Navigation Links
Unexpected role: EGFR protects cancer cells from starving
Date:5/5/2008

HOUSTON - A growth factor receptor found abundantly on the surface of cancer cells and long known to fuel cancer growth also protects tumor cells from starvation by a newly identified mechanism, researchers at The University of Texas M. D. Anderson Cancer Center report in the May 5 issue of Cancer Cell.

The epidermal growth factor receptor (EGFR) stabilizes another cell membrane protein that channels a constant supply of glucose to cancer cells, saving them from devouring themselves, a team led by Isaiah J. Fidler, D.V.M., Ph.D., professor and chair of M. D. Anderson's Department of Cancer Biology, and Mien-Chie Hung, Ph.D., professor and chair of the department of Molecular and Cellular Oncology.

Their findings could explain why some drugs that target what was previously thought to be EGFR's only role in cancer proliferation have had limited success in patients. Drugs that block EGFR's activation by growth factors - its tyrosine kinase activity -- have gotten response rates in 10 percent to 20 percent of patients across a variety of cancers.

"We show that the receptor is active independent of its kinase activity," Fidler said. "Up until now everyone - including us - focused on kinase, kinase, kinase."

The team shows that EGFR binds to another cell membrane protein called the sodium/glucose co-transporter (SGLT1), protecting SGLT1 from destruction by the cell's proteasome complex, Hung noted. "This complex stabilizes SGLT1 so it continues to transport glucose from the cell membrane into the cell," Hung said.

A "terrific target"

Cancer cells have a high metabolic rate and require more glucose to fuel their activities than do normal cells, Fidler said.

