Navigation Links
Simultaneous Applications Submitted to FDA and EMA for Siltuximab for the Treatment of Multicentric Castleman Disease, a Rare Blood Disorder
Date:9/3/2013

groups, with 53 receiving siltuximab and BSC, and 26 receiving placebo and BSC.5 Results of the primary study analysis have been submitted for presentation at a medical meeting later this year.

About Multicentric Castleman Disease
Unlike "unicentric" Castleman disease, which is localized and affects only a single area or group of lymph nodes,6 patients with MCD have more than one group of lymph nodes in different anatomical areas that are affected.3 Unicentric disease can be treated by surgically removing the diseased lymph node,7 while multicentric disease is usually much more difficult to treat.8 Currently, the focus of care is to reduce lymph node masses9, 10 and to attempt to put the disease in remission through a combination of treatments, including corticosteroids, chemotherapy and immunotherapy. While such treatments may initially help, the disease often returns.8

MCD can also affect lymphoid tissue of internal organs, causing the liver, spleen, or other organs to enlarge.11 Some symptoms can be life threatening.9,10 The most common symptoms include fever, weakness, fatigue, night sweats, weight loss, loss of appetite, nausea, vomiting and nerve damage that leads to numbness and weakness.3 Infections, renal failure, and malignancies including malignant lymphoma and Kaposi's sarcoma are common causes of death in patients with MCD.9,10 Castleman disease is formally diagnosed through a biopsy.11 The number of people diagnosed with Castleman disease is unknown, but the disease is known to be rare.12

About Siltuximab
Siltuximab is an investigational, anti Interleukin-6 (IL-6) chimeric monoclonal antibody that targets and binds to human IL-6. IL-6 is a multifunctional cytokine produced by various cells such as T cells, B cells, monocytes, fibroblasts and endothelial cells.'/>"/>

SOURCE Janssen Research & Development, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. First Large-Scale Population-Based Study in the U.S. Shows Hologics 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection
2. Philips IMR offers new capabilities to simultaneously reduce CT Radiation and enhance image quality
3. Ventana Receives FDA Clearance for p53 (DO-7) Image Analysis and Digital Read Applications
4. Rubicon Genomics Launches ThruPLEX™ Family of Sample Preparation Products for Next Generation Sequencing Applications
5. Philips demonstrates innovations in nuclear medicine imaging with a comprehensive portfolio of NM applications for IntelliSpace Portal
6. Clinical Safety Data for ChromaDex®s Patented pTeroPure® (pterostilbene) Released at 6th World Congress on Polyphenols Applications in Paris
7. UltraTape announces Cleanroom Labels for Cryogenic Laboratory applications
8. New, Affordable Flow Cytometer Cell Sorter Expands Access to Wider Range of Life Science Applications
9. New Wireless Keyboard Rechargeable, Washable for Healthcare Applications
10. Frost & Sullivan: Label-Free Technology is a High Potential Market with Myriad Unexplored Applications
11. Radiotherapy Devices Market By Technology, Applications & Products (2011 - 2016)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... , Aug. 28, 2015  Delays in ... projects can slow down the decision-making process, resulting ... therefore, absolutely critical for biopharmaceutical companies to develop ... approval process for quicker and more meaningful insights. ... Best Practices, LLC, nearly three-quarters of benchmarked study ...
(Date:8/28/2015)... , August 28, 2015 According ... by Tumor (Breast, Lung, Prostate) Type (Protein & Genetic ... Drug Discovery, Prognostic) & Geography - Global Forecast to ... expected to reach around 17,689.0 Million USD by 2020 ... of 2015 to 2020. Browse 191 ...
(Date:8/28/2015)... Research and Markets ( ... "Investigation Report on China,s Bevacizumab Market ,2010-2019" report ... the trade name of Avastin, bevacizumab injection is the ... it was approved by CFDA to treat metastatic colorectal ... all come from Roche and its subsidiary ...
Breaking Medicine Technology:Expediting the Pharmaceutical Market Research Process for Faster Insights 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 3Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 4Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 5Investigation Report on China's Bevacizumab Market 2015-2019 2
... have the ability to better identify risks for exposure to ... information and experiences as a result of a new program ... and Company) and the world,s leading provider of IV catheters. ... provide nurses and other healthcare professionals with a forum to ...
... (NYSE: IBM ) today announced that faculty from ... use IBM business analytics technology at the core of ... and spots potential safety issues. (Logo: ... advanced pharmacoepidemiology studies that look at the effects of ...
Cached Medicine Technology:Resource Now Available to Help Clinicians Reduce Risk of Blood Exposure from Short Peripheral IV Catheter Insertion 2Resource Now Available to Help Clinicians Reduce Risk of Blood Exposure from Short Peripheral IV Catheter Insertion 3Harvard Medical School Faculty Advances Drug Safety Research With IBM Business Analytics 2Harvard Medical School Faculty Advances Drug Safety Research With IBM Business Analytics 3
(Date:8/28/2015)... ... , ... Rio Salado College joined nine educational institutions in Washington ... the EDUCAUSE - Next Generation Learning Challenges 2015 Breakthrough Models Incubator funded by the ... Models Incubator hosted by EDUCAUSE and NGLC, which is designed to bring leadership ...
(Date:8/28/2015)... , ... August 28, 2015 , ... An article ... local pizza maker Paul LaRocco has gone through to open a pizzeria in Westchester. ... permitting process tends to take several months, but the current process, having already gone ...
(Date:8/28/2015)... ... ... The 6th Annual Survivor in the City, Chicago silent auction and cocktail ... its cadre of widespread support—an official letter of support and gratitude from the Mayor ... and the University of Illinois at Chicago’s Department of Neurosurgery, the Brain Aneurysm Foundation ...
(Date:8/28/2015)... ... August 28, 2015 , ... Altima Technologies, ... diagramming network and data center assets and audio-video devices, recently released Visio Stencils ... 5000 Series, HP ProLiant Gen9, EMC VNX Series , Super Micro Computer SuperStorage, ...
(Date:8/28/2015)... ... ... Dr. Gregory K. Toumayan, D.C., Q.M.E., is now treating patients with back pain ... pain, neck pain, stiffness, muscle spasms, and numbness. , Dr. Toumayan received his ... on to earn his title of Doctor of Chiropractic from the Palmer College of ...
Breaking Medicine News(10 mins):Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3
... In a new study, researchers have discovered that suffering from ... which is a dangerous condition in which blood clots form ... cause an increase in the risk of heart attacks and ... of more than three million patient records from across the ...
... deal with crimes committed by drug addicts have been extended ... be started all across the country. // The drug courts ... 2002. These will undergo further monitoring by the Scottish Executive’s. ... indicated that there were no significant difference in re-conviction rates ...
... according to the decision taken by the Tibetan government in ... ,'Under an integrated development programme by 2007, $25 ... of the Tibetan government led by the Dalai Lama. ... India and some of them have taken around 20,000 acres ...
... of the brain plays an important role in distinguishing ... at the National Institutes of Health's (NIH) National Institute ... scans has found how the brain's outer layer, cortex, ... childhood stage, reflecting a high-level thinking circuitry. On the ...
... pain killing medication helps by halting the production of an ... cancer. The name of the painkiller is Nimesulide. // ... scientists found that derivatives of nimesulide stopped the production of ... of cancer is the most common breast cancer in postmenopausal ...
... Rudland, Dr Guozheng Wang and Dr Roger Barraclough from the ... new gene that causes the spread of cancer. // An ... is the main cause for the spread of cancerous cells ... If S100P is present it trigger the rapid spread of ...
Cached Medicine News:Health News:Cortex Of Youth With Superior IQ Matures Fast 2Health News:Pain-killer Drug Can Help Fight Breast Cancer 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: