Navigation Links
Argos Therapeutics' Arcelis™ Immunotherapy for the Treatment of Renal Cell Carcinoma (RCC) in Combination With Sunitinib Demonstrates Strong Immunologic Response That Correlates to Improved Clinical Outcomes
Date:6/1/2011

DURHAM, N.C., June 1, 2011 /PRNewswire/ -- Argos Therapeutics announced today that its Arcelis™ immunotherapy for the treatment of renal cell carcinoma (RCC), AGS-003, in combination with sunitinib demonstrated a strong immunologic response that correlated to improved clinical outcomes. The Phase 2 combination study in newly diagnosed, metastatic RCC patients with unfavorable prognosis demonstrated decreases in T regulatory cells, along with a concurrent expansion of CD28+memory cytotoxic T lymphocytes (CTL). Results will be presented by Dr. Robert Figlin, director of the Division of Hematology/Oncology at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, in a poster and a discussion session at 8 a.m. CDT, and noon CDT, respectively, Saturday, June 4, 2011, at the 2011 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

The study is the first to demonstrate the combined immunologic and clinical effects of AGS-003, or any active immunotherapy, with sunitinib. Most patients experienced reversal of baseline tumor-induced immunosuppression and showed improved progression-free survival (PFS) compared to the expected PFS with sunitinib alone in an unfavorable risk, metastatic RCC patient population. Assessment of immunodynamicsusing multiparametric flow cytometry was performed on peripheral blood mononuclear cells isolated from blood draws collected prior to treatment and after treatment with AGS-003 during combination administration with sunitinib. Nine of 11 patients with PFS of >10 months demonstrated CTL population increases whereas two of four patients with PFS <10 months showed increases in this specific CTL population. Updates on the correlation between prolonged PFS and CTL expansion will be presented during ASCO.

"The study provides initial evidence that AGS-003
'/>"/>

SOURCE Argos Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Interleukin (IL)-12 Secretion Can Predict Potency of Argos Therapeutics Arcelis™ Dendritic Cell (DC) Immunotherapy and Can Be Used as Potency Marker in Phase 3 Clinical Trial
2. Argos Therapeutics to Present Potential of its Arcelis™ Immunotherapy as an Innovative, Effective Treatment for HIV at the APHA 138th Annual Meeting & Exposition
3. Argos Therapeutics to Present Overview of its Arcelis™ Dendritic Cell-based Immunotherapy, Participate in Panel Discussion at Inaugural Cancer Immunotherapy Conference
4. Argos Therapeutics to Present Recent Clinical Developments and Corporate Overview at 18th Annual BioPartnering Europe
5. Results From Argos Therapeutics Arcelis™ Immunotherapy Phase 2 Study for Treatment of Renal Cell Carcinoma (RCC) Accepted for Poster Presentation at Ninth International Kidney Cancer Symposium
6. Nektar Therapeutics President and CEO Howard W. Robin to Present at the Jefferies 2011 Global Healthcare Conference in New York
7. Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017
8. Reportlinker Adds Myelodysplastic Syndrome Therapeutics - Pipeline Assessment and Market Forecasts to 2017
9. Cell Therapeutics Regains Compliance with NASDAQ Minimum Bid Price Rule
10. Amicus Therapeutics to Present at Jefferies 2011 Global Healthcare Conference on Tuesday, June 7, 2011
11. Reportlinker Adds Risk Evaluation and Mitigation Strategy (REMS) - Opioids, Erythropoesis-Stimulating Agents and Cancer Therapeutics are the Most Important Classes That Require REMS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Aug. 22, 2014  Diplomat, the nation,s largest ... of two winners in the 2014 Innovations in ... LLC. The results of the competition were announced ... News. Diplomat was honored as ... & Training program. Through Diplomat University, the company ...
(Date:8/22/2014)... Aug. 22, 2014  As the Medical Affairs, role ... leaders in this area are exploring methods to develop ... Medical Affairs Consortium at Best Practices, LLC is designed ... insights about the key challenges they face. The consortium ... through three virtual roundtable discussions where leaders discuss key ...
(Date:8/22/2014)... 22, 2014 /CNW/ - On Aug. 20, at its ... Canadian Medical Association (CMA) voted on and approved a ... including medicinal cannabis. Bedrocan Cannabis Corp., a leading Canadian ... CMA motion. The CMA is quite right ... with smoking any plant material, including medicinal cannabis. While ...
Breaking Medicine Technology:Diplomat honored as a Top Innovator by Specialty Pharmacy News 2Best Practices' Medical Affairs Consortium Survey Has Achieved Strong Participation 2Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2
(Date:8/22/2014)... Natural Clear Vision , a how-to ... own vision from legally blind to perfect 20/20 vision has ... , “There is a huge portion of the population ... and most people just think that’s the way it will ... can be pretty risky at times,” reports Michaels. “This program ...
(Date:8/22/2014)... factor receptor (EGFR) mutations found in the circulating free ... cell lung cancer (NSCLC) patients correlates well with the ... tyrosine kinase inhibitor (TKI) therapy is approved for EGFR ... standard for determining mutation status is with DNA derived ... not available. A more abundant and less invasive source ...
(Date:8/22/2014)... August 22, 2014 Testosterone treatment ... in U.S. courts on behalf of men who ... use of prescription low testosterone therapies, Bernstein Liebhard ... claim was filed against Pfizer Inc. on July ... life-threatening heart issues due to his use of ...
(Date:8/22/2014)... -- An intensive effort to sterilize feral cats reduced the ... and euthanized, a new study reveals. "We investigated whether ... into animal control," Dr. Julie Levy, a professor of shelter ... said in a university news release. "Neutering a ... she explained, "so we wanted to pick a focused area ...
(Date:8/22/2014)... blockages in the kidney arteries may benefit patients ... trials, according to new recommendations for renal artery ... today by the Society for Cardiovascular Angiography ... Center,s Sahil Parikh, MD, Director, Interventional Cardiology Fellowship ... University School of Medicine was the lead author ...
Breaking Medicine News(10 mins):Health News:Natural Clear Vision: Review Exposes Kevin Richardson’s Program for Restoring Vision Naturally 2Health News:High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer 2Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 2Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 3Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 4Health News:Neutering Project Curbed Feral Cat Population 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 3
... at the University of Pittsburgh Schools of the Health ... disease called coronary artery calcification and body fat have ... advantages, at least for people particularly women ... including heart disease, are a leading cause of death ...
... distant ancestors won the battle against the now extinct virus ... species vulnerable to HIV today. AIDs one of the ... the most researched one still leaves many questions unanswered about ... the origin could be found in the jungles of central ...
... three-year-old who tested positive for bird flu has recovered from ... Saturday. ,The girl, admitted to the regional hospital ... contact with dead chickens that also tested positive with the ... positive on Friday, but she's now recovering quite well. She ...
... has banned fast-food companies from sponsoring or advertising on ... health problems caused by bad eating habits, news ... said the cabinet had agreed all fast-food chains be ... of their products, the Star daily reported. ,Chua ...
... A single injection of a type of virus known as ... study indicates. ,Researchers have found that rats bred ... for more than a month after being injected with engineered ... to alcohol because of mutations in the gene for aldehyde ...
... as Britain's national dish, but chicken tikka masala -- ... -- has remained largely a mystery on the ... Manju Malhi, wants to change that by introducing this ... ,Malhi is shooting a television cooking show in ...
Cached Medicine News:Health News:More Fat Leads to Less Coronary Artery Calcification 2Health News:More Fat Leads to Less Coronary Artery Calcification 3Health News:Ancient Ancestors Might Have Had a Clue to HIV 2Health News:India to Get a Taste of 'British' Curries 2Health News:India to Get a Taste of 'British' Curries 3
... Stereotactic System is the most ... world. Reliability, flexibility, versatility and ... of the Leksell Stereotactic System. ... the center-of-arc principle and the ...
Table-mounted, retraction for radiolucent anterior spine procedures. Fully-adjustable for any approach and any patient. Combine with our radiolucent blade kit for optimal visibility....
VG1 ALIF (Anterior Lateral) Anterior lumbar interbody fusion. Frozen freeze-dried preservation....
An all-cortical structure provides the structural benefits of cortical bone. Precision machined to exact specifications to promote healthy lordosis and vertebral body distraction....
Medicine Products: