Navigation Links
Virus caught in the act of infecting a cell
Date:1/10/2013

AUSTIN, Texas The detailed changes in the structure of a virus as it infects an E. coli bacterium have been observed for the first time, report researchers from The University of Texas at Austin and The University of Texas Health Science Center at Houston (UT Health) Medical School this week in Science Express.

To infect a cell, a virus must be able to first find a suitable cell and then eject its genetic material into its host. This robot-like process has been observed in a virus called T7 and visualized by Ian Molineux, professor of biology at The University of Texas at Austin, and his colleagues.

The researchers show that when searching for its prey, the virus briefly extends like feelers one or two of six ultra-thin fibers it normally keeps folded at the base of its head.

Once a suitable host has been located, the virus behaves a bit like a planetary rover, extending these fibers to walk randomly across the surface of the cell and find an optimal site for infection.

At the preferred infection site, the virus goes through a major change in structure in which it ejects some of its proteins through the bacterium's cell membrane, creating a path for the virus's genetic material to enter the host.

After the viral DNA has been ejected, the protein path collapses and the infected cell membrane reseals.

"Although many of these details are specific to T7," said Molineux, "the overall process completely changes our understanding of how a virus infects a cell."

For example, the researchers now know that most of the fibers are usually bound to the virus head rather than extended, as was previously thought. That those fibers are in a dynamic equilibrium between bound and extended states is also new.

Molineux said that the idea that phages "walk" over the cell surface was previously proposed, but their paper provides the first experimental evidence that this is the case.


'/>"/>
Contact: Lee Clippard, Media Relations
clippard@austin.utexas.edu
512-232-0675
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Investigators trace of role reusable grocery bag in norovirus outbreak
2. 16th-century Korean mummy provides clue to hepatitis B virus genetic code
3. New study shows why swine flu virus develops drug resistance
4. Vygone Introduces A New Zapper For Effective Relief From Herpes Virus Related Skin Problems
5. Vygone Presents A New Product To Deal With Genital Warts And Other Herpes Virus Related Skin Problems
6. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
7. Hepatitis C Virus Levels Higher in Certain Injection Drug Users
8. Antibodies for new rotavirus vaccines
9. SEARCH study shows 1-year drop in HIV virus levels in rural Ugandan parish after campaign
10. Human papillomavirus types do not replace others after large-scale vaccination
11. Only 1 in 4 Americans With HIV Has Virus Under Control: CDC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... ... ... " Core Organizer ” was featured on NewsWatch as part of its ... market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch and technology ... anyone get organized. , Wouldn’t it be great if everyone could be a little ...
(Date:7/29/2015)... ... July 29, 2015 , ... Join Luz Delia Gerber and Abbi Ferrin as ... begins with understanding how the body actually works. A state of mindfulness allows one ... receive tips on how to forge this new relationship with their bodies. , Abi ...
(Date:7/29/2015)... MA (PRWEB) , ... July 29, 2015 , ... Ticket ... Gillette Stadium featuring Brazil vs. USA . , The international soccer ... it has grown exponentially and now on September 8th, one of the world’s greatest ...
(Date:7/29/2015)... NJ (PRWEB) , ... July 29, 2015 , ... ... (the Commission) CCM® credential for a five-year period, expiring November 30, 2019, during ... CCM credential by submitting an application demonstrating the program’s compliance with the NCCA’s ...
(Date:7/29/2015)... , ... July 29, 2015 , ... ... are anticipating testing regulations imposed by the FDA for nicotine laced liquid products. ... of electronic cigarettes have raised considerably. E-Cigarettes are particularly troublesome to addiction professionals ...
Breaking Medicine News(10 mins):Health News:Get More Organized with the Core Organizer App 2Health News:Pampering and Empowerment Abound at Final Event in Luz Delia Gerber’s Book Unveiling 2Health News:Cheap USA vs. Brazil Tickets at Gillette Stadium: Ticket Down Cuts Presale Ticket Prices for Brazil vs. USA Men's National Soccer Team (USMNT) at Gillette Stadium 2Health News:Cheap USA vs. Brazil Tickets at Gillette Stadium: Ticket Down Cuts Presale Ticket Prices for Brazil vs. USA Men's National Soccer Team (USMNT) at Gillette Stadium 3Health News:Commission for Case Manager Certification Receives Re-Accreditation of its CCM® credential from the National Commission for Certifying Agencies (NCCA) 2Health News:Commission for Case Manager Certification Receives Re-Accreditation of its CCM® credential from the National Commission for Certifying Agencies (NCCA) 3Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 2Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 3
... your health if thin then do a rethink as a new ... in order to stay healthy. // ,The bone of ... as 'bad' cholesterol. ,Exercise is known to higher levels ... cholesterol in the blood.,The finding in the study was that LDL ...
... to emphasize the beneficial effects of breast feed over bottle ... during the growing up years. , ,Researchers at Bristol ... project, a study that followed the growth and development of ... who were fed formula milk instead of breast milk had ...
... their marriage, hurled at them, when they accidentally discover 'Gay' ... them and the marriage appears to come to a grinding ... a respiratory therapist in rural Minnesota, who in June of ... Though they spoke about it and wept over it, her ...
... is on the rise and is an important cause of ... the Filipinos is shooting up every year. Almost 10,000 Filipinos ... survival. About 31% of them have the most advanced stage ... a cure or prevent the further rise in number says ...
... in Australian society has steadily increased over the last 10 ... in women and elderly.// ,A South Australian survey ... "doctor-diagnosed asthma" in women increased from 7.3 percent in 1990 ... increase in asthma rates in people aged 55 and above. ...
... who have a slower rate of caffeine metabolism as ... increased risk //for development of non-fatal heart attack, following ... most important source of caffeine and deserves the credit ... worldwide. Several studies have highlighted the possibility of cardiovascular ...
Cached Medicine News:Health News:Kidney diseases and their complications, an alarming scenario in the Philippines 2
(Date:7/29/2015)... CAMBRIDGE, Mass. , July 29, ... ), the leader in RNA-targeted therapeutics, and Akcea ... The New England Journal of Medicine ... study evaluating volanesorsen (formerly ISIS-APOCIII Rx ) in ... This publication follows the December 2014 publication in ...
(Date:7/29/2015)...  Hologic, Inc. (NASDAQ: HOLX ) announced today ... ended June 27, 2015.  Quarterly revenues of $693.9 million ... a constant currency basis.  GAAP earnings per share (EPS) ... increased 16.2%. "Our third quarter financial results ... a company that can grow sustainably on both the ...
(Date:7/29/2015)... Inc. (Vanda) (NASDAQ: VNDA ), today announced financial ... 30, 2015. "We are impressed with U.S. ... H. Polymeropoulos M.D., Vanda,s President and CEO, "further investments ... products set the stage for the next level of ... , Total net product sales for the second quarter ...
Breaking Medicine Technology:Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 2Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 3Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 4Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 5Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 6Positive Clinical Data From Volanesorsen Published in the New England Journal of Medicine 7Hologic Announces Financial Results for Third Quarter of Fiscal 2015 2Hologic Announces Financial Results for Third Quarter of Fiscal 2015 3Hologic Announces Financial Results for Third Quarter of Fiscal 2015 4Hologic Announces Financial Results for Third Quarter of Fiscal 2015 5Hologic Announces Financial Results for Third Quarter of Fiscal 2015 6Hologic Announces Financial Results for Third Quarter of Fiscal 2015 7Hologic Announces Financial Results for Third Quarter of Fiscal 2015 8Hologic Announces Financial Results for Third Quarter of Fiscal 2015 9Hologic Announces Financial Results for Third Quarter of Fiscal 2015 10Hologic Announces Financial Results for Third Quarter of Fiscal 2015 11Hologic Announces Financial Results for Third Quarter of Fiscal 2015 12Hologic Announces Financial Results for Third Quarter of Fiscal 2015 13Hologic Announces Financial Results for Third Quarter of Fiscal 2015 14Hologic Announces Financial Results for Third Quarter of Fiscal 2015 15Hologic Announces Financial Results for Third Quarter of Fiscal 2015 16Hologic Announces Financial Results for Third Quarter of Fiscal 2015 17Hologic Announces Financial Results for Third Quarter of Fiscal 2015 18Hologic Announces Financial Results for Third Quarter of Fiscal 2015 19Hologic Announces Financial Results for Third Quarter of Fiscal 2015 20Hologic Announces Financial Results for Third Quarter of Fiscal 2015 21Hologic Announces Financial Results for Third Quarter of Fiscal 2015 22Hologic Announces Financial Results for Third Quarter of Fiscal 2015 23Hologic Announces Financial Results for Third Quarter of Fiscal 2015 24Hologic Announces Financial Results for Third Quarter of Fiscal 2015 25Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 2Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 3Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 4Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 5Vanda Pharmaceuticals Reports Second Quarter 2015 Financial Results 6
... Feb. 22, 2011 Proacta Incorporated and ... announced the execution of a definitive agreement ... commercialization of Proacta,s PR509, a hypoxia-activated pro-drug ... (Logo: http://photos.prnewswire.com/prnh/20110222/LA50556LOGO-a) (Logo: http://photos.prnewswire.com/prnh/20110222/LA50556LOGO-b) ...
... ResearchDx announced today the official launch of ... Recent FDA initiatives, such as the ... Paper, have spurred biopharmaceutical companies, interest in biomarker ... The traditional Contract Research Organization (CRO), which has ...
Cached Medicine Technology:Proacta Incorporated and Yakult Honsha Announce an Agreement for the Collaborative Research, Development and Commercialization for Proacta's PR509 Compound 2Proacta Incorporated and Yakult Honsha Announce an Agreement for the Collaborative Research, Development and Commercialization for Proacta's PR509 Compound 3ResearchDx Launches Contract Diagnostics Organization (CDO) 2
Very compressive support for submental liposuction...
Applies pressure on scalp to stretch it before surgery...
Deluxe Abdominal Binders...
Ideal for abdominal, flank, hip and thigh procedures....
Medicine Products: