Navigation Links
Data Published in Nature Methods Demonstrate Breakthrough Ability to Accurately Detect Somatic Single Nucleotide Variations in Single Cells
Date:3/20/2017

NEW YORK, March 20, 2017 /PRNewswire/ -- SingulOmics Corporation, a recently established genomic research and service company, announced today the publication of data validating the company's core mission of producing a new, high quality amplification method and computational pipeline for single cell sequencing. The data demonstrate that the company's new system -- AccuSomatic Amplification for Single Cell Sequencing -- enables accurate detection of somatic single nucleotide variations (SNVs) in single cells not possible with any prior methods. The data are presented in a paper, "Accurate identification of single nucleotide variants in whole genome amplified single cells," published online on March 20, 2017 in Nature Methods (doi:10.1038/nmeth.4227).

AccuSomatic Amplification for Single Cell Sequencing, the result of years of research conducted at the Albert Einstein College of Medicine, New York, enables the discovery of true somatic SNVs in single cells that could not be accurately detected by any prior method. While single cell sequencing holds great promise for studying genetic heterogeneity in cancer and normal tissues, existing methods suffer from multiple sources of artifacts that can result in more than 20,000 false somatic SNV calls per cell and >90% false positive results. According to the research data, AccuSomatic Amplification eliminates >99% of errors in somatic SNV calls while maintaining the same detection sensitivity.  

"This is really a game changer for our research. We are interested in studying low, physiological levels of somatic SNVs and other mutations in single cells, but these were simply drowning in the high background we experienced with published protocols or commercially available systems," stated Jan Vijg, Ph.D., Chair, Department of Genetics, Albert Einstein College of Medicine and an investor and co-founder of SingulOmics. "We are entering a single cell genomics era as the cost of human genome sequencing plummets. This new method allows researchers to unlock the full potential of single cell sequencing in cancer, drug development, and aging research and greatly expands the capability of researchers to explore the landscapes of somatic mutations in human and other organisms beyond the reach of other amplification techniques available to date."

About SingulOmics
SingulOmics Corporation was established in 2016 in New York as a genomics research and service company specializing in the emerging field of single-cell omics. Building on the unmatched expertise in single-cell genomics, transcriptomics and epigenomics developed since the mid-2000s at the Albert Einstein College of Medicine, the company's mission is to develop and provide high-quality innovative single-cell services to academic and industrial communities around the world. In addition to AccuSomatic Amplification for Single Cell Sequencing, Singulomics also offers single cell whole genome bisulfite sequencing service. For more information, visit http://www.singulomics.com.

 

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/data-published-in-nature-methods-demonstrate-breakthrough-ability-to-accurately-detect-somatic-single-nucleotide-variations-in-single-cells-300425847.html


'/>"/>
SOURCE SingulOmics Corporation
Copyright©2017 PR Newswire.
All rights reserved


Related medicine technology :

1. Center Point Clinical Services Article Published in The Journal of Clinical Therapeutics
2. New Study Published in Lancet Respiratory Medicine Highlights QIAGENs QuantiFERON-TB Potential to Predict Active Tuberculosis Risk in Infants
3. Well-Controlled Clinical Study Published by Journal of Clinical Orthodontics Demonstrates Effect of Vibration on Molar Distalization Using AcceleDent
4. UV Disinfection Proven Effective by Newly-published Duke Health Study
5. Landmark Study Published Today in The Lancet Shows Clear Myeloma Survival Benefit with Triple Drug Combination
6. Medical Marijuana Temporary Regulations for Dispensaries to be Published in Tomorrows Pennsylvania Bulletin
7. NCCN Imaging Appropriate Use Criteria Published for 15 Additional Guidelines
8. LifeVac, Life Saving Device Study Published in American Journal of Emergency Medicine
9. Studies Show Ixekizumab Improved Work Productivity for Patients with Moderate-to-Severe Plaque Psoriasis: Results Published in JAMA Dermatology
10. Review of Delcath Melphalan/HDS System Published in "Cardiovascular & Interventional Radiology"
11. Results of the First Study to Establish a Link Between Twitter and Illegal Online Pharmacies Published in JMIR
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: ... data solutions, today announced that its MyDario product is expected to appear ... listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The ... ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
(Date:9/13/2017)... , Sept. 13, 2017   OrthoAtlanta has ... the Atlanta Football Host Committee (AFHC) for the 2018 College ... Jan. 8, 2018, at Mercedes-Benz Stadium in Atlanta, ... of the AFHC "I,m In" campaign, participating in many activities ... ...
Breaking Medicine Technology:
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... HMP ... the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare ... City on October 11, 2017. , The annual award competition recognizes editorial and design ...
Breaking Medicine News(10 mins):