Navigation Links
ESBATech's Lead Antibody Fragment Enters Clinical Development for Ophthalmic Indications
Date:4/24/2008

ESBA105 Penetrates all Segments of the Eye via Topical Eye Drops

ZURICH, Switzerland, April 24 /PRNewswire/ -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced the initiation of Phase I clinical development of the company's lead product development candidate, ESBA105, in ophthalmology. This Phase I study is designed to evaluate the safety, tolerability and pharmacokinetic profile of ESBA105, when delivered topically via eye drops in healthy volunteers. The study is being conducted as a single and repeated dose escalation study in Switzerland. ESBA105 is a single-chain antibody fragment directed against TNFa. It is being developed initially for ophthalmic indications.

In previously reported in vivo, preclinical studies, ESBA105 achieved high therapeutic concentrations in all ocular tissues, when delivered topically via eye drops. Therapeutic concentrations of ESBA105 were observed throughout the anterior (front) and the posterior (back) segments of the eye, the latter including the vitreous humor, retina and choroid.

Peter Lichtlen, M.D., Ph.D., Head of Clinical Development at ESBATech AG, commented, "ESBA105 shows an entirely novel and unique intraocular distribution pattern upon topical administration to the eye. Therapeutic levels are reached in both the aqueous and vitreous humor after only a couple of hours following initiation of treatment. Our in vivo, preclinical studies have shown that ESBA105 has a prolonged half-life of 25 hours in the vitreous. Thus, the vitreous acts as a natural depot compartment for ESBA105, allowing for highly attractive maintenance dosing regimens. TNFa is a rapidly emerging target in ophthalmology and ESBA105 has the potential to be a significant advancement in anti-inflammatory ophthalmic medicine."

Dominik Escher, Ph.D., Chief Executive Officer of ESBATech AG, added, "This is a major corporate milestone for ESBATech. After having developed a repeatable technol
'/>"/>

SOURCE ESBATech AG
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Micromet Enrolls First Patient in a Phase 1 Clinical Trial with MT110, the First BiTE Antibody for Treatment of Solid Tumors
2. MedImmune Advances Asthma Program with Start of a Phase 2 Trial in Europe and Australia and First U.S.-Based Clinical Trial for Antibody Targeting IL-13
3. OncoMed Chooses SynCo Bio Partners to Fill and Finish its Lead Antibody
4. Micromet Shows Feasibility of Subcutaneous Delivery of BiTE Antibody in Preclinical Primate Study
5. Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma
6. MedImmune Advances Clinical Development of Antibody Targeting Interleukin-9 in Patients with Asthma
7. Micromet Announces Presentation of Five Posters Related to Its Proprietary BiTE Antibody Platform at Annual Meeting of American Association for Cancer Research
8. Raven Announces Completion of Enrollment in the Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for the Treatment of Adenocarcinomas
9. Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
10. Celltrion and CSL Announce Collaboration to Develop and Manufacture Monoclonal Antibody
11. Preclinical Studies Show Promise for Novel Antibody Therapy to Treat Acute Myeloid Leukemia (AML)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014  Decision ... changes brought about by the Affordable Care ... and prescribing of pharmaceutical therapies. The ACA ... beneficiaries through new regulations and expanded access ... in the health exchanges—state-based marketplaces set up ...
(Date:7/31/2014)... BURLINGTON, Mass. , July 31, 2014 /PRNewswire/ ... committee members—who make decisions about which therapies are ... influence formulary placement, according to a new Manhattan ... Makers 2014 . The study finds that P&T ... and pharmacy benefits managers (PBMs) have set a ...
(Date:7/31/2014)... -- Lazarus Effect, a medical device company focused on ... of blood clots, announced the closing of a $5 ... commercialization of several approved Lazarus Effect devices, as well ... Cover™ in the United States . ... value of our novel, platform technology as well as ...
Breaking Medicine Technology:Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 2Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 4Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 3Lazarus Effect Closes $5 Million Financing 2
... 14, 2011 OCuSOFT, Inc., an ophthalmic pharmaceutical research, ... agreement with Ardeo Health, LLC to distribute a novel ... of Evry, France, Nova23041. Nova23041 will be ... as Retaine® MGD™ Ophthalmic Emulsion under a brand license ...
... Better Health ™, a program of Lilly USA, LLC, ... healthier, more active lives, launches an enhanced multi-channel platform ... health information. The platform includes an array of patient ... manage their health, a dynamic website – lillyforbetterhealth.com ...
Cached Medicine Technology:Dry Eye Therapy Utilizing Cationic Novasorb® Technology Available Soon From OCuSOFT® 2Dry Eye Therapy Utilizing Cationic Novasorb® Technology Available Soon From OCuSOFT® 3Lilly for Better Health™ Launches Enhanced Multi-Channel Patient Education Platform 2Lilly for Better Health™ Launches Enhanced Multi-Channel Patient Education Platform 3
(Date:8/1/2014)... Hyden, KY (PRWEB) August 01, 2014 ... the Health Resources and Services Administration’s Advanced Education ... $700,000 and will provide direct support to 280 students ... of the AENT Program is to increase the number ... care providers and/or nursing faculty to address the nurse ...
(Date:8/1/2014)... invasive aesthetic injectable procedures have grown in popularity as ... treatments. As Botulinum toxin generally known as ... nonaesthetic health professionals have emerged to perform procedures utilizing ... M. Spinelli, MD from the Division of Plastic Surgery ... MD from Columbia University in New York have assessed ...
(Date:8/1/2014)... (PRWEB) August 01, 2014 With fast food ... and the convenience of processed, microwavable dinners, it is no ... does not offer patients a mere quick fix for shedding ... in any part of the country, get slimmer and healthier ... offer patients the tools and education on how to ...
(Date:8/1/2014)... St. Christopher's Hospital for Children announced ... of Innovations with Ed Begley Jr, airing later this ... TBA. , St. Christopher's Hospital for Children offers a ... birth through 21 years of age. With over 220 ... specialties, including autism and childhood obesity. , “St. ...
(Date:8/1/2014)... August 01, 2014 For many people, ... memory is still within the normal range, slips that ... of future decline. This merits a closer look, not ... August 2014 Harvard Men's Health Watch . ... they forget where their keys are they are on ...
Breaking Medicine News(10 mins):Health News:Frontier Nursing University Receives $700,000 in Scholarships for Advanced Practice Nursing and Midwifery Students 2Health News:Plastic surgeons or nurses: Who are the better injectors? 2Health News:Diet Doc Medical Weight Loss Programs Announces Diet Plans That Melt Excess Fat Rapidly While Teaching Patients How to Avoid Obesity 2Health News:Diet Doc Medical Weight Loss Programs Announces Diet Plans That Melt Excess Fat Rapidly While Teaching Patients How to Avoid Obesity 3Health News:Innovations with Ed Begley, Jr. to Feature St. Christopher's Hospital for Children in Upcoming Episode 2Health News:Innovations with Ed Begley, Jr. to Feature St. Christopher's Hospital for Children in Upcoming Episode 3Health News:Worried About Changes in Your Memory? It's Worth A Closer Look, From the August 2014 Harvard Men's Health Watch 2
... on new Baxter Heparin testing standards that are to be implemented ... deaths after the contaminated drug was used on patients, according to ... that caused the deaths of several and sickened hundreds. , ... ...
... drug warfarin for many patients, researchers say, , , SATURDAY, ... soon replace the anti-clotting drug warfarin as the first ... a new study suggests. , People with atrial fibrillation ... noted, and typically need to take warfarin for the ...
... 28 (HealthDay News) -- If your tummy feels funny, it ... a sign of something more serious. , Dr. ... Center in Dallas, says that everyone should know five things ... Alert your doctor if you have persistent symptoms, such as ...
... families even more vulnerable, aid agency warnsSEATTLE, March ... Dakota, Christian relief organization World Vision is dispatching ... staff to assess the needs of affected families."It,s ... homes flooded and be forced to evacuate. But ...
... American Dental Association (ADA) President John S. Findley, D.D.S., ... with funding the Indian Health Service (IHS) that the ... of retirements by the most experienced dentists. He ... "childhood caries and periodontal disease among diabetics are rampant." ...
... influenza vaccine and flu shot, will have Tamiflu available for purchase as well. ... ... caused by the influenza virus that is easily caught upon contact with the ... cases can be fatal. The best prevention of the flu is to get ...
Cached Medicine News:Health News:LegalView Informs Baxter Heparin Patients of New Testing Standards for Blood Thinner Following Deaths From Previous Contamination 2Health News:LegalView Informs Baxter Heparin Patients of New Testing Standards for Blood Thinner Following Deaths From Previous Contamination 3Health News:LegalView Informs Baxter Heparin Patients of New Testing Standards for Blood Thinner Following Deaths From Previous Contamination 4Health News:New Device Treats Common Heart Rhythm Disorder 2Health News:New Device Treats Common Heart Rhythm Disorder 3Health News:What You Need to Know When Your Stomach Aches 2Health News:Flooding in Fargo: World Vision Sending Supplies and Staff to Help Affected Families 2Health News:ADA President Urges Congress to Shore Up IHS Dental Care 2Health News:ADA President Urges Congress to Shore Up IHS Dental Care 3Health News:Nationwide Medical/Surgical Announces Availability of Tamiflu for the 2009-2010 Influenza Season 2
Idophor PVP Scrub Winged Sponges...
... E*Kits® can be a valuable tool in ... the items necessary for a procedure are ... and continuum of care are easier to ... in sequence of use, allowing the clinician ...
Triad Plus PVP-I Scrub Winged Sponges...
... wet trays to dry trays to specialty ... trays, Cardinal Health offers the widest offering ... contain components that are proven to be ... risk of surgical site infections. Cardinal Health ...
Medicine Products: