Navigation Links
University of Cincinnati researchers win $3.7M grant from US Department of Defense
Date:4/17/2012

CINCINNATIResearchers from the University of Cincinnati (UC) have received a four-year, $3.7 million grant from the U.S. Department of Defense for investigations into circadian rhythms that could lead to enhanced understanding of disease treatments, trauma care and human combat performance.

The research will be conducted by an interdisciplinary team led by Christian Hong, PhD, an assistant professor in the department of molecular and cellular physiology. The team includes Sookkyung Lim, PhD, an assistant professor in UC's mathematical sciences department, Seongho Song, PhD, an associate professor of mathematical sciences, and Sean Moore, MD, an assistant professor of pediatrics who conducts research at Cincinnati Children's Hospital Medical Center.

The grant is from the Defense Advanced Research Projects Agency (DARPA), an agency of the Department of Defense. Founded in 1958 as a response to the Soviet Union's launch of Sputnik, DARPA's mission is to prevent and create strategic surprise.

"So many things cycle on a schedulefor instance, we anticipate getting up in the morning because there is an internal clock that communicates with other molecular mechanisms resulting in changes," says Hong. "Our body temperature, feeding rhythms, rate of metabolism, hormonal balanceseverything has a schedule, and the Department of Defense is interested in understanding these schedules at the molecular level.

"Soldiers are constantly moving around and facing interruptions in their circadian rhythms, such as sleep deprivation. Also, when soldiers get hurt, it's important to understand the best time and target to treat themthe fastest solution at the given moment. So if the Department of Defense has a map of the temporal information, it could apply the appropriate regimen more readily."

Research goals are twofold, according to Hong: First, to investigate temporal information of four distinct yet interconnected cellular processes (circadian rhythms, cell cycle, DNA damage response and metabolism) using the filamentous (thread-like) fungi Neurospora crassa, and second, to establish general principles of coupled network dynamics from Neurospora and apply those principles to mammalian intestinal cell lines.

Researchers say the studies will elucidate potential methods to improve care for patients with abdominal trauma or exposure to gut pathogens.

Experimentally validated mathematical models from Neurospora will be used to make predictions in other Neurospora mutant strains and mammalian intestinal cells, focusing on responses to injury and nutritional deprivation.

"Each cellular mechanism is complex with multiple feedback loops," says Hong. "Therefore, we will use mathematical and statistical modeling to investigate network dynamics arising from these interlinked cellular responses."


'/>"/>

Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution
2. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
3. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
4. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
5. Smithsonian Institution, Arizona State University announce education and research partnership
6. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
7. Giarmarco, Mullins & Horton, P.C. President Joseph F. Page to Speak at University of Michigan
8. Arizona State Universitys Decision Theater offers balance to an off-kilter world
9. Forest City Announces Joint Venture with Health Care REIT for University Park Life Science Properties
10. Herzing University Online Launches Master and Bachelor of Science Degrees in Nursing
11. Nurtur Acquires ActivHealth and Wellness by Choice; Gains Exclusive Partnership with Duke University Center for Living
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2020)... ... ... Winemaker Grant Long Jr. is introducing three Toilet Paper Reserve wines. “These are ... complicated times,” he said, in announcing the new wines. The wines are 2019 Chardonnay ... Wine Blend are sourced in the Napa Valley; the Grenache comes from the El ...
(Date:5/21/2020)... (PRWEB) , ... May 21, 2020 , ... ... 10 years of experience of GSCG, VITA NOVAS has already gained ground with ... micro-nutrients , vitamins and stimulating biological products intravenously, guaranteeing an effective way for ...
(Date:5/21/2020)... ... May 21, 2020 , ... The Rise of Mental Health and ... lot of complications and adjustments, needless to say, more complications. With rising deaths, more ... great depression it can be hard to escape and find peace. Adding to these ...
(Date:5/16/2020)... (PRWEB) , ... May 15, 2020 , ... For patients who have gone to see ... processes that the office has always had in place. After being allowed to re-open during ... ensure that patients and staff are as safe and comfortable as possible while going through ...
(Date:5/15/2020)... (PRWEB) , ... May 15, 2020 , ... Collagen has ... in the natural channel alone in 2019, according to a 2020 Nutritional Outlook ‘Ingredients ... – moving further and further away from the high molecular weight, low-impact products of ...
Breaking Medicine News(10 mins):
(Date:5/27/2020)... ... May 27, 2020 , ... Focus Technology , a leading provider of ... will once again sponsor the American Heart Association’s 2020 Boston Heart Walk, ... third year the firm is sponsoring the AHA event. The sponsorship donation will be ...
(Date:5/26/2020)... ... May 26, 2020 , ... Coppe Healthcare ... Open CoVIDx, the laboratory division of the Open Medicine Institute based in San ... Dr. Konstance Knox, the Virologist who previously co-founded what is now Viracor-Eurofins in ...
(Date:5/21/2020)... ... May 21, 2020 , ... Latham ... to help manufacture 25,000 polymer film gowns that will be worn by doctors ... residential swimming pools and accessories, is excited to give back to the community ...
Breaking Medicine Technology: