Navigation Links
New Study Results Published in the New England Journal of Medicine Show Dabigatran Etexilate Mesylate Reduces the Risk of Recurrent Venous Thromboembolism
Date:2/20/2013

of PRADAXA is contraindicated in patients with mechanical prosthetic valves.

Use of PRADAXA for the prophylaxis of thromboembolic events in patients with atrial fibrillation and other forms of valvular heart disease, including bioprosthetic heart valve, has not been studied and is not recommended.

Temporary Discontinuation of PRADAXA
Discontinuing PRADAXA for active bleeding, elective surgery, or invasive procedures places patients at an increased risk of stroke. Minimize lapses in therapy.

Effect of P-gp Inducers & Inhibitors on Dabigatran Exposure
The concomitant use of PRADAXA with P-gp inducers (e.g., rifampin) reduces exposure to dabigatran and should generally be avoided. P-gp inhibition and impaired renal function are major independent factors in increased exposure to dabigatran. Concomitant use of P-gp inhibitors in patients with renal impairment is expected to increase exposure of dabigatran compared to either factor alone.

For patients with moderate renal impairment (CrCl 30-50 mL/min), consider reducing the dose of PRADAXA to 75 mg twice daily when dronedarone or systemic ketoconazole is coadministered with PRADAXA.

For patients with severe renal impairment (CrCl 15-30 mL/min), avoid concomitant use of PRADAXA and P-gp inhibitors.

ADVERSE REACTIONS
In the pivotal trial comparing PRADAXA to warfarin, the most frequent adverse reactions leading to discontinuation of PRADAXA were bleeding and gastrointestinal (GI) events. PRADAXA 150 mg resulted in a higher rate of major GI bleeds and any GI bleeds compared to warfarin. In patients ≥75 years of age, the risk of major bleeding may be greater with PRADAXA than with warfarin. Patients on PRADAXA 150 mg had an increased incidence of GI adverse reactions. These were commonly dyspepsia (including abdominal pain upper, abdominal pain, abdominal discomfort, and epigastric discomfort) and gastritis-like symptoms (including GERD, esop
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Study Finds Utilizing Integrated Medical and Pharmacy Data Improves Ability to Forecast Use of High-cost Specialty Treatments
2. Study Showed Patients Treated With The miraDry© System Experienced 82 Percent Sweat Reduction On Average
3. Asubio Initiates Landmark Clinical Study in Spinal Cord Injury
4. New Veridex Alliance Drives Study Of Circulating Tumor Cells In Men With Metastatic Prostate Cancer
5. Shingles Vaccine is Safe, According to New Study
6. Structural Trends to Profoundly Change Life Sciences Industry, Genpact Study Shows
7. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
8. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
9. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
10. Accuray Launches First Study to Compare CyberKnife® SBRT to Surgery and IMRT for Treatment of Early-Stage Prostate Cancer
11. Interim results of VITOBA™ (VImpaT® added to One Baseline AED) Study Presented at the 64th Annual Meeting of the American Academy of Neurology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... According to the new ... Systems- Warming & Cooling), Application (Acute & Perioperative ... Nursing & Paramedical Staff) - Global Forecasts & ... the global Temperature Management Market over the forecast ... expected to reach $2.5 Billion by 2019 at ...
(Date:9/18/2014)... --This BCC Research report discusses the medical device technologies in ... size, and opportunities for different devices and regions. It includes ... in the report focuses on technological trends in recent years ... and Japan . ... medical device technologies market. - Analyze market structure, including segments ...
(Date:9/18/2014)... FRANCISCO , Sept. 18, 2014   Fruit ... has secured an initial seed round of funding. ... investments, was led by a series of individual investors, ... investors whom participated in the initial round are; ... Valley Medical Center Urologist Stacy Childs, Rapha Family Medicine ...
Breaking Medicine Technology:Temperature Management Market Worth $2.5 Billion by 2019 2Temperature Management Market Worth $2.5 Billion by 2019 3Temperature Management Market Worth $2.5 Billion by 2019 4Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 2Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 3
(Date:9/19/2014)... There are thousands of older women who long ... there are thousands of younger men who would love to ... now provides the world's best collection of resources for ... women, and the younger men who would like to date ... people to meet each other and establish those romantic connections, ...
(Date:9/18/2014)... When Mary Ann Thompson and Mathieu Nikel decided it was ... Indonesia with their son, Isaac, said there was only one choice ... College in 2001 when Thompson was an undergraduate student and needed ... at the time, was French and so she asked him. ... United States when she was 7 years old. Nikel is ...
(Date:9/18/2014)... Dr. David A. F. Ellis is ... Academy of Facial Plastic and Reconstructive Surgery and a ... of Facial Plastic Surgery. He is recognized around ... , Dr. Ellis will be presenting on numerous ... on injection techniques and various treatments for complications associated ...
(Date:9/18/2014)... (HealthDay News) -- Rising temperatures in the Atlantic Ocean ... shallow waters that are becoming warmer, an expansion that ... report. A study of 40 species along the ... by the invasive and poisonous lionfish, according to researchers ... the University of North Carolina-Wilmington, who published their findings ...
(Date:9/18/2014)... 2014 It’s been just a few short ... pending bunion splint to website visitors, but already the response ... was absolutely delighted. It is perfect and I find it ... them. THANK YOU FOR LISTENING!!!" Another user compared the ... hole used to slip to the end of my toe. ...
Breaking Medicine News(10 mins):Health News:Dating Site "SeekingCougar.com" Now Offering Tips for Younger Men Seeking Older Women 2Health News:For The First Time in Over a Decade Mercy College Alumni Marry at College 2Health News:Dr. David A. F. Ellis Has Been Invited to Speak at a Conference of the American Academy of Facial Plastic and Reconstructive Surgery in Orlando, Florida 2Health News:Rising Atlantic Ocean Temperatures Could Pose Threat to Reefs 2Health News:Feedback for the New Bunion Bootie Design Feedback is Already Pouring In, and Bunion Sufferers Love It 2Health News:Feedback for the New Bunion Bootie Design Feedback is Already Pouring In, and Bunion Sufferers Love It 3
... or at birth has dropped dramatically around the country in ... That certainly is true for Florida, where each year, fewer ... fact that more than 600 HIV-positive women each year, on ... even further reduce the number of babies born with the ...
... HealthDay Reporter , THURSDAY, July 22 (HealthDay News) -- ... psychiatric illness are learning that acting can be a powerful ... educate audiences through deeply personal accounts of mental health issues. ... additional opportunity to piece their lives back together," said David ...
... A large academic study has demonstrated structural changes in specific ... a condition that causes pain and discomfort in the abdomen, ... A collaborative effort between UCLA and Canada,s McGill University, the ... Gastroenterology . The findings show that IBS ...
... study from American Cancer Society researchers finds it,s not ... much time you spend sitting that can affect your ... independently associated with total mortality, regardless of physical activity ... both being physically active and reducing time spent sitting. ...
... been extremely important tools aiding doctors in making medical diagnoses ... psychiatry is one area of medicine where there are few ... someday generate blood tests that can be used for these ... are genetics, the study of variations in the genes (DNA) ...
... , BOSTONA new understanding of insulin resistance and the ... could pave the way for improved medications that are ... Institute and The Scripps Research Institute. "Our findings ... drugs can be separated by designing second-generation drugs that ...
Cached Medicine News:Health News:Mother-to-child HIV transmission rate falling, but more can be done 2Health News:Mother-to-child HIV transmission rate falling, but more can be done 3Health News:Taking to the Stage to Battle Mental Illness 2Health News:Taking to the Stage to Battle Mental Illness 3Health News:Taking to the Stage to Battle Mental Illness 4Health News:Study finds structural brain alterations in patients with irritable bowel syndrome 2Health News:Study finds structural brain alterations in patients with irritable bowel syndrome 3Health News:Study links more time spent sitting to higher risk of death 2Health News:A blood test for depression? 2Health News:Scientists find unsuspected molecular link between obesity and insulin resistance 2Health News:Scientists find unsuspected molecular link between obesity and insulin resistance 3
... The use of waterless alcohol hand ... Gel are replacing soap and water as ... patients per the 2002 CDC Draft Guidelines ... 33% of healthcare associated infections can be ...
... hand prep is designed to replace ... antimicrobial soaps. The scrubless, waterless way ... fast-acting and effective, providing proven, persistent ... hours without water or scrubbing., Avagard ...
Hand antisepsis plays a significant role in preventing nosocomial infections and the associated morbidity, mortality and costs. 3M offers healthcare providers effective hand antisepsis products that ...
... antimicrobial skin cleanser will not leave your ... frequent washings. With persistent Antimicrobial action, CHG ... microorganisms, including gram-negative and gram-positive bacteria, fungi, ... a 15 second hand wash. The solution ...
Medicine Products: