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Dr. Diana Bianchi Presents Data Demonstrating Verinata Health's Proprietary Technology Detects Genetic Abnormalities In Twin Pregnancies
Date:2/15/2013

REDWOOD CITY, Calif., Feb. 15, 2013 /PRNewswire/ -- Verinata Health, Inc., a privately-held company dedicated to maternal and fetal health, today presented data demonstrating its approach to detect aneuploidies in maternal blood from multiple gestation pregnancies. 

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Contrary to previous study findings by other investigators, this study demonstrated that each fetus in twin pregnancies contributes approximately 50 percent less cell-free fetal DNA to a maternal blood sample when compared to the cell-free DNA makeup of singleton pregnancies.  As a result of this reduced fetal fraction, deeper sequencing is necessary to determine if a chromosome abnormality is or is not present in one or both of the fetuses with a high degree of confidence.

"While we were able to correctly detect aneuploidy in twin pregnancies with a sequencing depth similar to that currently implemented for singleton pregnancies, deeper sequencing offers better resolution and discrimination for these complex samples," said Richard Rava , Ph.D., Chief Scientific Officer of Verinata Health.  "Thus, it may reduce the number of false negatives and increase the confidence in the results for multiple gestation pregnancies."

The analysis included 85 maternal plasma samples that were previously excluded from Verinata's large, blinded, prospective validation study of singleton pregnancies.  The full singleton study results were previously published in the peer-reviewed journal, Obstetrics & Gynecology (Green Journal).  The results show that Verinata's technology correctly detected the one incidence of Down syndrome (trisomy 21) and one incidence of Edwards syndrome (trisomy 18) present within this study population.  Importantly, the study also demons
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