Navigation Links
Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
Date:12/8/2012

umulative toxicity or long-term safety concerns with a median follow-up of 16 months for treated patients.

Study Methodology and Results

116 CLL patients were enrolled in the study in a series of treatment cohorts, which included patients who were never treated (treatment-nave); those who had received two or more prior therapies (relapsed/refractory); those who had relapsed within two years of treatment (high-risk); and those over age 65. Two oral dosing regimens (420 mg or 840 mg) of ibrutinib were used daily. The primary goal of the study was to determine the safety of the low and high doses. Secondary objectives included efficacy, measures of the intensity of the drug's effect in the body and the long-term safety of administering continuously until relapse.

The majority of adverse effects were diarrhea (54%), fatigue (29%), upper respiratory tract infection (29%), rash (28%), nausea (26%) and arthralgias (25%). Hematologic toxicity ≥ Gr 3 was relatively infrequent. There was no evidence of cumulative toxicity or long-term safety concerns with a median follow-up of 16 months. Estimated 22 month progression free survival for the 85 relapsed or refractory and high-risk patients was 76 percent and 96 percent for treatment-nave patients. Estimated 22 month overall survival for the 85 relapsed or refractory patients and high-risk patients was 85 percent and 96 percent for treatment-nave patients. Funding from Pharmacyclics, Inc., supports this clinical trial.


'/>"/>

Contact: Liz Bryan, Spectrum
lbryan@spectrumscience.com
443-506-1931
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. EzCheckPrinting Updated with New Category Feature to Simplify Check Printing and Tax Reporting
2. Winning the battle against leukaemia: Positive early results in clinical trial for DNA vaccine
3. Pure Cocoa Powder, the Key Ingredient in Dark Chocolate and Found in Diabetes Support Supplements has been Clinically Proven to Reduce Cardiovascular Risk
4. USC Norris cancer research ranks among top clinical advances for 2012
5. American Society of Clinical Oncology issues annual report on state of clinical cancer science
6. Clinical trial at GHSU Cancer Center targets advanced prostate cancer
7. Study finds link between access to online health information and use of clinical services
8. Edison Pharmaceuticals announces initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
9. Molecular portraits of tumours match patients with trials in everyday clinical practice
10. New targeted therapy for advanced prostate cancer shows anti-tumor activity in clinical trials
11. Spread of human melanoma cells in mice correlates with clinical outcomes in patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... On Saturday, September 19, 2015, Diane ... Foundation (Meso Foundation) will present an educational program titled “Asbestos and Your Health.” ... through 9:30 PM (doors open at 6:45pm) at Calvary United Methodist Church, 16 E ...
(Date:8/29/2015)... ... August 29, 2015 , ... Brands like Toppik , Eau Thermale ... costs. , “Before, a threshold of $49.00 was required to qualify for free standard ... for free standard shipping for customers regardless of the item’s selling price.” , With ...
(Date:8/29/2015)... ... ... popular television program VOICES IN AMERICA, hosted by legendary star of the stage and ... segment to the subject of diabetes. Diabetes is a debilitating health condition that is ... advancements in medical science may prove to be a significant breakthrough that sufferers have ...
(Date:8/28/2015)... Columbus, Ohio (PRWEB) , ... August 28, 2015 ... ... Saturday’s Imagine No Malaria Day at the Zoo to celebrate children helping children, ... people and their congregations throughout West Ohio have contributed to the United Methodist ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... Devices:, Understanding the FDA’s Position and Best Practices for Compliance, **Presented by ... , This workshop, chaired by internationally renowned expert Fubin Wu, has been ...
Breaking Medicine News(10 mins):Health News:Mesothelioma Applied Research Foundation to Hold Educational Class About Asbestos and Mesothelioma Prevention 2Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5
... to toughen anti-smoking laws, restricting smoking in public places ... Cabinet further approved a Health and Family Welfare Ministry ... 2003 Act in the first week of the monsoon ... Dasmunsi told reporters after a Cabinet meeting in New ...
... has gripped people in Himachal Pradesh. ... Deol area of Baijnath sub-division in Himachal Pradesh's Kangra ... are suspecting the symptoms to be that of scrub ... which is spread through bites of ticks and mites. ...
... teens indulgence in non-suicidal injury is more common ... self-injury is the deliberate, direct destruction of body ... findings are important because it suggests that NSSI ... population than previously thought, says lead author Elizabeth ...
... both hands in a letter bomb explosion. Now the Austrian police ... a double hand transplant. ,His motto, he likes to ... medical wonder with an iron will, was one the victims of ... arrest in 1997 with a wave of xenophobic attacks that killed ...
... Restless legs syndrome (RLS) remains a common, yet ... years of research and increased disease recognition. ... among physicians and people with RLS, Boehringer Ingelheim ... about the symptoms, diagnosis and treatment of RLS ...
... to quality health care in India, has suggested two things ... private-public partnership. , , According to the Federation ... to spend around $203 billion (Rs 912,375 crores), if ... attained by 2012. ,The FICCI itself has put ...
Cached Medicine News:Health News:Government to Toughen Its Anti-smoking Laws 2Health News:Self-harming Among Teens More Common Than Thought 2Health News:Self-harming Among Teens More Common Than Thought 3Health News:Around the World in 86 Days ... on Motorbike With Double-hand Transplant 2Health News:Around the World in 86 Days ... on Motorbike With Double-hand Transplant 3Health News:Understanding Restless Legs Syndrome 2Health News:FICCI Proposes Models To Solve Indias Healthcare Crisis 2
(Date:8/28/2015)... -- The global mHealth market ... 2020, growing at a CAGR of 47.6% from 2013 ... View Research, Inc. Monitoring services is expected to grow ... 2020.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... of chronic diseases such as cancer, heart ailments, and ...
(Date:8/27/2015)... 2015  A recent study by Feucht et ... the Arthrosurface HemiCAP® Wave implant, which is based ... design implant for isolated patellofemoral disease. While both ... pain scores, none of the patients in the ... 53% of the patients in the "onlay" group, ...
(Date:8/27/2015)... , Aug. 27, 2015 Biosimilars are ... applauds the U.S. Food and Drug Administration (FDA) ... name in its draft guidance issued today. The ... products proposes distinguishable names, calling for biological products ... FDA-designated suffix. This proposal reflects the agency,s thinking ...
Breaking Medicine Technology:mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2
... 1, 2011    Advanced Biologics, ( www.advancedbiologics.com ) ... newest product within the OsteoAMP ® platform ... meeting this week in Chicago, IL.  OsteoAMP Structural ... that demonstrates osteoinductive properties in-vivo.  Initial product offerings ...
... 2011 Merz Aesthetics, Inc., the exclusive distributor of ... launch of the "STAND AND DELIVER" program.  In partnership ... selected for their significant abilities to STAND AND DELIVER, ... a stand by making a difference in their communities. ...
Cached Medicine Technology:Advanced Biologics Launches OsteoAMP® Structural at the 26th Annual Meeting of the North American Spine Society 2Merz Aesthetics and Inspirational Women Join Forces to Recognize Women Who STAND AND DELIVER 2Merz Aesthetics and Inspirational Women Join Forces to Recognize Women Who STAND AND DELIVER 3
... this age group?, ,Babies and young children ... an MDI. , ,Dry powder devices require ... efficiency. , ,Traditional nebulizers have high wastage ... used for this age group are inefficient at ...
... Introducing the new PRONEB® ULTRA compressor. This ... time while delivering more medication to the ... LC PLUS® or PARI LC STAR® Reusable ... optimized for inhalation and retention into the ...
... has been developing diverse medical ... years. Our medical-surgical products have ... innovation, quality and customer satisfaction. ... the Labtron® line of diagnostic ...
... Compressor is for active patients who want ... everywhere. The compressor is small and lightweight, ... AC compatibility (100 to 240V), 12 volt ... freedom to take aerosol treatments away from ...
Medicine Products: