Navigation Links
A New Approach to Manage Opiate Addiction

Withdrawal symptoms like severe pain, nausea, agitation and sweats motivate addicts to continue taking drugs. The findings// of a new study suggest new approaches to reduce withdrawal symptoms.

A new study finds that disrupting the brain's stress-response mechanism exacerbates behavioral withdrawal symptoms in mice, and that giving the mice the hormone corticosterone alleviates those symptoms.

Angelo Contarino of Université Victor Segalen Bordeaux 2 and colleagues published their findings in the February 15, 2007 issue of the journal Neuron, published by Cell Press.

In their studies, the researchers mimicked the pattern of opiate addiction and withdrawal in mice that were genetically deficient in a receptor called CRF1. Receptors are proteins on the cell surface that trigger reactions in the cell when activated.

CRF1 is a trigger for the corticotrophin-releasing factor system in the brain and is an essential protein for coping with stressful events. In mimicking addiction and withdrawal, the researchers gave the mice increasing doses of morphine and then stopped morphine administration to induce withdrawal symptoms.

The researchers found that the CRF1-deficient mice showed more severe and prolonged behavioral symptoms of withdrawal—such as jumping and "wet dog shaking"—when compared with normal mice as had been shown previously. Similarly, when the researchers administered a drug that blocks the receptor in normal mice, they saw the same aggravating effects.

The researchers also detected genetic changes in the brains of the mice, which indicated that the stress-response circuitry in the brain was impaired.

However, Contarino and colleagues found that giving the mice the steroid hormone corticosterone abolished the difference in withdrawal symptoms between the CRF1-deficient and normal mice. The hormone also restored the normal stress-response-related genetic activity in the brain, they found.

'"/>




Page: 1 2

Related medicine news :

1. New Dietary Approach To Manage Kidney Stones
2. Approaching through Telemedicine benefits patients
3. Gel Offers A More Targeted Approach
4. New Cost Effective Approach To Promote Sun Protection
5. Treatment Of Brain Aneurysms By A New Non-Surgical Approach
6. A New Approach In Treatment Neurogenic Detrusor Overactivity In Children
7. A New Diagnostic Approach To Pediatric Interstitial Lung Disease
8. Lazy Eye Can Be Effectively Treated By New Approach
9. Novel Approach to Identify Protein Links with Genetic Disorder
10. NHS To Be Reformed By Using A Hybrid Approach
11. Two-In One Approach To Prevent Incontinence After Prolapse Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Approach Manage Opiate Addiction

(Date:4/21/2015)... 2015 Atlantic Information Services, Inc. ... Medicare-Medicaid Dual Eligibles Database, a brand-new, continually updated ... to the more than 9 million Medicare-Medicaid dual ... than $300 billion in annual health care spending. ... team that also creates the industry-leading AIS’s Directory ...
(Date:4/21/2015)... One of the most difficult aspects ... food cravings. Many diets end badly due to dieters’ ... Some attempt to eat more often throughout the day, ... regular intervals. While this approach does work for many, ... after a meal. For those who are having trouble ...
(Date:4/21/2015)... April 21, 2015 Pharmacy point ... attend this year's Independent Pharmacy Cooperative trade show, to ... Fontainebleau Miami Beach. , Retail Management Solutions recently became ... according to Mike Gross, VP of Sales and Marketing. ... exclusive independent pharmacy trade shows in the country -- ...
(Date:4/21/2015)... On May 12, 2015, West ... its Center for Graduate Studies, located near Los ... campus recently completed a stunning renovation, but the ... has administrators and students abuzz. , The ... of Science in Nursing, Post-Master’s Family Nurse Practitioner ...
(Date:4/21/2015)... Hills, CA (PRWEB) April 21, 2015 Dr. ... has just released an interesting infographic that takes a close ... millennials. , The new infographic, which appears on both Dr. ... The Rise of Plastic Surgery in the Age of the ... surgery in Beverly Hills to a variety of A-list ...
Breaking Medicine News(10 mins):Health News:New AIS Database Tracks All Programs, Plans Serving the Dual-Eligible Community 2Health News:Diet Doc Introduces New Neuro Balance, A Proprietary Diet Aid to Help Dieters Eliminate Food Cravings 2Health News:Diet Doc Introduces New Neuro Balance, A Proprietary Diet Aid to Help Dieters Eliminate Food Cravings 3Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 2Health News:Retail Management Solutions to Attend Upcoming Independent Pharmacy Cooperative Trade Show 3Health News:West Coast University Opens a Center for Graduate Studies 2Health News:West Coast University Opens a Center for Graduate Studies 3Health News:Beverly Hills Plastic Surgery Expert Dr. Zain Kadri Releases Thought-Provoking New Infographic 2
... Heroes, WATERTOWN, Mass., Oct. 28 Bright ... child care,early education, and work/life solutions, salutes its ... Companies" by Working Mother magazine.,Nine out of the ... the critical role high-quality child care plays in ...
... #7720, PATIENTS, HOME PHOTOS HELP IDENTIFY ASTHMA TRIGGERS , ... of in-home photography may be a more cost-effective alternative ... Researchers from Truman Medical Center and the University of ... persistent asthma to take photos of a predetermined list ...
... MONDAY, OCTOBER 27 , #7720, PATIENTS, HOME PHOTOS ... EST), The use of in-home photography may be a ... and allergy triggers. Researchers from Truman Medical Center and ... adult subjects with persistent asthma to take photos of ...
... 28 URAC,s Board of,Directors has approved ... Workers, Compensation and Property and Casualty Pharmacy ... to URAC,s Pharmacy Quality,Management(R) suite of products., ... All standards within this suite of programs ...
... Calif., Oct. 28 Inspired by San ... Beautiful Plastic Surgery in,Encinitas and Carlsbad, CA ... creates a more sensuous, sculpted, fit appearance ... advanced,methods that shape surface contour to suggest ...
... Group, is Early Adopter in U.S., DENVER, ... or the "Company") (OTC Bulletin Board: GLOB), an,international ... Wyndgate Technologies(R) ("Wyndgate") division has,licensed its SafeTrace Tx(R) ... in Brevard County, Florida. The system is now,live ...
Cached Medicine News:Health News:Bright Horizons Congratulates 76 Clients Named to Working Mother's 100 Best 2Health News:New research about chronic lung disease presented at CHEST 2008 2Health News:New research about chronic lung disease presented at CHEST 2008 3Health News:New research about chronic lung disease presented at CHEST 2008 4Health News:New research about chronic lung disease presented at CHEST 2008 5Health News:New research about chronic lung disease presented at CHEST 2008 6Health News:New research about chronic lung disease presented at CHEST 2008 7Health News:CHEST 2008: Featured abstracts 2Health News:CHEST 2008: Featured abstracts 3Health News:CHEST 2008: Featured abstracts 4Health News:CHEST 2008: Featured abstracts 5Health News:CHEST 2008: Featured abstracts 6Health News:CHEST 2008: Featured abstracts 7Health News:CHEST 2008: Featured abstracts 8Health News:CHEST 2008: Featured abstracts 9Health News:CHEST 2008: Featured abstracts 10Health News:CHEST 2008: Featured abstracts 11Health News:CHEST 2008: Featured abstracts 12Health News:CHEST 2008: Featured abstracts 13Health News:CHEST 2008: Featured abstracts 14Health News:CHEST 2008: Featured abstracts 15Health News:CHEST 2008: Featured abstracts 16Health News:CHEST 2008: Featured abstracts 17Health News:CHEST 2008: Featured abstracts 18Health News:URAC Introduces New Pharmacy Benefit Management Accreditation for Workers' Compensation and Property and Casualty Programs 2Health News:New Tummy Tuck Technique Increases Sensuality 2Health News:Global Med Technologies(R), Inc. Implements Transfusion Management System in Large Private Physician Owned Laboratory 2Health News:Global Med Technologies(R), Inc. Implements Transfusion Management System in Large Private Physician Owned Laboratory 3Health News:Global Med Technologies(R), Inc. Implements Transfusion Management System in Large Private Physician Owned Laboratory 4
(Date:4/20/2015)... Mass. , April 20, 2015 ... and final clinical results for the Phase 1 ... in HER2-positive metastatic breast cancer.  The results were ... clinical trials plenary oral session at the 2015 ... in Philadelphia, PA. Data ...
(Date:4/20/2015)... , April 20, 2015  Sigma-Aldrich Corporation ... Corporate Responsibility (CR) Magazine,s list of the 100 ... on outstanding corporate responsibility performance.  Sigma-Aldrich ranked fifth, ... appearance on the list. "We are ... corporate responsibility efforts and we are extremely pleased ...
(Date:4/20/2015)... , April 20, 2015 The preclinical contract research ... testing of drugs and safety testing of medical devices, announces ... at this week,s workshop " Drug Transporters in ADME: From ... MD . The title of Dr. Hidalgo,s talk is ... a session entitled "Transporter Tools of the Future." ...
Breaking Medicine Technology:Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 2Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 3Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 4Merrimack Announces Final Clinical Results for MM-302 Phase 1 Study Demonstrating Robust Activity in Heavily Pre-Treated Patients with HER2-Positive Metastatic Breast Cancer 5Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2Absorption Systems Chief Scientist Ismael Hidalgo to Present at International Workshop on Drug Transporters 2
... , , , IRVINE, Calif., Dec. 9 ... CO-Oximetry and Measure-Through Motion and Low Perfusion pulse oximetry, announced ... equipment and service excellence from the American Association of ... Congress in San Antonio, Texas. Masimo Rainbow SET Acoustic ...
... FALL RIVER, Mass., Dec. 9 Millstone Medical Outsourcing ... professionals to head the leadership of the Memphis, TN, ... the Fall River, MA, headquarters, recently relocated to Memphis ... Millstone Memphis and provide management of operations and program ...
Cached Medicine Technology:Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 2Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 3Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 4Masimo Receives 2009 Zenith Award at the American Association of Respiratory Care Congress 5Millstone Medical Outsourcing Appoints New Leadership of Memphis Facility 2
... This is the comprehensive, simple and ... has a compact, bench-top design, but ... previously only found in high-volume systems. ... cost-effective solution and can also be ...
... KeraCel Ophthalmic Products are ... formulation of lint-free MEROCEL polyvinyl ... configured to be beneficial to ... being absorbent, and yet firm ...
... infant heelstick device uses a highly sharpened surgical ... gentle arc. The incision produced is carefully controlled ... most nerve fibers are located, but through the ... quality blood sample with significantly less pain and ...
Available in 5 different models to accommodate your blood sampling needs....
Medicine Products: