This study is the first to document evidence that daily doses of SE5-OH supplements containing 10 mg of Natural S-equol given for 12 months significantly inhibited bone break down, or resorption, in postmenopausal women. Moreover, treatment with the 10 mg Natural S-equol dose significantly prevented a decrease in whole body bone mineral density (BMD), compared to placebo.
"These findings raise the possibility that 10 mg daily of Natural S-equol supplementation may contribute to bone health without adverse effects in postmenopausal women who can not make S-equol themselves after eating soy. Further research is needed to determine the effects of S-equol on bone metabolism and safety," explains Jenks.
In this one-year, double-blind, placebo-controlled study, investigators randomized 93 Japanese women to receive a placebo or one of three daily doses of SE5-OH containing Natural S-equol: 2, 6 or 10 mg. Women studied were equol nonproducers, and averaged 53.8 plus or minus 3.7 years old and 2.7 plus or minus 1.2 years since menopause. After 12 months, women receiving the 10 mg dose of Natural S-equol had a significantly decreased, by 23.9 percent, the amount of urinary deoxypyridinoline (DPD) for 24 hours, a validated marker for bone resorption, compared to a reduction of just 2.9 percent in the placebo group (P=0.020).
In addition, the whole body BMD in the 10 mg group declined by 1.1 percent, significantly less than the 1.9 percent decrease of the placebo group (P=0.027) at 12 months. Serum sex and thyroid hormone concentrations did not differ among four groups at the study end.
Safety Data from 12-Week Study of Natural S-equol Use in Japanese Women
Investigators identified no safety problems, particularly in the female reproductive system, among 101 healthy Japanese postmenopausal women who took daily SE5-OH supplement doses conta
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