Navigation Links
Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain
Date:10/6/2008

- Data Presented at ACG Annual Scientific Conference -

ORLANDO, Fla., Oct. 6 /PRNewswire/ -- Ironwood Pharmaceuticals (formerly Microbia) today announced presentation of data from a pair of preclinical studies delineating the role that cyclic guanosine monophosphate (cGMP) plays in alleviating intestinal pain. These studies demonstrate that cGMP inhibits intestinal pain in a preclinical model of intestinal hyperalgesia and desensitizes colonic afferent nerves in a similar model of experimental colitis. These results are from separate, ongoing collaborations with Dr. Michael Pezzone of the University of Pittsburgh's Division of Gastroenterology, Hepatology, and Nutrition and Dr. Lionel Bueno of the Neuro-Gastroenterology & Nutrition Unit at the National Institute for Agricultural Research (INRA) in Toulouse, France. Drs. Pezzone and Bueno presented these studies at the American College of Gastroenterology (ACG) 2008 Annual Scientific Meeting in Orlando, Fla. yesterday and today respectively.

(Logo: http://www.newscom.com/cgi-bin/prnh/20081006/NEM080ALOGO )

Ironwood is actively exploring the role of cGMP in the control of intestinal function and is currently developing therapeutic agents that act through this mechanism. Ironwood's first cGMP modulator, linaclotide, acts in the intestine to increase intracellular and extracellular cGMP levels by stimulating guanylate cyclase C. Linaclotide is currently being evaluated in a comprehensive Phase 3 program by Ironwood and its partner Forest Laboratories for its potential to treat irritable bowel syndrome with constipation (IBS-C) and other gastrointestinal disorders. In a Phase 2b study in patients with IBS-C, linaclotide reduced abdominal pain and improved bowel habits. The detailed Phase 2b IBS-C study results will be presented tomorrow in a plenary session at ACG by Jeffrey M. Johnston, M.D., F.A.C.P.,
'/>"/>

SOURCE Ironwood Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results
2. Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference
3. Ironwood Raises $50 Million to Advance Linaclotide Through Phase 3
4. Novel PCT Method Unveiled by Pressure BioSciences, Inc. and Collaborators at the Harvard School of Public Health
5. Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain
6. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
7. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
8. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
9. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
10. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
11. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... , July 23, 2014 Research and ... "Sensor Market in Consumer Healthcare by Application, Sensor Type ... 2013 - 2020" report to their offering. ... has been an increasing momentum for consumer healthcare monitoring ... sophistication. The consumer healthcare will lessen the healthcare cost ...
(Date:7/23/2014)... and MOUNTAIN VIEW, Calif. ... a recognized leader in translational preclinical research, today unveiled ... www.surpassinc.com ), signaling the transformation of Surpass, corporate culture ... partner for our customers. This press release comes on ... integral hires were added to the Silicon Valley Team: ...
(Date:7/23/2014)... DUBLIN , July 23, 2014 ... "Diagnostic Electrocardiograph (ECG) Market by Product, End-user & ... report to their offering. ... market is segmented into three major segments, namely, holter ... overall market was valued at $3,683 million in 2013 ...
Breaking Medicine Technology:Sensor Market in Consumer Healthcare (Patient Monitoring, Therapeutic, Handheld and Homecare, & Fitness and wellness) - Analysis & Forecast to to 2013 - 2020 2Sensor Market in Consumer Healthcare (Patient Monitoring, Therapeutic, Handheld and Homecare, & Fitness and wellness) - Analysis & Forecast to to 2013 - 2020 3SURPASS Launches New Company Logo and Corporate Website, Symbolizing Transformation of Company Culture to Meet the Changing Needs of Clients in the Life Science Community Today. 2SURPASS Launches New Company Logo and Corporate Website, Symbolizing Transformation of Company Culture to Meet the Changing Needs of Clients in the Life Science Community Today. 3Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 2Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 3
(Date:7/23/2014)... The voice on the recording was low and ... news he was infected with the human immunodeficiency virus (HIV) that ... next thing you know I was on the floor flat on ... was hopeful when the recording ended less than 10 minutes later. ... . because it is just God setting you up for ...
(Date:7/23/2014)... 23, 2014 Four hospitals affiliated with ... in the latest ranking of the country’s best hospitals ... Released online today and slated for publication in August, ... General Hospital (AGH), Forbes Hospital, Saint Vincent Hospital and ... multiple clinical specialties. , “There is no ...
(Date:7/23/2014)... 2014 Olympic gold medal-winning speed skater ... on Friday, July 18. Hedrick visited Roanoke as the ... Games, an Olympic-style event celebrating its 25th Anniversary in ... a premier sponsor of the Commonwealth Games, which like ... ages and all activity levels. , Hedrick, a native ...
(Date:7/23/2014)... Kathleen Doheny HealthDay ... -- Weight-loss surgery appears to have an additional side ... women, according to a new study. The study ... surgery program reported having incontinence prior to the procedure. ... symptoms either improved or disappeared, said study researcher Dr. ...
(Date:7/23/2014)... News) --,Jealousy may not be the sole domain of ... possessive when it comes to the love of their ... was actually a stuffed dog, the real puppies in ... dog aside, report researchers from the University of California, ... when owners were attending to the stuffed dog and ...
Breaking Medicine News(10 mins):Health News:HIV clinic-based audio project emphasizes the power of patient voices 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 3Health News:Four Allegheny Health Network Hospitals Named High Performers by U.S. News 2Health News:Four Allegheny Health Network Hospitals Named High Performers by U.S. News 3Health News:US Olympian Chad Hedrick Visits Foot Levelers 2Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 2Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 3Health News:Dogs Can Get Jealous, Too 2
... clues to effects of aging, experts say , , THURSDAY, ... an important role in coordinating people,s circadian clocks and ... The circadian clock governs daily cycles of feeding, activity ... the Washington University School of Medicine said their finding ...
... more control of their high blood pressure (hypertension) when ... Dr. Ross D. Feldman, a clinical scientist with the ... recommends a simplified and more effective method of treating ... than multiple pills. The "Simplified Treatment Intervention to ...
... company cofounded by Beth Israel Deaconess Medical Center (BIDMC) ... has announced that it has closed an $8M Series ... Life Sciences (SVLS) and MedImmune Ventures. , The company ... T-cells, with their first program focusing on treatments for ...
... with the computer age comes the age of eye fatigue. ... at work or leisure), we develop a host of symptoms and ... ... sound familiar? Well, you are not alone. You ... The good news is that relief may be within your reach ...
... to Creating Realistic Development TimelinesRALEIGH, N.C., March 19 ... announces its Senior Vice President of Scientific and Medical ... site and country selection. The webinar will take place ... Thoelke will discuss how to mitigate one of the ...
... 19 The "Help is Here Express" bus tour ... 23-27 at various cities throughout the state in order ... programs that provide prescription medicines for free or nearly ... nine straight months, and having passed the national unemployment ...
Cached Medicine News:Health News:Internal Clock and Metabolism May Be Linked 2Health News:Biotech company cofounded by BIDMC scientists targets natural killer T-cells 2Health News:The Power of a Tiny Microscopic Plant Found To Reduce Computer Eye Strain 2Health News:PRA International Speaking Event: Beyond Global Feasibility 2Health News:Partnership for Prescription Assistance Prepared to Help Georgia Workers Hurt by Recession 2Health News:Partnership for Prescription Assistance Prepared to Help Georgia Workers Hurt by Recession 3Health News:Partnership for Prescription Assistance Prepared to Help Georgia Workers Hurt by Recession 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: