Navigation Links
Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
Date:12/8/2012

umulative toxicity or long-term safety concerns with a median follow-up of 16 months for treated patients.

Study Methodology and Results

116 CLL patients were enrolled in the study in a series of treatment cohorts, which included patients who were never treated (treatment-nave); those who had received two or more prior therapies (relapsed/refractory); those who had relapsed within two years of treatment (high-risk); and those over age 65. Two oral dosing regimens (420 mg or 840 mg) of ibrutinib were used daily. The primary goal of the study was to determine the safety of the low and high doses. Secondary objectives included efficacy, measures of the intensity of the drug's effect in the body and the long-term safety of administering continuously until relapse.

The majority of adverse effects were diarrhea (54%), fatigue (29%), upper respiratory tract infection (29%), rash (28%), nausea (26%) and arthralgias (25%). Hematologic toxicity ≥ Gr 3 was relatively infrequent. There was no evidence of cumulative toxicity or long-term safety concerns with a median follow-up of 16 months. Estimated 22 month progression free survival for the 85 relapsed or refractory and high-risk patients was 76 percent and 96 percent for treatment-nave patients. Estimated 22 month overall survival for the 85 relapsed or refractory patients and high-risk patients was 85 percent and 96 percent for treatment-nave patients. Funding from Pharmacyclics, Inc., supports this clinical trial.


'/>"/>

Contact: Liz Bryan, Spectrum
lbryan@spectrumscience.com
443-506-1931
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. EzCheckPrinting Updated with New Category Feature to Simplify Check Printing and Tax Reporting
2. Winning the battle against leukaemia: Positive early results in clinical trial for DNA vaccine
3. Pure Cocoa Powder, the Key Ingredient in Dark Chocolate and Found in Diabetes Support Supplements has been Clinically Proven to Reduce Cardiovascular Risk
4. USC Norris cancer research ranks among top clinical advances for 2012
5. American Society of Clinical Oncology issues annual report on state of clinical cancer science
6. Clinical trial at GHSU Cancer Center targets advanced prostate cancer
7. Study finds link between access to online health information and use of clinical services
8. Edison Pharmaceuticals announces initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
9. Molecular portraits of tumours match patients with trials in everyday clinical practice
10. New targeted therapy for advanced prostate cancer shows anti-tumor activity in clinical trials
11. Spread of human melanoma cells in mice correlates with clinical outcomes in patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Honey Gifts, premium Vancouver adult toys ... be selling purse-sized adult toys and erotic products. These ... can be carried in a woman’s purse with complete ... at Honey Gifts is also leak-free and will not ... batteries are common characteristics of Honey Gifts’ portable toys ...
(Date:8/29/2014)... Ore. (PRWEB) August 29, 2014 University ... of health sciences professionals, announced that Daniel Redwood, DC, ... was named “Educator of the Year,” by the Missouri ... banquet on August 21. , Patrick Montgomery, DC, president ... appointed member of the Missouri House Task Force for ...
(Date:8/29/2014)... August 29, 2014 The ... revenue growth over the five years to 2014 ... consumers had less disposable income and, consequently, reduced ... visited restaurants less frequently. As a result, demand ... hindering revenue growth. “After 2010, levels of household ...
(Date:8/29/2014)... Aug. 29, 2014 (HealthDay News) -- The West African Ebola ... Health Organization announcing an estimated 500 new cases this week ... of the new cases arose in Liberia, the U.N. health ... rose sharply, the Associated Press reported. "There ... control," according to the WHO report. "The situation is worsening ...
(Date:8/29/2014)... CA (PRWEB) August 29, 2014 Evolutions ... Santa Barbara in the Santa Barbara News-Press Readers’ Choice ... won the Readers’ Choice poll as Best Medical Spa. ... 2014 reads the following about Evolutions Medical Spa recognition: ... but it is recognized as a top-notch, cutting-edge medical ...
Breaking Medicine News(10 mins):Health News:Honey Gifts Now Provides Purse Sized Adult Toys in Vancouver 2Health News:University of Western States Director of Human Nutrition and Functional Medicine Daniel Redwood, DC, named Missouri Educator of the Year by MSCA 2Health News:Fruit and Vegetable Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Fruit and Vegetable Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 3Health News:Biggest Ever Weekly Rise in Ebola Cases, U.N. Agency Says 2Health News:Biggest Ever Weekly Rise in Ebola Cases, U.N. Agency Says 3Health News:Evolutions Named Best Medical Spa in Santa Barbara by Santa Barbara News Press 2Health News:Evolutions Named Best Medical Spa in Santa Barbara by Santa Barbara News Press 3
... March 22 (HealthDay News) -- New research suggests that middle-age ... less likely to suffer from heart disease over their lives. ... high-fiber diets to lower rates of high blood pressure, obesity ... to the conclusion after studying the results of a 2003-2008 ...
... to be female, suffer from a neurological or mental disorder, ... in the March issue of the Journal of the ... alcohol abuse by the perpetrator plays a substantial role and ... professor of environmental and occupational health sciences at the University ...
... To help continue its internationally recognized work in Lewy ... awarded Mayo Clinic a $1 million gift, pledged over four ... Alzheimer,s and Parkinson,s diseases , is the second ... VIDEO ALERT: Additional audio and video resources, including ...
... 22 (HealthDay News) -- A low-cost screening test detected potentially ... children and teens in a pilot study. The findings ... for heart conditions that can lead to sudden cardiac arrest ... said in a hospital news release. Researchers found that ...
... (March 22, 2011) When physical therapy and drugs fail to ... fusion surgery as a last resort, but two new studies ... involved, artificial disc replacement may give better long-term results at ... 49 percent lower, and four years out from surgery, artificial ...
... Salamon HealthDay Reporter , MONDAY, March 21 ... presumably have more opportunities for tanning -- are nearly ... cancer melanoma as their poorest counterparts, a new study ... incidence, ultraviolet (UV) light exposure and socioeconomic status, scientists ...
Cached Medicine News:Health News:Elderly victims of abuse often use alcohol or drugs, study says 2Health News:Gift will allow Mayo researchers to explore cause of dementia in the elderly 2Health News:Gift will allow Mayo researchers to explore cause of dementia in the elderly 3Health News:Screening Seems to Catch Dangerous Heart Condition in Kids 2Health News:For back, neck pain, artificial disc replacement has cost, outcome advantages over fusion surgery 2Health News:For back, neck pain, artificial disc replacement has cost, outcome advantages over fusion surgery 3Health News:Richer White Women More Prone to Melanoma, Study Finds 2Health News:Richer White Women More Prone to Melanoma, Study Finds 3
(Date:8/29/2014)... -- Pixcelldata, the innovative Irish developer of ... major new deal with Dutch based eX-Path, global providers ... Marius Nap . The announcement was ... Pathology which is taking placing between August 30th and ... where Pixcelldata will demonstrate its innovative solution. ...
(Date:8/29/2014)... ANDOVER, Mass. , Aug. ...  (NYSE: PHG ... at the  European Society of ... company is highlighting the full range of its cardiology solutions ... the care continuum from prevention and ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com ... report is available in its catalogue: ... Compliance Services Industry (U.S.): Analytics, Extensive ... to 2021, NAIC 541380 ... Testing Laboratories, Safety and Compliance ...
Breaking Medicine Technology:Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 3Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 4Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6
... Conn., Aug. 23 MedClean Technologies, Inc. (OTC Bulletin Board: ... technology for the treatment and disposal of ... media, today announced financial results for the 2010 second quarter ... of the recent highlights include : ...
... Reaffirms its 2010 Guidance -- XI,AN, China, Aug. 23 /PRNewswire-Asia-FirstCall/ -- ... ... ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
Cached Medicine Technology:MedClean Technologies Announces Second Quarter Results 2MedClean Technologies Announces Second Quarter Results 3MedClean Technologies Announces Second Quarter Results 4MedClean Technologies Announces Second Quarter Results 5Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 2Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 3Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 4Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 5Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 6Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 7Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 8Huifeng Bio-Pharmaceutical Reported Second Quarter 2010 Financial Results and Reaffirms its 2010 Guidance 9
Designed to minimize emblolic debris in SVGs and carotids...
... therapy extends the ability of interventional ... coronary artery disease, and provides non-interventional ... in the treatment of patients who ... EECP therapy provides a noninvasive, atraumatic ...
... The dual lumen petite titanium ... mm catheter (each lumen) and ... oval lumen catheters offer larger ... catheter strength. Dual lumen offset-tip ...
... The dual lumen M.R.I. model ... 1.2 mm inner diameter catheters ... catheters offer larger lumen equivalency ... ,Dual lumen offset-tip catheters are ...
Medicine Products: