date:4/21/2015)... 2015 A new study at a ... with peritoneal cancers like mesothelioma increased by 20 percent ... posted the results of the study. Click here ... at North Hampshire Hospital in Basingstoke performed a retrospective ... such as mesothelioma between 1994 and 2014. They ...
(Date:4/21/2015)... MO (PRWEB) April 21, 2015 The ... 2015 from 5:00 to 8:00 pm at the William and ... Chapel Hill, NC 27599. More than 50 hospitals, clinics and ... country. All specialties will be represented. Attendees will enjoy free ... of Career Fairs for PracticeMatch says “Chapel Hill ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes Offer Excellent Security for A Car 2Health News:LifeWings Announces New Physician Engagement Toolkit to Help Hospitals Weather Serious Ramifications of the Affordable Care Act 2Health News:New Findings Highlight Value of Experience in Peritoneal Mesothelioma Treatment, According to Surviving Mesothelioma 2Health News:PracticeMatch to Host Physician Career Fair at William and Ida Friday Center at UNC-Chapel Hill on April 29, 2015 2Health News:PracticeMatch to Host Physician Career Fair at William and Ida Friday Center at UNC-Chapel Hill on April 29, 2015 3
... MAY 31, 2009 The American Society for Gastrointestinal ... endoscopy during the fifth annual ASGE Crystal Awards on Sunday, ... year,s event will begin at 6:30 p.m. at Navy Pier ... Week (DDW), the ASGE Crystal Awards symbolize the finest in ...
... Calif., May 31 Impac Software joined the National ... today to announce recipients of the Seventh Annual Impac ... and JRM, the official journal of the NCRA, ... the cancer registry field throughout ...
... supplements boost vascular function, study finds , , SUNDAY, ... supplementation improved vascular function in young female runners ... was lower than their energy output, researchers say. ... decrease cardiovascular risk and also improve performance in ...
... BIO International Convention , ... Atlanta, GA (PRWEB) May 31, 2009 -- ... BIO International Convention. The leading hair regeneration company joined more ... largest annual event for the biotechnology industry, held May 18-21 at the ...
... but cure remains out of reach, studies show ... drugs offer incremental yet significant improvements in pushing ... of studies presented Saturday at the annual meeting ... in Orlando, Fla. , Lung cancer remains America,s ...
... Information about the high-speed accelerometers study presented on Saturday ... PDT presentation. Information about the other studies is not ... ASTHMA SYMPTOMS AS AN ALBUTEROL INHALER , An Indiana ... an hour of exercise can reduce the symptoms of ...
Cached Medicine News:Health News:ASGE and ASGE Foundation hold Crystal Awards Dinner as part of Digestive Disease Week 2Health News:ASGE and ASGE Foundation hold Crystal Awards Dinner as part of Digestive Disease Week 3Health News:ASGE and ASGE Foundation hold Crystal Awards Dinner as part of Digestive Disease Week 4Health News:ASGE and ASGE Foundation hold Crystal Awards Dinner as part of Digestive Disease Week 5Health News:ASGE and ASGE Foundation hold Crystal Awards Dinner as part of Digestive Disease Week 6Health News:ASGE and ASGE Foundation hold Crystal Awards Dinner as part of Digestive Disease Week 7Health News:National Cancer Registrars Association and Impac Software Announce Best Paper Award Recipients 2Health News:Women Who Run May Benefit From Extra Folic Acid 2Health News:Aderans Research BIO International Press Release 2Health News:Aderans Research BIO International Press Release 3Health News:Drug Trials Show Modest Gains Against Lung Cancer 2Health News:Drug Trials Show Modest Gains Against Lung Cancer 3Health News:Drug Trials Show Modest Gains Against Lung Cancer 4Health News:Indiana U. research at the American College of Sports Medicine conference 2Health News:Indiana U. research at the American College of Sports Medicine conference 3Health News:Indiana U. research at the American College of Sports Medicine conference 4Health News:Indiana U. research at the American College of Sports Medicine conference 5Health News:Indiana U. research at the American College of Sports Medicine conference 6
... These corrosion proof polypropylene exhaust hoods ... edge of tanks and draw a stream ... tank away from the operator. Other sizes ... semi-canopy, lateral, and double-slot are available on ...
These handy dispensers save space and organize gloves in labs and next to hand washers. Static-dissipative PVC eliminates static charges and the particles they attract . Many other sizes and custom c...
... base sliding microtome offers the ultimate in ... not least, safety. ,Designed to meet the ... 8000 will also meet the more demanding ... versatility and wide range of accessories will ...
... Starter Package is a solid ... laboratory. The package includes the ... additional mounting blocks, v-block adapter, ... a rotating stage assembly for ...
Medicine Products: