Navigation Links
Neurim Pharmaceuticals Announces Positive Phase 2 Clinical Trial Results of Piromelatine for the Treatment of Insomnia
Date:2/17/2013

ZURICH, February 18, 2013 /PRNewswire/ --

Neurim Pharmaceuticals announced today positive results from a phase II clinical study evaluating the efficacy and safety of Piromelatine (Neu-P11), a novel investigational multimodal sleep medicine developed for the treatment of patients with primary and co-morbid insomnia. The new results are from a  recent double-blind, randomized, placebo controlled, parallel group, non-confirmatory, sleep-laboratory study. The study evaluated piromelatine compared to placebo in 120 adult primary insomnia patients ages 18 years and older.

Piromelatine 20/50mg treatment for 4 weeks resulted in statistically significant and clinically meaningful improvements relative to placebo in key  polysomnographic (PSG) parameters including Wake After Sleep Onset (WASO) (p=0.02 for both doses) and in particular WASO for the first 6 hours of sleep (WASO-6h) (p=0.0008 and p=0.04 for the 50 mg and 20 mg groups, respectively). Piromelatine 50 mg also improved Sleep Efficiency (SEF) (p=0.02), Total Sleep Time (TST) (p=0.02), Total Time Awake (TTA) (p=0.01) and time in NREM sleep (p=0.028) indicating beneficial effects on sleep maintenance. Subjective improvements relative to placebo in quality of sleep and total sleep time measured by the Pittsburg Sleep Quality Questionnaire (PSQI) were also observed, confirming the PSG findings. Piromelatine enhanced NREM sleep EEG delta power and significantly reduced beta power (p<0.05). The decrease in EEG beta activity, a marker of cortical arousal, is a physiological surrogate marker of the efficacy of Piromelatine in sleep maintenance. Piromelatine was generally safe and well tolerated, had no detrimental effects on next-day psychomotor performance (as assessed by the Digit Symbol Substitution Test (DSST)) for any dose group and no deleterious effects on sleep structure and architecture.

"Piromelatine demonstrates a good potential for the treatm
'/>"/>

SOURCE Neurim Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
2. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
3. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
4. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
5. Icahn Issues Statement Regarding Amylin Pharmaceuticals
6. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
7. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
8. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
9. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
10. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
11. Avanir Pharmaceuticals To Present at Three Conferences In May
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... Jan. 14, 2014  Luminex Corporation (Nasdaq: LMNX ) ... fourth quarter of 2013 on Monday, February 3, 2014. A ... the close of trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ... discuss the operating highlights and financial results for the fourth ...
(Date:1/14/2014)... , Jan. 14, 2014 The Brandeis Medical Center, led by ... a premier and affordable laser tattoo removal experience with the ... focus is in providing high quality cosmetic services with cutting edge ... " Southern California has seen a dramatic ...
(Date:1/14/2014)... -- Acumed,s new SLIC Screw System - a jointed ... place and insert the screw accurately - offers surgeons ... repair or reconstruction as it holds the bones reduced ... http://photos.prnewswire.com/prnh/20140114/MN45636 ) The SLIC Screw is ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
(Date:4/24/2014)... for developing autism spectrum disorders (ASD), resides in genes ... to researchers from the Icahn School of Medicine at ... 2,500 families in the United States and throughout the ... Cellular Pathways Dysregulated in Autism Spectrum Disorders," was first ... Genetics on April 24. , ASD affects ...
(Date:4/24/2014)... 2014 Scientific research at UT Southwestern Medical Center ... itself completely, whereas the adult heart lacks this ability. ... why the heart loses its incredible regenerative capability in ... , Yes, oxygen. It is well-known that a ... blood throughout the body. But at the same time, ...
(Date:4/24/2014)... during and after colorectal surgery cut hospital stays by ... who led a study of the approach at Duke ... easier on patients before surgery, doing away with the ... After surgery, patients are encouraged to eat and move ... , Among findings published in the May 2014 issue ...
(Date:4/24/2014)... the corresponding terminology, and the relevance of palliation ... publications on randomized controlled trials (RCTs). This is ... Institute for Quality and Efficiency in Health Care ... report. , Together with external experts, IQWiG analysed ... lung cancer, malignant melanoma, and pancreatic cancer. For ...
(Date:4/24/2014)... Finnish team of researchers was the first in the ... is a tumour of the jaw. , Ameloblastoma is ... after treatment. Ameloblastoma is most often found in the ... surgery, often resulting in tissue deficiencies in the jaws ... drug therapy could reduce the need for surgery and ...
Breaking Medicine News(10 mins):Health News:Genetic alterations in shared biological pathways as major risk factor for ASD 2Health News:Oxygen diminishes the heart's ability to regenerate, researchers discover 2Health News:New approach for surgery patients cuts hospital stays and costs 2Health News:New approach for surgery patients cuts hospital stays and costs 3Health News:Palliation is rarely a topic in studies on advanced cancer 2Health News:Palliation is rarely a topic in studies on advanced cancer 3
... Diamond,Battle Against Newbies Erin Moran, Sommore, Brian Dunkleman, and A.J. Benza ... Hosted by Actor/Comedian ANT, ... on as,VH1 returns with a new twist on its popular series. "Celebrity ... leaner CFC,cast, with just those last 10-20 pounds to lose, battle together, ...
... at center of ability to control impulsive responses, study finds ... risk of developing a substance abuse disorder have deficits in ... researchers used functional MRI to study brain activity in 25 ... movement test. The scientists found a link between increased risk ...
... Mass., March 5 Effective February, 2008, Mr.,Paul Volcker has ... of,Directors. Mr. Volcker is well known for his service as ... addition to Mr. Volcker,s election, the Still River Systems Board,also ... a Portfolio Manager at,Seneca Capital, an investment firm in New ...
... just around the corner, but before families fire up ... burn yard debris, they should consider some common precautions ... , University of Florida researchers warn that the same ... of the leading causes of pediatric foot and ankle ...
... Phoenix Health Systems, a premier,provider of integrated professional ... healthcare organizations, announced today that it has,signed an ... to,provide information technology infrastructure outsourcing services., Under ... help desk,from its Leveraged Service Center in Dallas, ...
... from Canada and Japan have uncovered some remarkable results ... differently. , Across two studies, participants viewed images, ... four background models in each image. The researchers manipulated ... or background models and asked the participants to determine ...
Cached Medicine News:Health News:AT-TEN-TION!!! Fit Club Veterans Take on New Recruits in an All New Season of 'Celebrity Fit Club: Boot Camp' Premiering Thursday, March 13 at 9PM ET/PT 2Health News:Deficit in Brain Function Puts Teens at Risk of Drug Abuse 2Health News:UF researchers warn parents about dangers of childhood foot burns 2Health News:UF researchers warn parents about dangers of childhood foot burns 3Health News:Civista Health Inc. Selects Phoenix Health Systems for Information Technology Outsourcing Services 2Health News:When it comes to emotions, Eastern and Western cultures see things very differently: Study 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: