Navigation Links
LX4211 for Diabetes Shown to Reduce Fasting and Post-Prandial Blood Sugar in Healthy Subjects
Date:9/13/2011

trointestinal-derived peptide hormone that has also been associated with reducing food intake and has been studied as an anti-obesity agent. These two gastrointestinal peptides (GLP-1 and PYY) are secreted into circulation by neuroendocrine cells (L cells) as part of a natural homeostatic mechanism that senses nutrient transit through the gastrointestinal tract. Such nutrient sensing and related mechanisms are thought to be enhanced as a result of certain types of bariatric surgery for weight loss and control of diabetes.

LX4211 treatment also produced a 50.2 mg/dL adjusted mean decrease from baseline in triglycerides, consistent with the triglyceride reduction observed in the Phase 2a study in type 2 diabetics.  In addition, LX4211, compared to placebo, produced a significant adjusted mean decrease in serum uric acid (1.52 mg/dL from baseline to last study visit, p=0.005). Serum uric acid is an emerging marker for cardiovascular risk and renal disease.  These data, together with a trend of improved blood pressure observed in the Phase 2a study, demonstrate that LX4211 has effects on multiple cardiovascular and metabolic risk factors.  Also of importance in this study was the safety of LX4211, which showed no hypoglycemia and no abdominal pain or diarrhea, consistent with the favorable safety profile associated with dual inhibition of SGLT1 and SGLT2 by LX4211 in previous clinical trials. Enrollment in Lexicon's ongoing Phase 2b study of LX4211 in patients with type 2 diabetes is on schedule, with results anticipated in the first half of 2012.

"We have now observed results from several clinical studies of LX4211 which consistently support the concept of dual SGLT1/SGLT2 inhibition for the treatment of diabetes and indicate a long-term opportunity in diabetes prevention," said Pablo Lapuerta, M.D., senior vice president of clinical development and chief medical officer. "The favorab
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lexicon Completes Phase 1 Clinical Trial and Initiates Phase 2 Clinical Trial of LX4211 in Patients With Type 2 Diabetes
2. Phase 2 Trial of LX4211 Demonstrates Significant and Rapid Improvements in Multiple Parameters in Type 2 Diabetic Patients
3. Lexicon Presents Data Describing LX4211 Positive Phase 2 Clinical Results and Novel Mechanism of Action for Type 2 Diabetes
4. Lexicon Announces Positive Results from New Clinical Study of LX4211 in Type 2 Diabetes Patients
5. Lexicon Presents LX4211 Mechanism of Action Data at American Diabetes Association Meeting and Announces Commencement of Phase 2b Clinical Trial in Type 2 Diabetes
6. Lexicon Presents LX4211 Clinical Data at European Association for the Study of Diabetes Annual Meeting
7. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
8. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
9. The Heart, Diabetes, And Weight Loss Centers of New York Introduce the New Science of Metabolic Diagnosis and Weight Management
10. Isis Initiates Phase 1 Study of ISIS 325568 Targeting Glucagon Receptor to Treat Type 2 Diabetes
11. Diabetes Research Institute Invention Promotes Growth of Stem Cells into Insulin-Producing Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... July 31, 2014 TB Alliance, a ... better, faster and affordable treatments, announced the appointment ... President, External Affairs. Mr. Brock comes to TB ... Major Donor Relations for WWF International (formerly known ... Mr. Brock will guide the TB Alliance,s resource ...
(Date:7/31/2014)... SPRINGFIELD, Ill. , July 31, 2014 /PRNewswire/ ... (LRS) announced a new extension to its PageCenterX ... software is designed to provide downtime ... unplanned system outages. LRS is releasing the product ... the healthcare environment, EMR applications experience outages for ...
(Date:7/31/2014)... KISSING, Deutschland, 31. Juli 2014  invendo ... computerunterstützten („robotischen") Koloskopie-Systems für den Einmalgebrauch, verkündete ... ein weltweit anerkannter Manager im Bereich Medizintechnik, ... Unternehmen stößt. Logo - ... ein hochangesehener globaler Visionär der Medizintechnikbranche. Er ...
Breaking Medicine Technology:TB Alliance Appoints Willo Brock Senior Vice President, External Affairs 2LRS Announces Downtime Reporting Solution for Healthcare 2invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 2invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 3
... AutoGenomics, a leader in,developing automated molecular testing ... it submitted to the FDA for 510(k) clearance,late ... Harvard Medical,School-Partners HealthCare Center for Genetics and Genomics ... drug prescribed to help prevent,blood clots. With more ...
... to Yield a Strong and ... Highly Specific Immune Response, NEW ... a biopharmaceutical company focused on,development of disease-modifying therapeutic agents for ... today,that Dr. Rachel Eren, Vice President Research, will present new ...
Cached Medicine Technology:Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity 2Intellect Neurosciences, Inc. to Present Data on Alzheimer's Vaccine at 13th International Congress of Immunology Conference 2Intellect Neurosciences, Inc. to Present Data on Alzheimer's Vaccine at 13th International Congress of Immunology Conference 3
(Date:7/31/2014)... Reserve University medical and nursing school researchers hope ... patients who participate in clinical trials, a critical ... preventions. , For various reasonsincluding a lack of ... of cancer patients take part in trials of ... cancer patients who are eligible still don,t enroll, ...
(Date:7/31/2014)... Thousands of independent community pharmacists, ... have come together today to kick off ThoughtSpot ... , "ThoughtSpot 2014 is Good Neighbor Pharmacy’s annual ... to help their businesses thrive," stated AJ Caffentzis, ... long-standing commitment to independent community pharmacies, and at ...
(Date:7/31/2014)... India (PRWEB) July 31, 2014 Web ... an ISO 9001:2008 certified internet marketing firm, has recently ... order to make this service affordable for everyone, the ... of the service. , Web Programming Services has ... the world of brochure designing and likely expectations of ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Recently, Agebc.com, a ... dresses, has revealed its new selection of trendy mother ... them are offered at promotional prices now, up to 68% ... line by adding the new range of mother of the ... to the international clients. So far, our online shop has ...
(Date:7/31/2014)... Calif., July 31, 2014 -- A new study by ... that a peptide called caerulein can convert existing cells ... 1 diabetes-insulin-producing beta cells. The study, published online July ... a new approach to treating the estimated 3 million ... living with type 1 diabetes. , "We have found ...
Breaking Medicine News(10 mins):Health News:$1.6 million NCI grant to CWRU trains nurses to increase participation in clinical trials 2Health News:$1.6 million NCI grant to CWRU trains nurses to increase participation in clinical trials 3Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 2Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 3Health News:Web Programming Services Introduces Affordable Brochure Designing Service 2Health News:Mother of the Bride Dresses Now Available With Great Discounts at Agebc.com 2Health News:A new way to generate insulin-producing cells in Type 1 diabetes 2
... with four additional law suits, after the Liver Transplant Program ... ,Orange county Superior court has been a witness ... died just waiting for the transplants; the fourth, a patient ... program transparent to gross mismanagement has to also battle the ...
... are on tenterhooks, preventing the spread of the deadly virus H5N1, ... Eastern past of France. // The farm in Versailleux,on Thursday, that ... the lake where wild ducks were among the first to get ... ,This is perhaps the first time that a European Union farm ...
... prison in Guantanamo Bay to force feed the prisoners ... // through their noses has raised controversies among medical ... the fundamental principles of medical ethics. ,In ... targeted at extension of co-operation by the detainees. A ...
... mosquito-borne disease for which there is no known cure or ... of La Reunion Island // on Indian Ocean. As Nearly ... Xavier Bertrand, French Health Minister. ,More than 130, ... mortalities could be related directly or indirectly to the epidemic ...
... and unwholesomeness of visually appetizing foods, sugar coated cereals ... food strategies,// and yo-yo to consumer palettes, dictated by ... to keep heart disease and cancer at bay. ... a nutrition expert at the University of Maryland, ...
... offered insights into why Africans have an increased susceptibility ... compared to whites. // Worldwide, approximately more than ... 2 million people die due to the same every ... to official sources, the incidence of TB is eight ...
Cached Medicine News:Health News:Medical Ethics Violated By Prison Officials In Guantanamo Bay 2Health News:Wholly Ingrained: White or Brown? Food War Going Racist? Get to the Heart of the Matter 2Health News:Vitamin D May Help In Fight Against Tuberculosis 2
The first book to translate key medical data into clear guidelines capturing the highest treatment standards for heart disease....
... Reviews enable all those involved with healthcare ... the very latest evidence in their field ... harder each year as the volume of ... by delivering the best single source available ...
... topics included: Ergogenic aids, anabolic steroids, ... swimming, skiing, tennis, common sports problems, ... cardiology for athletes, exercise, exercise (treadmill) ... injuries, heat-related illness, acclimatization, neuropraxia, overtraining ...
Pocket Sports Medicine is the result of a collaboration between outstanding Editors and Contributors. The program covers the field so that both specialists and general orthopedists will find expert g...
Medicine Products: