Navigation Links
PharmaFocus: Vaccine Adjuvants in Infectious Disease
Date:4/11/2013

nvaccinated disease 30

4.3 Barriers 31

4.3.1 Barrier: Decreasing or stagnant vaccination rates 31

4.3.2 Barrier: Increasing vaccine prices 32

4.3.3 Barrier: Public opinion of vaccine and adjuvants 33

5 Current Adjuvant Options 34

5.1 Overview 34

5.2 Product Profiles – Major Adjuvant Classes 37

5.2.1 Aluminum Salts (Alum) 37

5.2.2 Emulsions 40

5.2.3 Particulate Delivery Mechanisms 43

5.2.4 Microbial Derivatives 46

5.2.5 Oligonucleotides 49

5.2.6 Adjuvant Systems 52

6 Needs Assessment and Opportunity Analysis 56

6.1 Overview 56

6.2 Unmet Needs Analysis 57

6.2.1 Adjuvant Safety 57

6.2.2 DC Recognition 57

6.2.3 Appropriate TLR Activation 58

6.2.4 Formulation and Dosing 58

6.3 Opportunity Analysis 60

6.3.1 Novel Routes of Administration and Splenic Involvement 60

6.3.2 Combinatorial Adjuvant Systems 61

6.3.3 Limited Use of Antigen Depot 61

7 Clinical Trials and Regulatory Strategy 63

7.1 Clinical Trial Design 63

7.1.1 Non-clinical Evaluation 63

7.1.2 Adjuvant Mechanism of Action Evaluation 64

7.1.3 Clinical Safety Evaluation 64

7.1.4 KOL Opinion on Clinical Design 65

7.2 Regulatory Strategy 67

7.2.1 Overview 67

7.2.2 World Health Organization (WHO) 68

7.2.3 US 69

7.2.4 EU 73

7.2.5 Cultural Differences in Adjuvant Use (US vs. Europe) 73

8 Appendix 75

8.1 Bibliography 75

8.2 Abbreviations 81

8.3 Research Methodology 82

8.4 Physicians and Specialists Included in this Study 83

8.5 About the Authors 85

8.5.1 Author 85

8.5.2 Reviewer 85

8.5.3 Global Head of Healthcare 86

8.6 About GlobalData 86

8.7 Contact Us 86

8.8 Disclaimer 87

List of Tables Table 1: Primary Physical (Epithelial) Barriers to Infection 12 <
'/>"/>

SOURCE Reportlinker
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Army Researcher Develops Potential Vaccine Carrier That May Give Stockpiling Efforts A Shot In The Arm
2. Shingles Vaccine is Safe, According to New Study
3. Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability
4. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
5. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
6. Sanofi Pasteur Presents Pediatric Data on Investigational Quadrivalent Influenza Vaccine
7. Generex Announces Presentations of Antigen Express AE37 Breast Cancer Vaccine Data at ASCO 2012
8. Inovio Pharmaceuticals Universal Avian Flu Vaccine Generates Protective Antibody Responses Against Six H5N1 Viruses in Phase I Trial
9. Global Human Vaccines Industry
10. Generex Announces New Members of Antigen Express Scientific Advisory Board for the AE37 Breast Cancer Vaccine
11. HIV Vaccine Trials Network Opens Enrollment for Phase 1 Trial of GeoVax Labs Second Generation HIV Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... DIEGO , April 20, 2015  Halozyme ... company developing novel oncology and drug-delivery therapies, today ... the American Association for Cancer Research (AACR) annual ... results of its randomized Phase 2 study in ... annual meeting of the American Society of Clinical ...
(Date:4/20/2015)... PALO ALTO, Calif. , April 20, 2015 ... study demonstrate positive trends in the ability of ... slow the progression of amyotrophic lateral sclerosis (ALS, ... over a 6-month treatment period. While NP001,s slowing ... of the study was not statistically significant, clinically ...
(Date:4/20/2015)...  OpGen, Inc., a molecular testing and bioinformatics ... management team with the appointments of former Foundation ... Krenitsky , M.D. as president, and Timothy ... With more than 15 years ... biotechnology operations, including senior commercial and operational responsibilities ...
Breaking Medicine Technology:Halozyme Presents New Preclinical Data At The American Association for Cancer Research Annual Meeting, Announces Clinical Data Presentation At ASCO 2Halozyme Presents New Preclinical Data At The American Association for Cancer Research Annual Meeting, Announces Clinical Data Presentation At ASCO 3Halozyme Presents New Preclinical Data At The American Association for Cancer Research Annual Meeting, Announces Clinical Data Presentation At ASCO 4Halozyme Presents New Preclinical Data At The American Association for Cancer Research Annual Meeting, Announces Clinical Data Presentation At ASCO 5Published Phase 2 Results Demonstrate Neuraltus Pharmaceuticals' NP001 Potential Efficacy and Safety in ALS 2Published Phase 2 Results Demonstrate Neuraltus Pharmaceuticals' NP001 Potential Efficacy and Safety in ALS 3Published Phase 2 Results Demonstrate Neuraltus Pharmaceuticals' NP001 Potential Efficacy and Safety in ALS 4Published Phase 2 Results Demonstrate Neuraltus Pharmaceuticals' NP001 Potential Efficacy and Safety in ALS 5OpGen Appoints Industry Veterans Dr. Kevin Krenitsky as President and Timothy Dec as Interim Chief Financial Officer 2OpGen Appoints Industry Veterans Dr. Kevin Krenitsky as President and Timothy Dec as Interim Chief Financial Officer 3OpGen Appoints Industry Veterans Dr. Kevin Krenitsky as President and Timothy Dec as Interim Chief Financial Officer 4
(Date:4/20/2015)... 2015 “Consumers deserve to know that their ... children’s hair will not put their health at risk,” said ... National Alliance for Hispanic Health, the nation’s leading Hispanic health ... not had authority to ensure cosmetic and personal care products ... had authority to get products off the shelves if they ...
(Date:4/20/2015)... April 20, 2015 Goodreads is sponsoring ... Insurance: Why It’s Good for You and Your Company ... Zane Pilzer and Rick Lindquist have released a ... Why It’s Good for You and Your Company. The ... health insurance woes - employer-funded individual health insurance. ...
(Date:4/20/2015)... The normal response from the doctor used to be, ... Especially if the patient sought medical care after the six-hour ... different. So it’s critical the patient’s loved ones or caregiver ... , Not every emergency room physician or neurosurgeon has the ... But, according to Ronald P. Benitez , neurosurgeon and ...
(Date:4/20/2015)... Early registration is open for the 2nd ... at the start line. Returning to James Kealoha Beach ... to 500 participants (actually there’s only 499 spots since Big ... Now thru April 30, the entry fee is only $150 ... 1st, the fee goes up to $200 and $100, respectively. ...
(Date:4/20/2015)... Florida Hospital at Connerton Long Term ... from Select Medical, during the annual ceremony hosted at ... Chief Operating Officer, Debi Martoccio, received the Leadership Award ... of six recipients out of 113 hospitals nationwide. The ... for the contributions to the community as well as ...
Breaking Medicine News(10 mins):Health News:Statement of National Alliance for Hispanic Health on Senate Introduction of Personal Care Products Safety Act 2Health News:Zane Benefits Announces Complimentary Book Giveaway On GoodReads: The End of Employer-Provided Health Insurance: Why It's Good for You and Your Company 2Health News:Zane Benefits Announces Complimentary Book Giveaway On GoodReads: The End of Employer-Provided Health Insurance: Why It's Good for You and Your Company 3Health News:"What More Can Be Done?” – The Critical Question That Can Save a Stroke Victim 2Health News:"What More Can Be Done?” – The Critical Question That Can Save a Stroke Victim 3Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 3Health News:Florida Hospital at Connerton Long Term Acute Care Earns Awards from Select Medical including the Stu Dinney Humanitarian Award 2Health News:Florida Hospital at Connerton Long Term Acute Care Earns Awards from Select Medical including the Stu Dinney Humanitarian Award 3
... , , RALEIGH ... SNN ; LSE: SN) Biologics & Spine is proceeding to ... of DUROLANE(R) Single Injection, Stabilized Hyaluronic Acid. , , ... and their global commercial partner, Smith & Nephew met today with ...
... , , , NEW YORK, Aug. ... the beauty industry is the naturals and organic market and HBA Global ... has obtained one of its most well-known innovators and activists to deliver ... the Special Events Hall of the Javits Center in New York. ...
... ... , ... 19, 2009 -- As parents across the country check off school items from their shopping ... season -- foot-friendly shoes. Whether on the school bus, in the classroom or on the ...
... , , , ELM GROVE, Wis., Aug. ... rgency D e partment Core Measures: A ... Comp i rion Healthcare Solutions to aid Hospital Emergency ... for AMI , CHA and CAP patients. Compliance with JCAHO ...
... Alahari, PhD, Associate Professor of Biochemistry and Molecular Biology at ... first time that a tiny piece of RNA appears to ... cancer and identified a gene that appears to inhibit invasive ... 2009 issue of the Journal of Biological Chemistry . ...
... for hand-held technologies , WEDNESDAY, Aug. 19 (HealthDay News) ... to smudge easily, but scientists say they have a ... of protective coatings, a finding that may lead to ... key to anti-smudge coatings is perfluoro alkyl ether, a ...
Cached Medicine News:Health News:Smith & Nephew Takes Single Injection PMA to Next Stage 2Health News:Smith & Nephew Takes Single Injection PMA to Next Stage 3Health News:Smith & Nephew Takes Single Injection PMA to Next Stage 4Health News:Horst M. Rechelbacher To Deliver HBA Global Expo Keynote Address 2Health News:Horst M. Rechelbacher To Deliver HBA Global Expo Keynote Address 3Health News:Give Shoes the '1,2,3 Test' During Back-To-School Shopping 2Health News:Give Shoes the '1,2,3 Test' During Back-To-School Shopping 3Health News:Compirion Hosts Free Webinar on Achieving JCAHO-Compliant Quality Outcomes 2Health News:Compirion Hosts Free Webinar on Achieving JCAHO-Compliant Quality Outcomes 3Health News:LSUHSC research discovers new targets for treatment of invasive breast cancer 2Health News:A Smudge-Free Smart Phone Screen? 2
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Low-profile, hand-held instrument....
Low-profile, hand-held instrument....
Medicine Products: