Navigation Links
Yale researchers see decline in hospitalizations for serious heart infection
Date:9/16/2013

Hospitalizations for endocarditis, a deadly heart infection that disproportionately affects older heart patients, have declined in recent years despite recommendations for limited use of antibiotics to prevent the illness. These findings were recently published by Yale School of Medicine researchers in the Journal of the American College of Cardiology.

Endocarditis is the most serious infection of the cardiovascular system, and the risk increases with surgical procedures. Past studies showed a marked increase in endocarditis hospitalization rates during the 1990s. As a preventative measure, many clinicians routinely prescribed antibiotics before dental procedures, and gastrointestinal and other types of surgeries.

While endocarditis risk factors, such as rheumatic heart disease, have declined recently, the risk has increased for those with cardiac pacemakers and prosthetic valves. In addition, the American Heart Association narrowed the use of antibiotics for endocarditis to only a subgroup of patients undergoing dental procedures.

In light of these changes, the Yale research team, led by first author Behnood Bikdeli, M.D., postdoctoral associate in cardiovascular medicine at the Yale Center for Outcomes Research and Evaluation, assessed the annual rates of endocarditis hospitalization and the related outcomes among 262,658 Medicare patients aged 65 and older from 1999 through 2010.

The study showed an increase in endocarditis hospitalizations from 1999 to 2005. However from 2006 to 2010, the team saw no increase, but instead noticed a decline. "We were surprised to see reduced rates of endocarditis hospitalizations during this time period," said Bikdeli who is also an internal medicine resident at Yale. "This downward trend was consistent in all major study subgroups, but certain subgroups, including black participants, had higher hospitalization rates and worse outcomes in the study period."

Bikdeli said this racial disparity in outcomes, as well as reasons for the overall decline in hospitalizations, should be investigated further. He added, "We would ideally like to see comparative effectiveness studies, such as randomized trials, to test antibiotics' efficacy, but due to the expense and the minimal potential effects of antibiotics, such a study would be unlikely in the near future. Therefore, surveillance investigations such as ours are particularly important to monitor the disease and outcomes."

"Clinicians should consider the risks and benefits of antibiotic-use on a case-by-case basis and should share the information with their patients for appropriate decision making," Bikdeli concluded.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. Researchers identify novel biomarker for diabetes risk
2. Tufts researchers identify how Yersinia spreads within infected organs
3. Approved cancer drug potentially could help treat diabetes, Stanford researchers find
4. Mount Sinai Researchers Show Stem Cells Are Wired for Cooperation, Down to the DNA
5. Virginia Tech Carilion researchers find surprising relationships in brain signaling
6. Researchers to identify genetic biomarkers for aggressive breast cancer
7. Researchers link obesity and the bodys production of fructose
8. Researchers find whats missing in teen health programs
9. UCLA researchers describe new form of irritable bowel syndrome
10. Researchers study survival in African American versus Caucasian lung cancer patients
11. Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) ... Improvements Act of 1976, as amended ("HSR"), with respect ... Nasdaq: CPXX ) expired effective June 24, ... As previously announced on May 31, 2016, Jazz Pharmaceuticals ... which Jazz Pharmaceuticals has commenced a tender offer for ...
(Date:6/24/2016)... , June 24, 2016  Consumers have ... and regulators/payers have placed more emphasis on patient ... patient support programs in the pharmaceutical industry have ... medications. Consequently, pharmaceutical companies are focusing on becoming ... are providing products and services that improve health. ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
Breaking Medicine Technology: