Navigation Links
New Research May Be Useful for Developing Drugs for HIV and Cancer

Researchers of Virginia Commonwealth University Massey Cancer Center have discovered a process of restraining a set of proteins, using small molecules containing platinum, which causes HIV and cancer. //

The breakthrough will be beneficial for the researchers to develop new drugs to fight HIV or cancer by selectively targeting proteins known as zinc fingers.

In the May 30 issue of the journal Chemistry & Biology, researchers reported that a zinc finger protein, known as HIV NCp7, can be inhibited when it is exposed to a platinum complex. They observed that when the HIV NCp7 protein interacts with platinum, the zinc portion of the molecule is ejected from the protein chain. This causes the protein to lose its tertiary structure or overall shape. For these molecules, shape is an important property that enables the protein to carry out certain biological functions.

The process, active site displacement, involved design of a platinum drug with higher affinity for the protein peptide backbone, thus eliminating the zinc from its active site.

In the specific case discussed in the paper, the HIV NCp7 protein is responsible for the proliferation of the HIV virus. If researchers can inhibit the action of this zinc finger protein, they can stop the spread of the virus.

'When we target specific viruses with drugs, over time patients can become resistant to treatment and the drug becomes ineffective. Therefore, novel biological processes and proteins are attractive targets for antiviral drug development,' said lead author Nicholas Farrell, Ph.D., professor and chair in the Department of Chemistry at VCU and a member scientist with the VCU Massey Cancer Center.

According to Farrell, these study findings may also one day be applied to the selective targeting of zinc fingers involved in the biological processes responsible for the spread of cancer. By applying the concept to development of anticancer drugs, th
'"/>




Page: 1 2

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Research May Useful for Developing Drugs for HIV and Cancer

(Date:5/23/2015)... On May 13, Nithyananda Yoga Foundation organized ... power learned through meditation and initiation at Special Holistic ... , Yogamaatha, a nine-year-old girl from North Carolina, stunned ... attending the 2015 Business Advocacy Summit at Capitol Hill ... , In a demonstration that lasted three hours, Yogamaatha ...
(Date:5/23/2015)... NY (PRWEB) May 23, 2015 On ... that, “the company has been the target of ... a part of the company’s ongoing Information Technology (IT) ... health insurers.” , The most notable attack on ... when Anthem Inc., the nation’s second largest health insurer, ...
(Date:5/23/2015)... Chicago, IL (PRWEB) May 23, 2015 A ... of medical equipment from hospitals, surgery centers and other medical ... will be sold including endoscopy, lab, radiology, surgery, anesthesia, exam ... place Wednesday, May 27 and Thursday, May 28 starting at ... warehouse located at 1400 N. 25th Avenue, Melrose Park, IL ...
(Date:5/23/2015)... Injury lawyer Steven H. Heisler commented today ... the Maryland legislature but which has not been signed to ... HB 449 with overwhelming bipartisan support on April ... into law. This bill ensures that fracking is prohibited in ... the danger of fracking to our water supplies and the ...
(Date:5/22/2015)... The American College of Traditional Chinese Medicine ... will hold a webinar on the updates of the ... Classical Chinese Medicine. , Webinar – First Professional Doctorate ... Dean of Clinical Education, will lead this webinar in ... program. ACTCM is currently developing this degree program based ...
Breaking Medicine News(10 mins):Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4Health News:Over 5,200 Lots of Medical Equipment Will Be Sold by Live Auction 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:ACTCM Announces Upcoming June Events 2
... , WEDNESDAY, Jan. 26 (HealthDay News) -- Diabetes now ... million people have what doctors call "prediabetes," according to 2011 ... and Prevention. Prediabetes, which the CDC says affects 35 ... are higher than normal but not yet high enough to ...
... researchers at Princess Margaret Hospital (PMH) have discovered ... can sensitize diseased tissue to radiation and chemotherapy, ... with head and neck cancer. The findings, ... ( http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.3001922 ) are significant because they ...
... FAIRFAX, Va.The Journal of Vascular and Interventional ... Society of Interventional Radiologyannounced several major changes for ... this minimally invasive medical specialty and its lead ... focuses on critical and cutting-edge medical, minimally invasive, ...
... CHAPEL HILL, N.C. -- New research from the University of ... key molecular mechanism in nerve fibers that ensures the rapid ... 27, 2011 in the journal Neuron . Our ... sheath, the myelin, made up of fatty white matter to ...
... caregiving for their preschool children may experience more conflict ... caregiver, according to a new study. Results showed ... when the father spent more time playing with their ... like preparing meals for the child or giving baths, ...
... for workers in highly hazardous jobs is most effective at ... to 40 years of research. However, less engaging training can ... when jobs are less dangerous. More interactive types ... the threats they face on the job and avoid making ...
Cached Medicine News:Health News:105 Million in U.S. Have Diabetes or Prediabetes, CDC Says 2Health News:105 Million in U.S. Have Diabetes or Prediabetes, CDC Says 3Health News:Princess Margaret Hospital researchers identify a key enzyme that affects radiation response 2Health News:Journal of Vascular and Interventional Radiology debuts new look, reflects global impact 2Health News:Journal of Vascular and Interventional Radiology debuts new look, reflects global impact 3Health News:Membrane molecule keeps nerve impulses hopping 2Health News:Membrane molecule keeps nerve impulses hopping 3Health News:Sharing child caregiving may increase parental conflict, study finds 2Health News:Sharing child caregiving may increase parental conflict, study finds 3Health News:Highly interactive training helps workers in dangerous jobs avoid deadly mistakes 2
(Date:5/22/2015)... 2015 Today, Rhodes Pharmaceuticals L.P. announced that ... indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) ... The announcement comes just one ... U.S. Food and Drug Administration (FDA). ... methylphenidate capsule with an onset of effect of ...
(Date:5/22/2015)...  China Nepstar Chain Drugstore Ltd. (NYSE: NPD ) ... in China based on the ... of Mr. Fuxiang Zhang as the Company,s ... Rebecca Yingnan Zhang has been appointed as ... effective immediately. Meanwhile, Ms. Zhang resigned from the position ...
(Date:5/21/2015)... , May 21, 2015 ... the addition of the "Market Assessment of ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... the respiratory imaging diagnostics market in ... Europe . The service provides detailed analysis ...
Breaking Medicine Technology:Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3United States and Europe Respiratory Diagnostics Market Assessment 2015 2
... the region,s premier provider of diagnostic imaging services, is ... Hospital Council of Western Pennsylvania,s newest business partner. ... the expertise of a large, highly-skilled team of imaging ... area. By partnering with FRG, community hospitals are able ...
... OAKS, Calif., Oct. 18 Amgen (Nasdaq: ... Trial to Reduce Cardiovascular Events with Aranesp® Therapy) and ... of erythropoiesis-stimulating agents (ESAs) for chronic renal failure (CRF) ... Administration,s (FDA) Cardiovascular and Renal Drugs Advisory Committee (CRDAC). ...
Cached Medicine Technology:Hospital Council of Western Pennsylvania Announces Foundation Radiology Group as Newest Partner 2Amgen to Review Results From TREAT and Propose Updates to ESA Labeling for Chronic Renal Failure Patients at an FDA Advisory Committee Meeting Today 2Amgen to Review Results From TREAT and Propose Updates to ESA Labeling for Chronic Renal Failure Patients at an FDA Advisory Committee Meeting Today 3Amgen to Review Results From TREAT and Propose Updates to ESA Labeling for Chronic Renal Failure Patients at an FDA Advisory Committee Meeting Today 4Amgen to Review Results From TREAT and Propose Updates to ESA Labeling for Chronic Renal Failure Patients at an FDA Advisory Committee Meeting Today 5Amgen to Review Results From TREAT and Propose Updates to ESA Labeling for Chronic Renal Failure Patients at an FDA Advisory Committee Meeting Today 6Amgen to Review Results From TREAT and Propose Updates to ESA Labeling for Chronic Renal Failure Patients at an FDA Advisory Committee Meeting Today 7Amgen to Review Results From TREAT and Propose Updates to ESA Labeling for Chronic Renal Failure Patients at an FDA Advisory Committee Meeting Today 8
Suction Catheter Trays with Sterile Water...
TOUCH-TROL Suction Catheters Kits, Sterile without Solution...
Sterile, Coil Packed Suction Catheter Mini Tray with (2) Walleted SAFESKIN PURPLE NITRILE Latex-Free Exam Gloves...
Clear plastic sleeve envelopes a plastic suction catheter. Sleeve slides over exudate to reduce potential clinician contact....
Medicine Products: