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SARcode Bioscience Announces Acquisition by Shire US Holdings Inc.
Date:3/25/2013

ed in both corneal and conjunctival staining, key indicators of ocular surface health.  Lifitegrast also improved eye dryness and ocular discomfort, the two most commonly reported symptoms of dry eye. Lifitegrast was well tolerated and there were no unexpected or serious ocular adverse events. The most commonly reported ocular adverse events were initial instillation site complaints, and were generally mild and transient in nature.

About Dry Eye Disease

Dry eye disease is a prevalent and often chronic condition estimated to affect approximately 25 million people in the US and 370 million people worldwide. This number is expected to grow substantially in the next decade due to an aging population and increasing incidence of type-2 diabetes, both of which contribute to higher rates of this condition.  Dry eye disease is among the most common disorders treated by ophthalmologists throughout the world.  Dry eye varies in severity and etiology, and symptoms most commonly manifest as ocular discomfort, eye dryness, and tear film instability due to decreased quality or quantity of tears.  A major contributing factor towards the development of dry eye is inflammation caused by T-cell infiltration, proliferation and inflammatory cytokine production that can lead to reduction in tear film quality and ocular surface damage.

About SARcode Bioscience

SARcode Bioscience, Inc., founded in 2006, is an ophthalmic biopharmaceutical company based in Brisbane, CA.  SARcode's lead development program is a novel class of lymphocyte function-associated antigen-1 (LFA-1) antagonists for the treatment T-cell mediated inflammatory diseases. www.sarcode.com


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