"Inhibiting the kinase activity of the receptor does not interfere with EGFR stabilizing SGLT1, allowing cancer cells to maintain intracellular glucose levels," Fidler said. "To destroy tumor cells by depriving them of glucose one n
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Osteotech Announces the Unexpected Passing of Audit Committee Member Leads to Receipt of Nasdaq Deficiency Letter
2. An unexpected way to cause leukemia
3. Longer flu season and unexpected strains make prevention plan key
4. LA BioMed researcher says unexpected increase in cancer risk found
5. Leicester scientist announces unexpected and exciting advance in study of cancer type
6. Men Are Vein Too: Innovative Treatment Sparks Unexpected Consumer Trend
7. Health effects of pesticide mixtures: Unexpected insights from the salmon brain
8. How to Survive an Unexpected Trip to the Hospital During Christmas and New Years
9. Treating Stomach Infection Early Protects Against Cancer
10. Gene Variant Protects Black Heart Failure Patients
11. New Drug Protects Against Radiation Damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unexpected role: EGFR protects cancer cells from starving
(Date:8/19/2014)... the brain involved in multitasking and ways to train ... the IUGM Institut universitaire de griatrie de Montral and ... to better predict the effectiveness of this training. Cooking ... the Web, or driving while listening to a radio ... our daily lives. Unfortunately, it decreases with age, which ...
(Date:8/19/2014)... Recently, UWDress.com, a professional company of women’s dresses and related ... formal evening dresses . Additionally, the firm has launched a ... moment, all of them can be ordered at discounted rates, ... until August 27, 2014. , The company puts much ... that women of all shapes can be graceful and charming. ...
(Date:8/19/2014)... August 19, 2014 “ Inbox Blueprint ... course designed to provide users with the tools necessary ... marketing techniques and strategies. The course which was ... of excitement throughout the internet marketing world. The commotion ... HonestyFirstReviews.com's Tiffany Hendricks prompting an updated review of the ...
(Date:8/19/2014)... NV (PRWEB) August 19, 2014 The ... the 2nd Annual Southwest CannaBusiness Symposium on ... Plaza Hotel & Casino in Las Vegas. , Featuring ... State Senator Tick Segerblom (D-Las Vegas), the event will ... practices, and the work NCIA is doing federally to ...
(Date:8/19/2014)... Grande Naturals, LLC is proud ... the 2014 Independent Cosmetics Manufacturers & Distributors Award ... position in “Product Innovation; Product Color Cosmetic” for ... includes a lash enhancement serum, GrandeLINER™. GrandeLINER™ ... , This all-new eyeliner is a ...
Breaking Medicine News(10 mins):Health News:Targeted brain training may help you multitask better 2Health News:Cheap Plus Size Formal Evening Dresses Announced By UWDress.com 2Health News:Anik Singal’s “Inbox Blueprint” Review Released By HonestyFirstReviews.com 2Health News:SATURDAY IN LAS VEGAS: U.S. Rep. Dina Titus, State Sen. Tick Segerblom Keynote National Cannabis Industry Association Southwest CannaBusiness Symposium 2Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 2Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 3
... ... are turning to unexpected sources for natural remedies and ways to conserve. Humidifiers , ... and relieving symptoms of colds and the flu through proper humidification. As a result ... ...
... ... advisory committee in pain management, , ... Maywood NJ (PRWEB) October 13, 2009 -- Advanced Data Systems (ADS) welcomes ... is a Managing Partner of Pain Centers of America, PA specializing in interventional pain management. ...
... ... of his new state-of-the-art website designed to provide comprehensive information on gastric sleeve surgery, ... obese men and women lose significant amounts of weight and reduce the risk of ... ...
... ... quality EMS bags and backpacks and other trauma bags for medical professionals. The updated website ... meet the growing demands of their customers in the medical community. , ... (PRWEB) October 13, 2009 -- Colorado Cases ...
... ... 15 to Dec. 31—for Medicare-eligible individuals to evaluate and choose the plan that best ... ... seniors and people with disabilities will be required to choose new healthcare coverage during ...
... team of scientists at the National Cancer Institute (NCI) in ... yield valuable information on how to diagnose and treat human ... team discusses an ongoing initiative in which spontaneously occurring cancers ... of new cancer drugs, devices and imaging strategies for human ...
Cached Medicine News:Health News:Humidifiers -- Not Just for Children Anymore -- AchooAllergy.com Announces All New Humidifiers Offering 2Health News:Humidifiers -- Not Just for Children Anymore -- AchooAllergy.com Announces All New Humidifiers Offering 3Health News:ADSC's Pain Management Reinforcement 2Health News:Dallas, Texas Lap-Band Surgeon Announces New Website to Educate Patients on the Lap-Band System and Other Advanced Weight Loss Solutions 2Health News:Dallas, Texas Lap-Band Surgeon Announces New Website to Educate Patients on the Lap-Band System and Other Advanced Weight Loss Solutions 3Health News:Colorado Cases Launches New Website to Add More Custom Cases for Medical Professionals and Expand Services 2Health News:Colorado Cases Launches New Website to Add More Custom Cases for Medical Professionals and Expand Services 3Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 2Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 3Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 4Health News:Healthcare Reform, Coverage Changes Highlight Key Questions for Medicare Annual Enrollment Season, Allsup Says 5
(Date:8/19/2014)... ALBANY, New York , August 19, 2014 /PRNewswire/ ... " Surgical Navigation Systems Market (Neurosurgical Navigation Systems, ... Industry Analysis, Size, Share, Growth, Trends and Forecast, 2014 ... valued at USD 218.5 million in 2013 and is ... 2014 to 2020, to reach an estimated value of ...
(Date:8/18/2014)... , August 19, 2014 Elbit ... EMITF ) announced today that Elbit Medical Technologies ... Company in which it holds approximately 86% of the ... Cell Ltd., in which Elbit Medical holds approximately 30.8% ... majority of Gamida Cell,s shareholders (including Elbit Medical), signed ...
(Date:8/18/2014)... 2014 Globavir Biosciences, Inc. ("Globavir"), a ... has announced intentions to develop its lead drug ... Ebola Virus outbreak in West Africa.  Globavir will ... combination of Food and Drug Administration (FDA) approved ... The discovery of the use of GBV006 for ...
Breaking Medicine Technology:Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 2Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 3Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 4Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 5Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 6Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 7Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 8Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 9Elbit Imaging Announces Gamida Cell Signs Option and Investment Agreements with Major Pharmaceutical Company 2Elbit Imaging Announces Gamida Cell Signs Option and Investment Agreements with Major Pharmaceutical Company 3Globavir Seeking Approval and Launch of Novel Ebola Treatment Before Year End 2Globavir Seeking Approval and Launch of Novel Ebola Treatment Before Year End 3Globavir Seeking Approval and Launch of Novel Ebola Treatment Before Year End 4
... 24 NacTel (North Atlantic Communications), a leading ... successfully installed and integrated a new state-of-the-art customer ... one of the fastest growing durable medical equipment ... sophisticated feature set to serve its customers, and ...
... Inc. and Cedarlane today announced that they have entered ... distribute high value reagent proteins produced by Pfenex to ... products initially distributed will be vaccine carrier proteins such ... related growth factors including G-CSF and Interferon beta 1-b. ...
Cached Medicine Technology:Drive Medical Equipment Chooses NacTel with ShoreTel as its Critical Communications Provider 2Drive Medical Equipment Chooses NacTel with ShoreTel as its Critical Communications Provider 3Drive Medical Equipment Chooses NacTel with ShoreTel as its Critical Communications Provider 4Pfenex Inc. Establishes Reagent Protein Distribution Agreement With Cedarlane Corporation 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: