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Overweight Siblings of Children With Type 2 Diabetes Likely to Have Abnormal Blood Sugar Levels
Date:12/9/2008

nce. Obesity decreases insulin sensitivity, as does puberty, when all adolescents experience a period of relative insulin resistance. In obese adolescents already at risk of developing type 2 diabetes, the increase in insulin resistance during puberty may be enough to unmask disease. Family history is also important; 74-100 percent of children with type 2 diabetes have a first- or second-degree relative who also has the condition.

Not all children with a family history of type 2 diabetes, insulin resistance or obesity develop type 2 diabetes, cautions Dr. Magge.

The researchers also add that identifying groups at high-risk for type 2 diabetes during childhood, such as obese siblings of children with type 2 diabetes, could help guide screening of obese children for abnormal glucose tolerance by primary care providers. This could also help to identify children who might benefit from participation in future type 2 diabetes prevention studies.

Dr. Magge's coauthors were: Nicolas Stettler, M.D., M.S.C.E., Abbas Jawad, M.Sc., Ph.D., and Lorraine E. Levitt Katz, M.D. all of The Children's Hospital of Philadelphia and the University of Pennsylvania.

The research was supported by grants from the National Institutes of Health and the National Center for Research Resources.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking second in National Institutes of Health funding. In addition, its unique family-centered care and publ
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SOURCE The Children's Hospital of Philadelphia
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