Navigation Links
New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs

An international research team, led by investigators from the Massachusetts General Hospital (MGH) Cancer Center and Dana-Farber Cancer Institute (DFCI), has found// a new way that some lung tumors become resistant to treatment with targeted therapy drugs like Iressa and Tarceva. Their report, which will appear in the journal Science and is receiving early online release, describes a totally new resistance mechanism that may apply to many types of cancer. It also suggests a treatment strategy for patients with these resistant tumors.

"We found that, for about 20 percent of patients with tumors that become resistant to Tarceva or Iressa, resistance is caused by the genetic activation of an oncogene that is not the normal target of the drug, which is something that has never been seen before," says Jeffrey Engelman, MD, PhD, scientific director of the MGH Center for Thoracic Cancers, the paper's lead author.

"Importantly, we also identified a potential new way to treat these resistant tumors with combination therapy directed against both protein targets," adds Pasi A. J?nne, MD, PhD, of the Lowe Center for Thoracic Oncology at DFCI, the study's senior author.

Drugs like Iressa (gefitinib) and Tarceva (erlotinib) are used to treat advanced non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths in the U.S. They act by blocking the epidermal growth factor receptor (EGFR), a molecule on the surface of cancer cells. In 2004 research teams from MGH and DFCI found that only tumors in which the EGFR gene has been mutated in a way that magnifies the cells' response to the growth factor, a process that fuels tumor growth, were sensitive to treatment with these drugs.

Although tumors that respond to EGFR inhibitors do so rapidly and dramatically, eventually the tumors become resistant and resume growing. About half the time, a secondary mutation that interferes with the drugs' binding to the receptor develops within
'"/>




Page: 1 2 3

Related medicine news :

1. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
2. New Gene Silencing Mechanism To Prevent Cancer
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Self-defense Mechanism of food borne bugs found
5. Specific Immune Mechanism against DNA viruses
6. A New Focus For The Mechanism Of Nerve Growth
7. Mechanism of Stem Cell Regulation Identified
8. Cancer-Killing Viruses Employ Multiple Mechanisms
9. Regulatory Mechanism for Tumor Suppressor Protein Identified
10. Study Identifies Mechanism Which May Help Tamoxifen Work Better
11. Genetic Mechanism Helps Explain Chronic Pain Disorders
Post Your Comments:
(Date:11/23/2014)... November 23, 2014 This evaluation ... as its significance, programs and manufacturing technological innovation. ... suppliers major market gamers in information. In this ... specifications, prospective, manufacturing value, and 2009-2014 market shares ... evaluation symbolizes the globally and Chinese suppliers finish ...
(Date:11/23/2014)... 23, 2014 Asher Milgrom, is ... & Wellness was recently featured on International ... president and CEO of American Medical Aesthetics & Wellness, ... received a full scholarship to attend an M.D./Ph.D program ... at the University of Chicago, where his field of ...
(Date:11/23/2014)... 2014 BambooFlooringChina.com , the world’s leader ... strand woven bamboo flooring collection. Now, the business is ... company’s CEO, the promotion is valid until Dec. 20, 2014. ... a smooth and dust-free surface, which makes it very easy ... industry, the company wants to make its website the best ...
(Date:11/22/2014)... 23, 2014 PrettyTailor , an ... a new big promotion. Customers can buy new dresses ... customers can visit its website. , As a matter ... occasion dresses. It mainly provides four types of wedding ... and flower girl dresses. It also provides a variety ...
(Date:11/22/2014)... (PRWEB) November 23, 2014 Today, Dylan ... its new collection of wedding dresses; the business offers ... other related accessories for ladies worldwide, allowing them to ... manager of the company, this new collection of chic ... launch. Moreover, they are offered at discounted rates now. ...
Breaking Medicine News(10 mins):Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 2Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 3Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 4Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 2Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 3Health News:Asher Milgrom Is the Founding Doctor of AMA Skincare and Is Featured in the International Business Times 4Health News:Click Strand Woven Bamboo Flooring From Famous Bamboo Flooring Company BambooFlooringChina.com 2Health News:Customers Are Welcome to Shop at PrettyTailor.com 2Health News:Dylan Queen Introduces Its New Wedding Dresses 2
... Corporation,(Nasdaq: PODD ), the leader in patch pump ... appointment of Sally W.,Crawford to its board of directors. ... operating officer of Healthsource Inc., a managed care,organization. She ... firm in life sciences, on Insulet,s board of directors., ...
... lost to HIV/AIDS in South Africa from 2000 and ... program was not implemented, assert researchers from the Harvard ... online by the Journal of Acquired Immune Deficiency ... estimated 35,000 babies were born with HIV during that ...
... Sechrist Industries, Inc.,announced that it has been ... Partners, L.P., the group purchasing unit of ... 2008 through September 30, 2010, allows,Sechrist to ... hospitals,and 53,000 additional healthcare sites., (Logo: ...
... work with federal and state health agencies,to increase ... themselves on MRSA and C. diff prevention, ... Authority supports "International Infection Prevention,Week," October 19-25, 2008 ... and the public from healthcare-associated infections., The ...
... Members Report Some Payers Scaling Back Chronic Disease,Initiatives, ... Continuum,Alliance, responding to reports that many Americans are ... called for renewed vigilance,in the fight against chronic ... some forms of belt-tightening make sense in tough ...
... Psychemedics,Corporation (Nasdaq: PMD ) today announced that Raymond ... Ray will be responsible for all internal and ... and planning,activities necessary for the company,s continued growth. Ray ... 2005, Ray has served as Director of International Finance ...
Cached Medicine News:Health News:Sally W. Crawford Joins Insulet's Board of Directors 2Health News:Sally W. Crawford Joins Insulet's Board of Directors 3Health News:Sally W. Crawford Joins Insulet's Board of Directors 4Health News:Researchers estimate lives lost due to delay in antiretroviral drug use for HIV/AIDS in South Africa 2Health News:Researchers estimate lives lost due to delay in antiretroviral drug use for HIV/AIDS in South Africa 3Health News:Researchers estimate lives lost due to delay in antiretroviral drug use for HIV/AIDS in South Africa 4Health News:Sechrist Industries, Inc. Awarded Premier Sole-Source Contract for Hyperbaric Oxygen Chambers 2Health News:Patient Safety Authority Supports 'International Infection Prevention Week' 2Health News:Patient Safety Authority Supports 'International Infection Prevention Week' 3Health News:Nation's Economic Downturn Threatens Continuity of Care for Chronic Conditions 2Health News:Raymond J. Ruddy Joins Psychemedics Corporation As Top Financial Officer 2
(Date:11/21/2014)... Ohio and MELVILLE, N.Y. ... CAH ), one of the world,s largest ... HSIC ), the world,s largest provider of ... health and medical practitioners, today announced that the companies ... one of the most comprehensive service and product offerings ...
(Date:11/21/2014)... Nov. 20, 2014  RedRick Technologies, a provider ... reading room environment guidance, has helped the new ... reading room, which may also serve as a ... Medicine. "In line with the ... of Radiology,s Imaging 3.0 ™ initiative, the ...
(Date:11/21/2014)... 20, 2014 Depomed, Inc. (NASDAQ: DEPO ) ... 26 th Annual Healthcare Conference in New York ... conference is scheduled for 8:00 am EST (5:00 am PST) on ... webcast can be accessed via the Investor Relations page of the ... will be archived for 30 days on the company,s website. ...
Breaking Medicine Technology:Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 2Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 3Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 4Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 5RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3Depomed To Present At Piper Jaffray 26th Annual Healthcare Conference 2
... Novavax, Inc. (Nasdaq: NVAX) a clinical-stage ... results from its 2009 H1N1 virus-like particle (VLP) pandemic ... 7th World Health Organization Meeting (WHO) on Evaluation of ... held at the WHO headquarters in Geneva, Switzerland where ...
... Technologies Corporation (Nasdaq: LIFE ), today ... winners of the European Ion Torrent Personal Genome Machine ... http://photos.prnewswire.com/prnh/20110216/MM49339LOGO ) Each scientist will receive an Ion ... Torrent sequencing technology, these scientists will be able to give ...
Cached Medicine Technology:NOVAVAX Presents Final Results from H1N1 Influenza Vaccine Trial at World Health Organization Meeting 2NOVAVAX Presents Final Results from H1N1 Influenza Vaccine Trial at World Health Organization Meeting 3NOVAVAX Presents Final Results from H1N1 Influenza Vaccine Trial at World Health Organization Meeting 4NOVAVAX Presents Final Results from H1N1 Influenza Vaccine Trial at World Health Organization Meeting 5Life Technologies Announces Visionary Winners of the Ion Torrent PGM Grants Program in Europe 2Life Technologies Announces Visionary Winners of the Ion Torrent PGM Grants Program in Europe 3Life Technologies Announces Visionary Winners of the Ion Torrent PGM Grants Program in Europe 4Life Technologies Announces Visionary Winners of the Ion Torrent PGM Grants Program in Europe 5
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: