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PharmaFocus: Vaccine Adjuvants in Infectious Disease


Table 2: Immune Cells and Their Corresponding Toll-like Receptors 15

Table 3: TLR Adjuvant Targets and Ligand Types in Clinical Trials for Infectious Disease Vaccines 24

Table 4: Vaccine Adjuvants – Drivers and Barriers, 2013 27

Table 5: Leading Adjuvants in Clinical Trials for Human Infectious Disease Vaccines 36

Table 6: Product Profile – Aluminum Salts/Alum 38

Table 7: Aluminum Salts/Alum SWOT Analysis, 2013 40

Table 8: Product Profile – Emulsions 42

Table 9: Emulsions SWOT Analysis, 2013 43

Table 10: Product Profile – Particulate Delivery Mechanisms 45

Table 11: Particulate Delivery Mechanisms SWOT Analysis, 2013 46

Table 12: Product Profile – Microbial Derivatives 48

Table 13: Microbial Derivatives SWOT Analysis, 2013 49

Table 14: Product Profile – Oligonucleotides 50

Table 15: Oligonucleotides SWOT Analysis, 2013 52

Table 16: Product Profile – Adjuvant Systems 53

Table 17: GSK's Adjuvant System Portfolio, 2013 53

Table 18: Adjuvant Systems SWOT Analysis, 2013 55

Table 19: Overall Unmet Needs – Current Level of Attainment 56

Table 20: Regulatory Guidelines for the Approval of Adjuvanted Vaccines 72

List of Figures Figure 1: Immune System – Stimulation of Innate and Adaptive Responses 13

Figure 2: Adjuvant Targets – Human Toll-like Receptor Family 23

Figure 3: Adjuvant – Host Immune Response Interactions 35

Figure 4: Chemical Structure of MPL 47

Figure 5: Chemical Structure of Dinitrophenylated CpG ODN 50

Figure 6: WHO Map to Vaccine Adjuvant Usage 69

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