Navigation Links
Amylin to Present Data Showing Investigational Metreleptin Treatment Led to Long-Term Improvements in Diabetes and Lipid Control in Patients with Lipodystrophy
Date:4/15/2011

therapy to market."

Study Findings

The findings involve an analysis of 55 lipodystrophy patients who received metreleptin treatment – the largest lipodystrophy cohort reported to date. At baseline, 75 percent of patients had diabetes and were not achieving adequate glycemic control (A1C greater than or equal to 7 percent), and 75 percent of patients had hypertriglyceridemia (triglycerides greater than or equal to 200 mg/dL). Metreleptin treatment resulted in robust reductions from baseline in both measures, an effect that was evident within four months post treatment initiation and sustained for up to several years of treatment. In patients with diabetes, mean A1C decreased from 9.4 percent at baseline to under 7.0 percent at year three; in patients with hypertriglyceridemia at baseline, median triglyceride concentrations decreased from 500 mg/dL at baseline to under 200 mg/dL at year three.

Adverse events were generally consistent with known co-morbid conditions of lipodystrophy (pancreatitis, proteinuria, autoimmune/chronic hepatitis) or expected pharmacological effects of metreleptin (weight loss or insulin-induced hypoglycemia in the setting of improved insulin sensitivity in patients on high doses of insulin).

About Lipodystrophy

Lipodystrophy syndromes are characterized by abnormalities in adipose (fat) tissue distribution. Because patients with lipodystrophy do not have enough fat tissue, they typically also have a deficiency of leptin, a hormone secreted by fat cells that plays a key role in regulating metabolism. Beginning typically in childhood or adolescence, patients affected by lipodystrophy experience a loss of subcutaneous fat, which can result in multiple, often severe metabolic abnormalities, including extreme insulin resistance, very high triglyceride levels, difficult-to-control diabetes and hepatic steatosis (excess fat accumulation in the liver). These abnormalities put patients at a high r
'/>"/>

SOURCE Amylin Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity
2. Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society
3. Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly
4. Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009
5. Amylin Pharmaceuticals Reports Third Quarter Financial Results
6. Amylin Pharmaceuticals and Eli Lilly and Company Statement on FDAs BYETTA(R) (Exenatide) Injection Update
7. Amylin Pharmaceuticals to Present at the 18th Annual Credit Suisse Healthcare Conference
8. Amylin Pharmaceuticals to Webcast Year-End Financial Results
9. Amylin Highlights 2010 Corporate Priorities at J.P. Morgan Healthcare Conference
10. Amylin and Takeda Announce Decision to Advance Development of Pramlintide/Metreleptin Combination Treatment for Obesity
11. Amylin Pharmaceuticals to Present at The Barclays Capital 2010 Global Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... EMERYVILLE, Calif. , Sept. 17, 2014 /PRNewswire/ ... newest data analytics solution that brings complete visibility ... minimize risks in an ever-evolving reimbursement landscape. Powered ... Integrity brings transparency to the critical point between ... operations impact revenue. The solution will improve revenue ...
(Date:9/17/2014)...   myMatrixx, a pharmacy and ancillary medical benefit manager ... magazine has awarded myMatrixx with a "Best Places to ... a row. Best Places to Work ... the Best Companies Group.  The competition, which involves months ... privately-held insurance industry companies with at least 25 employees ...
(Date:9/17/2014)... Women everywhere know how frustrating a vaginal ... they,re often also embarrassing and have a way of ... ( http://ph-defense.com ) is a new, over-the-counter product designed ... product. Odor, discharge, and discomfort or ... In many cases, the cause of such problems can ...
Breaking Medicine Technology:MedeAnalytics Unveils New Revenue Integrity Solution to Support the Transition to Value-Based Healthcare 2MedeAnalytics Unveils New Revenue Integrity Solution to Support the Transition to Value-Based Healthcare 3myMatrixx Honored with "Best Places to Work in Insurance" Award 2New Product from Vireo Systems: pH-D Feminine Health Support 2
... Trial for the Treatment of Pediatric Eosinophilic Esophagitis , ... Cephalon, Inc . (Nasdaq: CEPH ) and ... announced that the companies have signed an agreement providing ... stock of Ception. Under the terms of the ...
... of treatment, RAD001 halted tumor growth in 55% of ... Based on these promising data, Novartis will initiate a ... patients- Gastric cancer is the second leading cause of ... occurring in East AsiaEAST HANOVER, N.J., Jan. 13 ...
Cached Medicine Technology:Cephalon Signs Option Agreement to Acquire Ception Therapeutics 2Cephalon Signs Option Agreement to Acquire Ception Therapeutics 3Cephalon Signs Option Agreement to Acquire Ception Therapeutics 4RAD001 Phase II Trial Results Positive in Patients with Advanced Gastric Cancer After Failure of One or More Prior Treatments 2RAD001 Phase II Trial Results Positive in Patients with Advanced Gastric Cancer After Failure of One or More Prior Treatments 3RAD001 Phase II Trial Results Positive in Patients with Advanced Gastric Cancer After Failure of One or More Prior Treatments 4RAD001 Phase II Trial Results Positive in Patients with Advanced Gastric Cancer After Failure of One or More Prior Treatments 5RAD001 Phase II Trial Results Positive in Patients with Advanced Gastric Cancer After Failure of One or More Prior Treatments 6
(Date:9/17/2014)... UWDress.com, an innovative company that provides many kinds of ... its 2014 empire waist evening dress collection ... sale for these new and beautiful products. All of ... 15 to 65 percent off. , It is ... wear materials. Its elegant items include gold empire waist ...
(Date:9/17/2014)... 18, 2014 iFitDress.com, a renowned wedding dress ... petite evening dresses . All these outfits are now ... discounted shipping costs. , “iFitDress.com is a professional company ... We are now busy selling our new collection of petite ... an order above $800 can get free shipping. All these ...
(Date:9/17/2014)... Columbus, Ohio (PRWEB) September 18, 2014 ... cycle management services nationwide, announces today that they ... Fort Wayne Radiology (FWRadiology) in Fort Wayne, Indiana. ... range of billing services encompassing their proprietary suite ... Technology (EBT). EBT improves radiology billing and ...
(Date:9/17/2014)... As kinship care continues to be a primary ... their parents, emphasis on kinship care policy, practice, and ... supports for kinship caregivers and families. The Child ... is being held this week in Louisiana to highlight ... and service development for kinship caregivers, and identifies areas ...
(Date:9/17/2014)... been reserved for the very healthy. Astronauts are ... physical and psychological standards to prepare them for ... commercial spaceflight, average people can now fly for ... little information about what medical conditions or diseases ... environment, as most medical conditions have never been ...
Breaking Medicine News(10 mins):Health News:2014 Empire Waist Evening Dress Collection Now Unveiled At UWDress.com 2Health News:Elegant Petite Evening Dresses Introduced By Renowned Supplier iFitDress.com 2Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 2Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 3Health News:Arizona’s Children Association Kinship Service Providers Invited to Present at the CWLA National Conference 2Health News:Space: The final frontier… open to the public 2
... , , , , ... Month by enhancing the support services already available to its group life ... affected by the loss of a loved one - The Healing ... (written by Ellen Sabin and published by Watering Can Press). , ...
... young children , FRIDAY, Sept. 4 (HealthDay News) -- Since ... for complications from the H1N1 swine flu, U.S. health officials ... the virus in early childhood programs, such as day-care centers ... take the flu seriously, children less than 5 years old ...
... , , LOS ANGELES, Sept. 4 ... health insurance , Healthcare Reform is a TOP PRIORITY for the County,s working ... , On what is the eve of Congress, return to ... a creative approach to learn more about the importance of healthcare reform and ...
... PARK, Ill., Sept. 4 For the fourth consecutive year, Abbott (NYSE: ... Launch a Career" by BusinessWeek magazine. The list highlights companies ... Abbott moved up to No. 13, and was once again the top-ranked health ... every year since BusinessWeek initiated the list in 2006. , ...
... should be as safe as that for seasonal flu, officials ... public concern that H1N1 vaccines being tested might have unforeseen ... the shots seem safe. , "There have been no red ... National Institute of Allergy and Infectious Diseases, told HealthDay ...
... NEW HAVEN, Conn., Sept. 4 Rib-X Pharmaceuticals, Inc., a ... novel antibiotics for the treatment of acute care antibiotic-resistant infections, ... as Chief Business Officer. In his new role, Mr. Kassberg ... Mr. Kassberg, age 49, joins Rib-X from Proteolix, ...
Cached Medicine News:Health News:Anthem Life Offers The Healing Book to Help Young Life Insurance Beneficiaries Cope with Losing a Loved One 2Health News:U.S. Issues Swine Flu Guidelines for Day-Care Programs 2Health News:U.S. Issues Swine Flu Guidelines for Day-Care Programs 3Health News:Labor Day Event to Offer Angelenos Unique Opportunity to Learn About Healthcare Reform and Send a Strong Message to Washington D.C.! 2Health News:Abbott Again Named One of the 'Best Places to Launch a Career' by BusinessWeek 2Health News:Abbott Again Named One of the 'Best Places to Launch a Career' by BusinessWeek 3Health News:Swine Flu Vaccine Seems Safe: Experts 2Health News:Swine Flu Vaccine Seems Safe: Experts 3Health News:Rib-X Pharmaceuticals, Inc. Appoints Tom Kassberg Chief Business Officer 2
Sealing tape, white Rayon, breathable, NS...
Amplification Tape 96 featuring 3M adhesive technology. Good optical quality. Minimal autofluorescence. Certified RNase and DNase free....
Sealing tape featuring 3M adhesive technology. Compatible with DMSO. Good optical quality. Minimal autofluorescence....
Thermal Seal, Clear, Bulk...
Medicine Products: