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Metabolic Solutions Development Company Awarded Funding by The Michael J. Fox Foundation
Date:2/7/2013

KALAMAZOO, Mich., Feb. 7, 2013 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) announced today that it has received an award from The Michael J. Fox Foundation for Parkinson's Research (MJFF) to conduct preclinical research on a first-in-class mTOT Modulator, MSDC-0160, as a potential treatment for levodopa induced dyskinesia (LID). The study will be undertaken in collaboration with Patrik Brundin , MD, PhD, of Van Andel Institute (VAI).

The aim of the study, titled "Potential of Novel Insulin Sensitizers to Treat Dyskinesia," is to determine if MSDC-0160 can prevent or reverse LID in a preclinical model of Parkinson's disease (PD). Should the results show that MSDC-0160 can significantly modify LID in vivo, MSDC plans to begin a clinical trial to examine the effects of MSDC-0160 in PD patients with LID. Such a clinical trial could begin in 2014.

MSDC-0160
MSDC-0160 is a novel once-a-day oral insulin sensitizer and the first in a new class of therapeutic agents called mTOT Modulators. mTOT™ is newly identified protein complex in the inner mitochondrial membrane that appears to function as a molecular "sensor switch" that coordinates carbohydrate, lipid, and amino acid metabolism. MSDC-0160 selectively modulates proteins in the mTOT complex, effecting pyruvate utilization and resulting in improved insulin action, lipid oxidation, preservation of beta cell function, and generation of brown fat, an important organ in the control of body composition. In a recently completed Phase 2b clinical trial in 258 patients with type 2 diabetes, MSDC-0160 was shown to lower hemoglobin A1c significantly without the side effect profile of Actos®. The compound is also currently being studied in a pilot Phase 2a trial in patients with dementia due to Alzheimer's disease (NCT01374438).

About Parkinson's Disease
Over one million people in the US and an estimated
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SOURCE Metabolic Solutions Development Company, LLC
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