Navigation Links
UNC neuroscientists discover new 'mini-neural computer' in the brain
Date:10/27/2013

n lab at the University of North Carolina. They used patch-clamp electrophysiology to attach a microscopic glass pipette electrode, filled with a physiological solution, to a neuronal dendrite in the brain of a mouse. The idea was to directly "listen" in on the electrical signaling process.

"Attaching the pipette to a dendrite is tremendously technically challenging," Smith said. "You can't approach the dendrite from any direction. And you can't see the dendrite. So you have to do this blind. It's like fishing if all you can see is the electrical trace of a fish." And you can't use bait. "You just go for it and see if you can hit a dendrite," he said. "Most of the time you can't."

But Smith built his own two-photon microscope system to make things easier.

Once the pipette was attached to a dendrite, Smith's team took electrical recordings from individual dendrites within the brains of anesthetized and awake mice. As the mice viewed visual stimuli on a computer screen, the researchers saw an unusual pattern of electrical signals bursts of spikes in the dendrite.

Smith's team then found that the dendritic spikes occurred selectively, depending on the visual stimulus, indicating that the dendrites processed information about what the animal was seeing.

To provide visual evidence of their finding, Smith's team filled neurons with calcium dye, which provided an optical readout of spiking. This revealed that dendrites fired spikes while other parts of the neuron did not, meaning that the spikes were the result of local processing within the dendrites.

Study co-author Tiago Branco, PhD, created a biophysical, mathematical model of neurons and found that known mechanisms could support the dendritic spiking recorded electrically, further validating the interpretation of the data.

"All the data pointed to the same conclusion," Smith said. "The dendrites are not passive integrators of sensory-driven input; the
'/>"/>

Contact: Mark Derewicz
mark.derewicz@unch.unc.edu
919-923-0959
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Johns Hopkins neuroscientists win National Academy of Science Awards
2. Neuroscientists find excessive protein synthesis linked to autistic-like behaviors
3. John Templeton Foundation grant supports Princeton neuroscientists to study cognitive control
4. Discover Step-By-Step Plans On How To Learn French Fast With The “Rocket French Premium” Program – Vkoolelite
5. Discover How to Determine Baby Gender With the “Prince Or Princess” Book – Vkoolelite
6. Biosimulation Market (Drug Discovery & Development) Worth $1.2 Billion by 2017 - New Report by MarketsandMarkets
7. Tear Film Evaporation Begins at Birth Water and Health Researcher Discovers
8. New Case Management Order in New Jersey DePuy ASR Recall Litigation Extends Discovery to June 2014, More than 650 Metal Hip Lawsuits Filed in Consolidated Proceeding
9. Discover 13 Natural Tips for Whitening Skin – V kool
10. The Producers of the In View Series Announce Upcoming Airing on the Discovery Channel
11. Ethicon Transvaginal Mesh Lawsuits Move Forward, With Scheduling of Discovery Conferences in Federal Vaginal Mesh Litigation, Bernstein Liebhard LLP Reports
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC neuroscientists discover new 'mini-neural computer' in the brain
(Date:10/30/2014)... 2014 Timothy, InstaKNOT’s 4-year-old ... firefighters, showing that you are never too young to ... firefighters Tracey and Carl at the 2013 Santa Arriving ... Pompano Beach Chamber of Commerce. Tracey gave Timothy a ... Timothy wear his real fireman’s hat, and extending an ...
(Date:10/30/2014)... 2014 Don Allred Insurance, a leading ... plans for North Carolina residents, is excited to announce ... Holly Hill Mall. The new branch has been up ... customers through all facets of the insurance selection process ... spokesman Scott Allred couldn’t be happier with the timing ...
(Date:10/30/2014)... Portland, OR (PRWEB) October 30, 2014 ... law firm Hodgkinson Street LLC announces new branding ... Hodgkinson Street Mepham . After David Mepham’s promotion ... revitalizes their brand and website to include Mepham’s name ... leading medical malpractice and mediation firm, the decision to ...
(Date:10/30/2014)... 2014 Paramount Rx, a full-service prescription ... efforts to help people save money through its innovative ... for prescription drugs in the new health care system, ... to bridge the relationship between consumers, businesses and the ... challenges people face today with medical costs is the ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. ... with prostate cancer who also have certain heart problems may ... new study suggests. , , The therapy in question is called ... reduce levels of male hormones to prevent the growth of ... research, this hormone therapy was linked to triple the risk ...
Breaking Medicine News(10 mins):Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 2Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 3Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 4Health News:Allred Insurance Satellite Office Grand Opening 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3
... Kathleen Doheny HealthDay Reporter , MONDAY, March 19 ... spectrum disorders earn significantly less than what mothers of children ... has found. These moms even earn less than mothers ... with autism earned, on average, less than $21,000 a year, ...
... clearer understanding of glaucoma | Back to top , Glaucoma ... blindness worldwide. In glaucoma patients, the optic nerve, which relays ... the molecular cause of nerve damage is unclear. Dr. Simon ... to understand the earliest events that lead to optic nerve ...
... American children leaving doctors, offices with an attention deficit ... 10 years, according to a new Northwestern Medicine study. ... physicians, have begun treating an increasing number of these ... which was published in the March/April issue of the ...
... HealthDay Reporter , MONDAY, March 19 (HealthDay ... cholesterol, might reduce a bit the risk of developing ... from a large international study that looked at the ... trial included almost 18,000 adults aged 50 or older ...
... University of Granada researchers have developed a software tool ... a person has to suffer a heart disease. In ... risk estimations, i.e. it helps estimating the risk that ... condition. The researchers employed a sample including 3 000 patients. ...
... , SUNDAY, March 18 (HealthDay News) -- Varicose ... can be a sign of a serious medical problem for ... Americans have varicose veins, and about 6 percent have more ... Peter Gloviczki, a vascular surgeon at the Mayo Clinic in ...
Cached Medicine News:Health News:Mothers of Kids With Autism Earn Less, Study Shows 2Health News:Mothers of Kids With Autism Earn Less, Study Shows 3Health News:JCI early table of contents for March 19, 2012 2Health News:JCI early table of contents for March 19, 2012 3Health News:JCI early table of contents for March 19, 2012 4Health News:JCI early table of contents for March 19, 2012 5Health News:JCI early table of contents for March 19, 2012 6Health News:JCI early table of contents for March 19, 2012 7Health News:JCI early table of contents for March 19, 2012 8Health News:JCI early table of contents for March 19, 2012 9Health News:Diagnosis of ADHD on the rise 2Health News:Could Statins Help Prevent Pneumonia? 2Health News:Could Statins Help Prevent Pneumonia? 3Health News:Scientists develop a software tool for estimating heart disease risk 2
(Date:10/30/2014)... 30, 2014 , Extensively hydrolyzed ... milk   Cow milk protein allergy (CMPA) is the leading ... Until now, it has been managed by eliminating milk ... shown that it is possible to help build of ... of children during the first year of life by ...
(Date:10/30/2014)... YORK , Oct. 29, 2014 ... the basis of test type, technology, product, and ... register the highest growth rate in the newborn ... This high growth is attributed to various nations ... is a fundamental instrument used for expanded newborn ...
(Date:10/30/2014)... Hospital stretchers are apparatus used to ... inside or outside of medical infrastructure premises. In ... used for several specialized functions such as hospital ... The hospital stretchers market report studies ... potential of hospital stretchers globally. The hospital stretchers ...
Breaking Medicine Technology:Experts Present Latest Research at Allergy Day 2Experts Present Latest Research at Allergy Day 3NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 2NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 3Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3
... from the latest 60 series bronchoscopes., ... range, focussing on providing clinicians with ... Olympus has a impressive range of ... in the respiratory tract to meet ...
Fujinon's standard fiberoptic bronchoscope is fully submersible and offers a large image for more comfortable and efficient observation....
... performance fiberoptic imaging from the latest ... improved its fiberscope range, focussing on ... enhanced image performance. Olympus has a ... diagnosis and therapy in the respiratory ...
... The BF-1T40 has been designed with a ... in therapeutic applications. This permits the selection ... those for electrosurgical procedures. In addition, this ... field of view and a bright, high-resolution ...
Medicine Products: