Navigation Links
Cellular Dynamics International Unlocks the Potential of Banked Blood Samples
Date:6/27/2011

MADISON, Wis., June 27, 2011 /PRNewswire/ -- Cellular Dynamics International (CDI) today announced the online publication of an article in the journal Blood demonstrating for the first time a methodology for researchers to access the biology stored in repositories of banked blood samples through the creation of induced pluripotent stem cells (iPSCs). According to the article, entitled "Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells," the derived iPSCs retained genotypic identity and were differentiated into cell types comprising all three germ layers in the body, including blood, heart, neural, and liver cells.

Blood samples are often banked as reference material from the study of various diseases, rare genetic disorders and genome wide association studies (GWAS). To bank these blood lines, they are genetically modified through the introduction of Epstein-Barr virus (EBV) to enable them to be frozen, thawed and proliferate indefinitely, known as "immortalization." This Blood paper describes the ability to take small volumes of EBV-transformed blood and create induced pluripotent stem cells (iPSCs), as well as terminally differentiated somatic cells, that do not contain the EBV genetic modification.

"CDI's published methodology enables the unprecedented opportunity to take samples from disease cohort repositories worldwide, where blood has been collected and immortalized from patients with a wide variety of diseases and known genotypic and phenotypic backgrounds, and create iPSC-based human cellular models for disease research and drug discovery," said Nick Seay, CDI Chief Technology Officer and an author of the paper.  "Our ability to take samples of banked blood and create EBV-free iPSCs, and use that material to manufacture cells in the quantity, quality and purity required for research, is an important step forward in the study of human biology and understanding the promise of regenerative medicine.  CDI's research truly enables the study of human biology in a dish."

While prior research on these blood samples from healthy and diseased cohorts enabled the study of the patients' DNA, this new capability to create iPSCs free of EBV now enables researchers to study any cell type created from these known samples. "This is the next big step in leveraging the wealth of information in biological repositories worldwide to improve healthcare," said Seay.

More information on the paper, published online on June 27, 2011 (submitted January 21, 2011, and accepted June 12, 2011) can be found at http://bloodjournal.hematologylibrary.org/content/early/2011/06/24/blood-2011-01-332064.abstract.  

About Cellular Dynamics International, Inc.

Cellular Dynamics International, Inc. (CDI) is a leading developer of next-generation stem cell technologies for drug development and personalized medicine applications.  CDI harnesses the power of pluripotent stem cells and their ability to differentiate into any cell type for world-class drug development tools.  In addition, it is the leader in iPSC technology, the production of pluripotent stem cell lines from adult tissue.  CDI was founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research at the University of Wisconsin-Madison.  CDI's facilities are located in Madison, Wisconsin. See www.cellulardynamics.com.


'/>"/>
SOURCE Cellular Dynamics International, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Largest Acellular Dermal Allografts Available for Abdominal Wall Reconstruction Introduced at AWR 2011
2. iPS Academia Japan, Inc. to Distribute Cellular Dynamics iCell® Products in Japan
3. Cellular Dynamics Raises $30 Million to Expand Its Product Line of Human Stem Cells and Tissue Cells
4. FDA Approves Special Protocol Assessment for Phase 3 Trial of Polaris Groups Cancer Therapeutic, ADI-PEG 20, in the Treatment of Hepatocellular Carcinoma
5. Cellular Dynamics International and Roche Transition Early Access Collaboration into a Standard Supply Agreement Ahead of Schedule
6. Intra-Cellular Therapies and Takeda Enter into Worldwide Collaboration to Develop and Commercialize Compounds for Schizophrenia
7. SecuraTrac Reveals Revolutionary Safety Solution Based on GPS & Cellular Technology at CES 2011
8. Transposagen and Cellular Dynamics International Cross-License Technologies for Induced Pluripotent Stem Cells
9. Largest Acellular Dermal Allografts for Abdominal Wall Repair Now Available From MTF
10. Tengion Presents New Data Demonstrating Functional Regeneration in a Diabetic Chronic Kidney Failure Model at the International Society for Cellular Therapy
11. Intra-Cellular Therapies Announces the Successful Completion of a Phase Ib/II Study of ITI-007 in Patients with Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... 2017 FinancialBuzz.com News Commentary ... due to the significant development and innovation in EP ... Research, the global electrophysiology market was worth $3.42 billion ... by 2022, with a GAGR of 13.4%. Electrophysiology is ... abnormal heartbeats or arrhythmia. The report indicates that in ...
(Date:3/22/2017)... EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, ... Canada , today announced two new real-world data analyses ... 65 th Annual Pacific Coast Reproductive Society (PCRS) Meeting ... 24 th .   The results being presented are ... 2009 to December 2015 containing data from 15 fertility clinics ...
(Date:3/22/2017)... March 22, 2017  Levine Cancer Institute today ... unit designed to address lung cancer diagnosis, treatment ... Carolinas. The mobile lung unit is the first-of-its-kind ... and treatment interventions through integrated mobile technology, traditional ... Financial barriers and a lack of public transportation ...
Breaking Medicine Technology:
(Date:3/23/2017)... ... March 23, 2017 , ... “A Respectful ... “A Respectful Response To Atheist Manifesto” is the creation of published author Richard ... Nancy, for sixty years. He holds graduate degrees from Kent State University and ...
(Date:3/22/2017)... ... March 22, 2017 , ... Cosmetic Town, an ... issue of its companion print magazine. The new magazine, scheduled for release in ... information provided by board-certified doctors from across the country. , According to the ...
(Date:3/22/2017)... ... March 22, 2017 , ... Old School Labs™, makers of the best-selling Vintage ... new Brand Ambassador. Theophane, who trained with Floyd Mayweather, made his professional debut in ... racked up an impressive number of wins in contests in Britain, Germany and the ...
(Date:3/22/2017)... ... March 22, 2017 , ... Influence Health, ... digital marketing solutions have enabled Children’s Hospital of The King’s Daughters (CHKD) to ... Recognizing the value of a digital marketing approach, the 206-bed pediatric teaching hospital ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Burke Medical ... to translate advances in basic neuroscience at the BMRI labs into new and ... to improve movement, vision, and cognition impaired by stroke, traumatic brain injury, cerebral ...
Breaking Medicine News(10 mins):