Navigation Links
Virus caught in the act of infecting a cell
Date:1/10/2013

AUSTIN, Texas The detailed changes in the structure of a virus as it infects an E. coli bacterium have been observed for the first time, report researchers from The University of Texas at Austin and The University of Texas Health Science Center at Houston (UT Health) Medical School this week in Science Express.

To infect a cell, a virus must be able to first find a suitable cell and then eject its genetic material into its host. This robot-like process has been observed in a virus called T7 and visualized by Ian Molineux, professor of biology at The University of Texas at Austin, and his colleagues.

The researchers show that when searching for its prey, the virus briefly extends like feelers one or two of six ultra-thin fibers it normally keeps folded at the base of its head.

Once a suitable host has been located, the virus behaves a bit like a planetary rover, extending these fibers to walk randomly across the surface of the cell and find an optimal site for infection.

At the preferred infection site, the virus goes through a major change in structure in which it ejects some of its proteins through the bacterium's cell membrane, creating a path for the virus's genetic material to enter the host.

After the viral DNA has been ejected, the protein path collapses and the infected cell membrane reseals.

"Although many of these details are specific to T7," said Molineux, "the overall process completely changes our understanding of how a virus infects a cell."

For example, the researchers now know that most of the fibers are usually bound to the virus head rather than extended, as was previously thought. That those fibers are in a dynamic equilibrium between bound and extended states is also new.

Molineux said that the idea that phages "walk" over the cell surface was previously proposed, but their paper provides the first experimental evidence that this is the case.


'/>"/>
Contact: Lee Clippard, Media Relations
clippard@austin.utexas.edu
512-232-0675
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Investigators trace of role reusable grocery bag in norovirus outbreak
2. 16th-century Korean mummy provides clue to hepatitis B virus genetic code
3. New study shows why swine flu virus develops drug resistance
4. Vygone Introduces A New Zapper For Effective Relief From Herpes Virus Related Skin Problems
5. Vygone Presents A New Product To Deal With Genital Warts And Other Herpes Virus Related Skin Problems
6. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
7. Hepatitis C Virus Levels Higher in Certain Injection Drug Users
8. Antibodies for new rotavirus vaccines
9. SEARCH study shows 1-year drop in HIV virus levels in rural Ugandan parish after campaign
10. Human papillomavirus types do not replace others after large-scale vaccination
11. Only 1 in 4 Americans With HIV Has Virus Under Control: CDC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... TX (PRWEB) September 02, 2014 The Dream2Walk ... presenting Music4Miracles on Sept. 14th, 2014 during Spinal Cord Injury ... McKinney, Aubrey Lynn England, and Chuck Ligon. Linear Automotive will ... and Gasser show. , Doors open at 2pm. The car ... which includes one free pass to the concert. There will ...
(Date:9/2/2014)... Sept. 2, 2014 (HealthDay News) -- Two new studies ... suggests that 6-year-olds who were breast-fed have a lower ... bottle-fed infants, while the other finds a similar trend ... the "many benefits of breast-feeding in the immediate newborn ... Hill Hospital in New York City. She was not ...
(Date:9/2/2014)... HealthDay Reporter TUESDAY, Sept. 2, ... weight loss by blocking a certain nerve linked to appetite ... obese patients. Using electric impulses to block the vagus ... to suppress feelings of hunger. And, they did, just not ... blocks the nerve that connects the brain to the gut ...
(Date:9/2/2014)... Steven Reinberg HealthDay Reporter ... the Ebola outbreak continues to overwhelm health-care workers in ... States and the United Nations called on Tuesday for ... of the often-fatal virus. Dr. Thomas Frieden, director ... said that without a greater global commitment in resources ...
(Date:9/2/2014)... sleep apnea, tonsillectomies, hearing loss, head and neck ... in Orlando, FL, September 21-24, at the 2014 ... Academy of OtolaryngologyHead and Neck Surgery Foundation (AAO-HNSF), ... head and neck physicians in the world. , ... released today, and are available online at ...
Breaking Medicine News(10 mins):Health News:Gas Monkey Hosts Concert in Dallas Benefiting Dream2Walk Foundation with Linear Automotive 2Health News:More Evidence Breast-Feeding Lowers Child's Risk of Infections, Allergies 2Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 2Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 3Health News:More Global Help Needed to Fight Ebola Outbreak 2Health News:More Global Help Needed to Fight Ebola Outbreak 3
... The European Association of Urology (EAU) and Europa ... prostate cancer, have entered into an,affiliated partnership as ... improve,patient awareness in Europe with regards to urological ... "Thanks to this unique,EAU affiliated partnership, Europa Uomo ...
... a series of clinical trials in order to assess ... the application of personalised vaccines produced from healthy and ... designed to combat glioblastomas, one of the most aggressive ... to participating patients combined with the standard, first-line treatment ...
... time, so do knees, internal injuries, study finds, , MONDAY, ... warrior who likes to hit the basketball court or hockey ... of physical activity boost the risk of internal knee damage ... the injuries occurred in middle-age people who showed no symptoms ...
... , Red Cross ... name of others , WASHINGTON, Nov. 30 In spite ... support charities in two ways, with 62 percent planning to dig deep ... with others about donating to charity instead of buying them a gift, ...
... , KALAMAZOO, Mich., Nov. 30 Stryker ... agreement to acquire privately held Ascent Healthcare Solutions, Inc. ... devices in the U.S. , Under the terms of ... million in an all cash transaction. The closing is conditioned ...
... Here,s how the House and Senate bills stack up , ... bills moving through the U.S. Congress differ in a number ... in the number of uninsured Americans. , Legislation approved by ... to 96 percent of Americans. The Senate is preparing to ...
Cached Medicine News:Health News:Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines 2Health News:Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines 3Health News:Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines 4Health News:Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines 5Health News:Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines 6Health News:Lots of Exercise in Midlife May Lead to Osteoarthritis 2Health News:Lots of Exercise in Midlife May Lead to Osteoarthritis 3Health News:American Red Cross Survey Finds 62 Percent of Americans Plan to Donate More Than $25 to Charity This Holiday Season in Spite of Economic Downturn 2Health News:American Red Cross Survey Finds 62 Percent of Americans Plan to Donate More Than $25 to Charity This Holiday Season in Spite of Economic Downturn 3Health News:Stryker Announces Definitive Agreement To Acquire Ascent Healthcare Solutions 2Health News:Stryker Announces Definitive Agreement To Acquire Ascent Healthcare Solutions 3Health News:Health Reform: What's in It for You? 2Health News:Health Reform: What's in It for You? 3
(Date:9/2/2014)... Sept. 2, 2014 Depomed, Inc. (Nasdaq: ... offer, subject to market and other conditions, $230 million ... (the "Notes"). Depomed, Inc. ("Depomed") expects to grant the ... up to an additional $34.5 million aggregate principal amount ... RBC Capital Markets, LLC will act as joint book-running ...
(Date:9/2/2014)...  XBiotech announced today interim results from its ... US for its anti-cancer agent Xilonix™. ... being evaluated in advanced colorectal cancer patients where ... endpoint of the study is overall survival, comparing ... population provided only palliative therapy for cachexia. ...
(Date:9/2/2014)... New York , September 2, 2014 /PRNewswire/ ... report published by Transparency Market Research "Latin America ... Monitoring Devices, Therapeutic Home Healthcare Devices, Mobility Assist ... and Telemedicine, Respiratory Therapy, Infusion Therapy and Unskilled ... Growth, Trends and Forecast, 2014 - 2020" the ...
Breaking Medicine Technology:Depomed Announces Offering of $230 Million Convertible Senior Notes Due 2021 2Depomed Announces Offering of $230 Million Convertible Senior Notes Due 2021 3XBiotech Halts Study, Reports Positive Phase III Results with Antibody Therapy for Cancer 2Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 2Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 3Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 4Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 5Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 6
... has been designed so the surgeon can ... tissue away from the operative surface. It ... without stay-sutures or assistance. This controlled versatility ... to do other tasks, which will broaden ...
... The PowerPro® Battery System is a ... line of powered surgical instruments. The PowerPro ... software controlled battery powered instrument available on ... power system specifically designed to meet the ...
... GE OEC, the market leader ... decades of imaging experience and advanced ... with its latest entry, the MiniView ... extremity imaging has the workstation components ...
Lightweight & portable, compact station. Accurate and speedy measurement, auto-shot function, AI measuring function, focusing indicator....
Medicine Products: