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Methyl-DNA binding Proteins To Fight Cancer

one that can be used for such diagnostics. The cancer tumor is a highly heterogeneous dynamic system, which requires knowledge of almost the entire genetic profile containing 28,000 genes.

Researchers believe that there are another 10 and 30 key genes that can also serve as tumor characteristic markers. This will save resources and time, sparing the need of analyzing the entire genomic profile.

In cancer therapy, chimeric Kaiso protein could be created. The ordinary Kaiso protein (via DNA methylated binding) inhibits the work of cancer suppressor genes. However, using the same properties of the protein, it is possible to make it reinforce the work of these genes. This is what the researchers are struggling to achieve.

"There are hidden pitfalls here," explains Anna Prokhorchuk, project manager. "It is necessary to make chimeric Kaiso work only to activate cancer suppressor genes, not the other methylated DNA sequences. This is what we are working at in the Bioengineering Centre jointly with American colleagues."


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