Navigation Links
Metabolic Solutions Development Company Awarded Funding by The Michael J. Fox Foundation
Date:2/7/2013

KALAMAZOO, Mich., Feb. 7, 2013 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) announced today that it has received an award from The Michael J. Fox Foundation for Parkinson's Research (MJFF) to conduct preclinical research on a first-in-class mTOT Modulator, MSDC-0160, as a potential treatment for levodopa induced dyskinesia (LID). The study will be undertaken in collaboration with Patrik Brundin , MD, PhD, of Van Andel Institute (VAI).

The aim of the study, titled "Potential of Novel Insulin Sensitizers to Treat Dyskinesia," is to determine if MSDC-0160 can prevent or reverse LID in a preclinical model of Parkinson's disease (PD). Should the results show that MSDC-0160 can significantly modify LID in vivo, MSDC plans to begin a clinical trial to examine the effects of MSDC-0160 in PD patients with LID. Such a clinical trial could begin in 2014.

MSDC-0160
MSDC-0160 is a novel once-a-day oral insulin sensitizer and the first in a new class of therapeutic agents called mTOT Modulators. mTOT™ is newly identified protein complex in the inner mitochondrial membrane that appears to function as a molecular "sensor switch" that coordinates carbohydrate, lipid, and amino acid metabolism. MSDC-0160 selectively modulates proteins in the mTOT complex, effecting pyruvate utilization and resulting in improved insulin action, lipid oxidation, preservation of beta cell function, and generation of brown fat, an important organ in the control of body composition. In a recently completed Phase 2b clinical trial in 258 patients with type 2 diabetes, MSDC-0160 was shown to lower hemoglobin A1c significantly without the side effect profile of Actos®. The compound is also currently being studied in a pilot Phase 2a trial in patients with dementia due to Alzheimer's disease (NCT01374438).

About Parkinson's Disease
Over one million people in the US and an estimated
'/>"/>

SOURCE Metabolic Solutions Development Company, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Metabolic Solutions Development Company announces publication of Phase 2b data in Clinical Pharmacology & Therapeutics
2. Isis Pharmaceuticals Reports Positive Phase 1 Data On Three Drugs In Development To Treat Metabolic Disorders
3. Polaris Group Lead Therapeutic Candidate ADI-PEG 20 Demonstrates Potential Anticancer Activity in Various Metastatic Sarcomas and Bladder Cancers That Are Deficient in Key Metabolic Protein, and Enhanced Effects with Combination Therapy in Melanoma
4. Profil Institute Partners with Florida Hospital to Establish East Coast Center for Clinical Metabolic Research
5. New Wellness Products with Results that Identify Healthiness, Deficiencies and Solutions
6. H. D. Smith Specialty Solutions Appoints 20-year Industry Veteran Tim Booth To Executive Vice President, Smith Medical Partners
7. BioLife Solutions Appoints Rick Stewart To Board of Directors
8. New Findings Offer Systemic Solutions to Address Non-communicable Diseases (NCDs) in Low- and Middle-income Countries
9. Omnicell to Showcase Automation Solutions at Arab Health 2013
10. Elekta to Showcase Broad Portfolio of Cancer Management Solutions at 2013 Arab Health Congress and Exhibition
11. H. D. Smith Establishes Specialty Solutions Organization And Realigns Senior Leadership To Support Growing Geographic Reach, Diversified Businesses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 The Competitive Intelligence (CI) function is ... CI leaders who adjust will succeed, and those who ... Best Practices, LLC study CI leaders from 32 biopharmaceutical ... - Use secondary research whenever possible - it,s ... - Internal staff who are creative thinkers provide the ...
(Date:8/29/2014)... , Aug. 29, 2014  A Boston Scientific ... study on stent removability and preliminary long term ... published in the August issue of the peer-reviewed ... 1 is being conducted in 11 countries ... covered self-expanding metal stents (FCSEMS) after extended indwell ...
(Date:8/29/2014)... -- Thoratec Corporation (NASDAQ: THOR ), a ... save, support and restore failing hearts, said today it ... Healthcare Conference on Wednesday, September 10. ... will provide an update on the company, beginning at ... Time).   A webcast of the presentation ...
Breaking Medicine Technology:Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
... June 18 Naviscan,s Positron Emission Mammography (PEM) technology was the ... Annual Meeting in Salt Lake City .  The focus represents a ... in the fight against breast cancer.   , ... PEM scanners are high-resolution breast PET systems that can ...
... Allied Healthcare Products, Inc. (Nasdaq: AHPI ) today announced introduction ... patient safety over conventional absorbents in anesthesia procedures. , ... "Litholyme features a patented formulation ... absorbents, yet it has been developed in such a manner that ...
Cached Medicine Technology:Naviscan Positron Emission Mammography Technology Highlighted at the Society of Nuclear Medicine Annual Meeting 2Allied Healthcare Announces Litholyme(TM) -- New CO2 Absorbent Used in Anesthesia 2
(Date:8/31/2014)... (PRWEB) August 31, 2014 Just in time ... serving up only wild, sustainable Alaska Salmon, award winning ... at the Duke's Green Lake location , Sunday, September ... expect to sample several ethnic salmon BBQ culinary delights. Live ... Salmon recipes from Hawaii, Puerto Rico and Mexico will be ...
(Date:8/31/2014)... For many, fall turns daily life into an ... the most common cause of fall hay fever and affects ... symptoms of ragweed allergy include a stuffed up or runny ... also lead to wheezing, asthma attacks, and sinusitis. , Those ... allergy immunotherapy - the only treatment shown to change the ...
(Date:8/31/2014)... years of hard work, Delta has now become one of ... company has updated its wheel loader assortment with ... items are guaranteed to be great. Additionally, they are offered ... true that all items in Delta’s used cat 966 ... firm is making full efforts to help worldwide customers to ...
(Date:8/31/2014)... In the wake of growing consumer ... legislation to require mandatory labeling of GMOs on food ... decisions that affect their own health and the health ... stringent measures to eliminate GMOs from dietary supplements, NutriGold ... (I.C.E.) initiative with the objective of advancing the ...
(Date:8/31/2014)... a reliable review website, has recently compared many professional ... Hostgator are the best ASP.NET hosting suppliers of August ... the world, but good suppliers are not too many. ... server than running a Linux server, because it needs ... Arvixe and Hostgator are the most outstanding suppliers when ...
Breaking Medicine News(10 mins):Health News:Seattle Seafood Restaurant Duke's Chowder House on Green Lake Will Celebrate The Long Anticipated Indian Summer With First Annual Sizzling BBQ Salmon Tasting Event. 2Health News:AllergyEasy Announces Success Helping Patients Build Immunity To Autumn Ragweed Pollens With Under-the-tongue Drops 2Health News:AllergyEasy Announces Success Helping Patients Build Immunity To Autumn Ragweed Pollens With Under-the-tongue Drops 3Health News:Delta Updates Its Wheel Loader Assortment With A Lot Of Cheap Used Cat 966 Loaders 2Health News:NutriGold Announces its I.C.E. Initiative to Educate Consumers about GMOs in Dietary Supplements 2Health News:NutriGold Announces its I.C.E. Initiative to Educate Consumers about GMOs in Dietary Supplements 3Health News:Best ASP.NET Hosting Award for August 2014 Released By Top10BestSEOHosting.com 2
... Pricing Authority (NPPA) has been working// on bringing down ... with the manufacturers and has finally succeeded. According to ... to bring about a price reduction ranging between 2.14% ... personal hearing to explain the reasons for steep price ...
... heart failure increases// the survival rate by 22% compared ... Little and his research team from Wake Forest University, ... treated with statins has better survival rates. The study ... in the Journal Circulation: Journal of the American Heart ...
... recent article reviewing the research carried out so far into ... has revealed that a new phase III trial is scheduled ... for CoQ10 has escalated, causing soaring prices and reports of ... thought to have been triggered by the publication of Shults’ ...
... to treat childhood asthma in Western// countries, however it is ... children with asthma. ,A study has found no ... evidence for using Methylxanthines for children's cough that was not ... the study Dr.Anne Chang, from Royal Children's Hospital in ...
... running events may be a danger from exercise-associated //hyponatremia ... in the body. The risk to the condition is ... during exercises. ,Awareness of EAH is increasing, but ... the causes, recognition, prevention, and treatment of this potentially ...
... has become one of the most common diseases.// Almost half ... 50. Incidence of hemorrhoids is more in men compared to ... 65. ,Surgical removal and Rubber band ligation (RBL) ... removal of severe hemorrhoids is more effective in the long ...
Cached Medicine News:Health News:Statins Gives New Hope for Increased Survival Rate of Heart Failure Patients 2Health News:New Study to look at the Beneficial Effects of Coenzyme Q10 on Parkinson’s disease 2Health News:Study Warns About The Use Of Popular Asthma Drug To Stop Children's Coughs 2Health News:Athletes Warned Of Exercise-Associated Hyponatremia 2Health News:Surgery Offers Better Treatment For Third Degree Piles 2
... For the qualitative ... falciparum (P.f) antigen and an ... all four species of malaria:plasmodium ... Plasmodium ovale (P.o) and Plasmodium ...
For the qualitative detection of antibodies to Treponema pallidum in human serum, plasma and whole blood specimens...
For the qualitative detection of antibodies to HIV-1 and HIV-2 in human serum, plasma and whole blood specimens...
For the qualitative detection of antibodies to HIV-1 and HIV-2 in human serum, plasma and whole blood specimens...
Medicine Products: