Navigation Links
Metabolic Solutions Development Company Awarded Funding by The Michael J. Fox Foundation
Date:2/7/2013

KALAMAZOO, Mich., Feb. 7, 2013 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) announced today that it has received an award from The Michael J. Fox Foundation for Parkinson's Research (MJFF) to conduct preclinical research on a first-in-class mTOT Modulator, MSDC-0160, as a potential treatment for levodopa induced dyskinesia (LID). The study will be undertaken in collaboration with Patrik Brundin , MD, PhD, of Van Andel Institute (VAI).

The aim of the study, titled "Potential of Novel Insulin Sensitizers to Treat Dyskinesia," is to determine if MSDC-0160 can prevent or reverse LID in a preclinical model of Parkinson's disease (PD). Should the results show that MSDC-0160 can significantly modify LID in vivo, MSDC plans to begin a clinical trial to examine the effects of MSDC-0160 in PD patients with LID. Such a clinical trial could begin in 2014.

MSDC-0160
MSDC-0160 is a novel once-a-day oral insulin sensitizer and the first in a new class of therapeutic agents called mTOT Modulators. mTOT™ is newly identified protein complex in the inner mitochondrial membrane that appears to function as a molecular "sensor switch" that coordinates carbohydrate, lipid, and amino acid metabolism. MSDC-0160 selectively modulates proteins in the mTOT complex, effecting pyruvate utilization and resulting in improved insulin action, lipid oxidation, preservation of beta cell function, and generation of brown fat, an important organ in the control of body composition. In a recently completed Phase 2b clinical trial in 258 patients with type 2 diabetes, MSDC-0160 was shown to lower hemoglobin A1c significantly without the side effect profile of Actos®. The compound is also currently being studied in a pilot Phase 2a trial in patients with dementia due to Alzheimer's disease (NCT01374438).

About Parkinson's Disease
Over one million people in the US and an estimated
'/>"/>

SOURCE Metabolic Solutions Development Company, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Metabolic Solutions Development Company announces publication of Phase 2b data in Clinical Pharmacology & Therapeutics
2. Isis Pharmaceuticals Reports Positive Phase 1 Data On Three Drugs In Development To Treat Metabolic Disorders
3. Polaris Group Lead Therapeutic Candidate ADI-PEG 20 Demonstrates Potential Anticancer Activity in Various Metastatic Sarcomas and Bladder Cancers That Are Deficient in Key Metabolic Protein, and Enhanced Effects with Combination Therapy in Melanoma
4. Profil Institute Partners with Florida Hospital to Establish East Coast Center for Clinical Metabolic Research
5. New Wellness Products with Results that Identify Healthiness, Deficiencies and Solutions
6. H. D. Smith Specialty Solutions Appoints 20-year Industry Veteran Tim Booth To Executive Vice President, Smith Medical Partners
7. BioLife Solutions Appoints Rick Stewart To Board of Directors
8. New Findings Offer Systemic Solutions to Address Non-communicable Diseases (NCDs) in Low- and Middle-income Countries
9. Omnicell to Showcase Automation Solutions at Arab Health 2013
10. Elekta to Showcase Broad Portfolio of Cancer Management Solutions at 2013 Arab Health Congress and Exhibition
11. H. D. Smith Establishes Specialty Solutions Organization And Realigns Senior Leadership To Support Growing Geographic Reach, Diversified Businesses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology company ... announced today that Daniel P. Gold , Ph.D., President ... Fitzgerald Healthcare Conference on Wednesday, July 8, 2015 at 8:30 ... New York . A live webcast of ... replay will be available approximately one hour after the presentation. ...
(Date:7/1/2015)... Lupin , Strides , ... Sub-licensees to Fourteen Companies     ... of its network of generic manufacturers to 14 companies now ... (ARVs). New companies Lupin and Strides Arcolab recently signed agreements ... MPP licensed from ViiV Healthcare two months after its approval ...
(Date:7/1/2015)... , July 1, 2015  AVACEN, Inc. announced today the ... patent covering the medical technology platform supporting its unique Dry ... Logo - http://photos.prnewswire.com/prnh/20150630/227364LOGO ... methods patent no. 9,066,781 - Methods And Apparatus For Therapeutic ... AVACEN and specific methods of use, referred to by the ...
Breaking Medicine Technology:MEI Pharma to Present at Cantor Fitzgerald Healthcare Conference 2The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 2The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 3AVACEN Medical Patent Issued 2
... Accuray Incorporated (Nasdaq: ARAY ), a global leader ... report results for its third quarter of fiscal 2011, ended ... market closes. A conference call to review the ... will be hosted by Euan S. Thomson, Ph.D., president and ...
... YORK, April 14, 2011 Reportlinker.com announces that a ... North America Dental Devices Market ... North America Dental Devices Market Outlook ... GlobalData,s new report, "North America Dental Devices Market Outlook ...
Cached Medicine Technology:Accuray Incorporated to Report Financial Results for Third Quarter of Fiscal 2011 2Reportlinker Adds North America Dental Devices Market Outlook to 2017 2Reportlinker Adds North America Dental Devices Market Outlook to 2017 3Reportlinker Adds North America Dental Devices Market Outlook to 2017 4Reportlinker Adds North America Dental Devices Market Outlook to 2017 5Reportlinker Adds North America Dental Devices Market Outlook to 2017 6Reportlinker Adds North America Dental Devices Market Outlook to 2017 7Reportlinker Adds North America Dental Devices Market Outlook to 2017 8Reportlinker Adds North America Dental Devices Market Outlook to 2017 9Reportlinker Adds North America Dental Devices Market Outlook to 2017 10Reportlinker Adds North America Dental Devices Market Outlook to 2017 11Reportlinker Adds North America Dental Devices Market Outlook to 2017 12Reportlinker Adds North America Dental Devices Market Outlook to 2017 13
(Date:7/2/2015)... ... 02, 2015 , ... Denver-based SlimGenics Weight Control Centers, the ... No. 14 on ColoradoBiz magazine’s Top 100 Woman-Owned Companies list. ColoradoBiz compiles the ... The award identifies outstanding woman-owned businesses that demonstrate excellence and success in the ...
(Date:7/1/2015)... Angeles, CA (PRWEB) , ... July 01, 2015 , ... ... the great outdoors. Yet, in many Middle-Eastern countries like Saudi Arabia and Dubai, the ... to relax in more temperate climates. Celebrity dentist Dr. Sam Saleh of ORA Dentistry ...
(Date:7/1/2015)... ... ... Sir Fazle Hasan Abed, BRAC’s founder and chairperson, was announced as the ... for his outstanding contribution to enhancing the world's production and distribution of food to ... Prize Foundation, announced this year’s winner at a ceremony at the State Department in ...
(Date:7/1/2015)... Seattle, WA (PRWEB) , ... July 01, 2015 ... ... culture war in this land of liberty. Americans have been arguing over laws ... was a particularly contentious period, as a forthcoming historical comparative biography by Cindy ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... today announced that its fifth annual Smile for a Lifetime Foundation (S4L) fundraising ... non-profit organization. In addition to supporting S4L in its mission to provide free ...
Breaking Medicine News(10 mins):Health News:ColoradoBiz Magazine Names SlimGenics #14 on Top 100 Woman-Owned Companies List 2Health News:ColoradoBiz Magazine Names SlimGenics #14 on Top 100 Woman-Owned Companies List 3Health News:Dr. Sam Saleh Invites Vacationing International Patients to Get a Same-Day Hollywood Smile During the July Travel Season 2Health News:Sir Fazle Hasan Abed Receives World Food Prize 2Health News:Sir Fazle Hasan Abed Receives World Food Prize 3Health News:Biography by Cindy Safronoff to be Released July 4 Explores an 1870s Marriage Debate Over Women’s Rights and the Implications of the American Revolution for Sexuality 2Health News:Biography by Cindy Safronoff to be Released July 4 Explores an 1870s Marriage Debate Over Women’s Rights and the Implications of the American Revolution for Sexuality 3Health News:Biography by Cindy Safronoff to be Released July 4 Explores an 1870s Marriage Debate Over Women’s Rights and the Implications of the American Revolution for Sexuality 4Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 2Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 3
... ... every 6 men in the United States (1 in 3 in the African American community), ... by registering for Little Red Door,s Unite 2 Fight Race Against Prostate Cancer. , ... Indianapolis, IN (PRWEB) April 13, 2010 ...
... ... Multiple Sclerosis through Community , ... (PRWEB) April 13, 2010 -- Motivational Speaker/MS Advocate and Author Erin Morrow ... with Multiple Sclerosis. , , ,Published by iUniverse with a forward by Harold ...
... social fear and appear open, friendly to all, researchers ... Children with a rare condition called Williams syndrome appear ... a new study shows. , The finding suggests that ... stereotyping. , French and German researchers examined the behaviors ...
... Alzheimer,s patients with dignity and respect, researchers say ... memory loss can still "remember" feelings associated with happy ... University of Iowa researchers showed clips of happy and ... patients couldn,t remember what they had watched, but they ...
... Americans (96 percent of Republicans, 10 percent of Democrats ... care reform legislation that was signed into law by ... national survey conducted April 6 - 10 by researchers ... Research (CHPPR). Americans 18 to 34 years ...
... TCT 2010 (Transcatheter Cardiovascular Therapeutics) will provide ... in interventional cardiology that will directly affect patient ... interventional cardiology has figured prominently in recent current ... received a heart stent in February at New ...
Cached Medicine News:Health News:Registration Now Open for Little Red Door's Unite 2 Fight Race Against Prostate Cancer Saturday, July 10, 2010 2Health News:Author Erin Morrow Still Releases "Fighting MS: Strength in Numbers" 2Health News:Author Erin Morrow Still Releases "Fighting MS: Strength in Numbers" 3Health News:Kids With Rare Condition Lack Racial Prejudice 2Health News:Even As Memory Fades, Emotions Linger 2Health News:Health care reform 'important' even to those who want new law repealed 2Health News:TCT 2010 to have significant impact on interventional cardiology practices and patient care 2
The WatchMate LC model is a cost-effective solution for monitoring a single exit, and provides local notification of an alarm....
The WatchMate MR model displays multiple alarms locally without individual identification, but ID numbers and names can be displayed at a central station. Alarms may be cleared locally under password...
... RoamAlert Integrity system builds on the ... door controllers in the system are ... a standard Windows® operating system, which ... of a personal computer, RoamAlert Integrity ...
... Radianse indoor positioning solution ... of where and when ... flow through care processes. ... provides intelligence that hospitals ...
Medicine Products: