Navigation Links
A New Approach to Manage Opiate Addiction

Withdrawal symptoms like severe pain, nausea, agitation and sweats motivate addicts to continue taking drugs. The findings// of a new study suggest new approaches to reduce withdrawal symptoms.

A new study finds that disrupting the brain's stress-response mechanism exacerbates behavioral withdrawal symptoms in mice, and that giving the mice the hormone corticosterone alleviates those symptoms.

Angelo Contarino of Université Victor Segalen Bordeaux 2 and colleagues published their findings in the February 15, 2007 issue of the journal Neuron, published by Cell Press.

In their studies, the researchers mimicked the pattern of opiate addiction and withdrawal in mice that were genetically deficient in a receptor called CRF1. Receptors are proteins on the cell surface that trigger reactions in the cell when activated.

CRF1 is a trigger for the corticotrophin-releasing factor system in the brain and is an essential protein for coping with stressful events. In mimicking addiction and withdrawal, the researchers gave the mice increasing doses of morphine and then stopped morphine administration to induce withdrawal symptoms.

The researchers found that the CRF1-deficient mice showed more severe and prolonged behavioral symptoms of withdrawal—such as jumping and "wet dog shaking"—when compared with normal mice as had been shown previously. Similarly, when the researchers administered a drug that blocks the receptor in normal mice, they saw the same aggravating effects.

The researchers also detected genetic changes in the brains of the mice, which indicated that the stress-response circuitry in the brain was impaired.

However, Contarino and colleagues found that giving the mice the steroid hormone corticosterone abolished the difference in withdrawal symptoms between the CRF1-deficient and normal mice. The hormone also restored the normal stress-response-related genetic activity in the brain, they found.

"The findings of the present study demonstrate that, like hyperactive stress systems, severe deficiencies in major components of the stress-responsive system may worsen the somatic reactions to drug withdrawal," the researchers concluded.

Source-Eurekalert
PI
'"/>




Related medicine news :

1. New Dietary Approach To Manage Kidney Stones
2. Approaching through Telemedicine benefits patients
3. Gel Offers A More Targeted Approach
4. New Cost Effective Approach To Promote Sun Protection
5. Treatment Of Brain Aneurysms By A New Non-Surgical Approach
6. A New Approach In Treatment Neurogenic Detrusor Overactivity In Children
7. A New Diagnostic Approach To Pediatric Interstitial Lung Disease
8. Lazy Eye Can Be Effectively Treated By New Approach
9. Novel Approach to Identify Protein Links with Genetic Disorder
10. NHS To Be Reformed By Using A Hybrid Approach
11. Two-In One Approach To Prevent Incontinence After Prolapse Surgery
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... DC (PRWEB) , ... February ... ... Siemens Foundation today announced a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop ... The partnership will recruit top students from U.S. universities who will draw ...
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical Therapy Association ... CA at the Anaheim Convention Center. Almost 10,000 physical therapists across the country are ... action, learn more about their chosen field and network with their colleagues. As ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... Leadership Series at Zuckerberg San Francisco General Hospital on April 5-7. The series ... behaviors and create new habits. The workshops cover a broad range of topics, ...
(Date:2/12/2016)... NC (PRWEB) , ... February 12, 2016 , ... AssureVest ... surrounding areas, is initiating a charity drive that will raise funds earmarked to purchase ... John C. Tayloe Elementary School. , “My school is in a low-income area and ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a ... beginning of the latest charity campaign in their community enrichment program. Art Expression ... this worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Feb. 12, 2016  Apellis ... completed a $47.1 million Series D preferred ... Asset Management, Hillhouse Capital Group and venBio ... Venture Investments, AJU IB Investment, and Epidarex ... used to further advance clinical trials in ...
(Date:2/11/2016)... -- The primary goal of this research is to ... usage of liquid biopsy. Key information the survey seeks ... of liquid biopsy adoption amidst future users - Predominantly ... - Sample inflow to conduct liquid biopsy tests - ... so on. - Correlation analysis of sample type and ...
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016  Kindred ... focused on saving and improving the lives of pets, ... Technical Section of the New Animal Drug Application (NADA) ... the pivotal field study (KB0120) of Zimeta for the ... by the Company. --> ...
Breaking Medicine Technology: