Navigation Links
What makes cell division accurate?
Date:1/23/2014

Baltimore, MD As all school-children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA-containing chromosomes are pulled apart and separated into two distinct cells. Losing or gaining chromosomes during this process can lead to cancer and other diseases, so understanding mitosis is important for developing therapeutic strategies.

New research from a team led by Carnegie's Yixian Zheng focused on one important part of this process. Her results improve our understanding of how cell division gives rise to two daughter cells with an equal complement of chromosomes. It is published by Developmental Cell.

Cell division is helped along by a complex of more than 90 proteins, called a kinetochore, interacting with scaffolding-like structural fibers called microtubules. Together the kinetochore and microtubules provide the structure and force that pull the two duplicate halves of the chromosome apart and direct them to each daughter cell.

By looking beyond the microtubules and kinetochores themselves, Zheng's team identified a protein that regulates the interactions between the kinetochore and the microtubule fibers. Using super resolution microscopy, they were able to hone in on one particular phase of this process, namely the way that microtubules are "captured" by the kinetochore to promote proper alignment of the chromosomes in a way that facilitates equal partition of duplicated DNA.

"The study of mitosis has focused on microtubules and kinetochores, the most prominent structure that researchers observe. Our work demonstrates the importance of expanding the scope of study to include other cellular components because this is critical to achieving an in depth understanding of the mechanisms underlying chromosome alignment in preparation for dividing the DNA into two new cells." Zheng said.


'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
Carnegie Institution
Source:Eurekalert  

Page: 1

Related medicine news :

1. Practice makes perfect if you have a partners touch, according to new study
2. InventHelp Client Introduces Kit - Invention Makes Nebulizer Masks More Child-Friendly (AUP-318)
3. Collection of Long Island Hearing Aid Reviews from East End Hearing Makes Selecting an Audiologist and a First Hearing Aid Easier
4. Green Park & Golf Ventures Makes a Major Investment in Socrates Health Solutions
5. PolyU Expert Makes First Space Tool for Lunar Exploration
6. Renegade Diabetes Company DollarDiabetesClub.com Breaks Barriers to Glucose Testing; New Online Club Makes Daily Glucose Testing Affordable for Everyone
7. Gaspari Nutrition Makes Waves at the 2013 World Jiu Jitsu Expo
8. Dr. Steven Weiner Discusses the New FDA Approved Dermal Filler, Voluma, and What Makes It Different Than the Other Fillers
9. Midmark Corporation Makes Donation to The Ohio State University College of Medicine to Foster Efficient, Effective Patient Care
10. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
11. Life-Changing Ringing Cedars of Russia Book Series Makes the Perfect Holiday Gift
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What makes cell division accurate?
(Date:4/26/2017)... ... April 26, 2017 , ... New SUPRO® XT55 Isolated ... beverages by helping beverage manufacturers more effectively manage protein costs. “Soy protein has ... as well as more stable pricing over time. Now it’s even more relevant ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... support, and collaboration, announces Mirroring360 Pro . This new addition to the ... collaboration experience for education and business. , Mirroring360 Pro enables educators, business professionals ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... HR decision-makers are preparing for how his administration could impact the employee benefits ... into what changes are most likely to make it through Congress. His discussion ...
(Date:4/25/2017)... ... April 25, 2017 , ... Patients who ... achieves results in a fraction of the time as traditional braces – Wilckodontics®. ... Dental Specialists, now offers this revolutionary treatment with or without a referral. ...
(Date:4/25/2017)... Minneapolis MN (PRWEB) , ... April 25, 2017 , ... ... patients and recreational users to dispensaries and head shops –can’t help but be heartened ... loathing for the tell-tale cannabis odor aptly described as “skunk smell.” At last ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Mass. , April 20, 2017  RXi ... developing innovative therapeutics that address significant unmet medical ... data from the Company,s consumer product development program, ... at the Society for Investigative Dermatology (SID) 76 ... to advance and promote the sciences relevant to ...
(Date:4/20/2017)... Research and Markets has announced the ... Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies ... ... was valued at US$ 7,167.6 Mn in 2015, and is ... a CAGR of 5.6% from 2016 to 2024. ...
(Date:4/19/2017)... Cardiology devices segment is anticipated to reach the ... Cardiology Devices segment is likely to create absolute $ opportunity ... over 2017. By the end of 2027, Cardiology Devices segment ... 700 Mn, expanding at a CAGR of 18.4% over the ... Asia Pacific reprocessed medical devices market in terms ...
Breaking Medicine Technology: