Navigation Links
Unexpected role: EGFR protects cancer cells from starving
Date:5/5/2008

HOUSTON - A growth factor receptor found abundantly on the surface of cancer cells and long known to fuel cancer growth also protects tumor cells from starvation by a newly identified mechanism, researchers at The University of Texas M. D. Anderson Cancer Center report in the May 5 issue of Cancer Cell.

The epidermal growth factor receptor (EGFR) stabilizes another cell membrane protein that channels a constant supply of glucose to cancer cells, saving them from devouring themselves, a team led by Isaiah J. Fidler, D.V.M., Ph.D., professor and chair of M. D. Anderson's Department of Cancer Biology, and Mien-Chie Hung, Ph.D., professor and chair of the department of Molecular and Cellular Oncology.

Their findings could explain why some drugs that target what was previously thought to be EGFR's only role in cancer proliferation have had limited success in patients. Drugs that block EGFR's activation by growth factors - its tyrosine kinase activity -- have gotten response rates in 10 percent to 20 percent of patients across a variety of cancers.

"We show that the receptor is active independent of its kinase activity," Fidler said. "Up until now everyone - including us - focused on kinase, kinase, kinase."

The team shows that EGFR binds to another cell membrane protein called the sodium/glucose co-transporter (SGLT1), protecting SGLT1 from destruction by the cell's proteasome complex, Hung noted. "This complex stabilizes SGLT1 so it continues to transport glucose from the cell membrane into the cell," Hung said.

A "terrific target"

Cancer cells have a high metabolic rate and require more glucose to fuel their activities than do normal cells, Fidler said.

"Inhibiting the kinase activity of the receptor does not interfere with EGFR stabilizing SGLT1, allowing cancer cells to maintain intracellular glucose levels," Fidler said. "To destroy tumor cells by depriving them of glucose one n
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Osteotech Announces the Unexpected Passing of Audit Committee Member Leads to Receipt of Nasdaq Deficiency Letter
2. An unexpected way to cause leukemia
3. Longer flu season and unexpected strains make prevention plan key
4. LA BioMed researcher says unexpected increase in cancer risk found
5. Leicester scientist announces unexpected and exciting advance in study of cancer type
6. Men Are Vein Too: Innovative Treatment Sparks Unexpected Consumer Trend
7. Health effects of pesticide mixtures: Unexpected insights from the salmon brain
8. How to Survive an Unexpected Trip to the Hospital During Christmas and New Years
9. Treating Stomach Infection Early Protects Against Cancer
10. Gene Variant Protects Black Heart Failure Patients
11. New Drug Protects Against Radiation Damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unexpected role: EGFR protects cancer cells from starving
(Date:11/18/2014)... 2014 (HealthDay News) -- Routine screening for heart disease ... symptoms but are at high risk for a heart ... the screenings do not help prevent heart attacks or ... unstable angina (chest pain that occurs when the heart ... is still the best way to manage risks for ...
(Date:11/18/2014)... Recently, BellasDress has announced the launch of 85 ... and using comfortable fabrics, the new styles of prom dresses ... of wonderful holiday gifts in a variety of colors and ... dresses, and they are created by top designers,” said the ... great addition to our sales team and more than one ...
(Date:11/18/2014)... OpenWorks, one of America’s leading commercial cleaning ... Guild Invitational. The John C. Lincoln Health Foundation holds ... Desert Mission community programs. Open Works was a Tee ... held at Camelback Golf Club in Scottsdale. More than ... Desert Mission — including a food bank, children's dental ...
(Date:11/18/2014)... 2014 A+ Secure Packaging, a ... dietary supplements and more, announced today that its ... Manufacturing Practices (GMP) Registration for dietary supplements and ... NSF International verifies the A+ Secure Packaging facility ... requirements of its clients by demonstrating the proper ...
(Date:11/18/2014)... has introduced its newest collection of full lace wigs ... now, up to 85% off. , Wigsbuy is one of ... real and synthetic hair products. In order to provide top ... materials to make its hair wigs, which are sensitive to ... are offering a full line of human hair lace wigs ...
Breaking Medicine News(10 mins):Health News:Study Finds No Added Benefit From Routine Heart Scans for Diabetics 2Health News:Study Finds No Added Benefit From Routine Heart Scans for Diabetics 3Health News:85 New Models Of White Prom Dresses From BellasDress.com Online For Sale 2Health News:OpenWorks Sponsors 2014 Lincoln Guild Invitational Golf Tournament Hosted by Scottsdale's Camelback Golf Club 2Health News:A+ Secure Packaging, LLC Earns NSF International Good Manufacturing Practices (GMP) Registration for Dietary Supplements and Certification for Sport 2Health News:It Is The Most Wonderful Time To Buy Full Lace Wigs At Wigsbuy.com 2
... asked a federal judge to hold the American Red Cross ... blood collection program. FDA is acting today to ensure that ... guardian of the safety of the nation's blood supply, which ... a promise made by the Red Cross in a 1993 ...
... their physiques should know that many over-the-counter steroid supplements ... who buy these supplements are getting ripped off. // ... purchased in stores. They analyzed the products to determine ... the label were actually contained in the product, if ...
... used in vitro fertilisation (IVF) technique intracytoplasmic sperm injection ... with abnormalities such as ambiguous genitalia. Researchers from the ... infertility is genetic are likely to have other, more ... spermatozoa are injected directly into the egg. // ...
... could cause a lifelong allergy to a common chemical found ... trendy tattoos can lead to months of pain and discomfort. ... chemical para-phenylene diamine (PPD) which is sometimes added to make ... established practise in India, where it is called mehendi. Dr ...
... will grow up to be overweight adults isn't especially accurate. ... is very often reflected in body mass index in adulthood. ... tended to have the highest adult risk of disease. ... children. Two-thirds of the group// were followed until the age ...
... effective for inoperable liver cancer. It is a year since TheraSphere was ... ... either reducing tumour size or the number of tumours. Till date, it ... cannot be treated by any other means. ,TheraSphere involves injecting ...
Cached Medicine News:
(Date:11/18/2014)... , Nov. 18, 2014  A new global ... finds that a large majority of the general public ... (84%), a devastating disease that is responsible for 1.59 ... cancers combined 1,2,4 . The "Any One Any Lung" ... about the widespread impact of lung cancer, but also ...
(Date:11/18/2014)... , Nov. 18, 2014  AgeneBio, a pharmaceutical ... preserve and restore brain function, today announced that ... Michela Gallagher , PhD, has received the Society ... the past 35 years, Dr. Gallagher,s research at ... at Chapel Hill has led to advancements in ...
(Date:11/17/2014)... 2014 Asterias Biotherapeutics, Inc. (NYSE MKT: AST), ... regenerative medicine, today announced that Jane S. Lebkowski ... participate in a live Google Hangout session presented by ... latest progress in stem cell-based therapies for spinal cord ... is scheduled for Tuesday, November 18, 2014, from 12:00 ...
Breaking Medicine Technology:Global survey of more than 10,000 adults highlights misperceptions about lung cancer, a disease that kills 1.59 million people annually 2Global survey of more than 10,000 adults highlights misperceptions about lung cancer, a disease that kills 1.59 million people annually 3Global survey of more than 10,000 adults highlights misperceptions about lung cancer, a disease that kills 1.59 million people annually 4Global survey of more than 10,000 adults highlights misperceptions about lung cancer, a disease that kills 1.59 million people annually 5Global survey of more than 10,000 adults highlights misperceptions about lung cancer, a disease that kills 1.59 million people annually 6AgeneBio Founder and Chief Scientific Officer Receives Society for Neuroscience's Mika Salpeter Lifetime Achievement Award 2AgeneBio Founder and Chief Scientific Officer Receives Society for Neuroscience's Mika Salpeter Lifetime Achievement Award 3Asterias Biotherapeutics to Participate in Live Google Hangout Discussion of Stem Cell-Based Therapies for Spinal Cord Injury 2
... Exploratory study shows clinical improvement in patients with pulmonary ... have limited benefit for this debilitating, rapidly ... available as Gleevec(R) for treatment of certain ... Novartis to further explore potential of imatinib mesylate in PAH in ...
... at the Osteoarthritis Research Society,International,s 2008 World Congress, ... Inc.,recently presented results from the FLEXX Trial of ... hyaluronate), a highly pure,non-avian high molecular weight form ... saline (IA-saline) for the relief,of pain in knee ...
Cached Medicine Technology:Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 2Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 3Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 4Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 5Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 6Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 7Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 8Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 9Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 10Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 11Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease 12Study Shows EUFLEXXA(R) Patients Report Significant Improvements in Osteoarthritis of the Knee Pain over a Six Month Period 2Study Shows EUFLEXXA(R) Patients Report Significant Improvements in Osteoarthritis of the Knee Pain over a Six Month Period 3Study Shows EUFLEXXA(R) Patients Report Significant Improvements in Osteoarthritis of the Knee Pain over a Six Month Period 4
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
... Each ENDOPATH 5mm Instrument is ... has a rotating 5mm diameter insulated ... through appropriate ENDOPATH surgical trocars and ... knob located on the handle rotates ...
... holes and additional electrode tip insulation, ... dissection with decreased risk of collateral ... ,Flexible design options allow the choice ... multiple tip designs. Optimize specific surgical ...
Medicine Products: