Navigation Links
New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs

the EGFR gene. A new group of so-called irreversible EGFR inhibitors that permanently bind to the protein are currently being tested in clinical trials. But what leads to other cases of resistance has been unknown, and the current study was designed to discover additional mechanisms.

To do so, the investigators modeled in a laboratory setting what happens in lung cancer patients; they used a line of NSCLC cells with the sensitizing EGFR mutation and created a cell line resistant to treatment with Iressa. In a number of experiments comparing the resistant line with still-sensitive cells, they focused on the cell signalling pathway controlled by EGFR. In earlier research, Engelman and colleagues had found that the growth signal that starts with EGFR works through a related protein called ERBB3.

The current study showed that, in some of the resistant cells, ERBB3 is activated by amplification of a different oncogene called MET, in essence bypassing the blockage of EGFR. Analysis of samples from patients whose tumors became resistant after initially responding to Iressa revealed that MET was amplified in resistant samples from 4 of 18 patients. Although treating resistant cell lines with either Iressa or a MET inhibitor did not stop tumor growth, treatment with both agents did induce cell death.

"This method of reactivating the EGFR signalling pathway with MET may be a common resistance mechanism in other therapies that target receptors of the ERBB family, which are used against breast cancer, colon cancer, head and neck cancer, and the brain tumor glioblastoma multiforme," says J?nne, who is an assistant professor of Medicine at Harvard Medical School (HMS). Engelman is an HMS instructor of Medicine.

"Our results suggest that, when patients' tumors become resistant, repeat biopsies to identify which resistance mechanism is involved will be critical and could help us develop effective therapies for those resistant tumors,
'"/>




Page: 1 2 3

Related medicine news :

1. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
2. New Gene Silencing Mechanism To Prevent Cancer
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Self-defense Mechanism of food borne bugs found
5. Specific Immune Mechanism against DNA viruses
6. A New Focus For The Mechanism Of Nerve Growth
7. Mechanism of Stem Cell Regulation Identified
8. Cancer-Killing Viruses Employ Multiple Mechanisms
9. Regulatory Mechanism for Tumor Suppressor Protein Identified
10. Study Identifies Mechanism Which May Help Tamoxifen Work Better
11. Genetic Mechanism Helps Explain Chronic Pain Disorders
Post Your Comments:
(Date:4/26/2015)... Indiana (PRWEB) April 26, 2015 Indiana ... service provider announces that Brotherhood Mutual Insurance Company has ... Armstrong, Manager of Network Infrastructure at Brotherhood Mutual Insurance ... and the service reliability Brotherhood Mutual needed. ... diversity, and IFN worked with us to ensure we ...
(Date:4/26/2015)... FL (PRWEB) April 26, 2015 A ... pieces of medical equipment from hospitals, surgery centers and ... of equipment will be sold including radiology, surgery, endoscopy, ... live auction will take place Tuesday, April 28th starting ... Lauderdale warehouse located at 5025 North Hiatus Rd., Sunrise, ...
(Date:4/26/2015)... In an article published last month ... head-neck biomechanics occurring during the use of handheld electronic devices ... determine that use of a tablet increases mechanical demand on ... - more than when the neck is in a neutral ... but pointing out the potential hazards of overuse of mobile ...
(Date:4/26/2015)... MidSouth Pain Treatment Center has announced ... Treatment Center is a comprehensive pain management center including ... two ambulatory surgery centers in Germantown and Southaven, and ... , Dr. Michael Steuer , founder of MidSouth ... people, and when I discovered that I could make ...
(Date:4/25/2015)... California (PRWEB) April 26, 2015 Avid ... search for original 1965 Rolling Stones Greensboro Coliseum concert posters. ... was part of the Stone's Second American Tour. ... Globe Poster Company out of Baltimore, Maryland. This poster ... the northeast and southern cites. Globe uses garish lettering ...
Breaking Medicine News(10 mins):Health News:Brotherhood Mutual Insurance Company Selects Indiana Fiber Network, LLC for Fiber Transport Service 2Health News:Brotherhood Mutual Insurance Company Selects Indiana Fiber Network, LLC for Fiber Transport Service 3Health News:Centurion Service Group to Auction off 1,200 Lots of Medical Equipment 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 4Health News:Growing Pains for MidSouth Pain Treatment Center 2
... Enjoying the eating process without focus on dietary restrictions ... according to researchers who have unveiled a new and ... Competence Model, also known as ecSatter, was created by ... of Secrets of Feeding a Healthy Family, Kelcy ...
... Significant Data Detailed at a Late-Breaking Presentation at ... ... 18 Iomai,Corporation (Nasdaq: IOMI ) today announced that travelers ... be sickened as compared with travelers who receive a placebo,according to ...
... (NYSE: AGP ) today announced that it ... and Medicare Services (CMS) to offer both,Medicare Advantage ... plans to address the specialized needs of seniors ... currently coordinates care for approximately 5,000,individuals through Medicare ...
... N.C., Sept. 18 Contact centers have been,transformed ... movement,that has reps selling while conducting ongoing customer ... skills are critical for,converting service reps to sales ... Practices, LLC. Ninety-eight percent of the 57 ...
... Researchers at the University of Pennsylvania School of ... Quality (AHRQ) have developed a framework to help ... challenges of implementing health information technology (HIT) by ... and quality. , As documented in a ...
... WASHINGTON, Sept. 18, 2007 -- A long-term study found ... patients with life-threatening diseases, such as leukemia and lymphoma, ... Further, males are likely to recover from these changes ... compromised. In addition, neither male nor female long-term cancer ...
Cached Medicine News:Health News:Nutrition model stresses positive experience of eating 2Health News:Iomai Patch-Based Vaccine Cut Rate of Travelers' Diarrhea by 75 Percent in Phase 2 Field Study 2Health News:Iomai Patch-Based Vaccine Cut Rate of Travelers' Diarrhea by 75 Percent in Phase 2 Field Study 3Health News:Iomai Patch-Based Vaccine Cut Rate of Travelers' Diarrhea by 75 Percent in Phase 2 Field Study 4Health News:Iomai Patch-Based Vaccine Cut Rate of Travelers' Diarrhea by 75 Percent in Phase 2 Field Study 5Health News:AMERIGROUP Contracts with Federal Government to Offer Medicare Advantage Health Plans in Seven States 2Health News:AMERIGROUP Contracts with Federal Government to Offer Medicare Advantage Health Plans in Seven States 3Health News:Service-to-Sales Transformation at Contact Centers Hinges on Soft Skills 2Health News:Unanticipated consequences of health-care information technology 2Health News:Sexual function affected by stem cell transplant according to long-term study 2Health News:Sexual function affected by stem cell transplant according to long-term study 3Health News:Sexual function affected by stem cell transplant according to long-term study 4
(Date:4/24/2015)...  Elekta has CE marked the latest version (v5.10) ... enabling European clinics to deliver a sophisticated radiation therapy ... 3D planning, IMRT, VMAT and stereotactic planning – all ... Monaco ® v5.10 provides significant planning ... in 3D planning as well as the addition of ...
(Date:4/23/2015)... April 23, 2015  ResMed Inc. (NYSE: RMD ... 31, 2015.  Revenue for the quarter was $422.5 million, ... March 31, 2014 (a 13 percent increase on a ... increase of 1 percent compared to the quarter ended ... quarter were $0.64, an increase of 2 percent compared ...
(Date:4/23/2015)... April 23, 2015 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2015 on Thursday, April 30, 2015, after ... president and chief executive officer, will host a conference call ... (ET)/2:00 p.m. Pacific Time (PT). The press ... can be accessed through a link that is posted on ...
Breaking Medicine Technology:Elekta CE marks for Monaco v5.10 treatment planning system 2ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 11ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 12ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 13Nektar to Announce Financial Results for the First Quarter 2015 on Thursday, April 30, 2015, After Close of U.S.-Based Financial Markets 2
... 5, 2011 Express Scripts contributed more than $226 ... economic analysis of the company,s data by a university ... The economic impact study, presented today to state economic ... support 2,665 direct and indirect jobs in the state. ...
... NeuroVasx announced today that the FDA ... Humanitarian Use Device (HDE) for the treatment of large, ... most difficult to treat.  The HDE allows for the ... the U.S. (Logo: http://photos.prnewswire.com/prnh/20110405/CG77724LOGO ) ...
Cached Medicine Technology:Express Scripts Injects $226 Million Into Arizona Economy, Study Finds 2NeuroVasx Receives FDA Approval for cPAX Aneurysm Treatment System 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: