Navigation Links
New Insight Into the Controls on a Go-To Enzyme
Date:11/19/2008

wed up by calpain. Calpastatin's survival enables it to be repeatedly recycled to inhibit calpain, making it an even more effective regulator.

The researchers' structural information also showed how calpain changes its shape once it is activated by calcium and how this transformation renders it a target of calpastatin attachment and thus inhibition.

"This new structural information on calpastatin and on calpain's conformational changes not only explains a lot about calpain's regulation," Green said. "It also gives us information we can use to develop targets for drugs that could either activate or inhibit calpain."

Kalle Gehring of McGill University in Montreal is also an author of this paper.

This research was supported in part by the National Institutes of Health, the Canadian Institute of Health Research and ALSAC.

St. Jude Children's ResearchHospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit www.stjude.org.


'/>"/>
SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins
2. Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer
3. New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens
4. Apieron, Inc. Begins Customer Shipments of the Insight(TM) eNO System
5. Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS
6. Not Only Lipids and Inflammation: Insight Into a New Cause of Heart Attack and Other Vascular Disease
7. PDHI Launches ConXus Rewards, Announces Partnership With Hallmark Insights to Support Incentive-Driven Wellness Programs
8. Chemstar Corporation Announces a New Powerful, One-Step Product That Effectively Controls Listeria, Salmonella, E. coli and Fly Larvae in Floor Drains
9. RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors
10. Enobia Pharma Initiates Clinical Testing of Enzyme Replacement Therapy to Treat Hypophosphatasia
11. Genzyme and Isis Begin Second Phase 3 Trial Of Mipomersen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... , March 27, 2015 ... 2015" therapeutic market research report of 52 pages ... online business intelligence library. The report ... on the therapeutic development for Visceral Pain, complete ... by drug target, mechanism of action (MoA), route ...
(Date:3/26/2015)... HOUSTON , March 26, 2015  The ... of a study independently conducted by the Department ... Japan have been published. ... compared 5-fluorouracil hepatic arterial infusion as post-operative adjuvant ... colorectal metastasis of the liver. ...
(Date:3/26/2015)... March 26, 2015  OncoGenex Pharmaceuticals, Inc. (NASDAQ: ... clinical developments and announced fourth quarter and year ... Developments and Anticipated Near-term MilestonesCustirsen , ... to negotiate the termination of their collaboration and ... final termination agreement are ongoing. , Two ...
Breaking Medicine Technology:Visceral Pain Pipeline Review H1 2015 Market Research Report 2Visceral Pain Pipeline Review H1 2015 Market Research Report 3Visceral Pain Pipeline Review H1 2015 Market Research Report 4OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 2OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 3OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 4OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 5OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 6OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 7OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 8
...  Scientists at The Scripps Research Institute have shown that an ... of cocaine. The findings could lead to human clinical trials ... in case of emergency. Cocaine is involved in more than ... in the United States. The findings, reported recently ...
... FRANCISCO, April 18, 2012 Although adherence to hypertension ... total costs of care are higher for adherent patients ... a new study from pharmacy benefit manager Prime Therapeutics ... Academy of Managed Care Pharmacy (AMCP),s 24th Annual Meeting ...
Cached Medicine Technology:Scripps Research Institute Scientists Develop Antidote for Cocaine Overdose 2Scripps Research Institute Scientists Develop Antidote for Cocaine Overdose 3Scripps Research Institute Scientists Develop Antidote for Cocaine Overdose 4Hypertension Drug Adherence Associated with Fewer Hospitalizations and Lower Medical Costs but Increased Total Care Costs 2
(Date:3/27/2015)... Florida Hospital is excited to continue its ... health care provider for the 2015 and 2016 season. As ... care and an athletic trainer for the team throughout each ... season against the Cleveland Gladiators at Amalie Arena; the game ... important to us as it gives us the opportunity, to ...
(Date:3/27/2015)... 27, 2015 First Choice Emergency Room ... new facility is located 12665 W Lake Houston Pkwy, Houston, ... of Summerwood, I look forward to delivering the highest quality ... Facility Medical Director of First Choice Emergency Room Summerwood. ... made a donation to Summer Creek High School at First ...
(Date:3/27/2015)... NY (PRWEB) March 27, 2015 Top ... plastic surgery patients travel to the Dominican Republic to ... plastic surgery clinic is turning the medical tourism industry ... surgery patients — with trustworthy services becoming the central ... selecting a plastic surgeon. Patients are not only attracted ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 On ... EcoLuxe Lounge in the Stardust Penthouse on the ... Durkin, Los Angeles’ leading sustainable product TV and ... this unforgettable day-long event, which featured some of ... ecologically sound products and services. , “We were ...
(Date:3/27/2015)... 27, 2015 The report “CountryFocus ... an essential source of information on and analysis ... Germany. Germany’s increasingly elderly population and its associated ... market. In 2013, the elderly accounted for 27.1% ... Compound Annual Growth Rate (CAGR) of 1.2% to ...
Breaking Medicine News(10 mins):Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3Health News:Choices Recovery Releases 'Salute to the Oscars' EcoLuxe Lounge Compilation Video 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4
... 1,000 Reported Incidents, Caregivers Call for Comprehensive Process to Verify Signatures ... 31 Home care workers called for a hand-examination of each ... union, saying they had been subjected to lies, coercion, and fraud. ... the Service Employees International Union, United Healthcare Workers - West (SEIU-UHW), ...
... ... ... -- TDI, a leading provider of agent productivity solutions for contact centers, announced today that ... healthcare systems provider to the Greater New Orleans area. , , , , ,As an ...
... , , , ... HSP ), the world leader in generic injectable pharmaceuticals, today announced ... company,s applications for six new presentations of therapeutic heparin in single- ... to prevent clot formation in central venous catheters and for anticoagulant ...
... , , , CHADDS FORD, Pa., Aug. ... will present at the Thomas Weisel Partners Healthcare Conference 2009 on Thursday, Sept. ... Endo, will review the company,s products and development programs. , , ... website at www.endo.com under the investors section. ...
... , BERWYN, Pa., Aug. 31 Encorium ... clinical research organization (CRO) conducting studies in over 30 countries for ... that on August 25, 2009, it received a letter from The ... 10-Q for the period ended June 30, 2009, NASDAQ has determined ...
... , , , ... (the "Company") today announced that, at the Company,s 2009 Annual Meeting ... re-elect by an overwhelming majority all of the Company,s nominees to ... meeting were 63,725,589, representing approximately 56% of the 114,007,240 shares outstanding ...
Cached Medicine News:Health News:San Francisco Home Care Workers Describe Lies, Coercion, and Fraud in Union Signature Drive 2Health News:San Francisco Home Care Workers Describe Lies, Coercion, and Fraud in Union Signature Drive 3Health News:TDI Announces New Reseller Agreement With Executone 2Health News:Hospira Receives FDA Approval for Six New Presentations of Heparin 2Health News:Endo Pharmaceuticals to Present at Thomas Weisel Partners Healthcare Conference 2009 2Health News:Encorium Receives NASDAQ Deficiency Letter Regarding Stockholders' Equity 2Health News:Encorium Receives NASDAQ Deficiency Letter Regarding Stockholders' Equity 3Health News:Healthcare Trust of America, Inc. Announces Results of 2009 Annual Meeting of Stockholders 2Health News:Healthcare Trust of America, Inc. Announces Results of 2009 Annual Meeting of Stockholders 3
... provides a convenient reservoir of cooling water for the ... extended period of time or in a location which ... the hot side of the thermoelectric heat pump. ... is adequate to run the 900R for up to ...
Punch set for Advanced Tissue Arrayer, 2.0 mm...
Inquire...
Inquire...
Medicine Products: