Navigation Links
Simultaneous Applications Submitted to FDA and EMA for Siltuximab for the Treatment of Multicentric Castleman Disease, a Rare Blood Disorder
Date:9/3/2013

groups, with 53 receiving siltuximab and BSC, and 26 receiving placebo and BSC.5 Results of the primary study analysis have been submitted for presentation at a medical meeting later this year.

About Multicentric Castleman Disease
Unlike "unicentric" Castleman disease, which is localized and affects only a single area or group of lymph nodes,6 patients with MCD have more than one group of lymph nodes in different anatomical areas that are affected.3 Unicentric disease can be treated by surgically removing the diseased lymph node,7 while multicentric disease is usually much more difficult to treat.8 Currently, the focus of care is to reduce lymph node masses9, 10 and to attempt to put the disease in remission through a combination of treatments, including corticosteroids, chemotherapy and immunotherapy. While such treatments may initially help, the disease often returns.8

MCD can also affect lymphoid tissue of internal organs, causing the liver, spleen, or other organs to enlarge.11 Some symptoms can be life threatening.9,10 The most common symptoms include fever, weakness, fatigue, night sweats, weight loss, loss of appetite, nausea, vomiting and nerve damage that leads to numbness and weakness.3 Infections, renal failure, and malignancies including malignant lymphoma and Kaposi's sarcoma are common causes of death in patients with MCD.9,10 Castleman disease is formally diagnosed through a biopsy.11 The number of people diagnosed with Castleman disease is unknown, but the disease is known to be rare.12

About Siltuximab
Siltuximab is an investigational, anti Interleukin-6 (IL-6) chimeric monoclonal antibody that targets and binds to human IL-6. IL-6 is a multifunctional cytokine produced by various cells such as T cells, B cells, monocytes, fibroblasts and endothelial cells.'/>"/>

SOURCE Janssen Research & Development, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. First Large-Scale Population-Based Study in the U.S. Shows Hologics 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection
2. Philips IMR offers new capabilities to simultaneously reduce CT Radiation and enhance image quality
3. Ventana Receives FDA Clearance for p53 (DO-7) Image Analysis and Digital Read Applications
4. Rubicon Genomics Launches ThruPLEX™ Family of Sample Preparation Products for Next Generation Sequencing Applications
5. Philips demonstrates innovations in nuclear medicine imaging with a comprehensive portfolio of NM applications for IntelliSpace Portal
6. Clinical Safety Data for ChromaDex®s Patented pTeroPure® (pterostilbene) Released at 6th World Congress on Polyphenols Applications in Paris
7. UltraTape announces Cleanroom Labels for Cryogenic Laboratory applications
8. New, Affordable Flow Cytometer Cell Sorter Expands Access to Wider Range of Life Science Applications
9. New Wireless Keyboard Rechargeable, Washable for Healthcare Applications
10. Frost & Sullivan: Label-Free Technology is a High Potential Market with Myriad Unexplored Applications
11. Radiotherapy Devices Market By Technology, Applications & Products (2011 - 2016)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014   Acutus Medical, Inc. (ACM), ... 3D Cardiac Chamber Imaging and Dipole Density Mapping system ... sustain complex cardiac arrhythmias, including atrial fibrillation, announced it ... its imaging/mapping system as well as bring to market ... Medical to complete work on the AcQMap TM ...
(Date:9/30/2014)... , Sept. 30, 2014 One week after ... major milestone: Alzheimer,s Team reaches over 200,000 ... and caregivers, was developed to draw attention to clinical ... disease. It also provides inspirational support and fosters online ... as the leading healthcare concern for people over the ...
(Date:9/30/2014)... 2014 Organovo Holdings, Inc. (NYSE MKT: ... delivering breakthrough 3D bioprinting technology, announced today that ... a finalist in the Diagnostics & Research Tools ... Awards, sponsored by CONNECT. CONNECT, a regional program that ... sciences products in San Diego County ...
Breaking Medicine Technology:Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 2Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 3MediciGlobal's Alzheimer's Community Reaches 200,000 likes and more than half a million weekly visitors 2MediciGlobal's Alzheimer's Community Reaches 200,000 likes and more than half a million weekly visitors 3MediciGlobal's Alzheimer's Community Reaches 200,000 likes and more than half a million weekly visitors 4Organovo Inc. Selected As A Finalist In 27th Annual CONNECT Most Innovative New Product Awards 2Organovo Inc. Selected As A Finalist In 27th Annual CONNECT Most Innovative New Product Awards 3
... SPRING, Md., June 24, 2011 Breast cancer patients and ... 7:00 am outside of the Federal Drug Administration (FDA).  At ... anti-cancer drug Avastin from the approved medication list for treatment ... in 2008 for use to treat breast cancer. ...
...   - Dossier Re-Examination ... a leader in,the field of human gene therapy, ... its Marketing Authorisation Application,(MAA) for Glybera® (alipogene tiparvovec) ... Following a recent,meeting with the European Medicines Agency,s ...
Cached Medicine Technology:Breast Cancer Patients and Families Stand Up To FDA 2Amsterdam Molecular Therapeutics Receives Opinion on Glybera(R) Marketing Authorisation Application 2Amsterdam Molecular Therapeutics Receives Opinion on Glybera(R) Marketing Authorisation Application 3Amsterdam Molecular Therapeutics Receives Opinion on Glybera(R) Marketing Authorisation Application 4
(Date:9/30/2014)... 30, 2014 ADOAMNI, Inc. ... campaign through GoFundMe. The campaign, which surpassed its goal ... portion of the funds necessary to convert a diesel ... Stockton Unified School District (SUSD). The campaign rallied citizens ... portion of the funds necessary for the conversion of ...
(Date:9/30/2014)... 2014 The American Parkinson ... funding supporting seven Research grants to junior investigators ... to support post-doctoral scientists whose research training holds ... etiology and treatment of Parkinson’s disease, and eight ... and medical centers across the country intended to ...
(Date:9/30/2014)... With accolades like the Most Inspirational Lash Artist ... Brand of My Brand Lashes is a leader of lash ... the ability to teach. She leads with a passion for ... reputation. , With a background in Cosmetology that spans 11 ... and as an Instructor. She has operated two of her ...
(Date:9/30/2014)... Got grapes? UCLA researchers have demonstrated how resveratrol, an ... to inhibit growth of the bacteria that causes acne. ... a common acne medication, benzoyl peroxide, may enhance the ... into new treatments. , Published in the current online ... the early lab findings demonstrated that resveratrol and benzoyl ...
(Date:9/30/2014)... -- MIT engineers have devised a way to rapidly ... making it easier to discover promising new ways to ... antibodies, peptides, RNA, and DNA, to human patients. , ... Biology , the researchers used this technology to identify ... also to rodents. This type of high-speed screen could ...
Breaking Medicine News(10 mins):Health News:ADOMANI Raises More Than 100,000 Dollars Through GoFundMe to Convert a School Bus 2Health News:ADOMANI Raises More Than 100,000 Dollars Through GoFundMe to Convert a School Bus 3Health News:The American Parkinson Disease Association Awards $1.1 million in Research Grants and Continues to Lead the Way to Ease the Burden – Find the Cure for Parkinson’s Disease 2Health News:The American Parkinson Disease Association Awards $1.1 million in Research Grants and Continues to Lead the Way to Ease the Burden – Find the Cure for Parkinson’s Disease 3Health News:The American Parkinson Disease Association Awards $1.1 million in Research Grants and Continues to Lead the Way to Ease the Burden – Find the Cure for Parkinson’s Disease 4Health News:My Brand Lashes and Lash Affair By J. Paris Merge to Offer Premium Lash and Brow Products and Certifications 2Health News:My Brand Lashes and Lash Affair By J. Paris Merge to Offer Premium Lash and Brow Products and Certifications 3Health News:Antioxidant found in grapes uncorks new targets for acne treatment 2Health News:Antioxidant found in grapes uncorks new targets for acne treatment 3Health News:High-speed drug screen 2Health News:High-speed drug screen 3
... (NP) is pleased to share today the release of Mr. Umar ... the Mindanao region of the Philippines who was kidnapped from the ... 13. Jaleel is alive and is currently en route to ... the vicinity of Tipo Tipo on Basilan. Jaleel was released ...
... , ... final program for Biopolymers Symposium 2009 taking place September 28 - 30th in Chicago, ... ... -- IntertechPira is pleased to announce the Biopolymers Symposium 2009 conference and exhibit, taking ...
... A. Magana awarded $25,000 each for leadership in increasing diversity ... 3 Guillermo J. Camacho, a dentist in West Covina, ... at California State Polytechnic University, Pomona, that encourages students of ... founded and directs a program at Cabrillo College ...
... if you,re a woman trying to figure out how to please her ... the gift you really want for yourself. , , (Photo: ... that probably rules out the ,65 Mustang and the even-bigger screen TV. ... for millions of women - one that would actually be a true ...
... for early confirmation of bile duct, pancreatic cancers, , WEDNESDAY, ... have developed new tests that make it easier to diagnose ... study, the new tests more than doubled the detection rate ... are not discovered until their later stages. , "The earlier ...
... , Health insurer chooses Cincom Eloquence to streamline policy ... software provider Cincom Systems announces that Medica ( ... to more than 1.5 million members, has chosen Cincom ... document automation processes. , , Key considerations for ...
Cached Medicine News:Health News:Kidnapped Nonviolent Peaceforce Civilian Peacekeeper Released Unharmed 2Health News:Kidnapped Nonviolent Peaceforce Civilian Peacekeeper Released Unharmed 3Health News:Biopolymers Symposium 2009 Announces Final Program and Interactive Green Brochure 2Health News:Mentors Who Support Students Receive TCWF Champions of Health Professions Diversity Award 2Health News:Mentors Who Support Students Receive TCWF Champions of Health Professions Diversity Award 3Health News:Perfect Father's Day Gift: The Sound of Silence 2Health News:Perfect Father's Day Gift: The Sound of Silence 3Health News:New Tests Spot Tough-to-Detect Cancers Sooner 2Health News:Medica Selects Cincom's Document Automation Software 2Health News:Medica Selects Cincom's Document Automation Software 3
...
... The Slim-LOC Plate is a ... intervertebral body fixation. The Slim-LOC is ... design, modified by current market technology. ... versatility & integrated instrumentation. Reduced width ...
... Osmium is a cervical plate system ... spine. The implant provides for the ... the bone transplant has consolidated. Optimized ... and bicortical fixation. Maximum purchase also ...
... meet the clinical challenges of anterior cervical ... and the choice of fixed angle screws ... for ease of implantation in complex cases. ... the surgeon the versatility of creating a ...
Medicine Products: