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The ideal composition of intravenous lipid emulsion

nd anti-oxidants in intravenous nutrition may successfully modulate inflammation and immunosuppression.

The creation of soybean oil-based lipid emulsions, for use in parenteral nutrition, was an important landmark in the science of nutritional treatment of surgical patients and individuals requiring critical care.

The primary importance of this development was that the energy requirements of the patient could be met without the metabolic burden imposed by high-level glucose infusion in situations of respiratory distress and insulin insensitivity. In soybean oil-based emulsions the ratio of ù-6 to ù-3 fatty acids is approximately 7:1. These classes of fatty acids compete for inclusion in cell membranes and result in the production of lipid mediators of differing potency.

The authors concludes on the note that recent studies suggest that increasing the ratio of ù-3 to ù-6 fatty acids and raising the monounsaturated fatty acid (MUFA) content of intravenous lipid emulsion is beneficial. MUFAs exert a neutral effect on metabolism. Thus ideal lipid solutions can be designed by adjustment of the ratio of ù-3, ù-6 and MUFAs
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