Navigation Links
Amylin to Present Data Showing Investigational Metreleptin Treatment Led to Long-Term Improvements in Diabetes and Lipid Control in Patients with Lipodystrophy
Date:4/15/2011

therapy to market."

Study Findings

The findings involve an analysis of 55 lipodystrophy patients who received metreleptin treatment – the largest lipodystrophy cohort reported to date. At baseline, 75 percent of patients had diabetes and were not achieving adequate glycemic control (A1C greater than or equal to 7 percent), and 75 percent of patients had hypertriglyceridemia (triglycerides greater than or equal to 200 mg/dL). Metreleptin treatment resulted in robust reductions from baseline in both measures, an effect that was evident within four months post treatment initiation and sustained for up to several years of treatment. In patients with diabetes, mean A1C decreased from 9.4 percent at baseline to under 7.0 percent at year three; in patients with hypertriglyceridemia at baseline, median triglyceride concentrations decreased from 500 mg/dL at baseline to under 200 mg/dL at year three.

Adverse events were generally consistent with known co-morbid conditions of lipodystrophy (pancreatitis, proteinuria, autoimmune/chronic hepatitis) or expected pharmacological effects of metreleptin (weight loss or insulin-induced hypoglycemia in the setting of improved insulin sensitivity in patients on high doses of insulin).

About Lipodystrophy

Lipodystrophy syndromes are characterized by abnormalities in adipose (fat) tissue distribution. Because patients with lipodystrophy do not have enough fat tissue, they typically also have a deficiency of leptin, a hormone secreted by fat cells that plays a key role in regulating metabolism. Beginning typically in childhood or adolescence, patients affected by lipodystrophy experience a loss of subcutaneous fat, which can result in multiple, often severe metabolic abnormalities, including extreme insulin resistance, very high triglyceride levels, difficult-to-control diabetes and hepatic steatosis (excess fat accumulation in the liver). These abnormalities put patients at a high r
'/>"/>

SOURCE Amylin Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
2. Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society
3. Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly
4. Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009
5. Amylin Pharmaceuticals Reports Third Quarter Financial Results
6. Amylin Pharmaceuticals and Eli Lilly and Company Statement on FDAs BYETTA(R) (Exenatide) Injection Update
7. Amylin Pharmaceuticals to Present at the 18th Annual Credit Suisse Healthcare Conference
8. Amylin Pharmaceuticals to Webcast Year-End Financial Results
9. Amylin Highlights 2010 Corporate Priorities at J.P. Morgan Healthcare Conference
10. Amylin and Takeda Announce Decision to Advance Development of Pramlintide/Metreleptin Combination Treatment for Obesity
11. Amylin Pharmaceuticals to Present at The Barclays Capital 2010 Global Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... -- Excite Medical was established by its President, Saleem ... under the leadership of Mr. Musallam , has ... track record of providing unparalleled service and support to ... Photo - http://photos.prnewswire.com/prnh/20150529/219412 ... in large part, due to Mr. Musallam,s ...
(Date:5/29/2015)... Actinobac Biomed, NovoPedics, Inc. and MentiNova, Inc., ... Foundation Venture Capital Group (FVCG), have been selected to ... of the Start-Up Stadium and Company Presentation forums offered ... Golubieski . The annual convention, the largest ... in Philadelphia in June. ...
(Date:5/29/2015)... PARK, Calif. , May 29, 2015  The ... with 1-5 physicians ranks Praxis EMR as #1 across ... Black Book Market Research LLC conducts a poll of ... Survey with the results.    Praxis ... rating of the 18 performance based criteria used by ...
Breaking Medicine Technology:Foundation Venture Capital Group Portfolio Companies to be Highlighted at Bio International in June 2Foundation Venture Capital Group Portfolio Companies to be Highlighted at Bio International in June 3Praxis EMR Ranks #1 for Physician Satisfaction in Black Book's 2015 Survey of Solo and Small Practices 2
... The annual meeting of the Chinese food industry is approaching; Fi ... focusing on the growing health market in China, and offering thousands ... business developments in the country and beyond. ... continues to enjoy a global reputation for being a low cost ...
... NASHVILLE, Tenn., Feb. 24, 2011 Cumberland ... a specialty pharmaceutical company focused on the hospital ... it has appointed pharmaceutical industry veteran Tan Cheow ... Singapore, Choon will be primarily responsible for executing ...
Cached Medicine Technology:Health on the Agenda at Food ingredients Asia-China Trade Show 2Cumberland Pharmaceuticals Appoints Tan Cheow Choon as Director of International Business 2Cumberland Pharmaceuticals Appoints Tan Cheow Choon as Director of International Business 3Cumberland Pharmaceuticals Appoints Tan Cheow Choon as Director of International Business 4Cumberland Pharmaceuticals Appoints Tan Cheow Choon as Director of International Business 5
(Date:5/29/2015)... The science of hair restoration has ... to the efforts of internationally recognized hair transplant surgeon ... ARTAS hair restoration and manual FUE techniques to ... anywhere. , A Follicular Unit Extraction (FUE) ... follicle grafts from the donor areas of a patient. ...
(Date:5/29/2015)... LAKE, CO (PRWEB) May 29, 2015 ... brand new addiction, substance abuse, and co-occurring mental ... celebration and ribbon cutting for the general public ... June 2nd. , The Recovery Village at Palmer ... and intensive outpatient programming, utilizing traditional and evidence-based ...
(Date:5/29/2015)... 29, 2015 Red Hot & Blue ... Red Hot & Blue restaurant at 525 New Waverly Place ... 7, 2015. “The Red Hot & Blue Restaurant was previously ... but we have moved to a new location in the ... middle of all the activities on the Promenade–with outdoor seating ...
(Date:5/29/2015)... May 29, 2015 A group of doctors ... joined the national effort to teach this “new math” to ... U.S. have been “sickened” by the recent implementation of Common ... or hate it, Common Core is now a reality in ... Parents are now seeking ways to improve common core ...
(Date:5/29/2015)... 29, 2015 Mediaplanet has joined forces ... readers on the importance of proper sun protection. The ... Today, with a circulation of approximately 250,000 copies and ... is distributed nationally, through a vast social media strategy, ... partner outlets. To explore the digital version of the ...
Breaking Medicine News(10 mins):Health News:Los Angeles and Beverly Hills Hair Transplant Doctor Now Combines Robotic Hair Restoration (ARTAS) and Manual FUE Transplants for Maximum Hair Coverage 2Health News:Advanced Recovery Systems Announces the Opening of The Recovery Village at Palmer Lake 2Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 2Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 3Health News:Red Hot & Blue Restaurant Opens in Cary, North Carolina 4Health News:Doctors Discover a Cure for the Common Core 2
... of the societal impact of endometriosis has found a ... suffer from the condition, a researcher told the 26th ... and Embryology today (Monday). Dr. Kelechi Nnoaham, from the ... that the results of this multi-centre study would help ...
... ... mental parity law, contact Meena Dayak at MeenaD(at)thenationalcouncil(dot)org or 202.684.3728. , ... Washington, DC (Vocus) June 28, 2010 -- With the ... Equity Act (MHPAEA), Rep. Paul Tonko (D-NY) has sent a letter, also signed by ...
... HealthDay Reporter , SUNDAY, June 27 (HealthDay News) ... education about healthy living can help kids who are most ... children in schools without such programs, a new study suggests. ... of overweight and obese schoolchildren -- those numbers fell by ...
... ... with Peripheral Arterial Disease . Most had no idea they had it. Thank you, ... ... press release, it was reported that Minnesota Congressman Erik Paulsen (MN-03) proposed a resolution to ...
... , ... days in June, QuickMedical® converted their 11,000 square foot warehouse into a showcase for ... of free food and prizes, the QuickMedical® Open House and Benefit was an event ... ...
... for measles, mumps, rubella and chickenpox (MMRV) is associated ... to 2-year-old children compared with same-day administration of the ... varicella (V) vaccine for chicken pox, according to a ... the journal Pediatrics . A febrile seizure is ...
Cached Medicine News:Health News:Endometriosis has a significant effect on women's work productivity, first 2Health News:Endometriosis has a significant effect on women's work productivity, first 3Health News:National Council Applauds Rep. Tonko for Seeking Strict Enforcement of Mental Health Parity Law – July 1, 2010 Deadline Approaching 2Health News:School-Based Efforts May Help Curb Obesity in High-Risk Kids 2Health News:School-Based Efforts May Help Curb Obesity in High-Risk Kids 3Health News:Life Line Screening Applauds Rep. Paulsen on P.A.D. Resolution 2Health News:QuickMedical Open House and Benefit for Seattle Children's Hospital A Resounding Success 2Health News:QuickMedical Open House and Benefit for Seattle Children's Hospital A Resounding Success 3Health News:Combination MMRV vaccine linked with 2-fold risk of seizures 2Health News:Combination MMRV vaccine linked with 2-fold risk of seizures 3
... dot-blot assay system combining microwell EIA and ... antigen set at a clinically meaningful cutoff ... detected using the same reagent system used ... antigens detected in Auto 4 detecting the ...
... The ImmunoDOT Autoimmunity Screening Panel 6 is ... and detection of autoantibodies against various specific ... and Scl-70) in serum, and is used ... systemic lupus erythematosus (SLE), mixed connective tissue ...
... Cardiolipin Antibody (IgM) Test is ... the quantitative detection of antibodies ... and is used as an ... of thrombosis in individuals with ...
The Invacare Pulse Oximeter provides fast, reliable SpO2 and pulse-rate measurements on any patient from infant to adult. It's designed for simple, accurate spot-checking and is a member of a full-li...
Medicine Products: