Navigation Links
Cellular Dynamics International Unlocks the Potential of Banked Blood Samples
Date:6/27/2011

MADISON, Wis., June 27, 2011 /PRNewswire/ -- Cellular Dynamics International (CDI) today announced the online publication of an article in the journal Blood demonstrating for the first time a methodology for researchers to access the biology stored in repositories of banked blood samples through the creation of induced pluripotent stem cells (iPSCs). According to the article, entitled "Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells," the derived iPSCs retained genotypic identity and were differentiated into cell types comprising all three germ layers in the body, including blood, heart, neural, and liver cells.

Blood samples are often banked as reference material from the study of various diseases, rare genetic disorders and genome wide association studies (GWAS). To bank these blood lines, they are genetically modified through the introduction of Epstein-Barr virus (EBV) to enable them to be frozen, thawed and proliferate indefinitely, known as "immortalization." This Blood paper describes the ability to take small volumes of EBV-transformed blood and create induced pluripotent stem cells (iPSCs), as well as terminally differentiated somatic cells, that do not contain the EBV genetic modification.

"CDI's published methodology enables the unprecedented opportunity to take samples from disease cohort repositories worldwide, where blood has been collected and immortalized from patients with a wide variety of diseases and known genotypic and phenotypic backgrounds, and create iPSC-based human cellular models for disease research and drug discovery," said Nick Seay, CDI Chief Technology Officer and an author of the paper.  "Our ability to take samples of banked blood and create EBV-free iPSCs, and use that material to manufacture cells in the quantity, quality and purity required for research, is an important step forward in the study of human biology and understanding the promise of regenerative medicine.  CDI's research truly enables the study of human biology in a dish."

While prior research on these blood samples from healthy and diseased cohorts enabled the study of the patients' DNA, this new capability to create iPSCs free of EBV now enables researchers to study any cell type created from these known samples. "This is the next big step in leveraging the wealth of information in biological repositories worldwide to improve healthcare," said Seay.

More information on the paper, published online on June 27, 2011 (submitted January 21, 2011, and accepted June 12, 2011) can be found at http://bloodjournal.hematologylibrary.org/content/early/2011/06/24/blood-2011-01-332064.abstract.  

About Cellular Dynamics International, Inc.

Cellular Dynamics International, Inc. (CDI) is a leading developer of next-generation stem cell technologies for drug development and personalized medicine applications.  CDI harnesses the power of pluripotent stem cells and their ability to differentiate into any cell type for world-class drug development tools.  In addition, it is the leader in iPSC technology, the production of pluripotent stem cell lines from adult tissue.  CDI was founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research at the University of Wisconsin-Madison.  CDI's facilities are located in Madison, Wisconsin. See www.cellulardynamics.com.


'/>"/>
SOURCE Cellular Dynamics International, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Largest Acellular Dermal Allografts Available for Abdominal Wall Reconstruction Introduced at AWR 2011
2. iPS Academia Japan, Inc. to Distribute Cellular Dynamics iCell® Products in Japan
3. Cellular Dynamics Raises $30 Million to Expand Its Product Line of Human Stem Cells and Tissue Cells
4. FDA Approves Special Protocol Assessment for Phase 3 Trial of Polaris Groups Cancer Therapeutic, ADI-PEG 20, in the Treatment of Hepatocellular Carcinoma
5. Cellular Dynamics International and Roche Transition Early Access Collaboration into a Standard Supply Agreement Ahead of Schedule
6. Intra-Cellular Therapies and Takeda Enter into Worldwide Collaboration to Develop and Commercialize Compounds for Schizophrenia
7. SecuraTrac Reveals Revolutionary Safety Solution Based on GPS & Cellular Technology at CES 2011
8. Transposagen and Cellular Dynamics International Cross-License Technologies for Induced Pluripotent Stem Cells
9. Largest Acellular Dermal Allografts for Abdominal Wall Repair Now Available From MTF
10. Tengion Presents New Data Demonstrating Functional Regeneration in a Diabetic Chronic Kidney Failure Model at the International Society for Cellular Therapy
11. Intra-Cellular Therapies Announces the Successful Completion of a Phase Ib/II Study of ITI-007 in Patients with Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
Breaking Medicine News(10 mins):