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New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women
Date:10/7/2010

ining 30 mg Natural S-equol for 12 weeks as part of a randomized, placebo-controlled study.  

The investigators found no serious adverse events, and no abnormal changes in serum concentrations of five hormones measured at the study start and weeks four, eight and 12 of the study:  estradiol, follicle stimulating hormone, thyroid-stimulating hormone, free triiodothyronine (T3), and free-thyroxine (T4).  Also, ultrasound measures of the thickness of the endometrial lining of the uterus and cellular studies of the tissue lining the vagina revealed no biological effect of the supplement on the women's reproductive organs. Furthermore, mammography examination results documented no differences among the women groups or between the study start and end.  

The study participants were 101 healthy postmenopausal women aged 45 to 65 years who experienced the onset of menopause within the past five years prior to enrollment.  None of them were S-equol producers and they were randomized to receive either 10 mg or 30 mg daily doses of Natural S-equol or a placebo.  

How SE5-OH is Made

All three studies presented at NAMS used supplement tablets that contained Natural S-equol.  The SE5-OH is the product of fermentation of whole soy germ by the bacterial strain Lactococcus 20-92 using a patented and proprietary process by the Otsuka Pharmaceutical Co., Ltd. The process results in the conversion of the daidzein to S-equol. SE5-OH is created under current Good Manufacturing Practices.  Following fermentation, the bacteria undergo heat denaturation and are deactivated.  The process is designed to produce a Natural S-equol rich product, or nutraceutical ingredient.  The ingredient has self-affirmed GRAS (Generally Recognized As Safe) status.

Development and ongoing research of SE5-OH containing Natural S-equol is conducted by the Saga Nutraceuticals Research Institute of Otsuka Pha
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