Navigation Links
Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
Date:12/8/2012

umulative toxicity or long-term safety concerns with a median follow-up of 16 months for treated patients.

Study Methodology and Results

116 CLL patients were enrolled in the study in a series of treatment cohorts, which included patients who were never treated (treatment-nave); those who had received two or more prior therapies (relapsed/refractory); those who had relapsed within two years of treatment (high-risk); and those over age 65. Two oral dosing regimens (420 mg or 840 mg) of ibrutinib were used daily. The primary goal of the study was to determine the safety of the low and high doses. Secondary objectives included efficacy, measures of the intensity of the drug's effect in the body and the long-term safety of administering continuously until relapse.

The majority of adverse effects were diarrhea (54%), fatigue (29%), upper respiratory tract infection (29%), rash (28%), nausea (26%) and arthralgias (25%). Hematologic toxicity ≥ Gr 3 was relatively infrequent. There was no evidence of cumulative toxicity or long-term safety concerns with a median follow-up of 16 months. Estimated 22 month progression free survival for the 85 relapsed or refractory and high-risk patients was 76 percent and 96 percent for treatment-nave patients. Estimated 22 month overall survival for the 85 relapsed or refractory patients and high-risk patients was 85 percent and 96 percent for treatment-nave patients. Funding from Pharmacyclics, Inc., supports this clinical trial.


'/>"/>

Contact: Liz Bryan, Spectrum
lbryan@spectrumscience.com
443-506-1931
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. EzCheckPrinting Updated with New Category Feature to Simplify Check Printing and Tax Reporting
2. Winning the battle against leukaemia: Positive early results in clinical trial for DNA vaccine
3. Pure Cocoa Powder, the Key Ingredient in Dark Chocolate and Found in Diabetes Support Supplements has been Clinically Proven to Reduce Cardiovascular Risk
4. USC Norris cancer research ranks among top clinical advances for 2012
5. American Society of Clinical Oncology issues annual report on state of clinical cancer science
6. Clinical trial at GHSU Cancer Center targets advanced prostate cancer
7. Study finds link between access to online health information and use of clinical services
8. Edison Pharmaceuticals announces initiation of EPI-743 Phase 2B Leigh Syndrome Clinical Trial
9. Molecular portraits of tumours match patients with trials in everyday clinical practice
10. New targeted therapy for advanced prostate cancer shows anti-tumor activity in clinical trials
11. Spread of human melanoma cells in mice correlates with clinical outcomes in patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... , ... July 07, 2015 , ... ... report from Cambridge Consultants that discussed how innovation and technology would be the ... the need to address issues of accessibility and affordability, especially in emerging and ...
(Date:7/7/2015)... Calif. (PRWEB) , ... July 07, 2015 , ... Today, ... and other major medical facilities in Orange and San Bernardino counties, released a series ... be a particularly hazardous time of year for children, who spend more unsupervised time ...
(Date:7/7/2015)... ... July 07, 2015 , ... ... growth strategy expert Jay Warden as Senior Vice President, heading the firm’s Healthcare ... to provide the best solutions to healthcare providers’ needs in ways that strengthen ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... Difass USA, ... can help pass those long, stressful days at work is knowing that there is ... as laid back and stress free as imagined. Planning for a vacation can be ...
(Date:7/7/2015)... ... July 07, 2015 , ... ... the two firms have merged to form Camber Collective. Camber Collective provides ... The merger combines SwitchPoint’s strategy consulting expertise with Hope Consulting’s deep experience ...
Breaking Medicine News(10 mins):Health News:Recent Article on Pharmaceutical Innovation Highlights the Need for Creative Solutions to Common Problems, Says Medlife Pharmacy 2Health News:Recent Article on Pharmaceutical Innovation Highlights the Need for Creative Solutions to Common Problems, Says Medlife Pharmacy 3Health News:Allied Anesthesia Physicians Release Summertime Safety Tips 2Health News:Allied Anesthesia Physicians Release Summertime Safety Tips 3Health News:Hammes Company Hires Jay Warden to Lead Healthcare Advisory Services 2Health News:Hammes Company Hires Jay Warden to Lead Healthcare Advisory Services 3Health News:Difass USA Offers Eight Tips to Help Relax and Enjoy Summer Vacation 2Health News:Difass USA Offers Eight Tips to Help Relax and Enjoy Summer Vacation 3Health News:SwitchPoint and Hope Consulting Have Merged to Form Camber Collective 2
... suggests the benefits of mammography screening every other year outweigh ... are at an increased risk of developing breast cancer -- ... American women. The researchers also found greater harms from ... findings, with contributions from three national research groups, are published ...
... Contemplating death doesn,t necessarily lead to morose despondency, ... research has suggested. Following a review of dozens ... thoughts of mortality can lead to decreased militaristic ... and reduced divorce rates. "According to terror ...
... Mich. About one baby is born every hour ... new research from University of Michigan physicians. In the ... American Medical Association, U-M physicians found that diagnosis of ... tripled between 2000 and 2009. By 2009, the estimated ...
... Steven Reinberg HealthDay Reporter , MONDAY, April 30 ... have chronic kidney disease, but most don,t know it and ... However, there has been debate about whether healthy people ... Monday by the U.S. Preventive Services Task Force (USPSTF) says ...
... from St. Jude Children,s Research Hospital adds to evidence ... typically translates into equally good outcomes for most young ... significant difference in survival rates between African-American and white ... during a 15-year period ending in 2007. Racial ...
... police officer calling for backup while also keeping a strong ... take a two-tier approach to fighting off a threat, new ... For the first time, the scientists managed to capture that ... a model of virus-infected brain cells, while also sending signals ...
Cached Medicine News:Health News:Research examines when benefits of screening mammography outweigh the harms for women in their 40s 2Health News:Research examines when benefits of screening mammography outweigh the harms for women in their 40s 3Health News:The bright side of death: Awareness of mortality can result in positive behaviors 2Health News:About 1 baby born each hour addicted to opiate drugs in U.S., U-M study shows 2Health News:About 1 baby born each hour addicted to opiate drugs in U.S., U-M study shows 3Health News:Routine Kidney Disease Screening Not Worthwhile, Experts Say 2Health News:Routine Kidney Disease Screening Not Worthwhile, Experts Say 3Health News:Equal access to care helps close survival gap for young African-American cancer patients 2Health News:Equal access to care helps close survival gap for young African-American cancer patients 3Health News:How does the immune system fight off threats to the brain? New research yields fresh insight 2Health News:How does the immune system fight off threats to the brain? New research yields fresh insight 3
(Date:7/7/2015)... 2015 A power morcellator lawsuit ( http://www.morcellatorlawsuit2015.com ... for an undisclosed amount, Bernstein Liebhard LLP reports. According ... 2014 in the U.S. District Court, Eastern District of ... widower whose wife had died in February 2013, just ... involved the use of a power morcellator. Following the ...
(Date:7/7/2015)... Juli 2015 Sequent Medical, ein ... Entwicklung innovativer Geräte für die Behandlung neurovaskulärer ... von R. Michael Kleine in den ... verfügt über eine mehr als 25-jährige Erfahrung ... hat verschiedene globale biomedizinische Unternehmen erfolgreich geleitet ...
(Date:7/7/2015)... -- According to a new market research report ... Instrument), Application (Aerobic, Anaerobic, Yeast/ Fungi) & End User (Hospital, ... 2019", published by MarketsandMarkets, The global Blood Culture Tests Market ... Million in 2014 at a CAGR of 7.2% from 2014-2019. ... ma rket data T ables and ...
Breaking Medicine Technology:Lina Medical, Power Morcellator Lawsuit Plaintiff Reach Settlement in Case Scheduled for November Trial, Bernstein Liebhard LLP Reports 2Lina Medical, Power Morcellator Lawsuit Plaintiff Reach Settlement in Case Scheduled for November Trial, Bernstein Liebhard LLP Reports 3Sequent Medical beruft Mike Kleine in den Aufsichtsrat 2Sequent Medical beruft Mike Kleine in den Aufsichtsrat 3Blood Culture Tests Market Worth $3,893.5 Million by 2019 2Blood Culture Tests Market Worth $3,893.5 Million by 2019 3Blood Culture Tests Market Worth $3,893.5 Million by 2019 4
... Boston Scientific Corporation (NYSE: BSX ) ... MADIT-CRT trial data in the current issue of the ... showed women received a greater clinical benefit from cardiac ... sub-analysis demonstrated that both men and women experienced significant ...
... CUPERTINO, Calif., Feb. 8, 2011 DURECT Corporation (Nasdaq: ... CreoSalus, Inc., has launched commercial sales of its Food ... Equine, an injectable animal health drug utilizing DURECT,s SABER™ ... a royalty on net sales of SucroMate and will ...
Cached Medicine Technology:Boston Scientific Welcomes Publication of Gender Data Highlighting Benefits Women Receive From CRT-Ds 2Boston Scientific Welcomes Publication of Gender Data Highlighting Benefits Women Receive From CRT-Ds 3Boston Scientific Welcomes Publication of Gender Data Highlighting Benefits Women Receive From CRT-Ds 4DURECT Announces Launch of First FDA Approved SABER™-Injectable Peptide Product 2DURECT Announces Launch of First FDA Approved SABER™-Injectable Peptide Product 3
3 mm forked angled blades. Blade spread 7 mm. Flat serrated handle with polished finish. Overall length: 4.8 inches....
Nucleus divider with 1.25 mm tip and blade offset at a 60 degree angle is ideal for performing the "Phaco Chop" technique to be used in left hand. Round knurled handle....
#2 10 mm hook. Flat serrated handle with polished finish. Overall length: 5.5 inches....
Curved shaft with flat 4.5 mm hook. Flat serrated handle with polished finish. Overall length: 5.3 inches....
Medicine Products: