Navigation Links
UCLA stem cell researchers move toward treatment for rare genetic nerve disease
Date:5/10/2013

Led by Dr. Peiyee Lee and Dr. Richard Gatti, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have used induced pluripotent stem (iPS) cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia (A-T).

Their discovery shows the positive effects of drugs that may lead to effective new treatments for the neurodegenerative disease. iPS cells are made from patients' skin cells, rather than from embryos, and they can become any type of cells, including brain cells, in the laboratory. The study appears online ahead of print in the journal Nature Communications.

People with A-T begin life with neurological deficits that become devastating through progressive loss of function in a part of the brain called the cerebellum, which leads to severe difficulty with movement and coordination. A-T patients also suffer frequent infections due to their weakened immune systems and have an increased risk for cancer. The disease is caused by lost function in a gene, ATM, that normally repairs damaged DNA in the cells and preserves normal function.

Developing a human neural cell model to understand A-T's neurodegenerative process and create a platform for testing new treatments was critical because the disease presents differently in humans and laboratory animals. Scientists commonly use mouse models to study A-T, but mice with the disease do not experience the more debilitating effects that humans do. In mice with A-T, the cerebellum appears normal and they do not exhibit the obvious degeneration seen in the human brain.

Lee and colleagues used iPS cellderived neural cells developed from skin cells of A-T patients with a specific type of genetic mutation to create a disease-in-a-dish model. In the laboratory, researchers were able to model the characteristics of A-T, such as the cell's lack of ATM protein and its inability to repair DNA damage.
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers Pinpoint Cause of Port-Wine Stain Birthmarks
2. Duke researchers describe how breast cancer cells acquire drug resistance
3. CWRU School of Medicine researchers discover new target for personalized cancer therapy
4. U of M researchers discover link between heart, blood, and skeletal muscle
5. Researchers determine where best to place defibrillators
6. Researchers plot locations where AEDs could save more lives
7. Gene Mutation Linked to Migraines, Researchers Say
8. Discovery of New Cause of Congenital Hydrocephalus Opens the Door to Collaborative Research Study, Hydrocephalus Association Commends Researchers
9. Northwestern Medicine researchers work to improve heart attack response time
10. NYU and NYU Langone researchers devise method for enhancing CEST MRI
11. Medicaid-insured children have limited access to dermatologists, SLU researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... FL (PRWEB) April 01, 2015 South ... received Provisional Certificate of Authority (PCOA) approval from the ... step in the ongoing development of a retirement community ... individual health, wellness and spiritual development. , America’s aging ... to meet the housing needs of seniors, according to ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 IQ Formulations ... health and nutritional supplement companies in the U.S., today is ... testing and quality control standards for its herbal supplements.* GNC ... supply chain to ensure the accuracy of labeling on its ... veteran and IQ Formulations CEO Jay Cohen said: ...
(Date:4/1/2015)... Texas (PRWEB) April 01, 2015 ... and Distinguished Teaching Professor of the Department of ... with other doctors to review reports of blindness resulting ... cosmetic surgery . The group published their study, along ... and Reconstructive Surgery journal. , "We began to see ...
(Date:4/1/2015)... April 01, 2015 Senior Helpers of ... Home Care Provider of Choice Award by Home Care Pulse. ... is given to home care providers who receive the ... best-in-class for quality in home care. This recognition reassures you ... and will provide you with quality, trustworthy in home care. ...
(Date:4/1/2015)... Wayne, PA (PRWEB) April 01, 2015 ... critical points in the talent lifecycle, and the premiere ... Hiring Expert Series will feature a webinar on “Using ... presented by the chief human resources officer of MorseLife, ... support services for seniors and their families in Palm ...
Breaking Medicine News(10 mins):Health News:Casa Sant’Angelo Receives Approval for New Retirement Living 2Health News:IQ Formulations Applauds GNC for Enhancing Its Testing and Quality Control Processes for Herbal Supplements 2Health News:Dr. Rod J. Rohrich and Colleagues Study Rare Occurrences of Blindness Caused by Use of Facial Fillers 2Health News:Dr. Rod J. Rohrich and Colleagues Study Rare Occurrences of Blindness Caused by Use of Facial Fillers 3Health News:Senior Helpers of Central Texas Awarded Prestigious 2015 Senior Home Care Provider of Choice Award from Home Care Pulse 2Health News:SkillSurvey Hiring Expert Series Continues with Webinar Featuring MorseLife 2Health News:SkillSurvey Hiring Expert Series Continues with Webinar Featuring MorseLife 3
... The Center for Professional Innovation & Education (CfPIE) announced today ... existing list of highly-successful biotech and pharmaceutical training courses. ... developed to provide life sciences personnel with the kind of ... , ...
... , ... Denver, CO (PRWEB) July 8, 2008 --Innovative Routines ... FL, has just recorded its 30th year in the software industry ... in particular. IRI's flagship CoSort product is used worldwide in legacy ...
... to recruit large percentage of African American ... ... double,a person,s weight loss according to a study from Kaiser Permanente,s Center,for ... loss maintenance trials ever conducted, will be published in,the August issue of ...
... 7 Accuray,Incorporated (Nasdaq: ARAY ), a global ... will report results for its fourth quarter and,fiscal year ... 2008 after,the market closes., A conference call to ... p.m. EDT) and will be hosted by Euan S. ...
... Calif., July 7 Nationwide,Health Properties, Inc. (NYSE: ... second quarter earnings on Wednesday, August 6, 2008 after ... The Company will host a,conference call on Thursday, August ... time) in order to present the Company,s financial,performance and ...
... molecular "smart bombs" to target metastasis with anti-cancer drugs ... toxic chemotherapy, with less collateral damage to surrounding tissue, ... University of California, San Diego. By designing a ... led by Moores UCSD Cancer Center Director of Translational ...
Cached Medicine News:Health News:The Center for Professional Innovation and Education (CfPIE) Announces a New Global Regulatory Certification Track 2Health News:The Center for Professional Innovation and Education (CfPIE) Announces a New Global Regulatory Certification Track 3Health News:IRI, The CoSort Company, Marks 30 Years 2Health News:IRI, The CoSort Company, Marks 30 Years 3Health News:Kaiser Permanente Study Finds Keeping a Food Diary Doubles Diet Weight Loss 2Health News:Kaiser Permanente Study Finds Keeping a Food Diary Doubles Diet Weight Loss 3Health News:Kaiser Permanente Study Finds Keeping a Food Diary Doubles Diet Weight Loss 4Health News:Accuray Incorporated to Report Fourth Quarter and Fiscal Year 2008 Financial Results 2Health News:NHP Announces Second Quarter Earnings Release Date and Conference Call/Webcast 2Health News:NHP Announces Second Quarter Earnings Release Date and Conference Call/Webcast 3Health News:'Smart bomb' nanoparticle strategy impacts metastasis 2
(Date:4/1/2015)... MARLBOROUGH, Mass. , April 1, 2015  Boston Scientific ... on Tuesday, April 28, 2015 at 8 a.m. ET to ... 2015. The company will issue a news release announcing first ... The call will be hosted by Mike Mahoney , ... executive vice president and chief financial officer. A ...
(Date:4/1/2015)... 1, 2015  For many businesses and industries just ... the case, having the right management software can be ... better than software solutions company TraxStar Technologies , ... the company announced the release of the newest version ... "QATrax ...
(Date:4/1/2015)... 1, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... new medical paper has been published describing the ... patients with severe dry eye.  The results met ... physicians stated that statistically significant differences in both ... seen at various time points throughout the study.  ...
Breaking Medicine Technology:Boston Scientific To Webcast Conference Call On First Quarter 2015 Financial Results 2TraxStar Technologies Announces Latest QATrax Test Lab Management Software Now Available 2RegeneRx's RGN-259 Meets Key Efficacy Objectives in Phase 2 Clinical Trial in Patients with Severe Dry Eye Reported in Current Issue of Cornea 2RegeneRx's RGN-259 Meets Key Efficacy Objectives in Phase 2 Clinical Trial in Patients with Severe Dry Eye Reported in Current Issue of Cornea 3
... China, April 6, 2011 /PRNewswire-Asia-FirstCall/ -- Mindray Medical International ... manufacturer and marketer of medical devices worldwide, announced today ... Equipment Fair ("CMEF") in Shenzhen, China from April 16 ... more than 70 devices from its three core product ...
... BEACH, Fla., April 6, 2011 River Valley ... Messenger have partnered together to add ONC Certified(1) ... major curriculum bullets include: Electronic ... Patient Demographics, Clinical Decision Support, Patient ...
Cached Medicine Technology:Mindray Medical to Exhibit New Products at 65th China International Medical Equipment Fair 2River Valley Community College and Medical Messenger Team Up to Prepare the Future Nurses of New England 2
The Emit 2000 Digoxin Calibrators are intended for use with the Emit 2000 Digoxin Assay....
... Akers, our ultimate goal is to provide ... and immediate treatment. Each year millions of ... die from late detection or undetected disease ... cripple nations., ,By developing, manufacturing and marketing ...
... The BD Macro-Vue RPR (Rapid Plasma ... Tear-drop Tests are nontreponemal testing procedures ... described in A Manual of Tests ... this manual are the most widely ...
Rapid Plasma Reagin (RPR) set is a non-treponemal flocculation test that is,used for the qualitative and semi-quantitative determination of reagin,antibodies in serum or plasma from persons with syph...
Medicine Products: