Navigation Links
Methyl-DNA binding Proteins To Fight Cancer

Russians researchers are exploring the possibility for using Kaiso protein for early detection of cancer.

They are developing this new approach to treat intestinal cancer at the Bioengineering Centre, Russian Academy of Sciences, //under Anna Prokhorchuk's guidance jointly with American colleagues sponsored by the international CRDF foundation and the Federal Agency for Science and Innovation.

Any cancerous disease changes the genetic landscape - some genes are suppressed and others get activated, resulting in the growth of the tumor and the formation of metastases, and cancer spreads beyond the control of the immune system.

The universal mechanism that regulates genetic activity is DNA methylation, where a methyl group is joined to a section of a molecule. Special methyl-DNA binding proteins spring into action, bond with a section of the methylated DNA and suppress gene activity. One such protein that the researchers are interested in is Kaiso. They assume that this protein plays an important role in the intestine cancer development, and knowledge about it can be used for diagnostics and treatment.

First, the researchers measured the level of expression of the Kaiso protein gene in intestinal tumors in mice and in human patients. The level of expression turned out to be dozens of times higher than that in healthy organs and tissues. ‘Kaiso-zero' mice were then used which were found to be resistant to cancer. The same resistance to cancer was acquired by the mice whose DNA methylation had been suppressed by other methods.

The Kaiso protein can be potentially used for early detection of cancer, as its content in a majority of tumors is much higher than that in human healthy tissue.

Contemporary molecular methods allow the analysis of expression of dozens of genes in the cancerous tissues, and comparison of the resultant picture with the gene portrait of normal cells. Of course, the Kaiso gene is not the only one that can be used for such diagnostics. The cancer tumor is a highly heterogeneous dynamic system, which requires knowledge of almost the entire genetic profile containing 28,000 genes.

Researchers believe that there are another 10 and 30 key genes that can also serve as tumor characteristic markers. This will save resources and time, sparing the need of analyzing the entire genomic profile.

In cancer therapy, chimeric Kaiso protein could be created. The ordinary Kaiso protein (via DNA methylated binding) inhibits the work of cancer suppressor genes. However, using the same properties of the protein, it is possible to make it reinforce the work of these genes. This is what the researchers are struggling to achieve.

"There are hidden pitfalls here," explains Anna Prokhorchuk, project manager. "It is necessary to make chimeric Kaiso work only to activate cancer suppressor genes, not the other methylated DNA sequences. This is what we are working at in the Bioengineering Centre jointly with American colleagues."


'"/>




Related medicine news :

1. Understanding the RNA binding protein and its functions inside the cell
2. Levels Of Blood Proteins May Help Heart Disease Care
3. Cholesterol can be lowered using combination of Soy Proteins and Sterols
4. Neurological Disorders Overcome By Proteins
5. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
6. NR2B Proteins Lead To Chronic Pain
7. Ape Humans? Alterations in Proteins Affects Genes.
8. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
9. Blood Clotting Disorders Linked To Three Proteins
10. Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases
11. Proteins – A New Way to Treat Childrens Muscle Diseas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... ... A. Kevin Spann Insurance, a New York-based firm offering insurance and financial consultation ... drive to raise funds that will benefit the Marine Corps League. , The Marine ... Corpsmen. Working closely with the MCL, the A. Kevin Spann team plans to generate ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu cosmetic and ... website, which launched October 17, 2016, features comprehensive information regarding a wide range ... Visitors and patients can discover the latest clinical dermatology treatments for medical skin ...
(Date:12/7/2016)... ... 07, 2016 , ... Texas Premier Locksmith , a ... by unethical locksmith companies and is urging Search Engines to improve verification methods ... Premier Locksmith, these fraudulent locksmith services take advantage of consumers locked out of ...
(Date:12/7/2016)... ... , ... "ProBrand Flip allows FCPX editors to create unique logo reveals which ... Pixel Film Studios. , ProBrand Flip includes 30 flip book reveal animations. Easily reveal ... a variety of flip book animations. In Addition, users can modify each preset to ...
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen McLaughlin, ... at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years of ... acupuncturists to help patients realize their family building goals. Acupuncture helps fertility ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... -- "Lantus (Insulin Glargine) Biosimilar Clinical Trial & Opportunity Insight" report by ... drug in clinical pipeline. Currently 5 biosimilar version of Lantus are commercially ... Kenya , Czech Republic , ... , Slovakia , United Kingdom ... patent on Lantus expired in 2014. Lantus is the brand name ...
(Date:12/7/2016)... YORK , Dec. 7, 2016 Global ... This report on the global hospital linen supply and ... of this market on a global and regional level. ... forecast for the period between 2015 and 2024 based ... the dynamics of the market along with their impact ...
(Date:12/7/2016)... -- REPORT OBJECTIVES The report "SPF ... on a market segment, based on geography. Market ... the report. The primary objectives of this report ... through detailed segmentation, 2) market size and forecasts, ... market situation, trends, 3) detailed analysis of current ...
Breaking Medicine Technology: