Navigation Links
Yale researchers see decline in hospitalizations for serious heart infection
Date:9/16/2013

Hospitalizations for endocarditis, a deadly heart infection that disproportionately affects older heart patients, have declined in recent years despite recommendations for limited use of antibiotics to prevent the illness. These findings were recently published by Yale School of Medicine researchers in the Journal of the American College of Cardiology.

Endocarditis is the most serious infection of the cardiovascular system, and the risk increases with surgical procedures. Past studies showed a marked increase in endocarditis hospitalization rates during the 1990s. As a preventative measure, many clinicians routinely prescribed antibiotics before dental procedures, and gastrointestinal and other types of surgeries.

While endocarditis risk factors, such as rheumatic heart disease, have declined recently, the risk has increased for those with cardiac pacemakers and prosthetic valves. In addition, the American Heart Association narrowed the use of antibiotics for endocarditis to only a subgroup of patients undergoing dental procedures.

In light of these changes, the Yale research team, led by first author Behnood Bikdeli, M.D., postdoctoral associate in cardiovascular medicine at the Yale Center for Outcomes Research and Evaluation, assessed the annual rates of endocarditis hospitalization and the related outcomes among 262,658 Medicare patients aged 65 and older from 1999 through 2010.

The study showed an increase in endocarditis hospitalizations from 1999 to 2005. However from 2006 to 2010, the team saw no increase, but instead noticed a decline. "We were surprised to see reduced rates of endocarditis hospitalizations during this time period," said Bikdeli who is also an internal medicine resident at Yale. "This downward trend was consistent in all major study subgroups, but certain subgroups, including black participants, had higher hospitalization rates and worse outcomes in the study period."

Bikdeli said this racial disparity in outcomes, as well as reasons for the overall decline in hospitalizations, should be investigated further. He added, "We would ideally like to see comparative effectiveness studies, such as randomized trials, to test antibiotics' efficacy, but due to the expense and the minimal potential effects of antibiotics, such a study would be unlikely in the near future. Therefore, surveillance investigations such as ours are particularly important to monitor the disease and outcomes."

"Clinicians should consider the risks and benefits of antibiotic-use on a case-by-case basis and should share the information with their patients for appropriate decision making," Bikdeli concluded.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. Researchers identify novel biomarker for diabetes risk
2. Tufts researchers identify how Yersinia spreads within infected organs
3. Approved cancer drug potentially could help treat diabetes, Stanford researchers find
4. Mount Sinai Researchers Show Stem Cells Are Wired for Cooperation, Down to the DNA
5. Virginia Tech Carilion researchers find surprising relationships in brain signaling
6. Researchers to identify genetic biomarkers for aggressive breast cancer
7. Researchers link obesity and the bodys production of fructose
8. Researchers find whats missing in teen health programs
9. UCLA researchers describe new form of irritable bowel syndrome
10. Researchers study survival in African American versus Caucasian lung cancer patients
11. Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... The Masters of Science ... evaluation leaders with decades of experience who remain current practitioners in the field. ... system, there is a renewed demand for versatile, data-driven leadership.The American University’s MS ...
(Date:1/23/2017)... ... January 23, 2017 , ... Moisture measurement is a ... method is paramount to success. Selecting an inappropriate measurement method can cause costly ... use the same equipment. Rare or expensive substances are wasted and production may ...
(Date:1/23/2017)... ... January 23, 2017 , ... Gynecology Associates of ... gynecological services for women of all ages. The staff of Gynecology ... of reproductive services from routine health screenings to diagnosing and treating female concerns ...
(Date:1/23/2017)... ... ... “Some Infallible Characteristics of Christ”: a fascinating and entrancing novel exploring the ... of published author, Rev. Dr. Robert W. Thomas, the third of seven siblings. He ... nineteen, a pastor for over fifteen years. He is a graduate of N.C. College ...
(Date:1/22/2017)... ... January 22, 2017 , ... Medical lab testing through hospitals and ... a simple test will take days to arrive to the end customer, having to ... access to their lab tests, bypassing the cost and delay of traditional means. Now ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Jan 23, 2017 Research and Markets has announced ... Trends - Product - Forecast to 2025" report to their offering. ... Report Highlights: ... market trends to identify the investment opportunities Market forecasts ... Key market trends across the business segments, Regions and Countries ...
(Date:1/23/2017)... Jan. 23, 2017  Using Astute Medical,s ... risk for acute kidney injury (AKI) after open-heart ... care guidelines significantly improved outcomes by ... more than 33 percent, according to a ... Intensive Care Medicine. Experience ...
(Date:1/23/2017)... January 23, 2017 Ahead of today,s trading ... how they have fared at the close: Kite Pharma Inc. (NASDAQ: ... OVAS ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... were relative laggards on Friday, January 20 th , 2017, down ... research reports on these stocks now at: ...
Breaking Medicine Technology: