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Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration
Date:1/15/2014

GENE CORPORATION 136

CEPHALON, INC. 136

COLUMBIA LABORATORIES, INC. 137

EISAI CO., LTD 137

ELAN DRUG TECHNOLOGIES 138

ENZON PHARMACEUTICALS 138

GENENTECH INC. 139

GENEREX BIOTECHNOLOGY CORPORATION 139

GENZYME CORPORATION 140

GILEAD SCIENCES, INC. 141

GLAXOSMITHKLINE PLC 141

HISAMITSU PHARMACEUTICAL CO., INC. 142

IMCLONE SYSTEMS INC. 142

JANSSEN BIOTECH, INC. 143

JOHNSON & JOHNSON 143

KEMPHARM, INC. 144

K.V. PHARMACEUTICAL CO. 144

LAVIPHARM CORPORATION 145

MANNKIND CORPORATION 145

MERCK & CO. 146

MYLAN LABORATORIES INC. 146

NEKTAR THERAPEUTICS 147

NEUROGESX INC. 147

NEWGEN BIOPHARMA 148

NOVARTIS AG 148

NOVAVAX, INC. 149

NOVEN PHARMACEUTICALS, INC. 149

NYCOMED US INC. 150

OSI PHARMACEUTICALS, INC. 150

PAR PHARMACEUTICAL COMPANIES, INC. 151

PDL BIOPHARMA, INC. 151

PFIZER INC. 152

QLT INC. 152

ROCHE HOLDING AG 153

SANOFI SA 153

TEVA PHARMACEUTICAL INDUSTRIES LTD. 154

THERAJECT, INC. 155

UMEWORLD LTD. 155

VALEANT PHARMACEUTICALS INTERNATIONAL, INC. 156

XEL PHARMACEUTICALS, INC. 156

CHAPTER 11 APPENDIX I 158LIST OF TABLES SUMMARY TABLE GLOBAL REVENUE OF ADVANCED DRUG DELIVERY SYSTEMS,BY

REGION, THROUGH 2018 ($ MILLIONS) 7

TABLE 1 HISTORIC EVENTS IN DRUG DELIVERY 10

TABLE 2 ADVANTAGES AND DISADVANTAGES OF SUSTAINED RELEASE DRUG

DELIVERY 12

TABLE 3 CLASSIFICATION OF PRODRUGS 14

TABLE 4 ADVANTAGES AND DISADVANTAGES OF PRODRUGS 15

TABLE 5 ADVANTAGES AND DISADVANTAGES OF IMPLANTS AND IUDS 17

TABLE 6 ADVANTAGES AND DISADVANTAGES OF LIPOSOMES 19

TABLE 7 ADVANTAGES AND DISADVANTAGES OF MONOCLONAL ANTIBODIES 22

TABLE 8 ADVANTAGES AND DISADVANTAGES OF POLYMERS 23

TABLE
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