Navigation Links
What makes cell division accurate?
Date:1/23/2014

Baltimore, MD As all school-children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA-containing chromosomes are pulled apart and separated into two distinct cells. Losing or gaining chromosomes during this process can lead to cancer and other diseases, so understanding mitosis is important for developing therapeutic strategies.

New research from a team led by Carnegie's Yixian Zheng focused on one important part of this process. Her results improve our understanding of how cell division gives rise to two daughter cells with an equal complement of chromosomes. It is published by Developmental Cell.

Cell division is helped along by a complex of more than 90 proteins, called a kinetochore, interacting with scaffolding-like structural fibers called microtubules. Together the kinetochore and microtubules provide the structure and force that pull the two duplicate halves of the chromosome apart and direct them to each daughter cell.

By looking beyond the microtubules and kinetochores themselves, Zheng's team identified a protein that regulates the interactions between the kinetochore and the microtubule fibers. Using super resolution microscopy, they were able to hone in on one particular phase of this process, namely the way that microtubules are "captured" by the kinetochore to promote proper alignment of the chromosomes in a way that facilitates equal partition of duplicated DNA.

"The study of mitosis has focused on microtubules and kinetochores, the most prominent structure that researchers observe. Our work demonstrates the importance of expanding the scope of study to include other cellular components because this is critical to achieving an in depth understanding of the mechanisms underlying chromosome alignment in preparation for dividing the DNA into two new cells." Zheng said.


'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
Carnegie Institution
Source:Eurekalert  

Page: 1

Related medicine news :

1. Practice makes perfect if you have a partners touch, according to new study
2. InventHelp Client Introduces Kit - Invention Makes Nebulizer Masks More Child-Friendly (AUP-318)
3. Collection of Long Island Hearing Aid Reviews from East End Hearing Makes Selecting an Audiologist and a First Hearing Aid Easier
4. Green Park & Golf Ventures Makes a Major Investment in Socrates Health Solutions
5. PolyU Expert Makes First Space Tool for Lunar Exploration
6. Renegade Diabetes Company DollarDiabetesClub.com Breaks Barriers to Glucose Testing; New Online Club Makes Daily Glucose Testing Affordable for Everyone
7. Gaspari Nutrition Makes Waves at the 2013 World Jiu Jitsu Expo
8. Dr. Steven Weiner Discusses the New FDA Approved Dermal Filler, Voluma, and What Makes It Different Than the Other Fillers
9. Midmark Corporation Makes Donation to The Ohio State University College of Medicine to Foster Efficient, Effective Patient Care
10. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
11. Life-Changing Ringing Cedars of Russia Book Series Makes the Perfect Holiday Gift
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What makes cell division accurate?
(Date:4/18/2015)... 2015 Carinsurancesavings.biz has released a new ... are cheaper during Spring. , Spring can be ... Drivers should make sure they compare the newest policies ... can learn more about Spring car insurance offers by ... insurance quotes are becoming more and more popular. Many ...
(Date:4/18/2015)... SMITHTOWN, NEW YORK (PRWEB) April 18, 2015 ... Inc. (AMO) are hosting a ‘Strategies for Success’ program ... & Refractive Surgeons meeting in San Diego, where eye ... ‘Distinguished Moderator’ for this invitation-only event. Dr. Martin is ... AMO and Review of Ophthalmology chose Dr. Martin to ...
(Date:4/18/2015)... Patients who undergo radiation for a hematologic ... life, but the disease is likely to differ in ... radiation. Surviving Mesothelioma has just posted the details of ... to read it now. , Scientists from China, ... patients who had both a hematologic cancer (like lymphoma ...
(Date:4/18/2015)... On April 14th, 2015, Symantec released Volume ... say, “exposes a tactical shift by cyberattackers.” With everything from ... in 2014 - almost a million a day - to ... identified and patched by prominent manufacturers – as long as ... in a digital world can be fraught with peril, and ...
(Date:4/18/2015)... 2015 French physician and gastronome Anthelme ... when he uttered, “Tell me what you eat, and ... to cope with stress or sadness has often been ... indicates otherwise. Data collected from their Emotional Eating ... emotional eating, but for different reasons. , Collecting data ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6
... given the same procedure by an average of 4.5 years, ... ,And while younger people tend to live longest of ... life compared with those who have not had liver transplants, ... life expectancy and years of life lost of 2702 people ...
... performed by physicians experienced with the technique//, and pain ... one-year, multi-center cohort study. ,Among the 25 patients ... on a 10-point visual analog scale was 7.3 at ... at 24 weeks, and 0.3 at 52 weeks, according ...
... for treating patients with advanced colorectal cancer has been approved ... other parts of the body.//Panitumamab, which is being marketed as ... size and retard cancer cell growth. ,The approval has ... which has a high mortality rate. Colorectal cancer has been ...
... women after consumption of raw oysters. Further probing revealed that ... ,Agriculture Commissioner Tommy Irvin commenting on the deaths said “The ... and they lost their lives.” In his opinion, raw oysters ... DeKalb Farmers’ Market reiterated that they have always been enabling ...
... Recent studies conducted by Yale School Of Medicine have ... androgens or steroids to enhance muscle mass or for ... in the body can lead to a appalling loss ... steroids was previously proven to cause hyper excitability, volatile ...
... is the most notorious of cancers, going by the United Kingdom ... of three cases happens to be of the breast. , ... increase in cancer. The present record for breast cancer is 36,939 ... cancer is up since 1971 by almost 81%. ...
Cached Medicine News:Health News:Sacroplasty Safe and Effective to Reduce Low Back Pain 2Health News:Sacroplasty Safe and Effective to Reduce Low Back Pain 3Health News:FDA Approves Vectibix for Colorectal Cancer 2
(Date:4/17/2015)... DALLAS , April 17, 2015 ... report 2015 Market Research Report on Global and ... This is a professional and the deep ... the report introduces Lysine basic information including definition, ... overview (such as US, Europe ...
(Date:4/17/2015)... R.I , April 17, 2015 CVS ... a conference call on Friday, May 1, 2015, at ... its first quarter financial results. An audio ... through the Investor Relations portion of the CVS Health ... visit http://investors.cvshealth.com . This webcast will be archived ...
(Date:4/17/2015)... SAN DIEGO , April 17, 2015 /PRNewswire/ ... molecular diagnostics, announced today that clinical data presented ... demonstrate that its urine-based Precision Cancer Monitoring ℠ ... detection and monitoring of EGFR T790M ... titled Detection of EGFR T790M Mutation in ...
Breaking Medicine Technology:Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 4
... The ALS Therapy Development Institute (ALS ... with Neurotune to investigate a potential treatment ... (Photo: http://photos.prnewswire.com/prnh/20120514/DC05793 ) ... health of motor neurons and their connections to muscles ...
... 2012  NxStage® Medical, Inc. (Nasdaq: NXTM ... today announced that former NxStage® System One™ patient ... transplant following four successful years of more frequent ... (Logo: http://photos.prnewswire.com/prnh/20110503/MM94799LOGO ) The ...
Cached Medicine Technology:The ALS Therapy Development Institute Partners with Neurotune to Investigate Potential Treatments for Motor Neuron Disease 2The ALS Therapy Development Institute Partners with Neurotune to Investigate Potential Treatments for Motor Neuron Disease 3Former NxStage Patient Nikolas Gieske Celebrates Kidney Transplant 2Former NxStage Patient Nikolas Gieske Celebrates Kidney Transplant 3
Designed to provide occlusion while permitting observation of the eye. Helpful to determine if only one eye is deviating. Approximately 9 inches long....
Long handle occluders are approximately 9 inches long....
Lightweight, cordless lensmeter....
Lightweight, cordless lensmeter....
Medicine Products: