Navigation Links
Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
Date:12/8/2012

umulative toxicity or long-term safety concerns with a median follow-up of 16 months for treated patients.

Study Methodology and Results

116 CLL patients were enrolled in the study in a series of treatment cohorts, which included patients who were never treated (treatment-nave); those who had received two or more prior therapies (relapsed/refractory); those who had relapsed within two years of treatment (high-risk); and those over age 65. Two oral dosing regimens (420 mg or 840 mg) of ibrutinib were used daily. The primary goal of the study was to determine the safety of the low and high doses. Secondary objectives included efficacy, measures of the intensity of the drug's effect in the body and the long-term safety of administering continuously until relapse.

The majority of adverse effects were diarrhea (54%), fatigue (29%), upper respiratory tract infection (29%), rash (28%), nausea (26%) and arthralgias (25%). Hematologic toxicity ≥ Gr 3 was relatively infrequent. There was no evidence of cumulative toxicity or long-term safety concerns with a median follow-up of 16 months. Estimated 22 month progression free survival for the 85 relapsed or refractory and high-risk patients was 76 percent and 96 percent for treatment-nave patients. Estimated 22 month overall survival for the 85 relapsed or refractory patients and high-risk patients was 85 percent and 96 percent for treatment-nave patients. Funding from Pharmacyclics, Inc., supports this clinical trial.


'/>"/>

Contact: Liz Bryan, Spectrum
lbryan@spectrumscience.com
443-506-1931
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. EzCheckPrinting Updated with New Category Feature to Simplify Check Printing and Tax Reporting
2. Winning the battle against leukaemia: Positive early results in clinical trial for DNA vaccine
3. Pure Cocoa Powder, the Key Ingredient in Dark Chocolate and Found in Diabetes Support Supplements has been Clinically Proven to Reduce Cardiovascular Risk
4. USC Norris cancer research ranks among top clinical advances for 2012
5. American Society of Clinical Oncology issues annual report on state of clinical cancer science
6. Clinical trial at GHSU Cancer Center targets advanced prostate cancer
7. Study finds link between access to online health information and use of clinical services
8. Edison Pharmaceuticals announces initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
9. Molecular portraits of tumours match patients with trials in everyday clinical practice
10. New targeted therapy for advanced prostate cancer shows anti-tumor activity in clinical trials
11. Spread of human melanoma cells in mice correlates with clinical outcomes in patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... By Steven Reinberg ... -- Living close to a major highway may raise your ... Among more than 5,000 postmenopausal women, those who lived within ... greater risk of developing high blood pressure than women living ... "The results of this study highlight the importance of our ...
(Date:10/2/2014)... Dennis Thompson HealthDay Reporter ... that pull out all the stops to rescue surgical ... but the cost of such heroism is questionable, a ... 5 percent better at saving elderly patients with life-threatening ... with less intensity, said senior author Dr. Amir Ghaferi. ...
(Date:10/1/2014)... developed a model that could help to predict a ... from their very first psychotic episode. , The model ... symptoms, cognitive abilities, MRI scans of the brain,s structure, ... the lead up to World Mental Health Day (10 ... Professor Bernhard Baune , says the model is a ...
(Date:10/1/2014)... new research study published today in the Journal ... patients older than 50 years with moderate or severe ... , Researchers from the University of Melbourne randomly assigned ... pain to no acupuncture or sham or pretend laser ... with participants and acupuncturists blinded to laser and sham ...
(Date:10/1/2014)... Patients with increased inflammation, including those receiving ... risk of depression. For example, a 6-month treatment ... virus infection causes depression in approximately 30% of ... known as fish oil, have a long list ... heart disease and reducing triglyceride levels. These nutritional ...
Breaking Medicine News(10 mins):Health News:Living Near a Highway May Be Bad for Your Blood Pressure 2Health News:Living Near a Highway May Be Bad for Your Blood Pressure 3Health News:'High-Intensity' Hospitals Save More Elderly After Surgery: Study 2Health News:'High-Intensity' Hospitals Save More Elderly After Surgery: Study 3Health News:Predicting the future course of psychotic illness 2Health News:Study finds acupuncture does not improve chronic knee pain 2Health News:Omega-3 fatty acids may prevent some forms of depression 2
... content among gamers, study finds , , FRIDAY, Jan. 16 ... not the violence or gore it depicts, that keeps players ... fact, actually detracts from a game,s "fun factor" for most ... and Immersyve Inc., a firm that researches gamers, experiences. ...
... patients with colorectal were more likely to present with ... worse five-year survival rate compared to Caucasian patients, according ... University. , The results are being presented at ... Cancers Symposium. The study was led by Edith Mitchell, ...
... firm that initiated the nation,s largest federal whistleblower case to date, which ... settlement with the U.S. Attorney,s Office, Eli Lilly & Company will pay ... and fraudulent marketing of the highly profitable prescription drug Zyprexa. ... ...
... ATLANTA, Jan. 16, 2009 The AMERIGROUP Foundation announced ... executive director of Atlanta,s Ron Clark Academy, by designating ... administrator and classroom teacher at Ron Clark Academy, a ... DeKalb and Clayton counties. Over the past two ...
... Witness ,Greatest Moment of His Life,NASHVILLE, Tenn., Jan. 16 , WHO: ... Senior Living independent and assisted living community in, ... WHAT: Bouey has been honored as a winner of ... Lifetime, and is headed to Washington, D.C. to witness and, ...
... SAN ANTONIO, Jan. 16 For many pet owners, ... beloved four-legged friends. They understand,that caring for their ... the,day they bring their new best friends home. ... advances in veterinary medicine, today,s,involved owner wants access to ...
Cached Medicine News:Health News:Game, Not Gore, Keeps Video Players Playing 2Health News:African-Americans have worse prognosis at colorectal cancer diagnosis 2Health News:Law Firm Freedland Russo Spearheads Record-Setting Whistleblower Case Against Pharmaceutical Giant Eli Lilly -- Firm Expands Offices to Include L.A. Entertainment Branch 2Health News:Law Firm Freedland Russo Spearheads Record-Setting Whistleblower Case Against Pharmaceutical Giant Eli Lilly -- Firm Expands Offices to Include L.A. Entertainment Branch 3Health News:Atlanta Educator Kim Bearden Honored as 'Healthy Hero' by AMERIGROUP Foundation 2Health News:Grandson of Slaves Wins Experience of a Lifetime, Heads to Washington, D.C. to Attend Presidential Inauguration Events 2Health News:Grandson of Slaves Wins Experience of a Lifetime, Heads to Washington, D.C. to Attend Presidential Inauguration Events 3Health News:Grandson of Slaves Wins Experience of a Lifetime, Heads to Washington, D.C. to Attend Presidential Inauguration Events 4Health News:New PurinaCare(R) Pet Health Library Helps Pet Owners Provide a Lifetime of Health and Happiness for Their Dogs and Cats 2Health News:New PurinaCare(R) Pet Health Library Helps Pet Owners Provide a Lifetime of Health and Happiness for Their Dogs and Cats 3Health News:New PurinaCare(R) Pet Health Library Helps Pet Owners Provide a Lifetime of Health and Happiness for Their Dogs and Cats 4
(Date:10/2/2014)... FAIRFAX, Va. , Oct. 2, 2014 /PRNewswire/ ... quality and Manufacturing Intelligence, today announces key client ... Manufacturing Intelligence Conference . The event will ... Marriott Downtown Magnificent Mile. Presentations include projects from ... and Prince Seafood, and Snak King. The two-day ...
(Date:10/2/2014)... 2, 2014  MinuteClinic, the largest and fastest growing provider of ... has opened its first walk-in clinics in the Corpus ... Corpus Christi and Portland . ... in December. The clinics are part of MinuteClinic,s ... With the Corpus Christi -area openings, there are ...
(Date:10/2/2014)... 2, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ... Webcast and conference call to provide an update ... of ISIS-SMN Rx in infants and children ... presented on the morning (CEST) of Friday, October ... in Berlin, GermanyWhen:Friday, October 10 at 11:30 a.m. ...
Breaking Medicine Technology:InfinityQS Infusion Chicago to Spotlight Manufacturers' Key Successes in Achieving Enterprise Quality 2InfinityQS Infusion Chicago to Spotlight Manufacturers' Key Successes in Achieving Enterprise Quality 3First MinuteClinic Walk-in Medical Clinics Open in Corpus Christi 2First MinuteClinic Walk-in Medical Clinics Open in Corpus Christi 3Isis Pharmaceuticals to Host Webcast to Discuss ISIS-SMN Rx Results Presented at the World Muscle Society Congress 2
... June 1, 2011 Reportlinker.com ... research report is available in ... Cardiovascular Monitoring and Diagnostic Devices ... Landscape and Market Forecasts to ...
... June 1, 2011 Reportlinker.com announces that ... in its catalogue: ... Market Forecasts to 2017 ... Pain Therapeutics - Pipeline Assessment and Market ...
Cached Medicine Technology:Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 2Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 3Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 4Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 5Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 6Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 7Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 8Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 9Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 10Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 11Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 12Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 13Reportlinker Adds Cardiovascular Monitoring and Diagnostic Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 14Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 9Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 10
... cup system has been designed to enhance ... and cluster hole configurations. The objective of ... on three primary modes: Tilt, migration and ... result in initial and long-term fixation. The ...
Optimal solution for normal acetabulum and younger patients....
Biopro rimmed acetabular is manufactured from titanium and is porous coated on the outside of its shell. The rimmed acetabular accommodates a polyethylene inert....
The MPF cup is specifically designed to achieve high primary stability, a critical factor for long term success....
Medicine Products: