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New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women
Date:10/7/2010

receptors for the naturally occurring female sex hormone estrogen, with a strong affinity to the estrogen receptor beta.  On binding to these receptors, S-equol mimics some, but not all, activities of natural estrogen. Because of these actions at the receptor, it has been proposed that S-equol may alleviate some of the symptoms caused by diminished estrogen production during menopause.

Natural S-equol Supplement Reduces Menopausal Hot Flashes in U.S. Women

In the double-blinded study of 102 U.S. postmenopausal women, eight weeks of daily SE5-OH supplement doses containing 10, 20 or 40 milligrams (mg) of Natural S-equol reduced the frequency of moderate to severe hot flashes as did 50 mg doses of a soy isoflavone supplement.  Because isoflavones are known to have mild effects on the reduction of hot flashes in menopausal women, the investigators used an isoflavone supplement as a comparator in the study.

More women in the 10, 20 and 40 mg Natural S-equol groups achieved a 50 percent or more reduction in their hot flash frequency, a primary endpoint of the study, than in the isoflavone group:  respectively, 42.9 (P=0.056), 27.3, 25.0 and 16.0 percent.  To enroll in the study, all of the women had to experience more than 35 hot flashes per week.

The 20 mg Natural S-equol dose neared statistical superiority (P=0.076), the 10 mg dose was similar (P=0.503) and the 40 mg dose was significantly more effective than the soy isoflavones in reducing hot flash frequency (P=0.021), according to a Mixed-Effect Model Repeated Measure analysis incorporating the eight weekly reports of women's hot flash frequency, a secondary endpoint of the study.

Moreover, muscle and joint pain was reduced significantly in the 10 and 20 mg Natural S-equol groups compared to those in the isoflavone group (P<0.05).  Investigators used the validated Greene Climacteric Scale that measures 20 symptoms to produce three symptom measure
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