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New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice
Date:7/13/2014

INDIANAPOLIS, July 13, 2014 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced results from its non-clinical study in genetically engineered mice examining combination therapy with the murine version of the beta-amyloid antibody N3pG and beta-secretase inhibitor BACE (LY2811376). Data results found that combination therapy was more effective in removing clumps of amyloid-beta protein in the brain – a component that is thought to lead to Alzheimer's disease (AD) – than use of one therapy. These data were presented today at the Alzheimer's Association International Conference 2014 (AAIC 2014) in Copenhagen, Denmark by Ron DeMattos, Ph.D., research fellow in the Neuroscience Division at Eli Lilly and Company. The data was also featured by the AAIC in a research media tips sheet.

"This non-clinical study demonstrates that by simultaneously targeting two different steps in the beta-amyloid disease process, researchers can slow the progression of Alzheimer's disease pathology in genetically engineered mice," said Dr. DeMattos. "These results may have a significant impact on the future of Alzheimer's disease therapies as they support the clinical rationale for using future testing of combination therapy against the a-beta protein in the clinical practice."

Alzheimer's disease, the most common form of dementia, causes progressive decline in memory and other aspects of cognition. A number of new investigational mechanisms for the treatment of Alzheimer's disease are currently in development. One type of investigational mechanism, called beta-secretase inhibitors, aims to block the body's ability to produce beta-amyloid protein, a possible component that leads to Alzheimer's disease. The other type of investigational drug is called a beta-amyloid antibody, which target
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