Navigation Links
UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
Date:11/14/2008

Receptor positive cancers. These patients have several drugs available, such as Tamoxifen, that suppress the actions of estrogen on breast cancer tissue and thus control the disease.

Next up, Lane and his team plan to use protein chemistry and genetic tools to uncover the molecular components that participate in this new proteasome targeting complex, which could identify alterations like HER-2 - that can be targeted in cancer cells and leave the healthy cells alone. That would give patients with this aggressive cancer sub-type a more effective and less toxic option than chemotherapy.

"This research has the potential to identify clinically relevant markers of a large subgroup of human breast cancer and find a novel therapeutic target that could be exploited with appropriate pharmaceutical agents," said Lane, who is an associate professor of obstetrics and gynecology. "We need a new paradigm to think about how to treat these cancers."

Lane's research also showed that basal-like breast cancer cells are most like breast stem cells, which generate the tissues of the breast. One way they're alike is that they are resistant to chemotherapy and do not express mature breast markers like estrogen receptor. These features make basal-like breast cancers so difficult to treat.

Another mystery Lane and his team hope to focus on is why basal-like breast cancers are over-represented in African American women. It could be related to genetic features in the patient, or to other complex factors such as access to effective early intervention, Lane said.

Lane is currently working to validate his work in human disease and identify all the key players in this molecular pathway.

"We're still missing a couple of the key players. We currently understand the shape and general features of the complex, but hope to find all the components in the next couple of years," Lane said. "It is a great time to be involved in this research."
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2804
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... flu season approaches, the best way to stay healthy ... and a checkup, according to an infectious disease specialist. ... against the flu, and also address other health concerns ... flu shots for their customers, but they can,t dole ... of infection prevention and control for the Loyola University ...
(Date:9/20/2014)... New York, New York (PRWEB) September 20, 2014 ... of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in ... notes that yet another insurer has announced plans ... a statement posted on its website last month, ... such procedures effective November 1, 2014. The insurer ...
(Date:9/20/2014)... 20, 2014 Traditionally dentists have advised their ... South Charlotte Dentistry is re-visiting that advice and changing ... that coffee and wine have on oral health. “There’s good ... that coffee may be beneficial in protecting against gum disease, ... The study on coffee was from the September 2014 ...
(Date:9/20/2014)... NY (PRWEB) September 20, 2014 Earlier this ... their customers may have had their credit card information pilfered ... year, spawning a slew of headline articles like this ... weren’t the only eye opening numbers. , “Most people ... stolen, almost like it’s a way to score a game,” ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 The Arizona ... College (MCC) is celebrating National Manufacturing Day by opening ... enhanced machining, processing and additive manufacturing labs will be ... 3, 2014 at MCC’s Southern and Dobson campus (1833 ... in southeast Lot D. , The AzAMI at MCC ...
Breaking Medicine News(10 mins):Health News:Get a Flu Shot During Checkup, Doctor Says 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2
... , ... on the Practice Turf of Physicians? A Study Commissioned by Jackson & Coker Offers an ... Alpharetta, GA ... health care -- compounded with the shortage of physicians in major medical specialties -- the ...
... , ... its second flagship location as part of its national expansion plan revolutionizing the ... fitness, while Throwdown®, one of the leading brands in action and impact sports, debuts ... ...
... of what makes those relationships so golden during the ... more likely to forgive and respect one,s elders, according ... better marriages, more supportive friendships and less conflict with ... in Gerontology, Developmental and Family Studies. "While physical and ...
... HealthDay Reporter , THURSDAY, June 24 (HealthDay News) -- Diabetes ... attack, stroke or other heart condition, a new study finds. ... deaths from cardiovascular disease, or about 325,000 deaths a year ... people with diabetes are more likely to have heart attacks," ...
... ... Tests, including QuantiFERON®-TB, to Diagnose Tuberculosis Infection in Certain Populations , ... Valencia, CA (PRWEB) June 25, 2010 ... and important guidelines on the detection of Mycobacterium tuberculosis infections, the causative agent of ...
... ... at providing resources that will educate staff to make positive choices aimed at optimizing ... ... Company for carriers, service providers, VARs, and equipment manufacturers, is pleased to announce a ...
Cached Medicine News:Health News:Are Advanced Practitioners Stepping on the Practice Turf of Physicians? 2Health News:Are Advanced Practitioners Stepping on the Practice Turf of Physicians? 3Health News:Are Advanced Practitioners Stepping on the Practice Turf of Physicians? 4Health News:Are Advanced Practitioners Stepping on the Practice Turf of Physicians? 5Health News:Are Advanced Practitioners Stepping on the Practice Turf of Physicians? 6Health News:Throwdown, a Leader in Impact and Action Sports, Debuts Latest Innovations at the Newest UFC Gym™ in Rosemead, California 2Health News:Throwdown, a Leader in Impact and Action Sports, Debuts Latest Innovations at the Newest UFC Gym™ in Rosemead, California 3Health News:Throwdown, a Leader in Impact and Action Sports, Debuts Latest Innovations at the Newest UFC Gym™ in Rosemead, California 4Health News:Throwdown, a Leader in Impact and Action Sports, Debuts Latest Innovations at the Newest UFC Gym™ in Rosemead, California 5Health News:Friendships, family relationships get better with age thanks to forgiveness, stereotypes 2Health News:Friendships, family relationships get better with age thanks to forgiveness, stereotypes 3Health News:Diabetes May Double Risk of Heart Attack, Stroke 2Health News:Diabetes May Double Risk of Heart Attack, Stroke 3Health News:TB Claims One Life Every 17 Seconds; Almost Two Million People Each Year 2Health News:TB Claims One Life Every 17 Seconds; Almost Two Million People Each Year 3Health News:Endeavor Telecom Introduces Upgraded Company Health Initiative to Encourage Healthy Lifestyle Choices 2
(Date:9/19/2014)... 2014  Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ... and approved all parts required to build nine ... to manufacture the new PCT-based instrument system.  The ... for shipment by mid-October and that additional Barozyme ... rate of about one per week thereafter.  ...
(Date:9/19/2014)... , Sept. 19, 2014  The body of ... the publication of two papers this past week.  The ... Head and Neck Surgery , finds that withholding ... subjective measures of sleep disordered breathing, leading the paper,s ... in obstructive sleep apnea severity and improvement of quality ...
(Date:9/19/2014)... , Sept. 19, 2014 Intarcia ... interim clinical data for its lead candidate ITCA 650 ... patients with high baseline HbA1c levels at the 50 ... the Study of Diabetes (EASD). Data from the open-label, ... levels of blood sugar in patients with poorly controlled ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4
Baby Weitlaner retractor, blunt, 4"....
Daubenspeck sharp curette, 8....
MRI curette, 8.5" overall length....
9.5" overall length, 4.5" handle....
Medicine Products: