Navigation Links
Dr. Diana Bianchi Presents Data Demonstrating Verinata Health's Proprietary Technology Detects Genetic Abnormalities In Twin Pregnancies

REDWOOD CITY, Calif., Feb. 15, 2013 /PRNewswire/ -- Verinata Health, Inc., a privately-held company dedicated to maternal and fetal health, today presented data demonstrating its approach to detect aneuploidies in maternal blood from multiple gestation pregnancies. 


Contrary to previous study findings by other investigators, this study demonstrated that each fetus in twin pregnancies contributes approximately 50 percent less cell-free fetal DNA to a maternal blood sample when compared to the cell-free DNA makeup of singleton pregnancies.  As a result of this reduced fetal fraction, deeper sequencing is necessary to determine if a chromosome abnormality is or is not present in one or both of the fetuses with a high degree of confidence.

"While we were able to correctly detect aneuploidy in twin pregnancies with a sequencing depth similar to that currently implemented for singleton pregnancies, deeper sequencing offers better resolution and discrimination for these complex samples," said Richard Rava , Ph.D., Chief Scientific Officer of Verinata Health.  "Thus, it may reduce the number of false negatives and increase the confidence in the results for multiple gestation pregnancies."

The analysis included 85 maternal plasma samples that were previously excluded from Verinata's large, blinded, prospective validation study of singleton pregnancies.  The full singleton study results were previously published in the peer-reviewed journal, Obstetrics & Gynecology (Green Journal).  The results show that Verinata's technology correctly detected the one incidence of Down syndrome (trisomy 21) and one incidence of Edwards syndrome (trisomy 18) present within this study population.  Importantly, the study also demonstrated that 10 to 15 percent of cases may be at risk of having inadequate fetal cfDNA for accurate classification.  Verinata's unique approach using deeper sequencing is required to provide confidence that aneuploidies will be correctly identified. 

The study results were presented in an oral presentation entitled "Maternal Plasma DNA Sequencing: Effects of Multiple Gestation on Aneuploidy Detection and the Relative Cell-Free Fetal DNA (cffDNA) per Fetus," (Oral Concurrent Session 4, Program ID#52). Diana Bianchi , M.D. of the Mother Infant Research Institute at Tufts Medical Center presented the data at the 33rd Annual Meeting of the Society for Maternal-Fetal Medicine on February 15, 2013 at 3:15 p.m. Pacific Time.

Verinata Health, Inc.
Verinata is driven by a sole, extraordinary purpose – maternal and fetal health. Our initial focus is to develop and offer non-invasive tests for early identification of fetal chromosomal abnormalities using our proprietary technologies. We aim to reduce the anxiety associated with today's multi-step process, the unacceptable false-positive rates, the non-specific and sometimes confusing results of current prenatal screening methods, as well as the risk of current invasive procedures. We support national guidelines and the recent American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine Committee Opinion recommending cell-free DNA prenatal testing is one option that can be used as a primary or secondary screening test in women at increased risk of aneuploidy. We believe women who desire such testing should be offered a single blood draw test with a definitive result. The verifi® prenatal test is available through a physician. For more information about Verinata, please go to

SOURCE Verinata Health
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Wockhardt honoured with 2012 DIANA Award for Best Overall Generic Manufacturer
2. Indiana leads U.S. in life sciences jobs and growth
3. Indianas Stop-Sale System Achieves Significant Results In Battle Against Meth
4. Lilly to Expand Indianapolis Insulin Manufacturing Operations
5. Report Presents a Framework for Successful New Oncology Product Launches in the Pharmaceutical Sector
6. Foundation for Managed Care Pharmacy (FMCP) Presents Awards for 2012 National P&T Competition and Best Posters
7. Sanofi Pasteur Presents Pediatric Data on Investigational Quadrivalent Influenza Vaccine
8. Grant & Eisenhofer Represents Lead Whistleblower in Historic $1.6 Billion Settlement with Abbott Laboratories Over Off-Label Marketing of Antiepileptic Medication Depakote
9. Boston Scientific Endoscopy Presents Promising Clinical Data During Digestive Disease Week ®
10. Lilly Diabetes Presents Phase II Blood Pressure and Heart Rate Data on Investigational GLP-1 Analog Candidate, Dulaglutide, in Patients with Type 2 Diabetes at the 27th American Society of Hypertension Scientific Meeting
11. Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma
Post Your Comments:
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... of the "2016 Future Horizons and Growth ... Market: Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> --> ... of the Italian therapeutic drug monitoring market, including ...
(Date:11/25/2015)... Nov. 25, 2015  Amgen (NASDAQ: AMGN ) ... (BLA) with the United States ... a biosimilar candidate to Humira ® (adalimumab). Amgen ... submitted to the FDA and represents Amgen,s first BLA ... E. Harper , M.D., executive vice president of Research ...
(Date:11/25/2015)... MINNEAPOLIS , Nov. 25, 2015  ARKRAY ... care products, continues to provide evidence demonstrating the accuracy ... the World Congress on Insulin Resistance, Diabetes and Cardiovascular ... showed that both the Company,s GLUCOCARD ® 01 ... met high accuracy requirements. The ability to accurately measure ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... November 25, 2015 , ... ... direct sauna parts and accessories. , Sauna accessories help improve the bather experience ... and personality. From basic styles for the purist looking for simplicity in design ...
(Date:11/25/2015)... ... 2015 , ... For the first time, Vitalalert is donating half of its ... The partnership between the two groups began in 2014 with Vitalalert pledging a portion ... International was founded in 1954 and is an international Christian-based health organization whose mission ...
(Date:11/25/2015)... , ... November 25, 2015 , ... On November 25, ... center for the Narconon network, announced the release of a new cutting edge recovery ... Narconon organization has been working with drug- and alcohol-addicted individuals with the purpose to ...
(Date:11/25/2015)... ... 2015 , ... Smiles by Stevens is pleased to announce the ... While many patients are aware of the benefits of Botox® in the treatment of ... suffering with discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... In an ... Resurrection Medical Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy of ... and surgical intensive care units (totaling 30 beds) from May 2014 through October 2015 ...
Breaking Medicine News(10 mins):