Navigation Links
What makes cell division accurate?
Date:1/23/2014

Baltimore, MD As all school-children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA-containing chromosomes are pulled apart and separated into two distinct cells. Losing or gaining chromosomes during this process can lead to cancer and other diseases, so understanding mitosis is important for developing therapeutic strategies.

New research from a team led by Carnegie's Yixian Zheng focused on one important part of this process. Her results improve our understanding of how cell division gives rise to two daughter cells with an equal complement of chromosomes. It is published by Developmental Cell.

Cell division is helped along by a complex of more than 90 proteins, called a kinetochore, interacting with scaffolding-like structural fibers called microtubules. Together the kinetochore and microtubules provide the structure and force that pull the two duplicate halves of the chromosome apart and direct them to each daughter cell.

By looking beyond the microtubules and kinetochores themselves, Zheng's team identified a protein that regulates the interactions between the kinetochore and the microtubule fibers. Using super resolution microscopy, they were able to hone in on one particular phase of this process, namely the way that microtubules are "captured" by the kinetochore to promote proper alignment of the chromosomes in a way that facilitates equal partition of duplicated DNA.

"The study of mitosis has focused on microtubules and kinetochores, the most prominent structure that researchers observe. Our work demonstrates the importance of expanding the scope of study to include other cellular components because this is critical to achieving an in depth understanding of the mechanisms underlying chromosome alignment in preparation for dividing the DNA into two new cells." Zheng said.


'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
Carnegie Institution
Source:Eurekalert  

Page: 1

Related medicine news :

1. Practice makes perfect if you have a partners touch, according to new study
2. InventHelp Client Introduces Kit - Invention Makes Nebulizer Masks More Child-Friendly (AUP-318)
3. Collection of Long Island Hearing Aid Reviews from East End Hearing Makes Selecting an Audiologist and a First Hearing Aid Easier
4. Green Park & Golf Ventures Makes a Major Investment in Socrates Health Solutions
5. PolyU Expert Makes First Space Tool for Lunar Exploration
6. Renegade Diabetes Company DollarDiabetesClub.com Breaks Barriers to Glucose Testing; New Online Club Makes Daily Glucose Testing Affordable for Everyone
7. Gaspari Nutrition Makes Waves at the 2013 World Jiu Jitsu Expo
8. Dr. Steven Weiner Discusses the New FDA Approved Dermal Filler, Voluma, and What Makes It Different Than the Other Fillers
9. Midmark Corporation Makes Donation to The Ohio State University College of Medicine to Foster Efficient, Effective Patient Care
10. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
11. Life-Changing Ringing Cedars of Russia Book Series Makes the Perfect Holiday Gift
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What makes cell division accurate?
(Date:2/28/2015)... A study out of the University of ... for the treatment of a hereditary ocular condition that ... by Dr. Robert MacLaren, professor of ophthalmology at the ... Journal on January 16, 2014 , the study treated ... that mostly affects men and leads to the degeneration ...
(Date:2/28/2015)... 28, 2015 The Mesothelioma Applied ... awards at the International Symposium on Malignant Mesothelioma on ... at the Hyatt Regency Bethesda in Bethesda, Maryland. The ... work and commitment to the mission to cure mesothelioma. ... will be presented to Miriam Ratner. Miriam runs the ...
(Date:2/28/2015)... St. Louis, MO (PRWEB) February 28, 2015 ... a leading provider of outsourced sales, marketing and ... announces their client, BIOTA Botanicals, is bringing its ... , Celebrated worldwide, BIOTA Botanicals’ products are specifically ... the herbal care experts, BIOTA is committed to ...
(Date:2/28/2015)... FL (PRWEB) February 28, 2015 ... organization has sponsored visitor health insurance programs for visitors ... years. Most Indian elderly parents traveling to the United ... such as diabetes and blood pressure. These diseases are ... not even list them as medical conditions. There were ...
(Date:2/28/2015)... 2015 Kaylie Corrigan, Outdoor Supervisor at ... , and current student obtaining her Masters degree in ... weekly forum in psychoeducation on substance use for teens ... as part of her studies. , “Even though these ... and counseling at the high school and junior high ...
Breaking Medicine News(10 mins):Health News:New Gene Therapy Procedure Could Hold Key to Preventing Blindness for Certain Patients 2Health News:Cancer Research Foundation Honors Award Recipients 2Health News:Cancer Research Foundation Honors Award Recipients 3Health News:Cancer Research Foundation Honors Award Recipients 4Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 3Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 2Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 3Health News:Staff at Arizona Drug Addiction Treatment Center Starts Teen Sobriety Support Group at Local High School 2
... West Bengal was first refused treatment by government hospitals ... human rights group intervened to unshackle him, reports said ... by the Association for the Protection of Democratic Rights ... North 24 Parganas district freed., ,Debnath had developed ...
... Watch had explored the physiology// of hot flashes experienced by ... flashes are well known to most menopausal women—and to many ... tend to come on suddenly and last from one to ... to a feeling of being on fire. , ,Although ...
... authorities are pouring cold water on hopes for a new drug ... and Drug Administration (FDA) wants more studies to be done on ... find out what long-term side effects the drug may induce, the ... "female Viagra" as it promises to restore healthy sexual appetites to ...
... pollution levels may have an increased chance of a heart ... ,The research done by scientists from Loma Linda University had ... Environmental Health Perspectives. Their research findings suggest that the rate ... more if they happen to live in areas that have ...
... ,Chennai's Adyar Cancer Institute director Dr.V. Shanta is among ... was awarded the prize for public service and her "untiring ... and compassion for the study and treatment of cancer// in ... She has also won a number of national and international ...
... from kidney diseases may have increased risk of death ... from Johns Hopkins University School of Medicine have found ... peritoneal dialysis over hemodialysis increases their risk of dying ... published in the journal Annals of Internal Medicine online ...
Cached Medicine News:Health News:Insight for Hot Flashes In Postmenopausal Women 2Health News:FDA Diminish Hopes On ‘Female Viagra 2Health News:FDA Diminish Hopes On ‘Female Viagra 3Health News:Air Pollution Increases Risk For Heart Disease In Women 2Health News:Magsaysay Award for Dr.Shanta from Chennai Cancer Institute 2Health News:Choice Of Treatment Increases Risk Of Death In Kidney Disease 2
(Date:2/27/2015)... Calif., Feb. 27, 2015 Isis Pharmaceuticals, Inc. ... outperformed both its pro forma net operating loss (NOL) ... a strong financial position.  Isis, significantly improved financial results ... $230 million in payments the Company received from its ... 2014 was a nearly 60% improvement over its 2013 ...
(Date:2/27/2015)... --  Synageva BioPharma Corp. (Synageva) (NASDAQ: ... products for rare diseases, joins the National Organization ... Rare Diseases™ (EURORDIS™), The Global Genes Project™, and ... Day. On the last day of ... participants conduct special events to raise awareness and ...
(Date:2/27/2015)... TEL-AVIV, Israel , February 27, 2015 ... Unternehmen baut sein bahnbrechendes Überwachungssystem für kongestive ... weiter aus -   ... Medical Technologies, die ein neuartiges Herzüberwachungssystem für ... gab heute bekannt, dass sie ein Finanzierungsvorhaben ...
Breaking Medicine Technology:Isis Reports Financial Results and Highlights for 2014 2Isis Reports Financial Results and Highlights for 2014 3Isis Reports Financial Results and Highlights for 2014 4Isis Reports Financial Results and Highlights for 2014 5Isis Reports Financial Results and Highlights for 2014 6Isis Reports Financial Results and Highlights for 2014 7Isis Reports Financial Results and Highlights for 2014 8Isis Reports Financial Results and Highlights for 2014 9Isis Reports Financial Results and Highlights for 2014 10Isis Reports Financial Results and Highlights for 2014 11Isis Reports Financial Results and Highlights for 2014 12Isis Reports Financial Results and Highlights for 2014 13Isis Reports Financial Results and Highlights for 2014 14Isis Reports Financial Results and Highlights for 2014 15Isis Reports Financial Results and Highlights for 2014 16Isis Reports Financial Results and Highlights for 2014 17Synageva BioPharma Joins NORD, EURORDIS, And The Global Genes Project In Support Of Rare Disease Day 2015 2Synageva BioPharma Joins NORD, EURORDIS, And The Global Genes Project In Support Of Rare Disease Day 2015 3Synageva BioPharma Joins NORD, EURORDIS, And The Global Genes Project In Support Of Rare Disease Day 2015 4Synageva BioPharma Joins NORD, EURORDIS, And The Global Genes Project In Support Of Rare Disease Day 2015 5Synageva BioPharma Joins NORD, EURORDIS, And The Global Genes Project In Support Of Rare Disease Day 2015 6Vectorious Medical Technologies schließt Finanzierungsvorhaben über 5 Mio. USD ab 2
... 31, 2011 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (NASDAQ: ... announced today the appointment of Mr. Kenneth Lee as a ... 31, 2011 to replace Mr. Xianping Wang who resigned from ... Lee is a Principal at SAIF Partners, a leading growth ...
... May 31, 2011 Volcano Corporation (NASDAQ: VOLC ... and therapy guidance tools designed to enhance the treatment of ... be participating in the Goldman Sachs 32nd Annual Global Healthcare ... begin at 2:40 p.m., Pacific Daylight Time (5:40 p.m., Eastern ...
Cached Medicine Technology:Sinovac Appoints Kenneth Lee to Board of Directors 2