Navigation Links
New Study Results Published in the New England Journal of Medicine Show Dabigatran Etexilate Mesylate Reduces the Risk of Recurrent Venous Thromboembolism
Date:2/20/2013

of PRADAXA is contraindicated in patients with mechanical prosthetic valves.

Use of PRADAXA for the prophylaxis of thromboembolic events in patients with atrial fibrillation and other forms of valvular heart disease, including bioprosthetic heart valve, has not been studied and is not recommended.

Temporary Discontinuation of PRADAXA
Discontinuing PRADAXA for active bleeding, elective surgery, or invasive procedures places patients at an increased risk of stroke. Minimize lapses in therapy.

Effect of P-gp Inducers & Inhibitors on Dabigatran Exposure
The concomitant use of PRADAXA with P-gp inducers (e.g., rifampin) reduces exposure to dabigatran and should generally be avoided. P-gp inhibition and impaired renal function are major independent factors in increased exposure to dabigatran. Concomitant use of P-gp inhibitors in patients with renal impairment is expected to increase exposure of dabigatran compared to either factor alone.

For patients with moderate renal impairment (CrCl 30-50 mL/min), consider reducing the dose of PRADAXA to 75 mg twice daily when dronedarone or systemic ketoconazole is coadministered with PRADAXA.

For patients with severe renal impairment (CrCl 15-30 mL/min), avoid concomitant use of PRADAXA and P-gp inhibitors.

ADVERSE REACTIONS
In the pivotal trial comparing PRADAXA to warfarin, the most frequent adverse reactions leading to discontinuation of PRADAXA were bleeding and gastrointestinal (GI) events. PRADAXA 150 mg resulted in a higher rate of major GI bleeds and any GI bleeds compared to warfarin. In patients ≥75 years of age, the risk of major bleeding may be greater with PRADAXA than with warfarin. Patients on PRADAXA 150 mg had an increased incidence of GI adverse reactions. These were commonly dyspepsia (including abdominal pain upper, abdominal pain, abdominal discomfort, and epigastric discomfort) and gastritis-like symptoms (including GERD, esop
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Study Finds Utilizing Integrated Medical and Pharmacy Data Improves Ability to Forecast Use of High-cost Specialty Treatments
2. Study Showed Patients Treated With The miraDry© System Experienced 82 Percent Sweat Reduction On Average
3. Asubio Initiates Landmark Clinical Study in Spinal Cord Injury
4. New Veridex Alliance Drives Study Of Circulating Tumor Cells In Men With Metastatic Prostate Cancer
5. Shingles Vaccine is Safe, According to New Study
6. Structural Trends to Profoundly Change Life Sciences Industry, Genpact Study Shows
7. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
8. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
9. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
10. Accuray Launches First Study to Compare CyberKnife® SBRT to Surgery and IMRT for Treatment of Early-Stage Prostate Cancer
11. Interim results of VITOBA™ (VImpaT® added to One Baseline AED) Study Presented at the 64th Annual Meeting of the American Academy of Neurology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , July 2, 2015 Leading ... to capture critical product and market insights in ... benefits to employee-based studies, it is essential for ... own internal employees to capture critical business-related insights. ... benchmarking firm, Best Practices, LLC, most benchmarked companies ...
(Date:7/2/2015)... , July 2, 2015 /PRNewswire/ - ESSA Pharma Inc. ... common shares have been approved for listing and trading on ... ESSA will begin trading on NASDAQ on July 9, ... Venture Exchange under the symbol "EPI". As a ... NASDAQ, each of the Company,s outstanding special warrants issued on ...
(Date:7/2/2015)... July 2, 2015 ResMed Inc. (NYSE: RMD ... and fiscal year ended June 30, 2015 results on Thursday, ... close. A press release with ResMed,s results will be issued ... host a webcast to discuss operating results and future outlook. ... 1:30 p.m. US Pacific Time and the live webcast of ...
Breaking Medicine Technology:Leveraging Employee Insights to Produce Cutting-Edge Market Research 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4ResMed to Announce Fourth Quarter and Fiscal Year-End 2015 Results 2
... SARcode Bioscience, Inc., a privately-held biopharmaceutical company, ... enrolled in the company,s pivotal Phase 3 clinical ... (Logo: http://photos.prnewswire.com/prnh/20110718/FL36481LOGO) SAR 1118 ... by blocking the binding of two key cellular ...
... response to the growing needs of its clients, Avrio ... Hull 72FXS100-SS25C Freeze Drying System and a new M&O ... Alu-Crimp Capping Machine. The acquisition of these leading-edge technologies ... and Bosch FLT Automated Filling/Stoppering/Capping systems allow Avrio to ...
Cached Medicine Technology:First Patient Enrolled in SARcode Bioscience's Pivotal Dry Eye Study of SAR 1118 Ophthalmic Solution 2First Patient Enrolled in SARcode Bioscience's Pivotal Dry Eye Study of SAR 1118 Ophthalmic Solution 3Avrio Purchases a New Lyophilizer and Liquid Vial Filling Machine - New Capabilities and Added Capacity 2
(Date:7/2/2015)... ... 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of ... located in the Lone Star State. The premium frozen yogurt chain was listed as ... store, which opened July 1 at Duke’s Travel Plaza, is located at:, 30176 Hwy ...
(Date:7/2/2015)... ... ... Following the recent report by JAMA Internal Medicine published on June ... Becic emphatically declared a war on obesity in the United States. , "Obesity is ... understand the magnitude of this discovery. For that reason, I am declaring, along with ...
(Date:7/2/2015)... ... July 02, 2015 , ... ... (D-Md.) for her introduction of the Stop Overdose Stat (S.O.S.) Act of 2015 ... Jack Reed (D-R.I.), this Act seeks to decrease drug overdose – especially of ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... the parking structure retrofit project at the University of Minnesota, they knew it ... that it would also be an award-winning choice: the total energy savings after ...
(Date:7/2/2015)... ... July 02, 2015 , ... Many Fourth of July celebrations will include ... Amica Insurance is sharing some tips to promote the proper use of fireworks. ... to the emergency room daily with fireworks-related injuries in the month surrounding the Fourth ...
Breaking Medicine News(10 mins):Health News:sweetFrog Expands Texas Footprint with Location in Canton 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2Health News:6 Fireworks Safety Tips from Amica Insurance 2
... acidity of stomach contents backwashed into the esophagus allows ... throat discomfort// associated with the conventional wired monitor used ... while the new technology appears be better tolerated, no ... managing these patients, said David Mark, M.D., lead author ...
... of women in the Nurses' Health Study has shown that ... (POAG), the most common form of glaucoma//, accounting for about ... in the July issue of the journal Ophthalmology. ... Women's ,Hospital, Harvard School of Public Health and Harvard Medical ...
... A new report has revealed that U.S. emergency medical ... to handle disasters. The need of the hour is ... improve coordination before and after patients arrive. ... of Sciences' Institute of Medicine (IOM) have pointed out ...
... research has revealed that age-related macular degeneration (AMD) is twice ... also found // that those among the elderly who ate ... to have AMD than those who eat fish less than ... by Johanna Seddon, MD, and colleagues who work at the ...
... sleep would probably help the human brain to enhance memories ... ,It was reported that previous studies had established the benefits ... to tap numeric sequences on a keyboard. It was explained ... those used for recalling the facts for a test, where ...
... of General Psychiatry, says that obese people are not jolly ... on more than 9,000 adults found that obese persons were ... anxiety disorders including, depression. ,"Understanding the connection between ... both of these conditions are so common and have a ...
Cached Medicine News:Health News:New Reflux Disease Technology More Comfortable, Not More Effective 2Health News:New Reflux Disease Technology More Comfortable, Not More Effective 3Health News:Type 2 Diabetes Increases the Risk of Glaucoma in Women 2Health News:US Emergency Rooms ill prepared for Disasters 2Health News:Save your Vision with Fish Oil and Quitting Smoking 2Health News:Sleep Essential For A Strong Memory 2
... with elastic fabric, these head cap systems ... to begin testing. Each Electro-Cap System features ... International 10-20 System. When you place your ... using with your head cap system and ...
... head cap systems are packaged to provide ... Electro-Cap System features pure tin electrodes positioned ... you place your order, please specify which ... cap system and whether you want regular ...
... OR, ER, or ICU, be sure you take ... Keeping noise low and signal quality high, each ... special shielded cable that insulates the recording lead ... That means you get a cleaner, quieter signaleven ...
... The Bio-eye hydroxyapatite (HA) orbital implant ... in the early 1980s, after a comprehensive ... which included the earliest manuscripts dating back ... with an ongoing dissatisfaction with the performance ...
Medicine Products: