Navigation Links
Unexpected role: EGFR protects cancer cells from starving
Date:5/5/2008

eeds to interfere with the receptor per se rather than activation of the receptor. Whether we can target EGFR and therefore interfere with SGLT and therefore interfere with intracellular glucose remains to be seen, but it's a terrific target to shoot for."

The team concludes that it may be necessary to knock down both EGFR's glucose-related role and its growth-inducing kinase activity in order to attack cancers of the epithelium - tissue that lines the surfaces and cavities of the body's organs. Epithelial cancers, or carcinomas, make up 80 percent of all cancers.

EGFR resides on the surface of cell membranes, where epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-a) can bind to the receptor, launching a molecular phosphorylation cascade, which stimulates the cell to divide. This normal tyrosine kinase activity is put on overdrive in cancer cells because EGFR is heavily overexpressed on the cell's surface.

Block EGFR and cancer cells die of self-cannibalization

In the current research, the team looked at expression of EGFR but not its kinase activity. They found that blocking expression of the receptor with small interfering RNA killed prostate cancer cells. The cells did not die from apoptosis - programmed cell death that forces a defective cell to commit suicide by destroying its DNA complex and its energy-producing mitochondria.

Rather, these cells died of autophagy - a self-cannibalization response in which a cell under stress or lacking nutrients devours part of its cytoplasm and other organelles to survive. When this response goes on long enough, the cell essentially eats itself until it dies. In cancer research, autophagy is thought to be a second type of programmed cell death.

This self-eating response was also seen in breast cancer and colon cancer cells.

Next, the team measured glucose levels in two sets of prostate cancer cells - one treated by a tyrosine kinase
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Osteotech Announces the Unexpected Passing of Audit Committee Member Leads to Receipt of Nasdaq Deficiency Letter
2. An unexpected way to cause leukemia
3. Longer flu season and unexpected strains make prevention plan key
4. LA BioMed researcher says unexpected increase in cancer risk found
5. Leicester scientist announces unexpected and exciting advance in study of cancer type
6. Men Are Vein Too: Innovative Treatment Sparks Unexpected Consumer Trend
7. Health effects of pesticide mixtures: Unexpected insights from the salmon brain
8. How to Survive an Unexpected Trip to the Hospital During Christmas and New Years
9. Treating Stomach Infection Early Protects Against Cancer
10. Gene Variant Protects Black Heart Failure Patients
11. New Drug Protects Against Radiation Damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unexpected role: EGFR protects cancer cells from starving
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 (HealthDay ... condition that causes a life-threatening irregular heartbeat, a new study ... lower risk of developing atrial fibrillation, compared to women who ... of the Journal of the American Heart Association . ... disorder even if they were obese, the study found. Obesity ...
(Date:8/20/2014)... Doheny HealthDay Reporter WEDNESDAY, ... mastectomy has long been an option, but a new study ... "The most common reasons women didn,t undergo reconstruction was ... more surgery or they were focused on their cancer treatment," ... at Memorial Sloan Kettering Cancer Center, in New York City. ...
(Date:8/20/2014)... Park Cities Pet Sitter , Inc. ... Pets supply donation drive that benefits the animal shelter and ... that coincides with the Humane Society of the United States’ ... 8th, 2014. , As part of their participation, Park Cities ... donations for the Presents 4 Pets drive from their client ...
(Date:8/20/2014)... PITTSBURGH, Aug. 20, 2014 A common approach to ... blood did not improve survival chances for people who ... experts at the University of Pittsburgh School of Medicine. ... PLOS One , suggest acute hemodialysis, an aggressive method ... failure, may not provide a definitive benefit to the ...
(Date:8/20/2014)... August 20, 2014 With 3943.8% growth, Connexion ... of the nation’s fastest growing companies. The Inc. 500 ranks ... care sector. Connexion Point is the #1 fastest growing company ... Medicare and Medicaid, and its clients include four of the ... employs 1,000 people and has offices and contact centers in ...
Breaking Medicine News(10 mins):Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 3Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 2Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 3Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 2Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 3Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 4Health News:Pitt analysis questions use of acute hemodialysis treatment 2Health News:With 3943.8% Growth, Connexion Point, a Leader in Contact Centers for Health Care, Ranks 86th on the Inc. 500 List as One of the Nation’s Fastest Growing Companies 2
... imported food increases, the urgency for quality controls does also ... News) -- One Sunday after church, Rich Miller headed to ... dipped into the house salsa that came with the meal. ... forever. What Miller didn,t know was that imported Mexican green ...
... live bacteria, have a tangible effect on the metabolism, according ... 15 January) in the journal Molecular Systems Biology. , The ... probiotics change the biochemistry of bugs known as gut microbes, ... part in a persons metabolic makeup. Different people have different ...
... time to think about fun ways,to get fit, says Natasha ... in southern California., (Photo: http://www.newscom.com/cgi-bin/prnh/20071220/AQTHFNS1 ), Aside ... a variety of things that help me stay in shape ... some ideas to get you started:, 1. Try ...
... Md., Jan. 15 /Xinhua-PRNewswire/ --,Synutra International, Inc. (Nasdaq: ... nutritional products for infants,children and adults, today filed ... on August 22, 2005 and its Annual Report ... 31, 2007 with the U.S. Securities and Exchange,Commission. ...
... BOSTON As the incidence of liver cancer continues to ... C infections so too does the need for tests ... A study appearing in the January 15 issue of ... of proteomic profiling is more accurate than traditional biomarkers in ...
... promotes a more informed health care experience, ... studies,indicate that informed patients make better health care ... a member feedback feature in,Spring 2008 that enables ... with each other about their provider experiences through,myRegence.com, ...
Cached Medicine News:Health News:U.S. Food Safety: The Import Alarm Keeps Sounding 2Health News:U.S. Food Safety: The Import Alarm Keeps Sounding 3Health News:U.S. Food Safety: The Import Alarm Keeps Sounding 4Health News:U.S. Food Safety: The Import Alarm Keeps Sounding 5Health News:U.S. Food Safety: The Import Alarm Keeps Sounding 6Health News:U.S. Food Safety: The Import Alarm Keeps Sounding 7Health News:U.S. Food Safety: The Import Alarm Keeps Sounding 8Health News:Probiotics affect metabolism, says new study 2Health News:10 Great Ways for Teens to Stay Fit - from One Teen to Another 2Health News:10 Great Ways for Teens to Stay Fit - from One Teen to Another 3Health News:Synutra International, Inc. Amends August 2005 Current Report on Form 8-K and Annual Report on Form 10-K for the Fiscal Year Ended March 31, 2007 2Health News:Synutra International, Inc. Amends August 2005 Current Report on Form 8-K and Annual Report on Form 10-K for the Fiscal Year Ended March 31, 2007 3Health News:Synutra International, Inc. Amends August 2005 Current Report on Form 8-K and Annual Report on Form 10-K for the Fiscal Year Ended March 31, 2007 4Health News:Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer 2Health News:Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer 3Health News:Regence Enables Members to Share Feedback With Each Other When Researching Health Care Provider Options 2
(Date:8/20/2014)... 2014  The National Association of Drug Diversion ... by the real-time, pseudoephedrine (PSE) blocking system in ... Exchange (NPLEx), automatically blocks unlawful PSE sales and ... and make arrests. Data released by NPLEx shows ... blocked the sale of more than 32,105 boxes of ...
(Date:8/20/2014)... , Aug. 20, 2014  The National Association ... latest results achieved by the real-time, pseudoephedrine (PSE) ... National Precursor Log Exchange (NPLEx), automatically blocks unlawful ... down methamphetamine offenders and make arrests. Data released ... Missouri blocked the sale of more ...
(Date:8/20/2014)... NEW YORK , Aug. 20, ... a new market research report is ... The Market for Hospital-Acquired Infection Control ... http://www.reportlinker.com/p01618925/The-Market-for-Hospital-Acquired-Infection-Control-Sterilization-Disinfection-Testing-and-Treatment.html ... and healthcare-associated infections (HAIs), demand has ...
Breaking Medicine Technology:Indiana's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Missouri's Stop-Sale System Achieves Significant Results In Battle Against Meth 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6
... Regado Biosciences, Inc., a privately held company pioneering ... announced today the primary results of the RADAR Phase ... anticoagulation system REG1, at the i2 Summit during the ... & Expo in New Orleans, LA.  REG1 is a ...
... her husband, Andrew, filed suit today against DePuy Orthopaedics, Inc. ... by the failures of Vickie,s two DePuy ASR XL Acetabular ... of John David Hart in Fort Worth, Texas, is the ... in the United States District Court for the Western District ...
Cached Medicine Technology:Regado Biosciences, Inc. Presents Results of the RADAR Phase 2b Clinical Trial of its REG1 Anticoagulation System 2Regado Biosciences, Inc. Presents Results of the RADAR Phase 2b Clinical Trial of its REG1 Anticoagulation System 3Regado Biosciences, Inc. Presents Results of the RADAR Phase 2b Clinical Trial of its REG1 Anticoagulation System 4Regado Biosciences, Inc. Presents Results of the RADAR Phase 2b Clinical Trial of its REG1 Anticoagulation System 5Bilateral DePuy Hip Implant Failures Lead to Lawsuit 2
... The first step to treatment is accurate ... an innovative and quick, patient-friendly tool designed ... urinary incontinence while minimizing patient discomfort. Designed ... features a new type of urethral pressure ...
...
...
...
Medicine Products: