Navigation Links
Amylin to Present Data Showing Investigational Metreleptin Treatment Led to Long-Term Improvements in Diabetes and Lipid Control in Patients with Lipodystrophy
Date:4/15/2011

isk for serious medical problems such as acute pancreatitis, accelerated atherosclerosis, and blood vessel and nerve damage from diabetes and liver cirrhosis, which can markedly reduce quality of life and life expectancy. Metreleptin works to treat metabolic abnormalities in patients with lipodystrophy.

It is estimated that there are a few thousand patients worldwide with this condition, although robust epidemiological data are not available, as is common with rare diseases. There are no therapies currently indicated specifically for the treatment of metabolic abnormalities associated with lipodystrophy. Presently, patients may receive a combination of dietary modification, anti-diabetic medications and lipid-lowering agents. These traditional treatment approaches do not address the underlying cause of the metabolic abnormalities in lipodystrophy and are often rendered marginally effective due to the severity of the condition.

About Metreleptin for Lipodystrophy

Data from clinical studies conducted by investigators at the NIH and other academic institutions in the U.S., Europe and Japan, have demonstrated that metreleptin can have profound effects on improving insulin sensitivity, high trigylcerides, hyperglycemia and liver fat in patients with lipodystrophy who are not responsive to conventional lipid and glucose-lowering agents, even those undergoing intensive insulin therapy.

Globally, approximately 150 patients with lipodystrophy are being treated with metreleptin under investigator-sponsored trials and expanded access programs.

In 2010, Amylin submitted the non-clinical and clinical sections of a rolling submission for a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for the use of metreleptin to treat diabetes and/or hypertriglyceridemia in patients with rare inherited or acquired forms of lipodystrophy. The Company plans to submit the chemistry, manufacturing and controls (CMC) se
'/>"/>

SOURCE Amylin Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
2. Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society
3. Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly
4. Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009
5. Amylin Pharmaceuticals Reports Third Quarter Financial Results
6. Amylin Pharmaceuticals and Eli Lilly and Company Statement on FDAs BYETTA(R) (Exenatide) Injection Update
7. Amylin Pharmaceuticals to Present at the 18th Annual Credit Suisse Healthcare Conference
8. Amylin Pharmaceuticals to Webcast Year-End Financial Results
9. Amylin Highlights 2010 Corporate Priorities at J.P. Morgan Healthcare Conference
10. Amylin and Takeda Announce Decision to Advance Development of Pramlintide/Metreleptin Combination Treatment for Obesity
11. Amylin Pharmaceuticals to Present at The Barclays Capital 2010 Global Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 22, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... device R&D outsourcing company with operations in China ... today announced that it will release financial results for the ... closes on Wednesday, August 13, 2014 (which will be Thursday ... be available on the investor relations section of the Company,s ...
(Date:7/22/2014)... 22, 2014  Pressure BioSciences, Inc. (OTCQB: ... Genomics ("Parabase"), (together "the companies"), today announced ... and development agreement (the "collaboration"). Under the ... a front-end, sample preparation method for Parabase,s ... testing process. The sample preparation method will ...
(Date:7/22/2014)... New York , July 22, ... Neue Partnerschaft für umfassenden Schutz von ... in Österreich    Equashield ... von geschlossenen Transfersystemen (Closed System Transfer Devices, CSTDs) für ... , einen Vertriebshändler und Hersteller von ...
Breaking Medicine Technology:WuXi PharmaTech Schedules Second-Quarter 2014 Earnings Release 2Pressure BioSciences to Develop Front-end Sample Preparation for Parabase Genomics' Targeted Next Generation Sequencing Testing Platform 2Pressure BioSciences to Develop Front-end Sample Preparation for Parabase Genomics' Targeted Next Generation Sequencing Testing Platform 3Pressure BioSciences to Develop Front-end Sample Preparation for Parabase Genomics' Targeted Next Generation Sequencing Testing Platform 4Equashield ernennt Medikus zu seinem exklusiven österreichischen Vertriebspartner für seine geschlossenen Arzneimitteltransfersysteme 2
(Date:7/22/2014)... says women are often in the dark. Historically, it was ... has shown that post-menopausal women are just as likely as ... be adequately diagnosed and treated. New research from Western University ... Clinical Pharmacology brings to light a genetic basis for ... are more prone to heart disease. , The study, led ...
(Date:7/22/2014)... July 22, 2014 As reported on July ... caller request to name her favorite beauty products, “ Botox ... to say that “ Botox has changed my life” ... makeup chair preparing for her various, daily appearances. “Suddenly ... Ms. Ripa (see: goo.gl/shmTQM). , “I think that Kelly Ripa’s ...
(Date:7/22/2014)... New guidelines on cholesterol treatment and cardiovascular risk assessment ... of dying from atherosclerotic cardiovascular disease or of having ... a similar risk profile (based on age, smoking history, ... this finding for when and how aggressively to treat ... Journal of Men,s Health , a peer-reviewed publication from ...
(Date:7/22/2014)... Ticket Down is a reliable source for ... Field in Landover, MD. There has never been a better ... soccer. After the success of the American national soccer team at ... well. One way that fans of the world’s sport will be ... 2014 Guinness International Champions Cup. The tournament will kick off on ...
(Date:7/22/2014)... The park is the heart of ... Homeowners Association, Inc., made a recent investment in ... the purchase of playground equipment from American Parks Company™. ... Miami Florida, and is a 475-unit community that was ... landscape has created a tropical paradise with lush shade ...
Breaking Medicine News(10 mins):Health News:Gene variant identified as a heart disease risk factor for women 2Health News:Celebrity Botox: Kelly Ripa Confesses to Getting Botox Injections 2Health News:Manchester United vs. Inter Milan Tickets Fedex Field Landover: Ticket Down Slashes Ticket Prices for Inter Milan ManU International Champions Cup Match in Washington, DC 2Health News:Manchester United vs. Inter Milan Tickets Fedex Field Landover: Ticket Down Slashes Ticket Prices for Inter Milan ManU International Champions Cup Match in Washington, DC 3Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 2Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 3
... Provides An Annualized Yield Of 13% LARGO, Fla., May 1 ... Venture Exchange: UVI) Board of Directors today declared its regular ... May 28, 2009 to stockholders of record at the close ... the U.S. $0.09 per share quarterly dividend, which on a ...
... As H1N1 influenza A (swine flu) spreads, keeping hands ... prevent infection and illness. "Frequent handwashing is probably ... do to protect yourself and your family," according to ... Microbiology."Influenza A viruses, of which swine flu is one, ...
... IBM ) today announced the opening ... IBM will work with hospitals and rural medical cooperatives ... widespread healthcare reform. (Logo: http://www.newscom.com/cgi-bin/prnh/20090416/IBMLOGO ... Lab -- which is one of eight IBM solution ...
... Research at Drexel University*PHILADELPHIA, May 1 Research conducted ... of natural killer, or NK, cells in controlling primary ... understand how the body,s immune system may best respond ... been conducted on the specific H1N1 strain of influenza ...
... guidance for employers, patients and doctors on helping people with ... Tuesday May 5 at the University of Leicester. , It ... billion a year with people taking time off work ... not associated with healthcare but due to lost work production ...
... associated with higher income levels, study finds , , FRIDAY, ... of education and income tend to eat healthier diets, ... energy-dense (lower calorie/higher nutrient content), a U.S. study finds. ... of obesity, type 2 diabetes, cardiovascular disease and some ...
Cached Medicine News:Health News:Unilens Vision Inc. Declares Regular Quarterly Cash Dividend of U.S. $0.09 Per Share 2Health News:American Society for Microbiology Emphasizes Hand Hygiene as Flu Protective Measure 2Health News:IBM Announces New Healthcare Industry Solutions Lab in China 2Health News:IBM Announces New Healthcare Industry Solutions Lab in China 3Health News:IBM Announces New Healthcare Industry Solutions Lab in China 4Health News:Natural Killer Cells May Help Protect Against New Strains of Influenza Virus 2Health News:Natural Killer Cells May Help Protect Against New Strains of Influenza Virus 3Health News:New guidance on making work less of a pain in the back 2Health News:More Educated Choose Healthier Foods, But Pay More 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: