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Amsterdam Molecular Therapeutics Receives Opinion on Glybera(R) Marketing Authorisation Application
Date:6/23/2011

reak down large chylomicron molecules, the accumulation of which, after intake of dietary fat, seems to be responsible for the occurrence of pancreatitis in LPLD patients. AMT is initiating study CT-AMT-011-04 to examine further how already treated patients handle chylomicrons over time. In addition, AMT will continue to collect follow up data on pancreatitis incidence. AMT's available funds will support its existing operations beyond the completion of the re-examination process into 2012.

"Based on communication from EMA, we understand that our technology platform using adeno-associated virus (AAV) vectors is approvable," Mr. Aldag added. "While we pursue the re-examination of Glybera, we will also continue development of other products in our pipeline such as hemophilia B and GDNF gene therapy for Parkinson's disease and Huntington's disease. We will also continue our preparations for registrations in Canada and the US."

For investors, AMT will conduct a conference call at 9:00 AM CET on June 24, 2011. To participate in the conference call, please call one of the following telephone numbers 15 minutes prior to the event, using access code 2788745: +44-(0)20-7136-2054 for the UK; +1-718-247-0881 for the US; and + 31-(0)20-201-5468 for the Netherlands. A pdf version of the presentation is available in the news and investor relations sections of the corporate website. Following the presentation, the lines will be opened for a question and answer session. A replay of the call will be available following the event.

About Glybera

AMT has developed Glybera as a treatment for patients with the genetic disorder lipoprotein lipase deficiency. LPLD is an orphan disease for which no treatment exists today. The disease is caused by mutations in the LPL gene, resulting in highly decreased or absent activity of LPL protein in patients. This protein is needed in order to break down large fat-carrying particles that circ
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SOURCE Amsterdam Molecular Therapeutics B.V
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